Endothelial lipase is upregulated by interleukin-6 partly via the p38 MAPK and p65 NF-κB signaling pathways

Molecular Medicine Reports

Volumn 14, Issue 3, 2016, Pages 1979-1985

  Yue, Xin ^a   Wu, Minghui ^a   Jiang, Hong ^a   Hao, Jing ^b   Zhao, Qinghao ^b   Zhu, Qing ^a   Saren, Gaowa ^a   Zhang, Yun ^a   Zhang, Xiaoli ^b  

^a SHANDONG UNIVERSITY   (China)

^b SHANDONG UNIVERSITY   (China)

Author keywords

EL; IL 6; p38 MAPK; p65 NF B

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CYCLINE; ENDOTHELIAL LIPASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE P38; PYRROLIDINE DITHIOCARBAMATE; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR; IL6 PROTEIN, HUMAN; LIPG PROTEIN, HUMAN;

ARTICLE; ATHEROSCLEROSIS; CELL PROLIFERATION; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE; PATHOGENESIS; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION; WESTERN BLOTTING; GENETICS; METABOLISM; NEWBORN; PHYSIOLOGY;

ATHEROSCLEROSIS; CELL PROLIFERATION; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INFANT, NEWBORN; INTERLEUKIN-6; LIPASE; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84989184468     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2016.5457     Document Type: Article

References (33)

1. Rattazzi M, Puato M, Faggin E, Bertipaglia B, Zambon A and Pauletto P: C-reactive protein and interleukin-6 in vascular disease: Culprits or passive bystanders? J Hypertens 21: 1787-1803, 2003
2. Bernberg E, Ulleryd MA, Johansson ME and Bergström GM: Social disruption stress increases IL-6 levels and accelerates atherosclerosis in ApoE-/-mice. Atherosclerosis 221: 359-365, 2012
3. Nishimoto N: Interleukin-6 in rheumatoid arthritis. Curr Opin Rheumatol 18: 277-281, 2006
4. Barton BE: Interleukin-6 and new strategies for the treatment of cancer, hyperproliferative diseases and paraneoplastic syndromes. Expert Opin Ther Targets 9: 737-752, 2005
5. Smolen JS and Maini RN: Interleukin-6: A new therapeutic target. Arthritis Res Ther 8: S5, 2006
6. Genovese MC, McKay JD, Nasonov EL, Mysler EF, da Silva NA, Alecock E, Woodworth T and Gomez-Reino JJ: Interleukin-6 receptor inhibition with tocilizumab reduces disease activity in rheumatoid arthritis with inadequate response to disease-modifying antirheumatic drugs: The tocilizumab in combination with traditional disease-modifying antirheumatic drug therapy study. Arthritis Rheum 58: 2968-2980, 2008
7. Williams SC: First IL-6-blocking drug nears approval for rare blood disorder. Nat Med 19: 1193, 2013
8. Jaye M, Lynch KJ, Krawiec J, Marchadier D, Maugeais C, Doan K, South V, Amin D, Perrone M and Rader DJ: A novel endothelial-derived lipase that modulates HDL metabolism. Nat Genet 21: 424-428, 1999
9. Ishida T, Choi S, Kundu RK, Hirata K, Rubin EM, Cooper AD and Quertermous T: Endothelial lipase is a major determinant of HDL level. J Clin Invest 111: 347-355, 2003
10. Gordon DJ and Rifkind BM: High-density lipoproteins-The clinical implications of recent studies. N Engl J Med 321: 1311-1316, 1989
11. Broedl UC, Maugeais C, Millar JS, Jin W, Moore RE, Fuki IV, Marchadier D, Glick JM and Rader DJ: Endothelial lipase promotes the catabolism of ApoB-containing lipoproteins. Circ Res 94: 1554-1561, 2004
12. Ishida T, Choi SY, Kundu RK, Spin J, Yamashita T, Hirata K, Kojima Y, Yokoyama M, Cooper AD and Quertermous T: Endothelial lipase modulates susceptibility to atherosclerosis in apolipoprotein-E-deficient mice. J Biol Chem 279: 45085-45092, 2004
13. Jin W, Sun GS, Marchadier D, Octtaviani E, Glick JM and Rader DJ: Endothelial cells secrete triglyceride lipase and phospholipase activities in response to cytokines as a result of endothelial lipase. Circ Res 92: 644-650, 2003
14. Choi SY, Hirata K, Ishida T, Quertermous T and Cooper AD: Endothelial lipase: A new lipase on the block. J Lipid Res 43: 1763-1769, 2002
15. Han J, Lee JD, Bibbs L and Ulevitch RJ: A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 265: 808-811, 1994
16. Monaco C, Andreakos E, Kiriakidis S, Mauri C, Bicknell C, Foxwell B, Cheshire N, Paleolog E and Feldmann M: Canonical pathway of nuclear factor kappa B activation selectively regulates proinflammatory and prothrombotic responses in human atherosclerosis. Proc Natl Acad Sci 101: 5634-5639, 2004
17. Annema W and Tietge UJ: Role of hepatic lipase and endothelial lipase in high-density lipoprotein-mediated reverse cholesterol transport. Nat Rev Drug Discov 4: 193-205, 2005
18. Badellino KO, Wolfe ML, Rielly MP and Rader DJ: Endothelial lipase concentrations are increased in metabolic syndrome and associated with coronary atherosclerosis. PLoS Med 3: e22, 2006
19. Cai G, He G and Qi C: The association between endothelial lipase 2384A/C gene polymorphism and acute coronary syndrome in a Chinese population. Mol Biol Rep 39: 9879-9884, 2012
20. Singaraja RR, Sivapalaratnam S, Hovingh K, Dubé MP, Castro-Perez J, Collins HL, Adelman SJ, Riwanto M, Manz J, Hubbard B, et al: The impact of partial and complete loss of function mutations in endothelial lipase on high-density lipoprotein levels and functionality in humans. Circ Cardiovasc Genet 6: 54-62, 2013
21. Fang YQ, Huang L and Li AM: Correlation between the expression of endothelial lipase in CECs and the improved jeopardy score in CAD patients. Chinese Journal of Critical Care Medicine 28: 5-8, 2008
22. Hirata K, Ishida T, Matsushita H, Tsao PS and Quertermous T: Regulated expression of endothelial cell-derived lipase. Biochem Biophys Res Commun 272: 90-93, 2000
23. Jin W, Sun GS, Marchadier D, Octtaviani E, Glick JM and Rader DJ: Endothelial cells secrete triglyceride lipase and phospholipase activities in response to cytokines as a result of endothelial lipase. Circ Res 92: 644-650, 2003
24. Badellino KO, Wolfe ML, Reilly MP and Rader DJ: Endothelial lipase is increased in vivo by inflammation in humans. Circulation 117: 678-685, 2008
25. Paradis ME, Badellino KO, Rader DJ, Deshaies Y, Couture P, Archer WR, Bergeron N and Lamarche B: Endothelial lipase is associated with inflammation in humans. J Lipid Res 47: 2808-2813, 2006
26. Yogi A, Callera GE, Aranha AB, Antunes TT, Graham D, McBride M, Dominiczak A and Touyz RM: Sphingosine-1-phosphate-induced inflammation involves receptor tyrosine kinase transactivation in vascular cells: Upregulation in hypertension. Hypertension 57: 809-818, 2011
27. Gerthoffer WT: Mechanisms of vascular smooth muscle cell migration. Circ Res 100: 607-621, 2007
28. Jacobsen JC, Mulvany MJ and Holstein-Rathlou NH: A mechanism for arteriolar remodeling based on maintenance of smooth muscle cell activation. Am J Physiol Regul Integr Comp Physiol 294: R1379-R1389, 2008
29. Paravicini TM, Montezano AC, Yusuf H and Touyz RM: Activation of vascular p38 MAPK by mechanical stretch is independent of c-Src and NADPH oxidase: Influence of hypertension and angiotensin II. J Am Soc Hypertension 6: 169-178, 2012
30. Oeckinghaus A and Ghosh S: The NF-kappaB family of transcription factors and its regulation. Cold Spring Harb Perspect Biol 1: a000034, 2009
31. Brand K, Page S, Rogler G, Bartsch A, Brandl R, Knuechel R, Page M, Kaltschmidt C and Baeuerle PA: Activated transcription factor nuclear factor-kappa B is present in the atherosclerotic lesion. J Clin Invest 97: 1715-1722, 1996
32. Hajra L, Evans AI, Chen M, Hyduk SJ, Collins T and Cybulsky MI: The NF-kappa B signal transduction pathway in aortic endothelial cells is primed for activation in regions predisposed to atherosclerotic lesion formation. Proc Natl Acad Sci USA 97: 9052-9057, 2000
33. Cao Y, Zhou X, Liu H, Zhang Y, Yu X and Liu C: The NF-κB pathway: Regulation of the instability of atherosclerotic plaques activated by Fg, Fb and FDPs. Mol Cell Biochem 383: 29-37, 2013