Light-Activated nuclear translocation of adeno-Associated virus nanoparticles using phytochrome B for enhanced, tunable, and spatially programmable gene delivery

ACS Nano

Volumn 10, Issue 1, 2016, Pages 225-237

  Gomez, Eric J ^a   Gerhardt, Karl ^a   Judd, Justin ^a   Tabor, Jeffrey J ^a,b,c   Suh, Junghae ^a,b,c  

^a Department of Bioengineering ^*  (United States)

^b Systems   (United States)

^c RICE UNIVERSITY   (United States)

Author keywords

Light Activatable; Light switchable; Optogenetics; Phytochrome; Stimulus responsive; Synthetic biology; Synthetic virology; Viral gene delivery

Indexed keywords

EFFICIENCY; GENE THERAPY; GENE TRANSFER; GENES; MOLECULAR BIOLOGY; NUCLEIC ACIDS; PLANTS (BOTANY); PROTEINS; SIGNALING; VIRUSES;

OPTOGENETICS; PHYTOCHROME; STIMULUS-RESPONSIVE; SWITCHABLE; SYNTHETIC BIOLOGY; SYNTHETIC VIROLOGY; VIRAL GENES;

GENE EXPRESSION;

ARABIDOPSIS PROTEIN; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; NANOPARTICLE; NUCLEAR LOCALIZATION SIGNAL; PHYTOCHROME B; PIF6 PROTEIN, ARABIDOPSIS; PROTEIN BINDING; RECOMBINANT PROTEIN;

ARABIDOPSIS; CELL NUCLEUS; CHEMISTRY; DEPENDOPARVOVIRUS; DICTYOSTELIUM; ESCHERICHIA COLI; GENE EXPRESSION; GENE TRANSFER; GENE VECTOR; GENETICS; HEK293 CELL LINE; HUMAN; LIGHT; METABOLISM; NUCLEAR LOCALIZATION SIGNAL; OPTOGENETICS; PROCEDURES; PROTEIN ENGINEERING; RADIATION RESPONSE; ULTRASTRUCTURE; VIRUS CAPSID;

ARABIDOPSIS; ARABIDOPSIS PROTEINS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CAPSID; CELL NUCLEUS; DEPENDOVIRUS; DICTYOSTELIUM; ESCHERICHIA COLI; GENE EXPRESSION; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HEK293 CELLS; HUMANS; LIGHT; NANOPARTICLES; NUCLEAR LOCALIZATION SIGNALS; OPTOGENETICS; PHYTOCHROME B; PROTEIN BINDING; PROTEIN ENGINEERING; RECOMBINANT PROTEINS;

EID: 84989846607     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/acsnano.5b05558     Document Type: Article

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