Systemic inflammation is associated with differential gene expression and airway neutrophilia in Asthma

OMICS A Journal of Integrative Biology

Volumn 17, Issue 4, 2013, Pages 187-199

  Fu, Juan Juan ^a,b,c   Baines, Katherine J ^a,b,c   Wood, Lisa G ^a,b,c   Gibson, Peter G ^a,b,c,d  

^a UNIVERSITY OF NEWCASTLE   (Australia)

^b HUNTER MEDICAL RESEARCH INSTITUTE   (Australia)

^c JOHN HUNTER HOSPITAL   (Australia)

^d WOOLCOCK INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; CHEMOKINE RECEPTOR CX3CR1; HIGH SENSITIVITY C REACTIVE PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 6; L SELECTIN; MONOCYTE CHEMOTACTIC PROTEIN 2; PHOSPHATIDYLINOSITOL 3 KINASE; STEM CELL FACTOR RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADULT; ARTICLE; ASTHMA; BODY MASS; CELL COUNT; CLINICAL ARTICLE; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; FEMALE; FORCED VITAL CAPACITY; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMAN; INFLAMMATION; INNATE IMMUNITY; MALE; MICROARRAY ANALYSIS; NEUTROPHIL; NEUTROPHILIA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; QUANTITATIVE ASSAY; RESPIRATORY TRACT INFLAMMATION; SMOKING; SPUTUM; SYSTEMIC INFLAMMATION;

ADULT; AGED; ASTHMA; C-REACTIVE PROTEIN; CLUSTER ANALYSIS; CROSS-SECTIONAL STUDIES; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION; INTERLEUKIN-6; MALE; MIDDLE AGED; NEUTROPHILS; REPRODUCIBILITY OF RESULTS; SIGNAL TRANSDUCTION; SPUTUM;

EID: 84876122356     PISSN: 15362310     EISSN: 15578100     Source Type: Journal    
DOI: 10.1089/omi.2012.0104     Document Type: Article

References (50)

1. Abraham WM, Ahmed A, Sabater JR, et al. (1999). Selectin blockade prevents antigen-induced late bronchial responses and airway hyperresponsiveness in allergic sheep. Am J Respir Crit Care Med 159, 1205-1214. (Pubitemid 29202557)
2. Alvarez-Rodriguez L, Lopez-Hoyos M, Munoz-Cacho P, and Martinez-Taboada VM. (2012). Aging is associated with circulating cytokine dysregulation. Cell Immunol 273, 124-132.
3. ATS Board of Directors 1987). Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, November 1986. Am Rev Respir Dis, 136, 225-244.
4. Baines KJ, Simpson JL, Wood LG, Scott RJ, and Gibson PG. (2011a). Systemic upregulation of neutrophil alpha-defensins and serine proteases in neutrophilic asthma. Thorax 66, 942-947.
5. Baines KJ, Simpson JL, Wood LG, Scott RJ, and Gibson PG. (2011b). Transcriptional phenotypes of asthma defined by gene expression profiling of induced sputum samples. J Allergy Clin Immunol 127, 153-160.
6. Baines KJ, Wood LG, and Gibson PG. (2009). The nutrigenomics of asthma: Molecular mechanisms of airway neutrophilia following dietary antioxidant withdrawal. OMICS 13, 355-365.
7. Barnes PJ, and Celli BR. (2009). Systemic manifestations and comorbidities of COPD. Eur Respir J 33, 1165-1185.
8. Bastard JP, Maachi M, Lagathu C, et al. (2006). Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw 17, 4-12.
9. Birrer P, McElvaney NG, Rudeberg A, et al. (1994). Proteaseantiprotease imbalance in the lungs of children with cystic fibrosis. Am J Respir Crit Care Med 150, 207-213. (Pubitemid 24209960)
10. Chabot B, Stephenson DA, Chapman VM, Besmer P, and Bernstein A. (1988). The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus. Nature 335, 88-89.
11. Chang SS, Vaz Fragoso CA, Van Ness PH, Fried LP, and Tinetti ME. (2011). Association between combined interleukin-6 and C-reactive protein levels and pulmonary function in older women: Results from the Women's Health and Aging Studies I and II. J Am Geriatr Soc 59, 113-119.
12. Charo IF, and Ransohoff RM. (2006). The many roles of chemokines and chemokine receptors in inflammation. N Engl J Med 354, 610-621. (Pubitemid 43209108)
13. Dahl M, Vestbo J, Lange P, Bojesen SE, Tybjaerg-Hansen A, and Nordestgaard BG. (2007). C-reactive protein as a predictor of prognosis in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 175, 250-255. (Pubitemid 46203128)
14. Dickens JA, Miller BE, Edwards LD, et al. (2011). COPD association and repeatability of blood biomarkers in the ECLIPSE cohort. Respir Res 12, 146.
15. Dreborg S. (1991). Bronchial hyper-reactivity and skin sensitivity. Clin Exp Allergy 21, 529.
16. Fishman D, Faulds G, Jeffery R, et al. (1998). The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest 102, 1369-1376. (Pubitemid 28467565)
17. Gadek JE, Fells GA, Zimmerman RL, Rennard SI, and Crystal RG. (1981). Antielastases of the human alveolar structures. Implications for the protease-antiprotease theory of emphysema. J Clin Invest 68, 889-898. (Pubitemid 11023517)
18. Gibson PG, Simpson JL, and Saltos N. (2001). Heterogeneity of airway inflammation in persistent asthma : Evidence of neutrophilic inflammation and increased sputum interleukin-8. Chest 119, 1329-1336. (Pubitemid 32686012)
19. Gibson PG, Wlodarczyk JW, Hensley MJ, et al. (1998). Epidemiological association of airway inflammation with asthma symptoms and airway hyperresponsiveness in childhood. Am J Respir Crit Care Med 158, 36-41. (Pubitemid 28337155)
20. Greenwood KK, Proper SP, Saini Y, et al. (2012). Neonatal epithelial hypoxia inducible factor-1alpha expression regulates the response of the lung to experimental asthma. Am J Physiol Lung Cell Mol Physiol 302, L455-462.
21. Haldar P, Pavord ID, Shaw DE, et al. (2008). Cluster analysis and clinical asthma phenotypes. Am J Respir Crit Care Med 178, 218-224.
22. Hancox RJ, Poulton R, Greene JM, et al. (2007). Systemic inflammation and lung function in young adults. Thorax 62, 1064-1068. (Pubitemid 350206198)
23. Hankinson JL, Odencrantz JR, and Fedan KB. (1999). Spirometric reference values from a sample of the general U.S. population. Am J Respir Crit Care Med 159, 179-187. (Pubitemid 29036522)
24. Heinrich PC, Castell JV, and Andus T. (1990). Interleukin-6 and the acute phase response. Biochem J 265, 621-636. (Pubitemid 20053863)
25. Heinrich PC, Horn F, Graeve L, et al. (1998). Interleukin-6 and related cytokines: Effect on the acute phase reaction. Z Ernahrungswiss 37, 43-49.
26. Hingorani AD, and Casas JP. (2012). The interleukin-6 receptor as a target for prevention of coronary heart disease: A Mendelian randomisation analysis. Lancet 379, 1214-1224.
27. Kaneko K, Furuyama K, Aburatani H, and Shibahara S. (2009). Hypoxia induces erythroid-specific 5-aminolevulinate synthase expression in human erythroid cells through transforming growth factor-beta signaling. FEBS J 276, 1370-1382.
28. Kinoshita T, Sawai N, Hidaka E, Yamashita T, and Koike K. (1999). Interleukin-6 directly modulates stem cell factordependent development of human mast cells derived from CD34( + ) cord blood cells. Blood 94, 496-508. (Pubitemid 29323864)
29. Kluft C, and de Maat MP. (2003). Genetics of C-reactive protein: New possibilities and complications. Arterioscler Thromb Vasc Biol 23, 1956-1959. (Pubitemid 37433185)
30. Kushner I, Rzewnicki D, and Samols D. (2006). What does minor elevation of C-reactive protein signify? Am J Med 119, 166 e117-128.
31. Licastro F, Candore G, Lio D, et al. (2005). Innate immunity and inflammation in ageing: a key for understanding age-related diseases. Immun Ageing 2, 8.
32. Mukaida N. (2003). Pathophysiological roles of interleukin-8/CXCL8 in pulmonary diseases. Am J Physiol Lung Cell Mol Physiol 284, L566-577. (Pubitemid 36343304)
33. Myers GL, Rifai N, Tracy RP, et al. (2004). CDC/AHA Workshop on Markers of Inflammation and Cardiovascular Disease: Application to Clinical and Public Health Practice: Report from the laboratory science discussion group. Circulation 110, e545-549.
34. Ochi H, Hirani WM, Yuan Q, Friend DS, Austen KF, and Boyce JA. (1999). T helper cell type 2 cytokine-mediated comitogenic responses and CCR3 expression during differentiation of human mast cells in vitro. J Exp Med 190, 267-280. (Pubitemid 29354919)
35. Olafsdottir IS, Thjodleifsson B, Olafsson I, Gislason D, Jogi R, and Janson C. (2005). C reactive protein levels are increased in non-allergic but not allergic asthma: A multicentre epidemiological study. Thorax 60: 451-454. (Pubitemid 40814042)
36. Qiu Y, Zhu J, Bandi V, Atmar RL, Hattotuwa K, Guntupalli KK, et al. (2003). Biopsy neutrophilia, neutrophil chemokine and receptor gene expression in severe exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 168, 968-975. (Pubitemid 37267175)
37. Ridker PM. (2003). Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Circulation 107, 363-369. (Pubitemid 36158034)
38. Royce SG, Lee M, and Tang ML. (2010). The contribution of Lselectin to airway hyperresponsiveness in chronic allergic airways disease. J Asthma Allergy 3, 9-17.
39. Saini Y, Kim KY, Lewandowski R, Bramble LA, Harkema JR, and Lapres JJ. (2010). Role of hypoxia-inducible factor 1{alpha} in modulating cobalt-induced lung inflammation. Am J Physiol Lung Cell Mol Physiol 298, L139-147.
40. Sallenave JM, Shulmann J, Crossley J, Jordana M, and Gauldie J. (1994). Regulation of secretory leukocyte proteinase inhibitor (SLPI) and elastase-specific inhibitor (ESI/elafin) in human airway epithelial cells by cytokines and neutrophilic enzymes. Am J Respir Cell Mol Biol 11, 733-741.
41. Scott HA, Gibson PG, Garg ML, and Wood LG. (2011). Airway inflammation is augmented by obesity and fatty acids in asthma. Eur Respir J 38, 594-602.
42. Simpson AJ, Cunningham GA, Porteous DJ, Haslett C, and Sallenave JM. (2001). Regulation of adenovirus-mediated elafin transgene expression by bacterial lipopolysaccharide. Hum Gene Ther 12, 1395-1406. (Pubitemid 32881345)
43. Simpson JL, Grissell TV, Douwes J, Scott RJ, Boyle MJ, and Gibson PG. (2007). Innate immune activation in neutrophilic asthma and bronchiectasis. Thorax 62, 211-218. (Pubitemid 46579799)
44. Strieter RM, Lukacs NW, Standiford TJ, and Kunkel SL. (1993). Cytokines. 2. Cytokines and lung inflammation: Mechanisms of neutrophil recruitment to the lung. Thorax 48, 765-769. (Pubitemid 23214873)
45. Struyf S, Proost P, Vandercappellen J, Dempe S, Noyens B, Nelissen S, et al. (2009). Synergistic up-regulation of MCP-2/CCL8 activity is counteracted by chemokine cleavage, limiting its inflammatory and anti-tumoral effects. Eur J Immunol 39, 843-857.
46. Takemura M, Matsumoto H, Niimi A, et al. (2006). High sensitivity C-reactive protein in asthma. N Engl J Med 27, 908-912. (Pubitemid 44911102)
47. Tedder TF, Steeber DA, Chen A, and Engel P. (1995). The selectins: Vascular adhesion molecules. FASEB J 9, 866-873.
48. Thyagarajan B, Jacobs DR, Apostol GG, Smith LJ, Lewis CE, and Williams OD. (2006). Plasma fibrinogen and lung function: The CARDIA Study. Int J Epidemiol 35, 1001-1008. (Pubitemid 44540754)
49. Wood LG, Baines KJ, Fu J, Scott HA, and Gibson PG. (2012). The neutrophilic inflammatory phenotype is associated with systemic inflammation in asthma systemic inflammation in neutrophilic asthma. Chest 142, 86-93.
50. Yokoyama A, Kohno N, Fujino S, et al. (1995). Circulating interleukin-6 levels in patients with bronchial asthma. Am J Respir Crit Care Med 151, 1354-1358.