Determinants of platelet count in humans

Haematologica

Volumn 96, Issue 1, 2011, Pages 10-13

  Daly, Martina E ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

THROMBOPOIETIN;

CELL CYCLE REGULATION; CELL DIFFERENTIATION; EDITORIAL; GENE MUTATION; GENETIC ASSOCIATION; GENETIC TRANSCRIPTION; HEREDITY; HUMAN; MEGAKARYOCYTE; PLURIPOTENT STEM CELL; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; THROMBOCYTE COUNT; THROMBOCYTE MEMBRANE; THROMBOCYTOPENIA; THROMBOCYTOSIS;

BLOOD PLATELETS; HUMANS; PLATELET COUNT; RISK FACTORS; THROMBOCYTOSIS;

EID: 78650985681     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2010.035287     Document Type: Editorial

References (20)

1. Kaushansky K. Determinants of platelet number and regulation of thrombopoiesis. Hematology Am Soc Hematol Educ Program. 2009; 147-52.
2. Nagata Y, Shozaki Y, Nagahisa H, Nagasawa T, Abe T, Todokoro K. Serum thrombopoietin level is not regulated by transcription but by the total counts of both megakaryocytes and platelets during thrombocytopenia and thrombocytosis. Thromb Haemost. 1997;77 (5):808-14.
3. Drachman JG. Inherited thrombocytopenia: when a low platelet count does not mean ITP. Blood. 2004;103(2):390-8.
4. Skoda RC. Thrombocytosis. Hematology Am Soc Hematol Educ Program. 2009;159-67.
5. Biino G, Balduini C, Casula L, Cavallo P, Vaccargiu S, Parracciani D et al. Analysis of 12,517 inhabitants of a Sardinian geographic isolate reveals that predispositions to thrombocytopenia and thrombocytosis are inherted traits. Haematologica. 2011;96(1):96-101.
6. Fraumene C, Petretto E, Angius A, Pirastu M. Striking differentiation of sub-populations within a genetically homogeneous isolate (Ogliastra) in Sardinia as revealed by mtDNA analysis. Hum Genet. 2003;114(1):1-10.
7. Whitfield JB, Martin NG. Genetic and environmental influences on the size and number of cells in the blood. Genet Epidemiol. 1985;2(2):133-44.
8. Segal JB, Moliterno AR. Platelet counts differ by sex, ethnicity, and age in the United States. Ann Epidemiol. 2006;16(2):123-30.
9. Buckley MF, James JW, Brown DE, Whyte GS, Dean MG, Chesterman CN, Donald JA. A novel approach to the assessment of variations in the human platelet count. Thromb Haemost. 2000(3);83:480-4.
10. Cheung CC, Martin ICA, Zenger KR, Donald JA, Thomson PC, Moran C, et al. Quantitative trait loci for steady-state platelet count in mice. Mamm Genome. 2004;15(10):784-97.
11. Soranzo N, Rendon A, Gieger C, Jones CI, Watkins NA, Menzel S, et al. A novel variant on chromosome 7q22.3 associated with mean platelet volume, counts and function. Blood 2009;113(16):3831-7.
12. Hawkins PT, Stephens LR. PI3Kgamma is a key regulator of inflammatory responses and cardiovascular homeostasis. Science. 2007;318(5847):64-6.
13. Wojcikiewicz RJ, Luo SG. Phosphorylation of inositol 1,4,5-trisphosphate receptors by cAMP-dependent protein kinase. Type I, II, and III receptors are differentially susceptible to phosphorylation and are phosphorylated in intact cells. J Biol Chem. 1998;273(10):5670-7.
14. Soranzo N, Spector TD, Mangino M, Kühnel B, Rendon A, Teumer A, et al. A genome-wide meta-analysis identified 22 loci associated with eight hematological parameters in the HaemGen consortium. Nat Genet. 2009;41(11):1182-90.
15. Mason KD, Carpinelli MR, Fletcher JI, Collinge JE, Hilton AA, Ellis S, et al. Programmed anuclear cell death delimits platelet life span. Cell. 2007;128(6):1173-86.
16. Takizawa H, Eto K, Yoshikawa A, Nakauchi H, Takatsu K, Takaki S. Growth and maturation of megakaryocytes is regulated by Lnk/Sh2b3 adaptor protein through crosstalk between cytokine- and integrin-mediated signals. Exp Hematol. 2008;36(7):897-906.
17. Butkiewicz AM, Kemona H, Dymicka-Piekarska V, Matowicka- Karna J, Radziwon P, Lipska A. Platelet count, mean platelet volume and thrombocytopoietic indices in healthy women and men. Thromb Res. 2006;118(2):199-204.
18. Khetawat G, Faraday N, Nealen ML, Vijayan KV, Bolton E, Noga SJ, Bray PF. Human megakaryocytes and platelets contain the estrogen receptor beta and androgen receptor (AR): testosterone regulates AR expression. Blood. 2000;95 (7):2289-96.
19. Bord S, Frith E, Ireland DC, Scott MA, Craig JIO, Compston JE. Estrogen stimulates differentiation of megakaryocytes and modulates their expression of estrogen receptors alpha and beta. J Cell Biochem. 2004;92(2):249-57.
20. Nagata Y, Yoshikawa J, Hashimoto A, Yamamoto M, Payne AH, Todokoro K. Proplatelet formation of megakaryocytes is triggered by autocrine-synthesized estradiol. Genes Dev. 2003;17(23):2864-69.