메뉴 건너뛰기




Volumn 16, Issue 5, 2016, Pages 1339-1351

Inflammatory Th17 Cells Express Integrin αvβ3 for Pathogenic Function

Author keywords

[No Author keywords available]

Indexed keywords

BETA3 INTEGRIN; CD51 ANTIGEN; CILENGITIDE; INTERLEUKIN 23; VITRONECTIN RECEPTOR;

EID: 84989828372     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2016.06.065     Document Type: Article
Times cited : (34)

References (53)
  • 1
    • 78649819162 scopus 로고    scopus 로고
    • αv Integrin expression by DCs is required for Th17 cell differentiation and development of experimental autoimmune encephalomyelitis in mice
    • Acharya, M., Mukhopadhyay, S., Païdassi, H., Jamil, T., Chow, C., Kissler, S., Stuart, L.M., Hynes, R.O., Lacy-Hulbert, A., αv Integrin expression by DCs is required for Th17 cell differentiation and development of experimental autoimmune encephalomyelitis in mice. J. Clin. Invest. 120 (2010), 4445–4452.
    • (2010) J. Clin. Invest. , vol.120 , pp. 4445-4452
    • Acharya, M.1    Mukhopadhyay, S.2    Païdassi, H.3    Jamil, T.4    Chow, C.5    Kissler, S.6    Stuart, L.M.7    Hynes, R.O.8    Lacy-Hulbert, A.9
  • 2
    • 0037449737 scopus 로고    scopus 로고
    • Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17
    • Aggarwal, S., Ghilardi, N., Xie, M.H., de Sauvage, F.J., Gurney, A.L., Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J. Biol. Chem. 278 (2003), 1910–1914.
    • (2003) J. Biol. Chem. , vol.278 , pp. 1910-1914
    • Aggarwal, S.1    Ghilardi, N.2    Xie, M.H.3    de Sauvage, F.J.4    Gurney, A.L.5
  • 3
    • 80052942855 scopus 로고    scopus 로고
    • Central role of JC virus-specific CD4+ lymphocytes in progressive multi-focal leucoencephalopathy-immune reconstitution inflammatory syndrome
    • Aly, L., Yousef, S., Schippling, S., Jelcic, I., Breiden, P., Matschke, J., Schulz, R., Bofill-Mas, S., Jones, L., Demina, V., et al. Central role of JC virus-specific CD4+ lymphocytes in progressive multi-focal leucoencephalopathy-immune reconstitution inflammatory syndrome. Brain 134 (2011), 2687–2702.
    • (2011) Brain , vol.134 , pp. 2687-2702
    • Aly, L.1    Yousef, S.2    Schippling, S.3    Jelcic, I.4    Breiden, P.5    Matschke, J.6    Schulz, R.7    Bofill-Mas, S.8    Jones, L.9    Demina, V.10
  • 4
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T.B., Oukka, M., Weiner, H.L., Kuchroo, V.K., Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441 (2006), 235–238.
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3    Korn, T.4    Strom, T.B.5    Oukka, M.6    Weiner, H.L.7    Kuchroo, V.K.8
  • 8
    • 79956116032 scopus 로고    scopus 로고
    • RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation
    • Codarri, L., Gyülvészi, G., Tosevski, V., Hesske, L., Fontana, A., Magnenat, L., Suter, T., Becher, B., RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation. Nat. Immunol. 12 (2011), 560–567.
    • (2011) Nat. Immunol. , vol.12 , pp. 560-567
    • Codarri, L.1    Gyülvészi, G.2    Tosevski, V.3    Hesske, L.4    Fontana, A.5    Magnenat, L.6    Suter, T.7    Becher, B.8
  • 9
    • 16844377086 scopus 로고    scopus 로고
    • Src kinase activity is required for integrin alphaVbeta3-mediated activation of nuclear factor-kappaB
    • Courter, D.L., Lomas, L., Scatena, M., Giachelli, C.M., Src kinase activity is required for integrin alphaVbeta3-mediated activation of nuclear factor-kappaB. J. Biol. Chem. 280 (2005), 12145–12151.
    • (2005) J. Biol. Chem. , vol.280 , pp. 12145-12151
    • Courter, D.L.1    Lomas, L.2    Scatena, M.3    Giachelli, C.M.4
  • 10
    • 0037434789 scopus 로고    scopus 로고
    • Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
    • Cua, D.J., Sherlock, J., Chen, Y., Murphy, C.A., Joyce, B., Seymour, B., Lucian, L., To, W., Kwan, S., Churakova, T., et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 421 (2003), 744–748.
    • (2003) Nature , vol.421 , pp. 744-748
    • Cua, D.J.1    Sherlock, J.2    Chen, Y.3    Murphy, C.A.4    Joyce, B.5    Seymour, B.6    Lucian, L.7    To, W.8    Kwan, S.9    Churakova, T.10
  • 13
    • 84876808514 scopus 로고    scopus 로고
    • Cutting edge: the pathogenicity of IFN-γ-producing Th17 cells is independent of T-bet
    • Duhen, R., Glatigny, S., Arbelaez, C.A., Blair, T.C., Oukka, M., Bettelli, E., Cutting edge: the pathogenicity of IFN-γ-producing Th17 cells is independent of T-bet. J. Immunol. 190 (2013), 4478–4482.
    • (2013) J. Immunol. , vol.190 , pp. 4478-4482
    • Duhen, R.1    Glatigny, S.2    Arbelaez, C.A.3    Blair, T.C.4    Oukka, M.5    Bettelli, E.6
  • 15
    • 79956152607 scopus 로고    scopus 로고
    • The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF
    • El-Behi, M., Ciric, B., Dai, H., Yan, Y., Cullimore, M., Safavi, F., Zhang, G.X., Dittel, B.N., Rostami, A., The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF. Nat. Immunol. 12 (2011), 568–575.
    • (2011) Nat. Immunol. , vol.12 , pp. 568-575
    • El-Behi, M.1    Ciric, B.2    Dai, H.3    Yan, Y.4    Cullimore, M.5    Safavi, F.6    Zhang, G.X.7    Dittel, B.N.8    Rostami, A.9
  • 19
    • 83755184226 scopus 로고    scopus 로고
    • Cutting edge: loss of α4 integrin expression differentially affects the homing of Th1 and Th17 cells
    • Glatigny, S., Duhen, R., Oukka, M., Bettelli, E., Cutting edge: loss of α4 integrin expression differentially affects the homing of Th1 and Th17 cells. J. Immunol. 187 (2011), 6176–6179.
    • (2011) J. Immunol. , vol.187 , pp. 6176-6179
    • Glatigny, S.1    Duhen, R.2    Oukka, M.3    Bettelli, E.4
  • 20
    • 16644372935 scopus 로고    scopus 로고
    • Deactivation of endothelium and reduction in angiogenesis in psoriatic skin and synovium by low dose infliximab therapy in combination with stable methotrexate therapy: a prospective single-centre study
    • Goedkoop, A.Y., Kraan, M.C., Picavet, D.I., de Rie, M.A., Teunissen, M.B., Bos, J.D., Tak, P.P., Deactivation of endothelium and reduction in angiogenesis in psoriatic skin and synovium by low dose infliximab therapy in combination with stable methotrexate therapy: a prospective single-centre study. Arthritis Res. Ther. 6 (2004), R326–R334.
    • (2004) Arthritis Res. Ther. , vol.6 , pp. R326-R334
    • Goedkoop, A.Y.1    Kraan, M.C.2    Picavet, D.I.3    de Rie, M.A.4    Teunissen, M.B.5    Bos, J.D.6    Tak, P.P.7
  • 21
    • 67349216357 scopus 로고    scopus 로고
    • Autoimmune T cell responses in the central nervous system
    • Goverman, J., Autoimmune T cell responses in the central nervous system. Nat. Rev. Immunol. 9 (2009), 393–407.
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 393-407
    • Goverman, J.1
  • 24
    • 84855566011 scopus 로고    scopus 로고
    • Progressive multifocal leukoencephalopathy and natalizumab
    • Hellwig, K., Gold, R., Progressive multifocal leukoencephalopathy and natalizumab. J. Neurol. 258 (2011), 1920–1928.
    • (2011) J. Neurol. , vol.258 , pp. 1920-1928
    • Hellwig, K.1    Gold, R.2
  • 26
    • 33846998653 scopus 로고    scopus 로고
    • Osteopontin-induced relapse and progression of autoimmune brain disease through enhanced survival of activated T cells
    • Hur, E.M., Youssef, S., Haws, M.E., Zhang, S.Y., Sobel, R.A., Steinman, L., Osteopontin-induced relapse and progression of autoimmune brain disease through enhanced survival of activated T cells. Nat. Immunol. 8 (2007), 74–83.
    • (2007) Nat. Immunol. , vol.8 , pp. 74-83
    • Hur, E.M.1    Youssef, S.2    Haws, M.E.3    Zhang, S.Y.4    Sobel, R.A.5    Steinman, L.6
  • 27
    • 0037145037 scopus 로고    scopus 로고
    • Integrins: bidirectional, allosteric signaling machines
    • Hynes, R.O., Integrins: bidirectional, allosteric signaling machines. Cell 110 (2002), 673–687.
    • (2002) Cell , vol.110 , pp. 673-687
    • Hynes, R.O.1
  • 28
    • 33748588423 scopus 로고    scopus 로고
    • The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
    • Ivanov, I.I., McKenzie, B.S., Zhou, L., Tadokoro, C.E., Lepelley, A., Lafaille, J.J., Cua, D.J., Littman, D.R., The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126 (2006), 1121–1133.
    • (2006) Cell , vol.126 , pp. 1121-1133
    • Ivanov, I.I.1    McKenzie, B.S.2    Zhou, L.3    Tadokoro, C.E.4    Lepelley, A.5    Lafaille, J.J.6    Cua, D.J.7    Littman, D.R.8
  • 29
    • 73349109145 scopus 로고    scopus 로고
    • Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes
    • Jäger, A., Dardalhon, V., Sobel, R.A., Bettelli, E., Kuchroo, V.K., Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes. J. Immunol. 183 (2009), 7169–7177.
    • (2009) J. Immunol. , vol.183 , pp. 7169-7177
    • Jäger, A.1    Dardalhon, V.2    Sobel, R.A.3    Bettelli, E.4    Kuchroo, V.K.5
  • 30
    • 0029048586 scopus 로고
    • Adhesion molecule expression on peripheral blood mononuclear cells in rheumatoid arthritis: positive correlation between the proportion of L-selectin and disease activity
    • Kurohori, Y., Sato, K., Suzuki, S., Kashiwazaki, S., Adhesion molecule expression on peripheral blood mononuclear cells in rheumatoid arthritis: positive correlation between the proportion of L-selectin and disease activity. Clin. Rheumatol. 14 (1995), 335–341.
    • (1995) Clin. Rheumatol. , vol.14 , pp. 335-341
    • Kurohori, Y.1    Sato, K.2    Suzuki, S.3    Kashiwazaki, S.4
  • 32
    • 0031032421 scopus 로고    scopus 로고
    • Cytotoxic T lymphocytes express a beta3 integrin which can induce the phosphorylation of focal adhesion kinase and the related PYK-2
    • Ma, E.A., Lou, O., Berg, N.N., Ostergaard, H.L., Cytotoxic T lymphocytes express a beta3 integrin which can induce the phosphorylation of focal adhesion kinase and the related PYK-2. Eur. J. Immunol. 27 (1997), 329–335.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 329-335
    • Ma, E.A.1    Lou, O.2    Berg, N.N.3    Ostergaard, H.L.4
  • 34
    • 79952741178 scopus 로고    scopus 로고
    • Cilengitide: the first anti-angiogenic small molecule drug candidate design, synthesis and clinical evaluation
    • Mas-Moruno, C., Rechenmacher, F., Kessler, H., Cilengitide: the first anti-angiogenic small molecule drug candidate design, synthesis and clinical evaluation. Anticancer. Agents Med. Chem. 10 (2010), 753–768.
    • (2010) Anticancer. Agents Med. Chem. , vol.10 , pp. 753-768
    • Mas-Moruno, C.1    Rechenmacher, F.2    Kessler, H.3
  • 35
    • 26444484570 scopus 로고    scopus 로고
    • An interaction between alphavbeta8 integrin and Band 4.1B via a highly conserved region of the Band 4.1 C-terminal domain
    • McCarty, J.H., Cook, A.A., Hynes, R.O., An interaction between alphavbeta8 integrin and Band 4.1B via a highly conserved region of the Band 4.1 C-terminal domain. Proc. Natl. Acad. Sci. USA 102 (2005), 13479–13483.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 13479-13483
    • McCarty, J.H.1    Cook, A.A.2    Hynes, R.O.3
  • 36
    • 36248965294 scopus 로고    scopus 로고
    • TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology
    • McGeachy, M.J., Bak-Jensen, K.S., Chen, Y., Tato, C.M., Blumenschein, W., McClanahan, T., Cua, D.J., TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology. Nat. Immunol. 8 (2007), 1390–1397.
    • (2007) Nat. Immunol. , vol.8 , pp. 1390-1397
    • McGeachy, M.J.1    Bak-Jensen, K.S.2    Chen, Y.3    Tato, C.M.4    Blumenschein, W.5    McClanahan, T.6    Cua, D.J.7
  • 38
    • 71849086031 scopus 로고    scopus 로고
    • Increased osteopontin expression in dendritic cells amplifies IL-17 production by CD4+ T cells in experimental autoimmune encephalomyelitis and in multiple sclerosis
    • Murugaiyan, G., Mittal, A., Weiner, H.L., Increased osteopontin expression in dendritic cells amplifies IL-17 production by CD4+ T cells in experimental autoimmune encephalomyelitis and in multiple sclerosis. J. Immunol. 181 (2008), 7480–7488.
    • (2008) J. Immunol. , vol.181 , pp. 7480-7488
    • Murugaiyan, G.1    Mittal, A.2    Weiner, H.L.3
  • 39
    • 0033638507 scopus 로고    scopus 로고
    • Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
    • Oppmann, B., Lesley, R., Blom, B., Timans, J.C., Xu, Y., Hunte, B., Vega, F., Yu, N., Wang, J., Singh, K., et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13 (2000), 715–725.
    • (2000) Immunity , vol.13 , pp. 715-725
    • Oppmann, B.1    Lesley, R.2    Blom, B.3    Timans, J.C.4    Xu, Y.5    Hunte, B.6    Vega, F.7    Yu, N.8    Wang, J.9    Singh, K.10
  • 41
    • 0142259710 scopus 로고    scopus 로고
    • Three or more routes for leukocyte migration into the central nervous system
    • Ransohoff, R.M., Kivisäkk, P., Kidd, G., Three or more routes for leukocyte migration into the central nervous system. Nat. Rev. Immunol. 3 (2003), 569–581.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 569-581
    • Ransohoff, R.M.1    Kivisäkk, P.2    Kidd, G.3
  • 42
    • 51449124031 scopus 로고    scopus 로고
    • Cilengitide: an integrin-targeting arginine-glycine-aspartic acid peptide with promising activity for glioblastoma multiforme
    • Reardon, D.A., Nabors, L.B., Stupp, R., Mikkelsen, T., Cilengitide: an integrin-targeting arginine-glycine-aspartic acid peptide with promising activity for glioblastoma multiforme. Expert Opin. Investig. Drugs 17 (2008), 1225–1235.
    • (2008) Expert Opin. Investig. Drugs , vol.17 , pp. 1225-1235
    • Reardon, D.A.1    Nabors, L.B.2    Stupp, R.3    Mikkelsen, T.4
  • 44
    • 84855475637 scopus 로고    scopus 로고
    • Th17 lymphocytes traffic to the central nervous system independently of α4 integrin expression during EAE
    • Rothhammer, V., Heink, S., Petermann, F., Srivastava, R., Claussen, M.C., Hemmer, B., Korn, T., Th17 lymphocytes traffic to the central nervous system independently of α4 integrin expression during EAE. J. Exp. Med. 208 (2011), 2465–2476.
    • (2011) J. Exp. Med. , vol.208 , pp. 2465-2476
    • Rothhammer, V.1    Heink, S.2    Petermann, F.3    Srivastava, R.4    Claussen, M.C.5    Hemmer, B.6    Korn, T.7
  • 45
    • 36148955067 scopus 로고    scopus 로고
    • Myelin basic protein-primed T cells induce neurotrophins in glial cells via alphavbeta3 [corrected] integrin
    • Roy, A., Liu, X., Pahan, K., Myelin basic protein-primed T cells induce neurotrophins in glial cells via alphavbeta3 [corrected] integrin. J. Biol. Chem. 282 (2007), 32222–32232.
    • (2007) J. Biol. Chem. , vol.282 , pp. 32222-32232
    • Roy, A.1    Liu, X.2    Pahan, K.3
  • 48
    • 53049102293 scopus 로고    scopus 로고
    • New targets for treatment of multiple sclerosis
    • Steinman, L., New targets for treatment of multiple sclerosis. J. Neurol. Sci. 274 (2008), 1–4.
    • (2008) J. Neurol. Sci. , vol.274 , pp. 1-4
    • Steinman, L.1
  • 49
    • 70349232886 scopus 로고    scopus 로고
    • Shifting therapeutic attention in MS to osteopontin, type 1 and type 2 IFN
    • Steinman, L., Shifting therapeutic attention in MS to osteopontin, type 1 and type 2 IFN. Eur. J. Immunol. 39 (2009), 2358–2360.
    • (2009) Eur. J. Immunol. , vol.39 , pp. 2358-2360
    • Steinman, L.1
  • 50
    • 0035184313 scopus 로고    scopus 로고
    • Coordinated induction of extracellular proteolysis systems during experimental autoimmune encephalomyelitis in mice
    • Teesalu, T., Hinkkanen, A.E., Vaheri, A., Coordinated induction of extracellular proteolysis systems during experimental autoimmune encephalomyelitis in mice. Am. J. Pathol. 159 (2001), 2227–2237.
    • (2001) Am. J. Pathol. , vol.159 , pp. 2227-2237
    • Teesalu, T.1    Hinkkanen, A.E.2    Vaheri, A.3
  • 51
    • 33750142276 scopus 로고    scopus 로고
    • Signals mediated by transforming growth factor-beta initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease
    • Veldhoen, M., Hocking, R.J., Flavell, R.A., Stockinger, B., Signals mediated by transforming growth factor-beta initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease. Nat. Immunol. 7 (2006), 1151–1156.
    • (2006) Nat. Immunol. , vol.7 , pp. 1151-1156
    • Veldhoen, M.1    Hocking, R.J.2    Flavell, R.A.3    Stockinger, B.4
  • 53
    • 84873635866 scopus 로고    scopus 로고
    • Th17 cell development: from the cradle to the grave
    • Zúñiga, L.A., Jain, R., Haines, C., Cua, D.J., Th17 cell development: from the cradle to the grave. Immunol. Rev. 252 (2013), 78–88.
    • (2013) Immunol. Rev. , vol.252 , pp. 78-88
    • Zúñiga, L.A.1    Jain, R.2    Haines, C.3    Cua, D.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.