A single mutation in the VP1 of enterovirus 71 is responsible for increased virulence and neurotropism in adult interferon-deficient mice

Journal of Virology

Volumn 90, Issue 19, 2016, Pages 8592-8604

  Caine, Elizabeth A ^a   Moncla, Louise H ^a   Ronderos, Monica D ^a   Friedrich, Thomas C ^a   Osorio, Jorge E ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN VP1; INTERFERON; MUTANT PROTEIN; VIRAL PROTEIN; VIRULENCE FACTOR;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; ENTEROVIRUS 71; GENETIC ANALYSIS; HAND FOOT AND MOUTH DISEASE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INTERFERON PRODUCTION; MOUSE; NEUROTROPISM; NEXT GENERATION SEQUENCING; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEFICIENCY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ALIGNMENT; TISSUE DISTRIBUTION; VIRUS LOAD; VIRUS NEUTRALIZATION; VIRUS REPLICATION; VIRUS STRAIN; VIRUS VIRULENCE; ANIMAL; ANIMAL STRUCTURES; DEFICIENCY; DISEASE MODEL; ENTEROVIRUS A; GENETICS; METABOLISM; MISSENSE MUTATION; PATHOGENICITY; PATHOLOGY; REVERSE GENETICS; SERUM; VIROLOGY; VIRULENCE; VIRUS ENCEPHALITIS; VIRUS MENINGITIS;

ADULT; ANIMAL STRUCTURES; ANIMALS; DISEASE MODELS, ANIMAL; ENCEPHALITIS, VIRAL; ENTEROVIRUS A, HUMAN; HUMANS; INTERFERONS; MENINGITIS, VIRAL; MICE; MUTANT PROTEINS; MUTATION, MISSENSE; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE GENETICS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SERUM; VIRAL LOAD; VIRAL STRUCTURAL PROTEINS; VIRULENCE; VIRULENCE FACTORS;

EID: 84990174430     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01370-16     Document Type: Article

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