Influence of genetic variants in EGF and other genes on hematological traits in Korean populations by a genome-wide approach

BioMed Research International

Volumn 2015, Issue , 2015, Pages

  Kim, Yun Kyoung ^a   Oh, Ji Hee ^a   Kim, Young Jin ^a   Hwang, Mi Yeong ^a   Moon, Sanghoon ^a   Low, Siew Kee ^b   Takahashi, Atsushi ^b   Matsuda, Koichi ^c   Kubo, Michiaki ^b   Lee, Juyoung ^a   Kim, Bong Jo ^a   Bonnefond, Amelie ^d  

^a Korea National Institute of Health   (South Korea)

^b RIKEN Center for Integrative Medical Sciences   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR; HEMOGLOBIN;

ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CORONARY ARTERY DISEASE; DYSLIPIDEMIA; ERYTHROCYTE; ERYTHROCYTE COUNT; GENE FREQUENCY; GENE LOCUS; GENETIC ASSOCIATION; GENETIC VARIABILITY; HEMATOCRIT; HEMATOPOIETIC STEM CELL; HEMOGLOBIN DETERMINATION; HUMAN; KOREAN (PEOPLE); LEUKOCYTE; LEUKOCYTE COUNT; PLEIOTROPY; SINGLE NUCLEOTIDE POLYMORPHISM; THROMBOCYTE; THROMBOCYTE COUNT; ASIAN CONTINENTAL ANCESTRY GROUP; GENETICS; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; META ANALYSIS; SOUTH KOREA;

ASIAN CONTINENTAL ANCESTRY GROUP; EPIDERMAL GROWTH FACTOR; ERYTHROCYTE COUNT; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HEMATOCRIT; HUMANS; LEUKOCYTE COUNT; PLATELET COUNT; POLYMORPHISM, SINGLE NUCLEOTIDE; REPUBLIC OF KOREA;

EID: 84929358897     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2015/914965     Document Type: Article

References (32)

1. N. C. Andrews, "Genes determining blood cell traits, " Nature Genetics, vol. 41, no. 11, pp. 1161-1162, 2009.
2. Y. Okada and Y. Kamatani, "Common genetic factors for hematological traits in humans, " Journal ofHumanGenetics, vol. 57, no. 3, pp. 161-169, 2012.
3. D. M. Evans, I. H. Frazer, and N. G. Martin, "Genetic and environmental causes of variation in basal levels of blood cells, " Twin Research, vol. 2, no. 4, pp. 250-257, 1999.
4. C. Garner, T. Tatu, J. E. Reittie et al., "Genetic influences on F cells and other hematologic variables: a twin heritability study, " Blood, vol. 95, no. 1, pp. 342-346, 2000.
5. S. K. Ganesh, N. A. Zakai, F. J. A. van Rooij et al., "Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium, " Nature Genetics, vol. 41, no. 11, pp. 1191-1198, 2009.
6. Y. Kamatani, K. Matsuda, Y. Okada et al., "Genome-wide association study of hematological and biochemical traits in a Japanese population, " Nature Genetics, vol. 42, no. 3, pp. 210-215, 2010.
7. M. A. Nalls, D. J. Couper, T. Tanaka et al., "Multiple loci are associated with white blood cell phenotypes, " PLoS Genetics, vol. 7, no. 6, Article ID e1002113, 2011.
8. P. van der Harst, W. Zhang, I. Mateo Leach et al., "Seventy-five genetic loci influencing the human red blood cell, " Nature, vol. 492, no. 7429, pp. 369-375, 2012.
9. N. Chami and G. Lettre, "Lessons and implications from genome-wide association studies (GWAS) findings of blood cell phenotypes, " Genes, vol. 5, no. 1, pp. 51-64, 2014.
10. B. Bain, M. Seed, and I. Godsland, "Normal values for peripheral blood white cell counts in women of four different ethnic origins, " Journal of Clinical Pathology, vol. 37, no. 2, pp. 188-193, 1984.
11. Y. Tsubakihara, S. Nishi, T. Akiba et al., "2008 Japanese society for dialysis therapy: guidelines for renal anemia in chronic kidney disease, " Therapeutic Apheresis and Dialysis, vol. 14, no. 3, pp. 240-275, 2010.
12. Y. S. Cho, M. J. Go, Y. J. Kim et al., "A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits, "NatureGenetics, vol. 41, no. 5, pp. 527-534, 2009.
13. J.Hwang, X. Sim, Y.Wu et al., "Genome-wide associationmetaanalysis identifies novel variants associated with fasting plasma glucose in EastAsians, " Diabetes, vol. 64, no. 1, pp.291-298, 2014.
14. J. Marchini, B. Howie, S. Myers, G. McVean, and P. Donnelly, "Anewmultipointmethod for genome-wide association studies by imputation of genotypes, " Nature Genetics, vol. 39, no. 7, pp. 906-913, 2007.
15. Y. J. Kim, M. J. Go, C. Hu et al., "Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits, " Nature Genetics, vol. 43, no. 10, pp. 990-995, 2011.
16. S. Purcell, B. Neale, K. Todd-Brown et al., "PLINK: a tool set for whole-genome association and population-based linkage analyses, "The American Journal of Human Genetics, vol. 81, no. 3, pp. 559-575, 2007.
17. C. J.Willer, Y. Li, and G. R. Abecasis, "METAL: fast and efficient meta-analysis of genomewide association scans, " Bioinformatics, vol. 26, no. 17, Article ID btq340, pp. 2190-2191, 2010.
18. V. Moskvina and K. M. Schmidt, "On multiple-testing correction in genome-wide association studies, " Genetic Epidemiology, vol. 32, no. 6, pp. 567-573, 2008.
19. J.-Y. Lee, B.-S. Lee, D.-J. Shin et al., "A genome-wide association study of a coronary artery disease risk variant, " Journal of Human Genetics, vol. 58, no. 3, pp. 120-126, 2013.
20. C. Gieger, A. Radhakrishnan, A. Cvejic et al., "New gene functions in megakaryopoiesis and platelet formation, " Nature, vol. 480, no. 7376, pp. 201-208, 2011.
21. D. Welter, J. MacArthur, J. Morales et al., "The NHGRI GWAS Catalog, a curated resource of SNP-trait associations, " Nucleic Acids Research, vol. 42, no. 1, pp. D1001-D1006, 2014.
22. A. P. Reiner, G. Lettre, M. A. Nalls et al., "Genome-wide association study of white blood cell count in 16, 388 African Americans: the continental origins and genetic epidemiology network (COGENT), " PLoS Genetics, vol. 7, no. 6, Article ID e1002108, 2011.
23. T.-P. Yang, C. Beazley, S. B. Montgomery et al., "Genevar: a database and Java application for the analysis and visualization of SNP-gene associations in eQTL studies, " Bioinformatics, vol. 26, no. 19, Article IDbtq452, pp. 2474-2476, 2010.
24. B. E. Stranger, S. B.Montgomery, A. S. Dimas et al., "Patterns of Cis regulatory variation in diverse human populations, " PLoS Genetics, vol. 8, no. 4, Article ID e1002639, 2012.
25. M. Gawaz, H. Langer, and A. E.May, "Platelets in inflammation and atherogenesis, "The Journal of Clinical Investigation, vol. 115, no. 12, pp. 3378-3384, 2005.
26. S. Margetic, "Inflammation and haemostasis, " Biochemia Medica, vol. 22, no. 1, pp. 49-62, 2012.
27. P. P. Steele, H. S. Weily, H. Davies, and E. Genton, "Platelet function studies in coronary artery disease, " Circulation, vol. 48, no. 6, pp. 1194-1200, 1973.
28. W. Tong, J. Zhang, and H. F. Lodish, "Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways, " Blood, vol. 105, no. 12, pp. 4604-4612, 2005.
29. A. Hinks, P. Martin, E. Flynn et al., "Investigation of type 1 diabetes and coeliac disease susceptibility loci for association with juvenile idiopathic arthritis, " Annals of the Rheumatic Diseases, vol. 69, no. 12, pp. 2169-2172, 2010.
30. S. Saade, J.-B. Cazier, M. Ghassibe-Sabbagh et al., "Large scale association analysis identifies three susceptibility loci for coronary artery disease, " PLoS ONE, vol. 6, no. 12, Article ID e29427, 2011.
31. C. Newton-Cheh, T. Johnson, V. Gateva, and et al, "Genomewide association study identifies eight loci associated with blood pressure, " Nature Genetics, vol. 41, no. 6, pp. 666-676, 2009.
32. T. A.Manolio, F. S. Collins, N. J. Cox et al., "Finding the missing heritability of complex diseases, " Nature, vol. 461, no. 7265, pp. 747-753, 2009.