MiR-138-5p promotes TNF-α-induced apoptosis in human intervertebral disc degeneration by targeting SIRT1 through PTEN/PI3K/Akt signaling

Experimental Cell Research

Volumn 345, Issue 2, 2016, Pages 199-205

  Wang, Bing ^a   Wang, Dongqi ^a   Yan, Tao ^b   Yuan, Huijun ^a  

^a MEDICAL SCHOOL OF XI AN JIAOTONG UNIVERSITY   (China)

^b Xi'an XD Group Hospital   (China)

Author keywords

Apoptosis; Intervertebral disc degeneration (IDD); MiR 138 5p; Nucleus pulposus (NP); SIRT1 PTEN PI3K Akt

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CASPASE 3; LUCIFERASE; MICRORNA; MICRORNA 138 5P; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; SIRTUIN 1; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; 3' UNTRANSLATED REGION; MIRN138 MICRORNA, HUMAN; PTEN PROTEIN, HUMAN;

ADULT; APOPTOSIS; ARTICLE; CELL SURVIVAL; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; INTERVERTEBRAL DISK DEGENERATION; NUCLEUS PULPOSUS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; 3' UNTRANSLATED REGION; ADOLESCENT; DRUG EFFECTS; GENETICS; METABOLISM; NUCLEOTIDE SEQUENCE; PATHOLOGY; YOUNG ADULT;

3' UNTRANSLATED REGIONS; ADOLESCENT; ADULT; APOPTOSIS; BASE SEQUENCE; DOWN-REGULATION; HUMANS; INTERVERTEBRAL DISC DEGENERATION; MICRORNAS; NUCLEUS PULPOSUS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; SIGNAL TRANSDUCTION; SIRTUIN 1; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION; YOUNG ADULT;

EID: 84990052494     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2016.05.011     Document Type: Article

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