메뉴 건너뛰기




Volumn 48, Issue 4, 2016, Pages 1052-1062

Comorbidities and elevated IL-6 associate with negative outcome in adult-onset asthma

Author keywords

[No Author keywords available]

Indexed keywords

BUDESONIDE; C REACTIVE PROTEIN; CORTICOSTEROID; HIGH SENSITIVITY C REACTIVE PROTEIN; INTERLEUKIN 6; UNCLASSIFIED DRUG; IL6 PROTEIN, HUMAN;

EID: 84990046735     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/13993003.02198-2015     Document Type: Article
Times cited : (77)

References (45)
  • 1
    • 77955896917 scopus 로고    scopus 로고
    • Long-term studies of the natural history of asthma in childhood
    • Bisgaard H, Bønnelykke K. Long-term studies of the natural history of asthma in childhood. J Allergy Clin Immunol 2010; 126: 187-197.
    • (2010) J Allergy Clin Immunol , vol.126 , pp. 187-197
    • Bisgaard, H.1    Bønnelykke, K.2
  • 2
    • 84946045172 scopus 로고    scopus 로고
    • Phenotypes, risk factors and mechanisms of adult-onset asthma
    • Ilmarinen P, Tuomisto LE, Kankaanranta H. Phenotypes, risk factors and mechanisms of adult-onset asthma. Mediators Inflamm 2015; 2015: 1-19.
    • (2015) Mediators Inflamm , vol.2015 , pp. 1-19
    • Ilmarinen, P.1    Tuomisto, L.E.2    Kankaanranta, H.3
  • 3
    • 84876547480 scopus 로고    scopus 로고
    • Three phenotypes of adult-onset asthma
    • Amelink M, de Nijs SB, de Groot JC, et al. Three phenotypes of adult-onset asthma. Allergy 2013; 68: 674-680.
    • (2013) Allergy , vol.68 , pp. 674-680
    • Amelink, M.1    De Nijs, S.B.2    De Groot, J.C.3
  • 4
    • 84860679595 scopus 로고    scopus 로고
    • Asthma phenotypes: The evolution from clinical to molecular approaches
    • Wenzel SE. Asthma phenotypes: the evolution from clinical to molecular approaches. Nat Med 2012; 18: 716-725.
    • (2012) Nat Med , vol.18 , pp. 716-725
    • Wenzel, S.E.1
  • 5
    • 84933071619 scopus 로고    scopus 로고
    • Prognosis of new-onset asthma diagnosed at adult age
    • Tuomisto LE, Ilmarinen P, Kankaanranta H. Prognosis of new-onset asthma diagnosed at adult age. Respir Med 2015; 109: 944-954.
    • (2015) Respir Med , vol.109 , pp. 944-954
    • Tuomisto, L.E.1    Ilmarinen, P.2    Kankaanranta, H.3
  • 6
    • 77955293478 scopus 로고    scopus 로고
    • Burden of comorbidity in individuals with asthma
    • Gershon AS, Wang C, Guan J, et al. Burden of comorbidity in individuals with asthma. Thorax 2010; 65: 612-618.
    • (2010) Thorax , vol.65 , pp. 612-618
    • Gershon, A.S.1    Wang, C.2    Guan, J.3
  • 7
    • 84971624311 scopus 로고    scopus 로고
    • Emerging comorbidities in adult asthma: Risks, clinical associations and mechanisms
    • Kankaanranta H, Kauppi P, Tuomisto LE, et al. Emerging comorbidities in adult asthma: risks, clinical associations and mechanisms. Mediators Inflamm 2016; 2016: 3690628.
    • (2016) Mediators Inflamm , vol.2016 , pp. 3690628
    • Kankaanranta, H.1    Kauppi, P.2    Tuomisto, L.E.3
  • 8
    • 0037407336 scopus 로고    scopus 로고
    • The influence of comorbidity on health-related quality of life in asthma and COPD patients
    • Wijnhoven HA, Kriegsman DM, Hesselink AE, et al. The influence of comorbidity on health-related quality of life in asthma and COPD patients. Respir Med 2003; 97: 468-475.
    • (2003) Respir Med , vol.97 , pp. 468-475
    • Wijnhoven, H.A.1    Kriegsman, D.M.2    Hesselink, A.E.3
  • 9
    • 33750079228 scopus 로고    scopus 로고
    • What is worse for asthma control and quality of life: Depressive disorders, anxiety disorders, or both?
    • Lavoie KL, Bacon SL, Barone S, et al. What is worse for asthma control and quality of life: depressive disorders, anxiety disorders, or both? Chest 2006; 130: 1039-1047.
    • (2006) Chest , vol.130 , pp. 1039-1047
    • Lavoie, K.L.1    Bacon, S.L.2    Barone, S.3
  • 10
    • 84906308272 scopus 로고    scopus 로고
    • Obesity and symptoms of depression contribute independently to the poor asthma control of obesity
    • Kapadia SG, Wei C, Bartlett SJ, et al. Obesity and symptoms of depression contribute independently to the poor asthma control of obesity. Respir Med 2014; 108: 1100-1107.
    • (2014) Respir Med , vol.108 , pp. 1100-1107
    • Kapadia, S.G.1    Wei, C.2    Bartlett, S.J.3
  • 11
    • 84901301340 scopus 로고    scopus 로고
    • Comorbidity between depression and asthma via immune-inflammatory pathways: A meta-analysis
    • Jiang M, Qin P, Yang X. Comorbidity between depression and asthma via immune-inflammatory pathways: a meta-analysis. J Affect Disord 2014; 166: 22-29.
    • (2014) J Affect Disord , vol.166 , pp. 22-29
    • Jiang, M.1    Qin, P.2    Yang, X.3
  • 12
    • 84906055605 scopus 로고    scopus 로고
    • Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes
    • Esser N, Legrand-Poels S, Piette J, et al. Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes. Diabetes Res Clin Pract 2014; 105: 141-150.
    • (2014) Diabetes Res Clin Pract , vol.105 , pp. 141-150
    • Esser, N.1    Legrand-Poels, S.2    Piette, J.3
  • 13
    • 84933678127 scopus 로고    scopus 로고
    • Atherosclerosis in rheumatoid arthritis: Is it all about inflammation?
    • Skeoch S, Bruce IN. Atherosclerosis in rheumatoid arthritis: is it all about inflammation? Nat Rev Rheumatol 2015; 11: 390-400.
    • (2015) Nat Rev Rheumatol , vol.11 , pp. 390-400
    • Skeoch, S.1    Bruce, I.N.2
  • 14
    • 84922642868 scopus 로고    scopus 로고
    • From stress to inflammation and major depressive disorder: A social signal transduction theory of depression
    • Slavich GM, Irwin MR. From stress to inflammation and major depressive disorder: a social signal transduction theory of depression. Psychol Bull 2014; 140: 774-815.
    • (2014) Psychol Bull , vol.140 , pp. 774-815
    • Slavich, G.M.1    Irwin, M.R.2
  • 15
    • 84863797299 scopus 로고    scopus 로고
    • The neutrophilic inflammatory phenotype is associated with systemic inflammation in asthma
    • Wood LG, Baines KJ, Fu J, et al. The neutrophilic inflammatory phenotype is associated with systemic inflammation in asthma. Chest 2012; 142: 86-93.
    • (2012) Chest , vol.142 , pp. 86-93
    • Wood, L.G.1    Baines, K.J.2    Fu, J.3
  • 16
    • 84876122356 scopus 로고    scopus 로고
    • Systemic inflammation is associated with differential gene expression and airway neutrophilia in asthma
    • Fu JJ, Baines KJ, Wood LG, et al. Systemic inflammation is associated with differential gene expression and airway neutrophilia in asthma. OMICS 2013; 17: 187-199.
    • (2013) OMICS , vol.17 , pp. 187-199
    • Fu, J.J.1    Baines, K.J.2    Wood, L.G.3
  • 17
    • 84933056028 scopus 로고    scopus 로고
    • Seinajoki Adult Asthma Study (SAAS): A protocol for a 12-year real-life follow-up study of new-onset asthma diagnosed at adult age and treated in primary and specialised care
    • Kankaanranta H, Ilmarinen P, Kankaanranta T, et al. Seinajoki Adult Asthma Study (SAAS): a protocol for a 12-year real-life follow-up study of new-onset asthma diagnosed at adult age and treated in primary and specialised care. NPJ Prim Care Respir Med 2015; 25: 15042.
    • (2015) NPJ Prim Care Respir Med , vol.25 , pp. 15042
    • Kankaanranta, H.1    Ilmarinen, P.2    Kankaanranta, T.3
  • 18
    • 84938505628 scopus 로고    scopus 로고
    • Global Initiative for Asthma (GINA), Global Initiative for Chronic Obstructive Lung Disease (GOLD)., Date last accessed: April, 2015. Date last updated: April, 2015
    • Global Initiative for Asthma (GINA), Global Initiative for Chronic Obstructive Lung Disease (GOLD). Asthma, COPD and Asthma-COPD Overlap Syndrome (ACOS). www.goldcopd.org/ Date last accessed: April, 2015. Date last updated: April, 2015.
    • Asthma, COPD and Asthma-COPD Overlap Syndrome (ACOS)
  • 20
    • 17644363081 scopus 로고    scopus 로고
    • ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005
    • American Thoracic Society, European Respiratory Society. ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005. Am J Respir Crit Care Med 2005; 171: 912-930.
    • (2005) Am J Respir Crit Care Med , vol.171 , pp. 912-930
  • 21
    • 0031726830 scopus 로고    scopus 로고
    • Asthma health status measurement in clinical practice: Validity of a new short and simple instrument
    • Barley EA, Quirk FH, Jones PW. Asthma health status measurement in clinical practice: validity of a new short and simple instrument. Respir Med 1998; 92: 1207-1214.
    • (1998) Respir Med , vol.92 , pp. 1207-1214
    • Barley, E.A.1    Quirk, F.H.2    Jones, P.W.3
  • 23
    • 84863426446 scopus 로고    scopus 로고
    • Epidemiology of multimorbidity and implications for health care, research, and medical education: A cross-sectional study
    • Barnett K, Mercer SW, Norbury M, et al. Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study. Lancet 2012; 380: 37-43.
    • (2012) Lancet , vol.380 , pp. 37-43
    • Barnett, K.1    Mercer, S.W.2    Norbury, M.3
  • 24
    • 79956351574 scopus 로고    scopus 로고
    • Sputum IL-6 concentrations in severe asthma and its relationship with FEV1
    • Morjaria JB, Babu KS, Vijayanand P, et al. Sputum IL-6 concentrations in severe asthma and its relationship with FEV1. Thorax 2011; 66: 537.
    • (2011) Thorax , vol.66 , pp. 537
    • Morjaria, J.B.1    Babu, K.S.2    Vijayanand, P.3
  • 25
    • 84928568835 scopus 로고    scopus 로고
    • IL-6 as a keystone cytokine in health and disease
    • Hunter CA, Jones SA. IL-6 as a keystone cytokine in health and disease. Nat Immunol 2015; 16: 448-457.
    • (2015) Nat Immunol , vol.16 , pp. 448-457
    • Hunter, C.A.1    Jones, S.A.2
  • 26
    • 84896985687 scopus 로고    scopus 로고
    • Proinflammatory cytokines, aging, and age-related diseases
    • Michaud M, Balardy L, Moulis G, et al. Proinflammatory cytokines, aging, and age-related diseases. J Am Med Dir Assoc 2013; 14: 877-882.
    • (2013) J Am Med Dir Assoc , vol.14 , pp. 877-882
    • Michaud, M.1    Balardy, L.2    Moulis, G.3
  • 27
    • 84869834766 scopus 로고    scopus 로고
    • Role of IL-6 in asthma and other inflammatory pulmonary diseases
    • Rincon M, Irvin CG. Role of IL-6 in asthma and other inflammatory pulmonary diseases. Int J Biol Sci 2012; 8: 1281-1290.
    • (2012) Int J Biol Sci , vol.8 , pp. 1281-1290
    • Rincon, M.1    Irvin, C.G.2
  • 28
    • 77952536377 scopus 로고    scopus 로고
    • Elevation of IL-6 in the allergic asthmatic airway is independent of inflammation but associates with loss of central airway function
    • Neveu WA, Allard JL, Raymond DM, et al. Elevation of IL-6 in the allergic asthmatic airway is independent of inflammation but associates with loss of central airway function. Respir Res 2010; 11: 28. 9921-11-28.
    • (2010) Respir Res , vol.11 , Issue.28 , pp. 1128-9921
    • Neveu, W.A.1    Allard, J.L.2    Raymond, D.M.3
  • 29
    • 16844377774 scopus 로고    scopus 로고
    • Interleukin-6 regulation of transforming growth factor (TGF)-beta receptor compartmentalization and turnover enhances TGF-beta1 signaling
    • Zhang XL, Topley N, Ito T, et al. Interleukin-6 regulation of transforming growth factor (TGF)-beta receptor compartmentalization and turnover enhances TGF-beta1 signaling. J Biol Chem 2005; 280: 12239-12245.
    • (2005) J Biol Chem , vol.280 , pp. 12239-12245
    • Zhang, X.L.1    Topley, N.2    Ito, T.3
  • 30
    • 56149097181 scopus 로고    scopus 로고
    • TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice
    • McKinley L, Alcorn JF, Peterson A, et al. TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice. J Immunol 2008; 181: 4089-4097.
    • (2008) J Immunol , vol.181 , pp. 4089-4097
    • McKinley, L.1    Alcorn, J.F.2    Peterson, A.3
  • 31
    • 45949102482 scopus 로고    scopus 로고
    • Beta2-agonists potentiate corticosteroid-induced neutrophil survival
    • Perttunen H, Moilanen E, Zhang X, et al. Beta2-agonists potentiate corticosteroid-induced neutrophil survival. COPD 2008; 5: 163-169.
    • (2008) COPD , vol.5 , pp. 163-169
    • Perttunen, H.1    Moilanen, E.2    Zhang, X.3
  • 32
    • 0037119038 scopus 로고    scopus 로고
    • Divergent effect of mometasone on human eosinophil and neutrophil apoptosis
    • Zhang X, Moilanen E, Adcock IM, et al. Divergent effect of mometasone on human eosinophil and neutrophil apoptosis. Life Sci 2002; 71: 1523-1534.
    • (2002) Life Sci , vol.71 , pp. 1523-1534
    • Zhang, X.1    Moilanen, E.2    Adcock, I.M.3
  • 33
    • 84890794285 scopus 로고    scopus 로고
    • Eosinophil apoptosis as a therapeutic target in allergic asthma
    • Ilmarinen P, Kankaanranta H. Eosinophil apoptosis as a therapeutic target in allergic asthma. Basic Clin Pharmacol Toxicol 2014; 114: 109-117.
    • (2014) Basic Clin Pharmacol Toxicol , vol.114 , pp. 109-117
    • Ilmarinen, P.1    Kankaanranta, H.2
  • 34
    • 0036830003 scopus 로고    scopus 로고
    • Chronic psychological stress and the regulation of pro-inflammatory cytokines: A glucocorticoid-resistance model
    • Miller GE, Cohen S, Ritchey AK. Chronic psychological stress and the regulation of pro-inflammatory cytokines: a glucocorticoid-resistance model. Health Psychol 2002; 21: 531-541.
    • (2002) Health Psychol , vol.21 , pp. 531-541
    • Miller, G.E.1    Cohen, S.2    Ritchey, A.K.3
  • 35
    • 34748902879 scopus 로고    scopus 로고
    • Outcome and severity of adult onset asthma: Report from the obstructive lung disease in northern Sweden studies (OLIN)
    • Rönmark E, Lindberg A, Watson L, et al. Outcome and severity of adult onset asthma: report from the obstructive lung disease in northern Sweden studies (OLIN). Respir Med 2007; 101: 2370-2377.
    • (2007) Respir Med , vol.101 , pp. 2370-2377
    • Rönmark, E.1    Lindberg, A.2    Watson, L.3
  • 36
    • 84946566999 scopus 로고    scopus 로고
    • Persistent airflow obstruction in patients with asthma: Characteristics of a distinct clinical phenotype
    • Konstantellou E, Papaioannou AI, Loukides S, et al. Persistent airflow obstruction in patients with asthma: characteristics of a distinct clinical phenotype. Respir Med 2015; 109: 1404-1409.
    • (2015) Respir Med , vol.109 , pp. 1404-1409
    • Konstantellou, E.1    Papaioannou, A.I.2    Loukides, S.3
  • 37
    • 78650909855 scopus 로고    scopus 로고
    • Mechanisms of corticosteroid resistance in severe asthma and chronic obstructive pulmonary disease (COPD)
    • Adcock IM, Marwick J, Casolari P, et al. Mechanisms of corticosteroid resistance in severe asthma and chronic obstructive pulmonary disease (COPD). Curr Pharm Des 2010; 16: 3554-3573.
    • (2010) Curr Pharm des , vol.16 , pp. 3554-3573
    • Adcock, I.M.1    Marwick, J.2    Casolari, P.3
  • 38
  • 39
    • 84860626824 scopus 로고    scopus 로고
    • Describing and quantifying asthma comorbidity: A population study
    • Gershon AS, Guan J, Wang C, et al. Describing and quantifying asthma comorbidity: a population study. PLoS One 2012; 7: e34967.
    • (2012) PLoS One , vol.7
    • Gershon, A.S.1    Guan, J.2    Wang, C.3
  • 40
    • 84895107629 scopus 로고    scopus 로고
    • Chronic disease comorbidity of asthma and unscheduled asthma care among adults: Results of the national telephone health interview survey German Health Update (GEDA) 2009 and 2010
    • Steppuhn H, Langen U, Keil T, et al. Chronic disease comorbidity of asthma and unscheduled asthma care among adults: results of the national telephone health interview survey German Health Update (GEDA) 2009 and 2010. Prim Care Respir J 2014; 23: 22-29.
    • (2014) Prim Care Respir J , vol.23 , pp. 22-29
    • Steppuhn, H.1    Langen, U.2    Keil, T.3
  • 41
    • 49449093739 scopus 로고    scopus 로고
    • Obesity and asthma: A specific phenotype?
    • Lessard A, Turcotte H, Cormier Y, et al. Obesity and asthma: a specific phenotype? Chest 2008; 134: 317-323.
    • (2008) Chest , vol.134 , pp. 317-323
    • Lessard, A.1    Turcotte, H.2    Cormier, Y.3
  • 43
    • 84951773437 scopus 로고    scopus 로고
    • Predictors of asthma control by stepwise treatment in elderly asthmatic patients
    • Ban GY, Ye YM, Lee Y, et al. Predictors of asthma control by stepwise treatment in elderly asthmatic patients. J Korean Med Sci 2015; 30: 1042-1047.
    • (2015) J Korean Med Sci , vol.30 , pp. 1042-1047
    • Ban, G.Y.1    Ye, Y.M.2    Lee, Y.3
  • 44
    • 84903473961 scopus 로고    scopus 로고
    • Systemic Inflammation in Older Adults with Asthma-COPD Overlap Syndrome
    • Fu JJ, McDonald VM, Gibson PG, et al. Systemic Inflammation in Older Adults With Asthma-COPD Overlap Syndrome. Allergy Asthma Immunol Res 2014; 6: 316-324.
    • (2014) Allergy Asthma Immunol Res , vol.6 , pp. 316-324
    • Fu, J.J.1    McDonald, V.M.2    Gibson, P.G.3
  • 45
    • 84940824387 scopus 로고    scopus 로고
    • Aerobic training decreases bronchial hyperresponsiveness and systemic inflammation in patients with moderate or severe asthma: A randomised controlled trial
    • França-Pinto A, Mendes FA, de Carvalho-Pinto RM, et al. Aerobic training decreases bronchial hyperresponsiveness and systemic inflammation in patients with moderate or severe asthma: a randomised controlled trial. Thorax 2015; 70: 732-739.
    • (2015) Thorax , vol.70 , pp. 732-739
    • França-Pinto, A.1    Mendes, F.A.2    De Carvalho-Pinto, R.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.