SIRT1 inhibits apoptosis of degenerative human disc nucleus pulposus cells through activation of Akt pathway

Age

Volumn 35, Issue 5, 2013, Pages 1741-1753

  Wang, Dawu ^a   Hu, Zhenming ^a   Hao, Jie ^a   He, Bin ^a   Gan, Qiang ^a   Zhong, Xiaoming ^a   Zhang, Xiaojun ^a   Shen, Jieliang ^a   Fang, Ji ^a   Jiang, Wei ^a  

^a THE FIRST AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Akt pathway; Apoptosis; Degenerative disc disease; Nucleus pulposus cells; SIRT1

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CASPASE 3; MESSENGER RNA; NICOTINAMIDE; PROTEIN KINASE B; RESVERATROL; SIRTUIN 1; SMALL INTERFERING RNA;

ADULT; AGED; APOPTOSIS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; ENZYME PHOSPHORYLATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; LUMBAR VERTEBRA; MALE; NUCLEUS PULPOSUS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SPINE FRACTURE;

ADULT; AGED; APOPTOSIS; BLOTTING, WESTERN; CELLS, CULTURED; ENZYME INHIBITORS; FEMALE; GENE EXPRESSION REGULATION; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; INTERVERTEBRAL DISC DEGENERATION; LUMBAR VERTEBRAE; MALE; MIDDLE AGED; PROTO-ONCOGENE PROTEINS C-AKT; REAL-TIME POLYMERASE CHAIN REACTION; RIBONUCLEOTIDE REDUCTASES; RNA, MESSENGER; SIGNAL TRANSDUCTION; SIRTUIN 1; STILBENES; YOUNG ADULT;

EID: 84892581395     PISSN: 01619152     EISSN: 15744647     Source Type: Journal    
DOI: 10.1007/s11357-012-9474-y     Document Type: Article

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