A Pleiotropic Missense Variant in SLC39A8 Is Associated With Crohn's Disease and Human Gut Microbiome Composition

Gastroenterology

Volumn 151, Issue 4, 2016, Pages 724-732

  Li, Dalin ^a   Achkar, Jean Paul ^b   Haritunians, Talin ^a   Jacobs, Jonathan P ^c   Hui, Ken Y ^d   D'Amato, Mauro ^e,f   Brand, Stephan ^g   Radford Smith, Graham ^h,i,j   Halfvarson, Jonas ^k   Niess, Jan Hendrik ^l,m,n   Kugathasan, Subra ^o   Büning, Carsten ^p   Schumm, L Philip ^q   Klei, Lambertus ^r   Ananthakrishnan, Ashwin ^t   Aumais, Guy ^u,v   Baidoo, Leonard ^r   Dubinsky, Marla ^a,w   Fiocchi, Claudio ^b   Glas, Jürgen ^x   Milgrom, Raquel ^y   Proctor, Deborah D ^d   Regueiro, Miguel ^r   Simms, Lisa A ^h   Stempak, Joanne M ^y   Targan, Stephan R ^a   Törkvist, Leif ^e,z   Sharma, Yashoda ^w   Devlin, Bernie ^r,s   Borneman, James ^aa   Hakonarson, Hakon ^ab   Xavier, Ramnik J ^t,ac   Daly, Mark ^t,ac   Brant, Steven R ^ad,ae   Rioux, John D ^u,af   Silverberg, Mark S ^y   Cho, Judy H ^w   Braun, Jonathan ^c   McGovern, Dermot P B ^a   Duerr, Richard H ^r,s   more..

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d YALE UNIVERSITY   (United States)

^e KAROLINSKA INSTITUTE   (Sweden)

^f BIOCRUCES BIZKAIA HEALTH RESEARCH INSTITUTE   (Spain)

^g LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^h QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

ⁱ ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^j UNIVERSITY OF QUEENSLAND   (Australia)

^k Örebro University   (Sweden)

^l UNIVERSITY OF ULM   (Germany)

^m UNIVERSITY OF BERN   (Switzerland)

ⁿ UNIVERSITY HOSPITAL BASEL   (Switzerland)

^o EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^p Krankenhaus Waldfriede   (Germany)

^q UNIVERSITY OF CHICAGO   (United States)

^r UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^s UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^t MASSACHUSETTS GENERAL HOSPITAL   (United States)

^u UNIVERSITÉ DE MONTRÉAL   (Canada)

^v MAISONNEUVE ROSEMONT HOSPITAL   (Canada)

^w MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^x UNIVERSITY OF MUNICH   (Germany)

^y UNIVERSITY OF TORONTO   (Canada)

^z KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^aa UNIVERSITY OF CALIFORNIA   (United States)

^ab CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^ac BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^ad JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^ae JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^af MONTREAL HEART INSTITUTE   (Canada)

more..

Author keywords

Genetics; Inflammatory Bowel Diseases; Microbiota

Indexed keywords

ALANINE; LIPID; RNA 16S; SLC39A8 PROTEIN; THREONINE; UNCLASSIFIED DRUG; ZINC TRANSPORTER; CATION TRANSPORT PROTEIN; ZIP8 PROTEIN, HUMAN;

ALLELE; ARTICLE; BLOOD PRESSURE; COHORT ANALYSIS; COLON LAVAGE; COLON MUCOSA; CONTROLLED STUDY; CROHN DISEASE; GENE EXPRESSION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC CODE; GENETIC VARIABILITY; GENOTYPING TECHNIQUE; HUMAN; HUMAN CELL; INFLAMMATORY BOWEL DISEASE; INTESTINE FLORA; INTESTINE MUCOSA; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MISSENSE MUTATION; NONSENSE MUTATION; OBESITY; PHENOTYPE; PLEIOTROPY; PRIORITY JOURNAL; RISK FACTOR; RNA SEQUENCE; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM; CASE CONTROL STUDY; FEMALE; GENETICS; GENOTYPE; MALE; MICROBIOLOGY; ULCERATIVE COLITIS;

ALLELES; CASE-CONTROL STUDIES; CATION TRANSPORT PROTEINS; COLITIS, ULCERATIVE; CROHN DISEASE; FEMALE; GASTROINTESTINAL MICROBIOME; GENETIC PLEIOTROPY; GENOTYPE; HUMANS; MALE; MUTATION, MISSENSE; RISK FACTORS;

EID: 84989894301     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2016.06.051     Document Type: Article

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