A non-mouse-adapted enterovirus 71 (EV71) strain exhibits neurotropism, causing neurological manifestations in a novel mouse model of EV71 infection

Journal of Virology

Volumn 86, Issue 4, 2012, Pages 2121-2131

  Khong, Wei Xin ^a,b   Yan, Benedict ^c   Yeo, Huimin ^a   Tan, Eng Lee ^d   Lee, Jia Jun ^d   Ng, Jowin K W ^a   Chow, Vincent T ^a   Alonso, Sylvie ^a,b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c NATIONAL UNIVERSITY HEALTH SYSTEM   (Singapore)

^d SINGAPORE POLYTECHNIC   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON RECEPTOR; VIRUS VACCINE;

129 MOUSE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIVIRAL THERAPY; ARTICLE; BRAIN DAMAGE; BRAIN STEM; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DEATH; DISEASE ASSOCIATION; DISEASE MODEL; DISEASE SEVERITY; ENTEROVIRUS 71; ENTEROVIRUS 71 INFECTION; HAND FOOT AND MOUTH DISEASE; HISTOPATHOLOGY; INFECTION PREVENTION; INFECTION SENSITIVITY; INOCULATION; MOUSE; MUSCLE INJURY; NEUROLOGIC DISEASE; NEUROTROPISM; NONHUMAN; PARALYSIS; POLIOMYELITIS; PRIORITY JOURNAL; SOUTHEAST ASIA; SPINAL CORD LESION; SPINAL CORD VENTRAL HORN; VIRUS INFECTION; VIRUS PARTICLE; VIRUS PATHOGENESIS; VIRUS STRAIN; VIRUS TRANSMISSION;

ANIMALS; ANTIBODIES, VIRAL; CENTRAL NERVOUS SYSTEM; CYTOKINES; DISEASE MODELS, ANIMAL; ENTEROVIRUS A, HUMAN; ENTEROVIRUS INFECTIONS; HUMANS; MICE; MICE, INBRED STRAINS; SPECIFIC PATHOGEN-FREE ORGANISMS; VIRAL TROPISM;

ANIMALIA; HUMAN ENTEROVIRUS 71; MUS;

EID: 84863116695     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.06103-11     Document Type: Article

References (41)

1. Chang LY, Huang YC, Lin TY. 1998. Fulminant neurogenic pulmonary oedema with hand, foot, and mouth disease. Lancet 352:367-368.
2. Chen CY, et al. 2001. Acute flaccid paralysis in infants and young children with enterovirus 71 infection:MRimaging findings and clinical correlates. Am. J. Neuroradiol. 22:200-205.
3. Chen C-S, et al. 2007. Retrograde axonal transport: a major transmission route of enterovirus 71 in mice. J. Virol. 81:8996-9003.
4. Chen Y-C, et al. 2004. A murine oral enterovirus 71 infection model with central nervous system involvement. J. Gen. Virol. 85:69-77.
5. Douche-Aourik F, et al. 2003. Detection of enterovirus in human skeletal muscle from patients with chronic inflammatory muscle disease or fibromyalgia and healthy subjects. J. Med. Virol. 71:540-547.
6. Hashimoto I, Hagiwara A. 1983. Comparative studies on the neurovirulence of temperature-sensitive and temperature-resistant viruses of enterovirus 71 in monkeys. Acta Neuropathol. 60:266-270.
7. Huang CC, et al. 1999. Neurologic complications in children with enterovirus 71 infection. N. Engl. J. Med. 341:936-942.
8. Khong WX, Foo DGW, Trasti SL, Tan EL, Alonso S. 2011. Sustained high levels of interleukin-6 contribute to the pathogenesis of enterovirus 71 in a neonate mouse model. J. Virol. 85:3067-3076.
9. Kjerrulf M, et al. 1997. Interferon-gamma receptor-deficient mice exhibit impaired gut mucosal immune responses but intact oral tolerance. Immunology 92:60-68.
10. Kuebler JF, Czech-Schmidt G, Leonhardt J, Ure BM, Petersen C. 2006. Type-I but not type-II interferon receptor knockout mice are susceptible to biliary atresia. Pediatr. Res. 59:790-794.
11. Kuss SK, Etheredge CA, Pfeiffer JK. 2008. Multiple host barriers restrict poliovirus trafficking in mice. PLoS Pathog. 4:e1000082.
12. Lee M-S, Chang L-Y. 2010. Development of enterovirus 71 vaccines. Expert Rev. Vaccines 9:149-156.
13. Li Z-H, et al. 2008. Ribavirin reduces mortality in enterovirus 71-infected mice by decreasing viral replication. J. Infect. Dis. 197:854-857.
14. Lin T-Y, Hsia S-H, Huang Y-C, Wu C-T, Chang L-Y. 2003. Proinflammatory cytokine reactions in enterovirus 71 infections of the central nervous system. Clin. Infect. Dis. 36:269-274.
15. Liu L, et al. 2011. Neonatal rhesus monkey is a potential animal model for studying pathogenesis of EV71 infection. Virology 412:91-100.
16. Liu M-L, et al. 2005. Type I interferons protect mice against enterovirus 71 infection. J. Gen. Virol. 86:3263-3269.
17. Nagata N, et al. 2004. Differential localization of neurons susceptible to enterovirus 71 and poliovirus type 1 in the central nervous system of cynomolgus monkeys after intravenous inoculation. J. Gen. Virol. 85:2981-2989.
18. Nathanson N. 2008. The pathogenesis of poliomyelitis: what we don't know. Adv. Virus Res. 71:1-50.
19. Ong K, et al. 2008. Pathologic characterization of a murine model of human enterovirus 71 encephalomyelitis. J. Neuropathol. Exp. Neurol. 67:532.
20. Ooi MH, Wong SC, Lewthwaite P, Cardosa MJ, Solomon T. 2010. Clinical features, diagnosis, and management of enterovirus 71. Lancet Neurol. 9:1097-1105.
21. Ooi MH, et al. 2009. Identification and validation of clinical predictors for the risk of neurological involvement in children with hand, foot, and mouth disease in Sarawak. BMC Infect. Dis. 9:3.
22. Ooi MH, et al. 2007. Human enterovirus 71 disease in Sarawak, Malaysia: a prospective clinical, virological, and molecular epidemiological study. Clin. Infect. Dis. 44:646-656.
23. Ren R, Racaniello VR. 1992. Poliovirus spreads from muscle to the central nervous system by neural pathways. J. Infect. Dis. 166:747-752.
24. Ryman KD, Meier KC, Gardner CL, Adegboyega PA, Klimstra WB. 2007. Non-pathogenic Sindbis virus causes hemorrhagic fever in the absence of alpha/beta and gamma interferons. Virology 368:273-285.
25. Sasaki O, Karaki T, Imanishi J. 1986. Protective effect of interferon on infections with hand, foot, and mouth disease virus in newborn mice. J. Infect. Dis. 153:498-502.
26. Shen WC, Chiu HH, Chow KC, Tsai CH. 1999. MR imaging findings of enteroviral encephaloymelitis: an outbreak in Taiwan. Am. J. Neuroradiol. 20:1889-1895.
27. Singh S, Poh CL, Chow VTK. 2002. Complete sequence analyses of enterovirus 71 strains from fatal and non-fatal cases of the hand, foot and mouth disease outbreak in Singapore (2000). Microbiol. Immunol. 46:801-808.
28. Solomon T, et al. 2010. Virology, epidemiology, pathogenesis, and control of enterovirus 71. Lancet Infect. Dis. 10:778-790.
29. Tan GK, et al. 2010. A non mouse-adapted dengue virus strain as a new model of severe dengue infection in AG129 mice. PLoS Negl. Trop. Dis. 4:672.
30. van den Broek MF, Müller U, Huang S, Aguet M, Zinkernagel RM. 1995. Antiviral defense in mice lacking both alpha/beta and gamma interferon receptors. J. Virol. 69:4792-4796.
31. Verboon-Maciolek MA, et al. 2008. White matter damage in neonatal enterovirus meningoencephalitis. Neurology 71:536.
32. Wang S-M, et al. 2007. Cerebrospinal fluid cytokines in enterovirus 71 brain stem encephalitis and echovirus meningitis infections of varying severity. Clin. Microbiol. Infect. 13:677-682.
33. Wang S-M, et al. 2003. Pathogenesis of enterovirus 71 brainstem encephalitis in pediatric patients: roles of cytokines and cellular immune activation in patients with pulmonary edema. J. Infect. Dis. 188:564-570.
34. Wang S-M, et al. 2008. Acute chemokine response in the blood and cerebrospinal fluid of children with enterovirus 71-associated brainstem encephalitis. J. Infect. Dis. 198:1002-1006.
35. Wang W, et al. 2011. A mouse muscle-adapted enterovirus 71 strain with increased virulence in mice. Microbes Infect. 13:862-870.
36. Weng K-F, Chen L-L, Huang P-N, Shih S-R. 2010. Neural pathogenesis of enterovirus 71 infection. Microbes Infect. 12:505-510.
37. Wong KT, et al. 2008. The distribution of inflammation and virus in human enterovirus 71 encephalomyelitis suggests possible viral spread by neural pathways. J. Neuropathol. Exp. Neurol. 67:162-169.
38. Wu CN, et al. 2001. Protection against lethal enterovirus 71 infection in newborn mice by passive immunization with subunit VP1 vaccines and inactivated virus. Vaccine 20:895-904.
39. Yang K, Yang M, Li C, Lin S. 2001. Altered cellular but not humoral reactions in children with complicated enterovirus 71 infections in Taiwan. J. Infect. Dis. 183:85-86.
40. Yi L, Lu J, Kung H-F, He M-L. 9 June 2011, posting date. The virology and developments toward control of human enterovirus 71. Crit. Rev. Microbiol. doi:10.3109/1040841X.2011.580723.
41. Zhang Y, et al. 9 May 2011, posting date. Pathogenesis study of enterovirus 71 infection in rhesus monkeys. Lab. Invest. doi:10.1038/labinvest.2011.82.