Antiproliferative properties of oleuropein in human osteosarcoma cells

Natural Product Communications

Volumn 11, Issue 4, 2016, Pages 491-492

  Moran, Jose M ^a   Leal Hernandez, Olga ^a   Canal Macías, Maria L ^a   Roncero Martin, Raul ^a   Guerrero Bonmatty, Rafael ^a   Aliaga, Ignacio ^a   Zamorano, Juan D Pedrera ^a  

^a UNIVERSITY OF EXTREMADURA   (Spain)

Author keywords

Cell proliferation; Cytotoxicity; Dose response relationship; Oleuropein; Osteosarcoma

Indexed keywords

OLEUROPEIN; IRIDOID; PLANT EXTRACT;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY ASSAY; DRUG CYTOTOXICITY; DRUG EFFECT; HUMAN; HUMAN CELL; IC50; OSTEOSARCOMA CELL; CELL PROLIFERATION; DRUG EFFECTS; OSTEOSARCOMA; PHYTOTHERAPY; TUMOR CELL LINE;

CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; IRIDOIDS; OSTEOSARCOMA; PHYTOTHERAPY; PLANT EXTRACTS;

EID: 84989186776     PISSN: 1934578X     EISSN: 15559475     Source Type: Journal    
DOI: 10.1177/1934578x1601100418     Document Type: Article

References (24)

1. (a) Perona JS, Cabello-Moruno R, Ruiz-Gutierrez V. (2006) The role of virgin olive oil components in the modulation of endothelial function. Journal of Nutritional Biochemistry, 17, 429-445
2. (b) Owen RW, Giacosa A, Hull WE, Haubner R, Wurtele G, Spiegelhalder B, Bartsch H. (2000) Olive-oil consumption and health: The possible role of antioxidants. Lancet Oncology, 1, 107-112
3. (c) Owen RW, Giacosa A, Hull WE, Haubner R, Spiegelhalder B, Bartsch H. (2000) The antioxidant/anticancer potential of phenolic compounds isolated from olive oil. European Journal of Cancer, 36, 1235-1247
4. (d) Martin-Moreno JM, Willett WC, Gorgojo L, Banegas JR, Rodriguez-Artalejo F, Fernandez-Rodriguez JC, Maisonneuve P, Boyle P. (1994) Dietary fat, olive oil intake and breast cancer risk. International Journal of Cancer, 58, 774-780.
5. Cardeno A, Sanchez-Hidalgo M, Rosillo MA, Alarcon dlL. (2013) Oleuropein, a secoiridoid derived from olive tree, inhibits the proliferation of human colorectal cancer cell through downregulation of HIF-1alpha. Nutrition and Cancer, 65, 147-156.
6. Notarnicola M, Pisanti S, Tutino V, Bocale D, Rotelli MT, Gentile A, Memeo V, Bifulco M, Perri E, Caruso MG. (2011) Effects of olive oil polyphenols on fatty acid synthase gene expression and activity in human colorectal cancer cells. Genes & Nutrition, 6, 63-69.
7. Acquaviva R, Di GC, Sorrenti V, Galvano F, Santangelo R, Cardile V, Gangia S, D'Orazio N, Abraham NG, Vanella L. (2012) Antiproliferative effect of oleuropein in prostate cell lines. International Journal of Oncology, 41, 31-38.
8. Fabiani R, De BA, Rosignoli P, Servili M, Selvaggini R, Montedoro GF, Di SC, Morozzi G. (2006) Virgin olive oil phenols inhibit proliferation of human promyelocytic leukemia cells (HL60) by inducing apoptosis and differentiation. Journal of Nutrition, 136, 614-619.
9. Goldsmith CD, Vuong QV, Sadeqzadeh E, Stathopoulos CE, Roach PD, Scarlett CJ. (2015) Phytochemical properties and anti-proliferative activity of Olea europaea L. leaf extracts against pancreatic cancer cells. Molecules, 20, 12992-13004.
10. Yan CM, Chai EQ, Cai HY, Miao GY, Ma W. (2015) Oleuropein induces apoptosis via activation of caspases and suppression of phosphatidylinositol 3-kinase/protein kinase B pathway in HepG2 human hepatoma cell line. Molecular Medicine Reports, 11, 4617-4624.
11. (a) Yao J, Wu J, Yang X, Yang J, Zhang Y, Du L. (2014) Oleuropein induced apoptosis in HeLa cells via a mitochondrial apoptotic cascade associated with activation of the c-Jun NH2-terminal kinase. Journal of Pharmaceutical Sciences, 125, 300-311
12. (b) Chimento A, Casaburi I, Rosano C, Avena P, De LA, Campana C, Martire E, Santolla MF, Maggiolini M, Pezzi V, Sirianni R. (2014) Oleuropein and hydroxytyrosol activate GPER/GPR30-dependent pathways leading to apoptosis of ER-negative SKBR3 breast cancer cells. Molecular Nutrition & Food Research, 58, 478-489
13. (c) Goulas V, Exarchou V, Troganis AN, Psomiadou E, Fotsis T, Briasoulis E, Gerothanassis IP. (2009) Phytochemicals in olive-leaf extracts and their antiproliferative activity against cancer and endothelial cells. Molecular Nutrition & Food Research, 53, 600-608
14. (d) Hassan ZK, Elamin MH, Omer SA, Daghestani MH, Al-Olayan ES, Elobeid MA, Virk P. (2014) Oleuropein induces apoptosis via the p53 pathway in breast cancer cells. Asian Pacific Journal of Cancer Prevention, 14, 6739-6742
15. (e) Menendez JA, Vazquez-Martin A, Oliveras-Ferraros C, Garcia-Villalba R, Carrasco-Pancorbo A, Fernandez-Gutierrez A, Segura-Carretero A. (2008) Analyzing effects of extra-virgin olive oil polyphenols on breast cancer-associated fatty acid synthase protein expression using reverse-phase protein microarrays. International Journal of Molecular Medicine, 22, 433-439
16. (f) Quirantes-Pine R, Zurek G, Barrajon-Catalan E, Bassmann C, Micol V, Segura-Carretero A, Fernandez-Gutierrez A. (2013) A metabolite-profiling approach to assess the uptake and metabolism of phenolic compounds from olive leaves in SKBR3 cells by HPLC-ESI-QTOF-MS. Journal of Pharmaceutical and Biomedical Analysis, 72, 121-126
17. (g) Sirianni R, Chimento A, De LA, Casaburi I, Rizza P, Onofrio A, Iacopetta D, Puoci F, Ando S, Maggiolini M, Pezzi V. (2010) Oleuropein and hydroxytyrosol inhibit MCF-7 breast cancer cell proliferation interfering with ERK1/2 activation. Molecular Nutrition & Food Research, 54, 833-840.
18. (a) Bulotta S, Corradino R, Celano M, Maiuolo J, D'Agostino M, Oliverio M, Procopio A, Filetti S, Russo D. (2013) Antioxidant and antigrowth action of peracetylated oleuropein in thyroid cancer cells. Journal of Molecular Endocrinology, 51, 181-189
19. (b) Hamdi HK, Castellon R. (2005) Oleuropein, a non-toxic olive iridoid, is an anti-tumor agent and cytoskeleton disruptor. Biochemical and Biophysical Research Communications, 334, 769-778
20. (c) Hagiwara K, Goto T, Araki M, Miyazaki H, Hagiwara H. (2011) Olive polyphenol hydroxytyrosol prevents bone loss. European Journal of Pharmacology, 662, 78-84
21. (d) Pautke C, Schieker M, Tischer T, Kolk A, Neth P, Mutschler W, Milz S. (2004) Characterization of osteosarcoma cell lines MG-63, Saos-2 and U-2 OS in comparison to human osteoblasts. Anticancer Research, 24, 3743-3748.
22. (a) Pieme C, Santosh G, Tekwu E, Askun T, Aydeniz H, Ngogang J, Bhushan S, Saxena A. (2014) Fruits and barks extracts of Zanthozyllum heitzii a spice from Cameroon induce mitochondrial dependent apoptosis and Go/G1 phase arrest in human leukemia HL-60 cells. Biological Research, 47, 54-67
23. (b) Anter J, Fernandez-Bedmar Z, Villatoro-Pulido M, Demyda-Peyras S, Moreno-Millan M, Alonso-Moraga A, Munoz-Serrano A, Luque de Castro MD. (2011) A pilot study on the DNA-protective, cytotoxic, and apoptosis-inducing properties of olive-leaf extracts. Mutation Research, 723, 165-170
24. (c) Kikuchi M, Mano N, Uehara Y, Machida K, Kikuchi M. (2011) Cytotoxic and EGFR tyrosine kinase inhibitory activities of aglycone derivatives obtained by enzymatic hydrolysis of oleoside-type secoiridoid glucosides, oleuropein and ligustroside. Journal of Natural Medicines, 65, 237-240.