Regulation of hypoxia-inducible factor-1α, regulated in development and DNA damage response-1 and mammalian target of rapamycin in human placental BeWo cells under hypoxia

Placenta

Volumn 45, Issue , 2016, Pages 24-31

  Zhou, F ^a,b   Guan, L B ^a   Yu, P ^a   Wang, X D ^a,b   Hu, Y Y ^a  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

Author keywords

BeWo cells; Hypoxia; Hypoxia inducible factor 1; Mammalian target of rapamycin; Regulated in development and DNA damage response 1; Regulation; Trophoblast

Indexed keywords

CELL PROTEIN; DNA DAMAGE RESPONSE 1 PROTEIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; DDIT4 PROTEIN, HUMAN; HIF1A PROTEIN, HUMAN; MTOR PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE; TRANSCRIPTION FACTOR;

ARTICLE; BIOACCUMULATION; CELL HYPOXIA; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PLACENTA; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; UPREGULATION; CELL LINE; CYTOLOGY; FEMALE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHYSIOLOGY; PREGNANCY; SIGNAL TRANSDUCTION;

CELL HYPOXIA; CELL LINE; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; PLACENTA; PREGNANCY; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TRANSCRIPTION FACTORS;

EID: 84989908385     PISSN: 01434004     EISSN: 15323102     Source Type: Journal    
DOI: 10.1016/j.placenta.2016.07.003     Document Type: Article

References (37)

1. [1] Mol, B.W.J., Roberts, C.T., Thangaratinam, S., Magee, L.A., de Groot, C.J.M., Hofmeyr, G.J., Pre-eclampsia. Lancet 387:10022 (2016), 999–1011.
2. [2] Alfirevic, Z., Stampalija, T., Gyte, G.M., Fetal and umbilical doppler ultrasound in high-risk pregnancies. Cochrane Database Syst. Rev., 2013, Cd007529.
3. [3] ACOG practice bulletin no. 134: fetal growth restriction. Obstetrics Gynecol. 121:5 (2013), 1122–1133.
4. [4] Staff, A.C., Benton, S.J., von Dadelszen, P., Roberts, J.M., Taylor, R.N., Powers, R.W., Charnock-Jones, D.S., Redman, C.W., Redefining preeclampsia using placenta-derived biomarkers. Hypertension 61:5 (2013), 932–942.
5. [5] Lyall, F., Robson, S.C., Bulmer, J.N., Spiral artery remodeling and trophoblast invasion in preeclampsia and fetal growth restriction: relationship to clinical outcome. Hypertension 62:6 (2013), 1046–1054.
6. [6] Pijnenborg, R., Vercruysse, L., Hanssens, M., The uterine spiral arteries in human pregnancy: facts and controversies. Placenta 27:9–10 (2006), 939–958.
7. [7] Tuuli, M.G., Longtine, M.S., Nelson, D.M., Review: oxygen and trophoblast biology–a source of controversy. Placenta 32:Suppl. 2 (2011), S109–S118.
8. [8] Greer, S.N., Metcalf, J.L., Wang, Y., Ohh, M., The updated biology of hypoxia-inducible factor. EMBO J. 31:11 (2012), 2448–2460.
9. [9] Wang, G.L., Jiang, B.H., Rue, E.A., Semenza, G.L., Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc. Natl. Acad. Sci. U. S. A. 92:12 (1995), 5510–5514.
10. [10] Rajakumar, A., Conrad, K.P., Expression, ontogeny, and regulation of hypoxia-inducible transcription factors in the human placenta. Biol. Reprod. 63:2 (2000), 559–569.
11. [11] Caniggia, I., Mostachfi, H., Winter, J., Gassmann, M., Lye, S.J., Kuliszewski, M., Post, M., Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3). J. Clin. Investig. 105:5 (2000), 577–587.
12. [12] Genbacev, O., Zhou, Y., Ludlow, J.W., Fisher, S.J., Regulation of human placental development by oxygen tension. Sci. (New York, NY) 277:5332 (1997), 1669–1672.
13. [13] Iriyama, T., Wang, W., Parchim, N.F., Song, A., Blackwell, S.C., Sibai, B.M., Kellems, R.E., Xia, Y., Hypoxia-independent upregulation of placental hypoxia inducible factor-1alpha gene expression contributes to the pathogenesis of preeclampsia. Hypertension 65:6 (2015), 1307–1315.
14. [14] Rajakumar, A., Brandon, H.M., Daftary, A., Ness, R., Conrad, K.P., Evidence for the functional activity of hypoxia-inducible transcription factors overexpressed in preeclamptic placentae. Placenta 25:10 (2004), 763–769.
15. [15] Tal, R., Shaish, A., Barshack, I., Polak-Charcon, S., Afek, A., Volkov, A., Feldman, B., Avivi, C., Harats, D., Effects of hypoxia-inducible factor-1alpha overexpression in pregnant mice: possible implications for preeclampsia and intrauterine growth restriction. Am. J. Pathol. 177:6 (2010), 2950–2962.
16. [16] Zamudio, S., Wu, Y., Ietta, F., Rolfo, A., Cross, A., Wheeler, T., Post, M., Illsley, N.P., Caniggia, I., Human placental hypoxia-inducible factor-1alpha expression correlates with clinical outcomes in chronic hypoxia in vivo. Am. J. Pathol. 170:6 (2007), 2171–2179.
17. [17] Semenza, G.L., Hypoxia-inducible factors in physiology and medicine. Cell 148:3 (2012), 399–408.
18. [18] Horak, P., Crawford, A.R., Vadysirisack, D.D., Nash, Z.M., DeYoung, M.P., Sgroi, D., Ellisen, L.W., Negative feedback control of HIF-1 through REDD1-regulated ROS suppresses tumorigenesis. Proc. Natl. Acad. Sci. U. S. A. 107:10 (2010), 4675–4680.
19. [19] Shoshani, T., Faerman, A., Mett, I., Zelin, E., Tenne, T., Gorodin, S., Moshel, Y., Elbaz, S., Budanov, A., Chajut, A., Kalinski, H., Kamer, I., Rozen, A., Mor, O., Keshet, E., Leshkowitz, D., Einat, P., Skaliter, R., Feinstein, E., Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis. Mol. Cell Biol. 22:7 (2002), 2283–2293.
20. [20] Schwarzer, R., Tondera, D., Arnold, W., Giese, K., Klippel, A., Kaufmann, J., REDD1 integrates hypoxia-mediated survival signaling downstream of phosphatidylinositol 3-kinase. Oncogene 24:7 (2005), 1138–1149.
21. [21] Corradetti, M.N., Inoki, K., Guan, K.L., The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway. J. Biol. Chem. 280:11 (2005), 9769–9772.
22. [22] Hay, N., Sonenberg, N., Upstream and downstream of mTOR. Genes Dev. 18:16 (2004), 1926–1945.
23. [23] Thoreen, C.C., Chantranupong, L., Keys, H.R., Wang, T., Gray, N.S., Sabatini, D.M., A unifying model for mTORC1-mediated regulation of mRNA translation. Nature 485:7396 (2012), 109–113.
24. [24] Laplante, M., Sabatini, D.M., mTOR signaling in growth control and disease. Cell 149:2 (2012), 274–293.
25. [25] Roos, S., Powell, T.L., Jansson, T., Placental mTOR links maternal nutrient availability to fetal growth. Biochem. Soc. Transac. 37:Pt 1 (2009), 295–298.
26. [26] Wei, W., Hu, Y.Y., Expression of hypoxia-regulated genes and glycometabolic genes in placenta from patients with intrahepatic cholestasis of pregnancy. Placenta 35:9 (2014), 732–736.
27. [27] Hu, Y.Y., Liu, J.C., Xing, A.Y., You, Y., Wang, X.D., REDD1 expression in placenta during human gestation. Reprod. Sci. Thousand Oaks, Calif. 19:9 (2012), 995–1000.
28. [28] Aiko, Y., Askew, D.J., Aramaki, S., Myoga, M., Tomonaga, C., Hachisuga, T., Suga, R., Kawamoto, T., Tsuji, M., Shibata, E., Differential levels of amino acid transporters System L and ASCT2, and the mTOR protein in placenta of preeclampsia and IUGR. BMC Pregnancy Childbirth, 14, 2014, 181.
29. [29] Manalo, D.J., Rowan, A., Lavoie, T., Natarajan, L., Kelly, B.D., Ye, S.Q., Garcia, J.G., Semenza, G.L., Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1. Blood 105:2 (2005), 659–669.
30. [30] Maxwell, P.H., Wiesener, M.S., Chang, G.W., Clifford, S.C., Vaux, E.C., Cockman, M.E., Wykoff, C.C., Pugh, C.W., Maher, E.R., Ratcliffe, P.J., The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399:6733 (1999), 271–275.
31. [31] Salceda, S., Caro, J., Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. J. Biol. Chem. 272:36 (1997), 22642–22647.
32. [32] Wang, G.L., Semenza, G.L., General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia. Proc. Natl. Acad. Sci. U. S. A. 90:9 (1993), 4304–4308.
33. [33] Zhang, K., Zhao, T., Huang, X., He, Y., Zhou, Y., Wu, L., Wu, K., Fan, M., Zhu, L., Dissolved oxygen concentration in the medium during cell culture: defects and improvements. Cell Biol. Int. 40:3 (2016), 354–360.
34. [34] Chen, B., Longtine, M.S., Nelson, D.M., Pericellular oxygen concentration of cultured primary human trophoblasts. Placenta 34:2 (2013), 106–109.
35. [35] Katiyar, S., Liu, E., Knutzen, C.A., Lang, E.S., Lombardo, C.R., Sankar, S., Toth, J.I., Petroski, M.D., Ronai, Z., Chiang, G.G., REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A-DDB1 ubiquitin ligase. EMBO Rep. 10:8 (2009), 866–872.
36. [36] Hudson, C.C., Liu, M., Chiang, G.G., Otterness, D.M., Loomis, D.C., Kaper, F., Giaccia, A.J., Abraham, R.T., Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin. Mol. Cell Biol. 22:20 (2002), 7004–7014.
37. [37] Liu, F., Soares, M.J., Audus, K.L., Permeability properties of monolayers of the human trophoblast cell line BeWo. Am. J. Physiol. 273:5 Pt 1 (1997), C1596–C1604.