메뉴 건너뛰기




Volumn 9, Issue , 2016, Pages 269-279

Influence of saccharomyces boulardii CNCM I-745 on the gut-associated immune system

Author keywords

Diarrhea; Infectious gastrointestinal disease; Mode of action; Probiotic; Safety

Indexed keywords

B7 ANTIGEN; BETA GLUCAN; CD86 ANTIGEN; ENTEROTOXIN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; SECRETORY IMMUNOGLOBULIN; TUMOR NECROSIS FACTOR;

EID: 84989154365     PISSN: None     EISSN: 11787023     Source Type: Journal    
DOI: 10.2147/CEG.S111003     Document Type: Review
Times cited : (64)

References (90)
  • 1
    • 84904161657 scopus 로고    scopus 로고
    • Efficacy and safety of Saccharomyces boulardii for acute diarrhea
    • Feizizadeh S, Salehi-Abargouei A, Akbari V. Efficacy and safety of Saccharomyces boulardii for acute diarrhea. Pediatrics. 2014;134(1): e176–e191.
    • (2014) Pediatrics , vol.134 , Issue.1 , pp. e176-e191
    • Feizizadeh, S.1    Salehi-Abargouei, A.2    Akbari, V.3
  • 2
    • 33645455337 scopus 로고    scopus 로고
    • Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease
    • McFarland LV. Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease. Am J Gastroenterol. 2006;101(4):812–822.
    • (2006) Am J Gastroenterol , vol.101 , Issue.4 , pp. 812-822
    • McFarland, L.V.1
  • 3
    • 33846865120 scopus 로고    scopus 로고
    • Meta-analysis of probiotics for the prevention of traveler’s diarrhea
    • McFarland LV. Meta-analysis of probiotics for the prevention of traveler’s diarrhea. Travel Med Infect Dis. 2007;5(2):97–105.
    • (2007) Travel Med Infect Dis , vol.5 , Issue.2 , pp. 97-105
    • McFarland, L.V.1
  • 4
    • 33646713927 scopus 로고    scopus 로고
    • Efficacy of probiotics in prevention of acute diarrhoea: A meta-analysis of masked, randomised, placebo-controlled trials
    • Sazawal S, Hiremath G, Dhingra U, Malik P, Deb S, Black RE. Efficacy of probiotics in prevention of acute diarrhoea: a meta-analysis of masked, randomised, placebo-controlled trials. Lancet Infect Dis. 2006;6(6):374–382.
    • (2006) Lancet Infect Dis , vol.6 , Issue.6 , pp. 374-382
    • Sazawal, S.1    Hiremath, G.2    Dhingra, U.3    Malik, P.4    Deb, S.5    Black, R.E.6
  • 5
    • 84940035211 scopus 로고    scopus 로고
    • Saccharomyces boulardii CNCM i-745 supports regeneration of the intestinal microbiota after diarrheic dysbiosis‚ a review
    • Moré MI, Swidsinski A. Saccharomyces boulardii CNCM i-745 supports regeneration of the intestinal microbiota after diarrheic dysbiosis‚ a review. Clin Exp Gastroenterol. 2015;8:237–255.
    • (2015) Clin Exp Gastroenterol , vol.8 , pp. 237-255
    • Moré, M.I.1    Swidsinski, A.2
  • 6
    • 58149302567 scopus 로고    scopus 로고
    • Twenty-five years of research on Saccharomyces boulardii trophic effects: Updates and perspectives
    • Buts JP. Twenty-five years of research on Saccharomyces boulardii trophic effects: updates and perspectives. Dig Dis Sci. 2009;54(1): 15–18.
    • (2009) Dig Dis Sci , vol.54 , Issue.1 , pp. 15-18
    • Buts, J.P.1
  • 7
    • 78449246734 scopus 로고    scopus 로고
    • Interaction of Saccharomyces boulardii with intestinal brush border membranes: Key to probiotic effects?
    • Buts JP, De Keyser N. Interaction of Saccharomyces boulardii with intestinal brush border membranes: key to probiotic effects? J Pediatr Gastroenterol Nutr. 2010;51(4):532–533.
    • (2010) J Pediatr Gastroenterol Nutr , vol.51 , Issue.4 , pp. 532-533
    • Buts, J.P.1    De Keyser, N.2
  • 8
    • 0040699797 scopus 로고    scopus 로고
    • Immunological and trophical effects of Saccharomyces boulardii on the small intestine in healthy human volunteers
    • Jahn HU, Ullrich R, Schneider T, et al. Immunological and trophical effects of Saccharomyces boulardii on the small intestine in healthy human volunteers. Digestion. 1996;57(2):95–104.
    • (1996) Digestion , vol.57 , Issue.2 , pp. 95-104
    • Jahn, H.U.1    Ullrich, R.2    Schneider, T.3
  • 9
    • 0027516691 scopus 로고
    • Saccharomyces boulardii inhibits Clostridium difficile toxin A binding and enterotoxicity in rat ileum
    • Pothoulakis C, Kelly CP, Joshi MA, et al. Saccharomyces boulardii inhibits Clostridium difficile toxin A binding and enterotoxicity in rat ileum. Gastroenterology. 1993;104(4):1108–1115.
    • (1993) Gastroenterology , vol.104 , Issue.4 , pp. 1108-1115
    • Pothoulakis, C.1    Kelly, C.P.2    Joshi, M.A.3
  • 10
    • 0032919855 scopus 로고    scopus 로고
    • Saccharomyces boulardii protease inhibits the effects of Clostridium difficile toxins A and B in human colonic mucosa
    • Castagliuolo I, Riegler MF, Valenick L, LaMont JT, Pothoulakis C. Saccharomyces boulardii protease inhibits the effects of Clostridium difficile toxins A and B in human colonic mucosa. Infect Immun. 1999; 67(1):302–307.
    • (1999) Infect Immun , vol.67 , Issue.1 , pp. 302-307
    • Castagliuolo, I.1    Riegler, M.F.2    Valenick, L.3    Lamont, J.T.4    Pothoulakis, C.5
  • 11
    • 10544226189 scopus 로고    scopus 로고
    • Saccharomyces boulardii protease inhibits Clostridium difficile toxin A effects in the rat ileum
    • Castagliuolo I, LaMont JT, Nikulasson ST, Pothoulakis C. Saccharomyces boulardii protease inhibits Clostridium difficile toxin A effects in the rat ileum. Infect Immun. 1996;64(12):5225–5232.
    • (1996) Infect Immun , vol.64 , Issue.12 , pp. 5225-5232
    • Castagliuolo, I.1    Lamont, J.T.2    Nikulasson, S.T.3    Pothoulakis, C.4
  • 12
    • 77952522194 scopus 로고    scopus 로고
    • Interaction of Saccharomyces boulardii with Salmonella enterica serovar typhimurium protects mice and modifies T84 cell response to the infection
    • Martins FS, Dalmasso G, Arantes RME, et al. Interaction of Saccharomyces boulardii with Salmonella enterica serovar typhimurium protects mice and modifies T84 cell response to the infection. PLoS One.2010;5(1):e8925.
    • (2010) Plos One , vol.5 , Issue.1
    • Martins, F.S.1    Dalmasso, G.2    Arantes, R.3
  • 13
    • 84876096064 scopus 로고    scopus 로고
    • Inhibition of tissue inflammation and bacterial translocation as one of the protective mechanisms of Saccharomyces boulardii against Salmonella infection in mice
    • Martins FS, Vieira AlT, Elian SD, et al. Inhibition of tissue inflammation and bacterial translocation as one of the protective mechanisms of Saccharomyces boulardii against Salmonella infection in mice. Microbes Infect. 2013;15(4):270–279.
    • (2013) Microbes Infect , vol.15 , Issue.4 , pp. 270-279
    • Martins, F.S.1    Vieira, A.2    Elian, S.D.3
  • 14
    • 84905922203 scopus 로고    scopus 로고
    • Saccharomyces boulardii modifies Salmonella typhimurium traffic and host immune responses along the intestinal tract
    • Pontier-Bres R, Munro P, Boyer L, et al. Saccharomyces boulardii modifies Salmonella typhimurium traffic and host immune responses along the intestinal tract. PLoS One. 2014;9(8):e103069.
    • (2014) Plos One , vol.9 , Issue.8
    • Pontier-Bres, R.1    Munro, P.2    Boyer, L.3
  • 15
    • 70349213718 scopus 로고    scopus 로고
    • Review article: Anti-inflammatory mechanisms of action of Saccharomyces boulardii
    • Pothoulakis C. Review article: anti-inflammatory mechanisms of action of Saccharomyces boulardii. Aliment Pharmacol Ther. 2009;30(8): 826–833.
    • (2009) Aliment Pharmacol Ther , vol.30 , Issue.8 , pp. 826-833
    • Pothoulakis, C.1
  • 16
    • 34247625930 scopus 로고    scopus 로고
    • Genotypic and physiological characterization of Saccharomyces boulardii, the probiotic strain of Saccharomyces cerevisiae
    • Edwards-Ingram L, Gitsham P, Burton N, et al. Genotypic and physiological characterization of Saccharomyces boulardii, the probiotic strain of Saccharomyces cerevisiae. Appl Environ Microbiol. 2007;73(8):2458–2467.
    • (2007) Appl Environ Microbiol , vol.73 , Issue.8 , pp. 2458-2467
    • Edwards-Ingram, L.1    Gitsham, P.2    Burton, N.3
  • 17
    • 84877779889 scopus 로고    scopus 로고
    • S-Adenosyl-L-Methionine protects the probiotic yeast, Saccharomyces boulardii, from acid-induced cell death
    • Cascio V, Gittings D, Merloni K, Hurton M, Laprade D, Austriaco N. S-Adenosyl-L-Methionine protects the probiotic yeast, Saccharomyces boulardii, from acid-induced cell death. BMC Microbiol. 2013;13:35.
    • (2013) BMC Microbiol , vol.13 , pp. 35
    • Cascio, V.1    Gittings, D.2    Merloni, K.3    Hurton, M.4    Laprade, D.5    Austriaco, N.6
  • 18
    • 8644255761 scopus 로고    scopus 로고
    • Molecular and physiological comparisons between Saccharomyces cerevisiae and Saccharomyces boulardii
    • Fietto JL, Araujo RS, Valadao FN, et al. Molecular and physiological comparisons between Saccharomyces cerevisiae and Saccharomyces boulardii. Can J Microbiol. 2004;50(8):615–621.
    • (2004) Can J Microbiol , vol.50 , Issue.8 , pp. 615-621
    • Fietto, J.L.1    Araujo, R.S.2    Valadao, F.N.3
  • 19
    • 84911116602 scopus 로고    scopus 로고
    • Saccharomyces boulardii CNCM I-745 in different clinical conditions
    • Dinleyici EC, Kara A, Ozen M, Vandenplas Y. Saccharomyces boulardii CNCM I-745 in different clinical conditions. Expert Opin Biol Ther. 2014; 14(11):1593–1609.
    • (2014) Expert Opin Biol Ther , vol.14 , Issue.11 , pp. 1593-1609
    • Dinleyici, E.C.1    Kara, A.2    Ozen, M.3    Vandenplas, Y.4
  • 20
    • 0031709152 scopus 로고    scopus 로고
    • Development and maintenance of the gut-associated lymphoid tissue (GALT): The roles of enteric bacteria and viruses
    • Cebra JJ, Periwal SB, Lee G, Lee F, Shroff KE. Development and maintenance of the gut-associated lymphoid tissue (GALT): the roles of enteric bacteria and viruses. Dev Immunol. 1998;6(12):13–18.
    • (1998) Dev Immunol , vol.6 , Issue.1-2 , pp. 13-18
    • Cebra, J.J.1    Periwal, S.B.2    Lee, G.3    Lee, F.4    Shroff, K.E.5
  • 21
    • 67349250428 scopus 로고    scopus 로고
    • The gut microbiota shapes intestinal immune responses during health and disease
    • Round JL, Mazmanian SK. The gut microbiota shapes intestinal immune responses during health and disease. Nat Rev Immunol. 2009;9(5):313–323.
    • (2009) Nat Rev Immunol , vol.9 , Issue.5 , pp. 313-323
    • Round, J.L.1    Mazmanian, S.K.2
  • 22
    • 80054919389 scopus 로고    scopus 로고
    • Secretory IgA’s complex roles in immunity and mucosal homeostasis in the gut
    • Mantis NJ, Rol N, Corthesy B. Secretory IgA’s complex roles in immunity and mucosal homeostasis in the gut. Mucosal Immunol. 2011; 4(6):603–611.
    • (2011) Mucosal Immunol , vol.4 , Issue.6 , pp. 603-611
    • Mantis, N.J.1    Rol, N.2    Corthesy, B.3
  • 23
    • 69449102096 scopus 로고    scopus 로고
    • Comparative study of Bifidobacterium animalis, Escherichia coli, Lactobacillus casei and Saccharomyces boulardii probiotic properties
    • Martins FS, Silva AA, Vieira AT, et al. Comparative study of Bifidobacterium animalis, Escherichia coli, Lactobacillus casei and Saccharomyces boulardii probiotic properties. Arch Microbiol. 2009;191(8):623–630.
    • (2009) Arch Microbiol , vol.191 , Issue.8 , pp. 623-630
    • Martins, F.S.1    Silva, A.A.2    Vieira, A.T.3
  • 24
    • 0033833633 scopus 로고    scopus 로고
    • Saccharomyces boulardii stimulates sIgA production and the phagocytic system of gnotobiotic mice
    • Rodrigues AC, Cara DC, Fretez SH, et al. Saccharomyces boulardii stimulates sIgA production and the phagocytic system of gnotobiotic mice. J Appl Microbiol. 2000;89(3):404–414.
    • (2000) J Appl Microbiol , vol.89 , Issue.3 , pp. 404-414
    • Rodrigues, A.C.1    Cara, D.C.2    Fretez, S.H.3
  • 25
    • 0035077712 scopus 로고    scopus 로고
    • Saccharomyces boulardii stimulates intestinal immunoglobulin A immune response to Clostridium difficile toxin A in mice
    • Qamar A, Aboudola S, Warny M, et al. Saccharomyces boulardii stimulates intestinal immunoglobulin A immune response to Clostridium difficile toxin A in mice. Infect Immun. 2001;69(4):2762–2765.
    • (2001) Infect Immun , vol.69 , Issue.4 , pp. 2762-2765
    • Qamar, A.1    Aboudola, S.2    Warny, M.3
  • 26
    • 0025181832 scopus 로고
    • Stimulation of secretory IgA and secretory component of immunoglobulins in small intestine of rats treated with Saccharomyces boulardii
    • Buts JP, Bernasconi P, Vaerman JP, Dive C. Stimulation of secretory IgA and secretory component of immunoglobulins in small intestine of rats treated with Saccharomyces boulardii. Dig Dis Sci. 1990; 35(2):251–256.
    • (1990) Dig Dis Sci , vol.35 , Issue.2 , pp. 251-256
    • Buts, J.P.1    Bernasconi, P.2    Vaerman, J.P.3    Dive, C.4
  • 27
    • 0022654468 scopus 로고
    • Immunopharmacological effects of Saccharomyces boulardii in healthy human volunteers
    • Caetano JM, Parames M, Babo M, et al. Immunopharmacological effects of Saccharomyces boulardii in healthy human volunteers. Int J Immunopharmacol. 1986;8(3):245–259.
    • (1986) Int J Immunopharmacol , vol.8 , Issue.3 , pp. 245-259
    • Caetano, J.M.1    Parames, M.2    Babo, M.3
  • 28
    • 84857981933 scopus 로고    scopus 로고
    • Effect of Saccharomyces cerevisiae var. Boulardii and beta-galactomannan oligosaccharide on porcine intestinal epithelial and dendritic cells challenged in vitro with Escherichia coli F4 (K88)
    • Badia R, Zanello G, Chevaleyre C, et al. Effect of Saccharomyces cerevisiae var. Boulardii and beta-galactomannan oligosaccharide on porcine intestinal epithelial and dendritic cells challenged in vitro with Escherichia coli F4 (K88). Vet Res. 2012;43:4.
    • (2012) Vet Res , vol.43 , pp. 4
    • Badia, R.1    Zanello, G.2    Chevaleyre, C.3
  • 29
    • 84901236147 scopus 로고    scopus 로고
    • Yeast modulation of human dendritic cell cytokine secretion: An in vitro study
    • Smith IM, Christensen JE, Arneborg N, Jespersen L. Yeast modulation of human dendritic cell cytokine secretion: an in vitro study. PLoS One. 2014;9(5):e96595.
    • (2014) Plos One , vol.9 , Issue.5
    • Smith, I.M.1    Christensen, J.E.2    Arneborg, N.3    Jespersen, L.4
  • 30
    • 84857959173 scopus 로고    scopus 로고
    • Beta-galactomannan and Saccharomyces cerevisiae var. Boulardii modulate the immune response against Salmonella enterica serovar Typhimurium in porcine intestinal epithelial and dendritic cells
    • Badia R, Brufau MT, Guerrero-Zamora AM, et al. Beta-galactomannan and Saccharomyces cerevisiae var. boulardii modulate the immune response against Salmonella enterica serovar Typhimurium in porcine intestinal epithelial and dendritic cells. Clin Vaccine Immunol. 2012;19(3):368–376.
    • (2012) Clin Vaccine Immunol , vol.19 , Issue.3 , pp. 368-376
    • Badia, R.1    Brufau, M.T.2    Guerrero-Zamora, A.M.3
  • 31
    • 84864414721 scopus 로고    scopus 로고
    • Modulation of intestinal inflammation by yeasts and cell wall extracts: Strain dependence and unexpected anti-inflammatory role of glucan fractions
    • Jawhara S, Habib K, Maggiotto F, et al. Modulation of intestinal inflammation by yeasts and cell wall extracts: strain dependence and unexpected anti-inflammatory role of glucan fractions. PLoS One. 2012; 7(7):e40648.
    • (2012) Plos One , vol.7 , Issue.7
    • Jawhara, S.1    Habib, K.2    Maggiotto, F.3
  • 32
    • 0002986082 scopus 로고    scopus 로고
    • (1→3)-β-D-Glucans as biological response modifiers: A review of structure-functional activity relationships
    • Bohn JA, BeMiller JN. (1→3)-β-D-Glucans as biological response modifiers: a review of structure-functional activity relationships. Carbohyd Poly. 1995(28):3–14.
    • Carbohyd Poly , vol.1995 , Issue.28 , pp. 3-14
    • Bohn, J.A.1    Bemiller, J.N.2
  • 34
    • 76949094767 scopus 로고    scopus 로고
    • The effects of beta-glucan on human immune and cancer cells
    • Chan GC, Chan WK, Sze DM. The effects of beta-glucan on human immune and cancer cells. J Hematol Oncol. 2009;2:25.
    • (2009) J Hematol Oncol , vol.2 , pp. 25
    • Chan, G.C.1    Chan, W.K.2    Sze, D.M.3
  • 35
    • 23944442538 scopus 로고    scopus 로고
    • Oral delivery and gastrointestinal absorption of soluble glucans stimulate increased resistance to infectious challenge
    • Rice PJ, Adams EL, Ozment-Skelton T, et al. Oral delivery and gastrointestinal absorption of soluble glucans stimulate increased resistance to infectious challenge. J Pharmacol Exp Ther. 2005;314(3):1079–1086.
    • (2005) J Pharmacol Exp Ther , vol.314 , Issue.3 , pp. 1079-1086
    • Rice, P.J.1    Adams, E.L.2    Ozment-Skelton, T.3
  • 36
    • 77953464750 scopus 로고    scopus 로고
    • (1,3)-Beta-glucans activate both dectin-1 and NLRP3 inflammasome in human macrophages
    • Kankkunen P, Teirila L, Rintahaka J, Alenius H, Wolff H, Matikainen S. (1,3)-Beta-glucans activate both dectin-1 and NLRP3 inflammasome in human macrophages. J Immunol. 2011;184(11):6335–6342.
    • (2011) J Immunol , vol.184 , Issue.11 , pp. 6335-6342
    • Kankkunen, P.1    Teirila, L.2    Rintahaka, J.3    Alenius, H.4    Wolff, H.5    Matikainen, S.6
  • 37
    • 84900387104 scopus 로고    scopus 로고
    • Immune-modulatory effects of dietary yeast beta-1,3/1,6-D-glucan
    • Stier H, Ebbeskotte V, Gruenwald J. Immune-modulatory effects of dietary yeast beta-1,3/1,6-D-glucan. Nutr J. 2014;13(1):38.
    • (2014) Nutr J , vol.13 , Issue.1 , pp. 38
    • Stier, H.1    Ebbeskotte, V.2    Gruenwald, J.3
  • 38
    • 84861964286 scopus 로고    scopus 로고
    • Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis
    • Iliev ID, Funari VA, Taylor KD, et al. Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis. Science. 2012;336(6086):1314–1317.
    • (2012) Science , vol.336 , Issue.6086 , pp. 1314-1317
    • Iliev, I.D.1    Funari, V.A.2    Taylor, K.D.3
  • 40
    • 84903814971 scopus 로고    scopus 로고
    • Hemolysin of enterohemorrhagic Escherichia coli: Structure, transport, biological activity and putative role in virulence
    • Bielaszewska M, Aldick T, Bauwens A, Karch H. Hemolysin of enterohemorrhagic Escherichia coli: structure, transport, biological activity and putative role in virulence. Int J Med Microbiol. 2014;304(56):521–529.
    • (2014) Int J Med Microbiol , vol.304 , Issue.5-6 , pp. 521-529
    • Bielaszewska, M.1    Aldick, T.2    Bauwens, A.3    Karch, H.4
  • 41
    • 84881249125 scopus 로고    scopus 로고
    • Cell invasion and survival of Shiga toxin-producing Escherichia coli within cultured human intestinal epithelial cells
    • Cordeiro F, da Silva RI, Vargas-Stampe TL, Cerqueira AM, Andrade JR. Cell invasion and survival of Shiga toxin-producing Escherichia coli within cultured human intestinal epithelial cells. Microbiology. 2013;159(Pt 8):1683–1694.
    • (2013) Microbiology , vol.159 , pp. 1683-1694
    • Cordeiro, F.1    Da Silva, R.I.2    Vargas-Stampe, T.L.3    Cerqueira, A.M.4    Rade, J.R.5
  • 42
    • 33744827083 scopus 로고    scopus 로고
    • Saccharomyces boulardii prevents TNF-α-induced apoptosis in EHECinfected T84 cells
    • Dalmasso G, Loubat A, Dahan S, Calle G, Rampal P, Czerucka D. Saccharomyces boulardii prevents TNF-α-induced apoptosis in EHECinfected T84 cells. Res Microbiol. 2006;157(5):456–465.
    • (2006) Res Microbiol , vol.157 , Issue.5 , pp. 456-465
    • Dalmasso, G.1    Loubat, A.2    Dahan, S.3    Calle, G.4    Rampal, P.5    Czerucka, D.6
  • 43
    • 0001123420 scopus 로고    scopus 로고
    • Enterohemorrhagic Escherichia coli induces apoptosis which augments bacterial binding and phosphatidylethanolamine exposure on the plasma membrane outer leaflet
    • Barnett Foster D, Abul-Milh M, Huesca M, Lingwood CA. Enterohemorrhagic Escherichia coli induces apoptosis which augments bacterial binding and phosphatidylethanolamine exposure on the plasma membrane outer leaflet. Infect Immun. 2000;68(6):3108–3115.
    • (2000) Infect Immun , vol.68 , Issue.6 , pp. 3108-3115
    • Barnett Foster, D.1    Abul-Milh, M.2    Huesca, M.3    Lingwood, C.A.4
  • 44
    • 0037304989 scopus 로고    scopus 로고
    • Saccharomyces boulardii interferes with enterohemorrhagic Escherichia coli-induced signaling pathways in T84 cells
    • Dahan S, Dalmasso G, Imbert V, Peyron JF, Rampal P, Czerucka D. Saccharomyces boulardii interferes with enterohemorrhagic Escherichia coli-induced signaling pathways in T84 cells. Infect Immun. 2003;71(2):766–773.
    • (2003) Infect Immun , vol.71 , Issue.2 , pp. 766-773
    • Dahan, S.1    Dalmasso, G.2    Imbert, V.3    Peyron, J.F.4    Rampal, P.5    Czerucka, D.6
  • 45
    • 33645104228 scopus 로고    scopus 로고
    • Saccharomyces boulardii produces a soluble anti-inflammatory factor that inhibits NF-κB-mediated IL-8 gene expression
    • Sougioultzis S, Simeonidis S, Bhaskar KR, et al. Saccharomyces boulardii produces a soluble anti-inflammatory factor that inhibits NF-κB-mediated IL-8 gene expression. Biochem Biophys Res Commun. 2006;343(1):69–76.
    • (2006) Biochem Biophys Res Commun , vol.343 , Issue.1 , pp. 69-76
    • Sougioultzis, S.1    Simeonidis, S.2    Bhaskar, K.R.3
  • 46
    • 84938790688 scopus 로고    scopus 로고
    • The serine protease EspC from enteropathogenic Escherichia coli regulates pore formation and cytotoxicity mediated by the type III secretion system
    • Guignot J, Segura A, Tran Van Nhieu G. The serine protease EspC from enteropathogenic Escherichia coli regulates pore formation and cytotoxicity mediated by the type III secretion system. PLoS Pathog. 2015; 11(7):e1005013.
    • (2015) Plos Pathog , vol.11 , Issue.7
    • Guignot, J.1    Segura, A.2    Tran Van Nhieu, G.3
  • 47
    • 0032925379 scopus 로고    scopus 로고
    • Host cell death due to enteropathogenic Escherichia coli has features of apoptosis
    • Crane JK, Majumdar S, Pickhardt DF 3rd. Host cell death due to enteropathogenic Escherichia coli has features of apoptosis. Infect Immun. 1999;67(5):2575–2584.
    • (1999) Infect Immun , vol.67 , Issue.5 , pp. 2575-2584
    • Crane, J.K.1    Majumdar, S.2    Pickhardt, D.F.3
  • 48
    • 84862899672 scopus 로고    scopus 로고
    • Enteropathogenic E. Coli effectors EspG1/G2 disrupt tight junctions: New roles and mechanisms
    • Glotfelty LG, Hecht GA. Enteropathogenic E. coli effectors EspG1/G2 disrupt tight junctions: new roles and mechanisms. Ann N Y Acad Sci. 2012;1258:149–158.
    • (2012) Ann N Y Acad Sci , vol.1258 , pp. 149-158
    • Glotfelty, L.G.1    Hecht, G.A.2
  • 49
    • 0033806709 scopus 로고    scopus 로고
    • Saccharomyces boulardii preserves the barrier function and modulates the signal transduction pathway induced in enteropathogenic Escherichia coli-infected T84 cells
    • Czerucka D, Dahan S, Mograbi B, Rossi B, Rampal P. Saccharomyces boulardii preserves the barrier function and modulates the signal transduction pathway induced in enteropathogenic Escherichia coli-infected T84 cells. Infect Immun. 2000;68(10):5998–6004.
    • (2000) Infect Immun , vol.68 , Issue.10 , pp. 5998-6004
    • Czerucka, D.1    Dahan, S.2    Mograbi, B.3    Rossi, B.4    Rampal, P.5
  • 50
    • 42149097115 scopus 로고    scopus 로고
    • Analysis of data gaps pertaining to enterotoxigenic Escherichia coli infections in low and medium human development index countries, 1984–2005
    • Gupta SK, Keck J, Ram PK, Crump JA, Miller MA, Mintz ED. Part III. Analysis of data gaps pertaining to enterotoxigenic Escherichia coli infections in low and medium human development index countries, 1984–2005. Epidemiol Infect. 2008;136(6):721–738.
    • (2008) Epidemiol Infect , vol.136 , Issue.6 , pp. 721-738
    • Gupta, S.K.1    Keck, J.2    Ram, P.K.3    Crump, J.A.4    Miller, M.A.5    Mintz, E.D.6    Part, I.I.I.7
  • 51
    • 26044455874 scopus 로고    scopus 로고
    • Escherichia coli in postweaning diarrhea in pigs: An update on bacterial types, pathogenesis, and prevention strategies
    • Fairbrother JM, Nadeau E, Gyles CL. Escherichia coli in postweaning diarrhea in pigs: an update on bacterial types, pathogenesis, and prevention strategies. Anim Health Res Rev. 2005;6(1):17–39.
    • (2005) Anim Health Res Rev , vol.6 , Issue.1 , pp. 17-39
    • Fairbrother, J.M.1    Nadeau, E.2    Gyles, C.L.3
  • 52
    • 62149125521 scopus 로고    scopus 로고
    • Administration of Pediococcus acidilactici or Saccharomyces cerevisiae boulardii modulates development of porcine mucosal immunity and reduces intestinal bacterial translocation after Escherichia coli challenge
    • Lessard M, Dupuis M, Gagnon N, et al. Administration of Pediococcus acidilactici or Saccharomyces cerevisiae boulardii modulates development of porcine mucosal immunity and reduces intestinal bacterial translocation after Escherichia coli challenge. J Anim Sci. 2009;87(3): 922–934.
    • (2009) J Anim Sci , vol.87 , Issue.3 , pp. 922-934
    • Lessard, M.1    Dupuis, M.2    Gagnon, N.3
  • 53
    • 61849185743 scopus 로고    scopus 로고
    • Saccharomyces boulardii inhibits lipopolysaccharide-induced activation of human dendritic cells and T cell proliferation
    • Thomas S, Przesdzing I, Metzke D, Schmitz J, Radbruch A, Baumgart DC. Saccharomyces boulardii inhibits lipopolysaccharide-induced activation of human dendritic cells and T cell proliferation. Clin Exp Immunol. 2009;156(1):78–87.
    • (2009) Clin Exp Immunol , vol.156 , Issue.1 , pp. 78-87
    • Thomas, S.1    Przesdzing, I.2    Metzke, D.3    Schmitz, J.4    Radbruch, A.5    Baumgart, D.C.6
  • 54
    • 33748075169 scopus 로고    scopus 로고
    • Saccharomyces boulardii produces in rat small intestine a novel protein phosphatase that inhibits Escherichia coli endotoxin by dephosphorylation
    • Buts JP, Dekeyser N, Stilmant C, Delem E, Smets F, Sokal E. Saccharomyces boulardii produces in rat small intestine a novel protein phosphatase that inhibits Escherichia coli endotoxin by dephosphorylation. Pediatr Res. 2006;60(1):24–29.
    • (2006) Pediatr Res , vol.60 , Issue.1 , pp. 24-29
    • Buts, J.P.1    Dekeyser, N.2    Stilmant, C.3    Delem, E.4    Smets, F.5    Sokal, E.6
  • 55
    • 0031306875 scopus 로고    scopus 로고
    • Involvement of mitogenactivated protein kinase pathways in the nuclear responses and cytokine production induced by Salmonella typhimurium in cultured intestinal epithelial cells
    • Hobbie S, Chen LM, Davis RJ, Galan JE. Involvement of mitogenactivated protein kinase pathways in the nuclear responses and cytokine production induced by Salmonella typhimurium in cultured intestinal epithelial cells. J Immunol. 1997;159(11):5550–5559.
    • (1997) J Immunol , vol.159 , Issue.11 , pp. 5550-5559
    • Hobbie, S.1    Chen, L.M.2    Davis, R.J.3    Galan, J.E.4
  • 56
    • 84916640846 scopus 로고    scopus 로고
    • Salmonella-host interactions – modulation of the host innate immune system
    • Hurley D, McCusker MP, Fanning S, Martins M. Salmonella-host interactions – modulation of the host innate immune system. Front Immunol. 2014;5:481.
    • (2014) Front Immunol , vol.5 , pp. 481
    • Hurley, D.1    McCusker, M.P.2    Fanning, S.3    Martins, M.4
  • 57
    • 84934286471 scopus 로고    scopus 로고
    • Shigella manipulates host immune responses by delivering effector proteins with specific roles
    • Ashida H, Mimuro H, Sasakawa C. Shigella manipulates host immune responses by delivering effector proteins with specific roles. Front Immunol. 2015;6:219.
    • (2015) Front Immunol , vol.6 , pp. 219
    • Ashida, H.1    Mimuro, H.2    Sasakawa, C.3
  • 58
    • 1242306203 scopus 로고    scopus 로고
    • Shigella flexneri infection: Pathogenesis and vaccine development
    • Jennison AV, Verma NK. Shigella flexneri infection: pathogenesis and vaccine development. FEMS Microbiol Rev. 2004;28(1):43–58.
    • (2004) FEMS Microbiol Rev , vol.28 , Issue.1 , pp. 43-58
    • Jennison, A.V.1    Verma, N.K.2
  • 59
    • 41549123221 scopus 로고    scopus 로고
    • Saccharomyces boulardii interferes with Shigella pathogenesis by postinvasion signaling events
    • Mumy KL, Chen X, Kelly CP, McCormick BA. Saccharomyces boulardii interferes with Shigella pathogenesis by postinvasion signaling events. Am J Physiol Gastrointest Liver Physiol. 2008;294(3):G599–G609.
    • (2008) Am J Physiol Gastrointest Liver Physiol , vol.294 , Issue.3 , pp. G599-G609
    • Mumy, K.L.1    Chen, X.2    Kelly, C.P.3    McCormick, B.A.4
  • 60
    • 0029797776 scopus 로고    scopus 로고
    • Effect of Saccharomyces boulardii against experimental oral infection with Salmonella typhimurium and Shigella flexneri in conventional and gnotobiotic mice
    • Rodrigues AC, Nardi RM, Bambirra EA, Vieira EC, Nicoli JR. Effect of Saccharomyces boulardii against experimental oral infection with Salmonella typhimurium and Shigella flexneri in conventional and gnotobiotic mice. J Appl Bacteriol. 1996;81(3):251–256.
    • (1996) J Appl Bacteriol , vol.81 , Issue.3 , pp. 251-256
    • Rodrigues, A.C.1    Nardi, R.M.2    Bambirra, E.A.3    Vieira, E.C.4    Nicoli, J.R.5
  • 61
    • 0037204196 scopus 로고    scopus 로고
    • Clinical practice. Antibiotic-associated diarrhea
    • Bartlett JG. Clinical practice. Antibiotic-associated diarrhea. N Engl J Med. 2002;346(5):334–339.
    • (2002) N Engl J Med , vol.346 , Issue.5 , pp. 334-339
    • Bartlett, J.G.1
  • 62
    • 0023199624 scopus 로고
    • Suppression by Saccharomyces boulardii of toxigenic Clostridium difficile overgrowth after vancomycin treatment in hamsters
    • Elmer GW, McFarland LV. Suppression by Saccharomyces boulardii of toxigenic Clostridium difficile overgrowth after vancomycin treatment in hamsters. Antimicrob Agents Chemother. 1987;31(1):129–131.
    • (1987) Antimicrob Agents Chemother , vol.31 , Issue.1 , pp. 129-131
    • Elmer, G.W.1    McFarland, L.V.2
  • 63
    • 33747699728 scopus 로고    scopus 로고
    • Saccharomyces boulardii inhibits ERK1/2 mitogen-activated protein kinase activation both in vitro and in vivo and protects against Clostridium difficile toxin A-induced enteritis
    • Chen X, Kokkotou EG, Mustafa N, et al. Saccharomyces boulardii inhibits ERK1/2 mitogen-activated protein kinase activation both in vitro and in vivo and protects against Clostridium difficile toxin A-induced enteritis. J Biol Chem. 2006;281(34):24449–24454.
    • (2006) J Biol Chem , vol.281 , Issue.34 , pp. 24449-24454
    • Chen, X.1    Kokkotou, E.G.2    Mustafa, N.3
  • 64
    • 63149163533 scopus 로고    scopus 로고
    • Hospital-based surveillance to estimate the burden of rotavirus gastroenteritis among European children younger than 5 years of age
    • Forster J, Guarino A, Parez N, et al. Hospital-based surveillance to estimate the burden of rotavirus gastroenteritis among European children younger than 5 years of age. Pediatrics. 2009;123(3):e393–e400.
    • (2009) Pediatrics , vol.123 , Issue.3 , pp. e393-e400
    • Forster, J.1    Guarino, A.2    Parez, N.3
  • 66
    • 84903398974 scopus 로고    scopus 로고
    • Chloride secretion induced by rotavirus is oxidative stress-dependent and inhibited by Saccharomyces boulardii in human enterocytes
    • Buccigrossi V, Laudiero G, Russo C, et al. Chloride secretion induced by rotavirus is oxidative stress-dependent and inhibited by Saccharomyces boulardii in human enterocytes. PLoS One. 2014;9(6):e99830.
    • (2014) Plos One , vol.9 , Issue.6
    • Buccigrossi, V.1    Laudiero, G.2    Russo, C.3
  • 67
    • 57649142986 scopus 로고    scopus 로고
    • Effects of Saccharomyces boulardii on cytokine secretion from intraepithelial lymphocytes infected by Escherichia coli and Candida albicans
    • Fidan I, Kalkanci A, Yesilyurt E, et al. Effects of Saccharomyces boulardii on cytokine secretion from intraepithelial lymphocytes infected by Escherichia coli and Candida albicans. Mycoses. 2009;52(1):29–34.
    • (2009) Mycoses , vol.52 , Issue.1 , pp. 29-34
    • Fidan, I.1    Kalkanci, A.2    Yesilyurt, E.3
  • 68
    • 36348965867 scopus 로고    scopus 로고
    • Poulain D. Saccharomyces boulardii decreases inflammation and intestinal colonization by Candida albicans in a mouse model of chemically-induced colitis
    • Jawhara S, Poulain D. Saccharomyces boulardii decreases inflammation and intestinal colonization by Candida albicans in a mouse model of chemically-induced colitis. Med Mycol. 2007;45(8):691–700.
    • (2007) Med Mycol , vol.45 , Issue.8 , pp. 691-700
    • Jawhara, S.1
  • 70
    • 26644452974 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase involvement in the mechanism of action of Saccharomyces boulardii in castor oil-induced diarrhoea in rats
    • Girard P, Pansart Y, Gillardin JM. Inducible nitric oxide synthase involvement in the mechanism of action of Saccharomyces boulardii in castor oil-induced diarrhoea in rats. Nitric Oxide. 2005;13(3):163–169.
    • (2005) Nitric Oxide , vol.13 , Issue.3 , pp. 163-169
    • Girard, P.1    Pansart, Y.2    Gillardin, J.M.3
  • 71
    • 84873905376 scopus 로고    scopus 로고
    • Effectiveness of Saccharomyces boulardii in a rat model of colitis
    • Soyturk M, Saygili SM, Baskin H, et al. Effectiveness of Saccharomyces boulardii in a rat model of colitis. World J Gastroenterol. 2012;18(44):6452–6460.
    • (2012) World J Gastroenterol , vol.18 , Issue.44 , pp. 6452-6460
    • Soyturk, M.1    Saygili, S.M.2    Baskin, H.3
  • 72
    • 0000621394 scopus 로고
    • Prophylaxe der Reisediarrhöe mit Saccharomyces boulardii. Ergebnisse einer plazebokontrollierten Doppelblindstudie [Prevention of traveler’s diarrhea with Saccharomyces boulardii. Results of a placebo controlled double-blind study]
    • Kollaritsch H, Holst H, Grobara P, Wiedermann G. Prophylaxe der Reisediarrhöe mit Saccharomyces boulardii. Ergebnisse einer plazebokontrollierten Doppelblindstudie [Prevention of traveler’s diarrhea with Saccharomyces boulardii. Results of a placebo controlled double-blind study]. Fortschr Med. 1993;111(9):152–156. German.
    • (1993) Fortschr Med , vol.111 , Issue.9 , pp. 152-156
    • Kollaritsch, H.1    Holst, H.2    Grobara, P.3    Wiedermann, G.4
  • 73
    • 84868195398 scopus 로고    scopus 로고
    • Is primary prevention of Clostridium difficile infection possible with specific probiotics?
    • Johnson S, Maziade PJ, McFarland LV, et al. Is primary prevention of Clostridium difficile infection possible with specific probiotics? Int J Infect Dis. 2012;16(11):e786–e792.
    • (2012) Int J Infect Dis , vol.16 , Issue.11 , pp. e786-e792
    • Johnson, S.1    Maziade, P.J.2    McFarland, L.V.3
  • 74
    • 73349142966 scopus 로고    scopus 로고
    • Prevention of Clostridium difficile infection with Saccharomyces boulardii: A systematic review
    • Tung JM, Dolovich LR, Lee CH. Prevention of Clostridium difficile infection with Saccharomyces boulardii: a systematic review. Can J Gastroenterol. 2009;23(12):817–821.
    • (2009) Can J Gastroenterol , vol.23 , Issue.12 , pp. 817-821
    • Tung, J.M.1    Dolovich, L.R.2    Lee, C.H.3
  • 75
    • 24344493550 scopus 로고    scopus 로고
    • Meta-analysis: Non-pathogenic yeast Saccharomyces boulardii in the prevention of antibiotic-associated diarrhoea
    • Szajewska H, Mrukowicz J. Meta-analysis: non-pathogenic yeast Saccharomyces boulardii in the prevention of antibiotic-associated diarrhoea. Aliment Pharmacol Ther. 2005;22(5):365–372.
    • (2005) Aliment Pharmacol Ther , vol.22 , Issue.5 , pp. 365-372
    • Szajewska, H.1    Mrukowicz, J.2
  • 76
    • 34547155147 scopus 로고    scopus 로고
    • Probiotics for Clostridium difficile diarrhea: Putting it into perspective
    • Karpa KD. Probiotics for Clostridium difficile diarrhea: putting it into perspective. Ann Pharmacother. 2007;41(7):1284–1287.
    • (2007) Ann Pharmacother , vol.41 , Issue.7 , pp. 1284-1287
    • Karpa, K.D.1
  • 77
    • 0036278211 scopus 로고    scopus 로고
    • Seven cases of fungemia with Saccharomyces boulardii in critically ill patients
    • Lherm T, Monet C, Nougiere B, et al. Seven cases of fungemia with Saccharomyces boulardii in critically ill patients. Intensive Care Med. 2002;28(6):797–801.
    • (2002) Intensive Care Med , vol.28 , Issue.6 , pp. 797-801
    • Lherm, T.1    Monet, C.2    Nougiere, B.3
  • 78
    • 77952615260 scopus 로고    scopus 로고
    • Systematic review and meta-analysis of Saccharomyces boulardii in adult patients
    • McFarland LV. Systematic review and meta-analysis of Saccharomyces boulardii in adult patients. World J Gastroenterol. 2010; 16(18):2202–2222.
    • (2010) World J Gastroenterol , vol.16 , Issue.18 , pp. 2202-2222
    • McFarland, L.V.1
  • 79
    • 84946744926 scopus 로고    scopus 로고
    • Probiotics for the primary and secondary prevention of C. Difficile infections: A meta-analysis and systematic review
    • McFarland LV. Probiotics for the primary and secondary prevention of C. difficile infections: a meta-analysis and systematic review. Antibiotics. 2015;4(2):160–178.
    • (2015) Antibiotics , vol.4 , Issue.2 , pp. 160-178
    • McFarland, L.V.1
  • 80
    • 0000650388 scopus 로고    scopus 로고
    • The lack of therapeutic effect of Saccharomyces boulardii in the prevention of antibiotic-related diarrhoea in elderly patients
    • Lewis SJ, Potts LF, Barry RE. The lack of therapeutic effect of Saccharomyces boulardii in the prevention of antibiotic-related diarrhoea in elderly patients. J Infect. 1998;36(2):171–174.
    • (1998) J Infect , vol.36 , Issue.2 , pp. 171-174
    • Lewis, S.J.1    Potts, L.F.2    Barry, R.E.3
  • 81
    • 34249743666 scopus 로고    scopus 로고
    • Effect of Saccharomyces boulardii in children with acute gastroenteritis and its relationship to the immune response
    • Ozkan TB, Sahin E, Erdemir G, Budak F. Effect of Saccharomyces boulardii in children with acute gastroenteritis and its relationship to the immune response. J Int Med Res. 2007;35(2):201–212.
    • (2007) J Int Med Res , vol.35 , Issue.2 , pp. 201-212
    • Ozkan, T.B.1    Sahin, E.2    Erdemir, G.3    Budak, F.4
  • 82
    • 24644446058 scopus 로고    scopus 로고
    • Bacillus cereus var. Toyoii and Saccharomyces boulardii increased feed efficiency in broilers infected with Salmonella enteritidis
    • Gil de los Santos JR, Storch OB, Gil-Turnes C. Bacillus cereus var. toyoii and Saccharomyces boulardii increased feed efficiency in broilers infected with Salmonella enteritidis. Br Poult Sci. 2005;46(4):494–497.
    • (2005) Br Poult Sci , vol.46 , Issue.4 , pp. 494-497
    • Gil De Los Santos, J.R.1    Storch, O.B.2    Gil-Turnes, C.3
  • 83
    • 84943412498 scopus 로고    scopus 로고
    • Evaluation of yeast dietary supplementation in broilers challenged or not with Salmonella on growth performance, cecal microbiota composition and Salmonella in ceca, cloacae and carcass skin
    • Mountzouris KC, Dalaka E, Palamidi I, et al. Evaluation of yeast dietary supplementation in broilers challenged or not with Salmonella on growth performance, cecal microbiota composition and Salmonella in ceca, cloacae and carcass skin. Poult Sci. 2015;94(10):2445–2455.
    • (2015) Poult Sci , vol.94 , Issue.10 , pp. 2445-2455
    • Mountzouris, K.C.1    Dalaka, E.2    Palamidi, I.3
  • 84
    • 78449305654 scopus 로고    scopus 로고
    • Meta-analysis: The effects of Saccharomyces boulardii supplementation on Helicobacter pylori eradication rates and side effects during treatment
    • Szajewska H, Horvath A, Piwowarczyk A. Meta-analysis: the effects of Saccharomyces boulardii supplementation on Helicobacter pylori eradication rates and side effects during treatment. Aliment Pharmacol Ther. 2010;32(9):1069–1079.
    • (2010) Aliment Pharmacol Ther , vol.32 , Issue.9 , pp. 1069-1079
    • Szajewska, H.1    Horvath, A.2    Piwowarczyk, A.3
  • 85
    • 84908330396 scopus 로고    scopus 로고
    • Saccharomyces boulardii expresses neuraminidase activity selective for alpha2,3-linked sialic acid that decreases Helicobacter pylori adhesion to host cells
    • Sakarya S, Gunay N. Saccharomyces boulardii expresses neuraminidase activity selective for alpha2,3-linked sialic acid that decreases Helicobacter pylori adhesion to host cells. APMIS. 2014;122(10):941–950.
    • (2014) APMIS , vol.122 , Issue.10 , pp. 941-950
    • Sakarya, S.1    Gunay, N.2
  • 86
    • 33845683428 scopus 로고    scopus 로고
    • Saccharomyces boulardii inhibits inflammatory bowel disease by trapping T cells in mesenteric lymph nodes
    • Dalmasso G, Cottrez F, Imbert V, et al. Saccharomyces boulardii inhibits inflammatory bowel disease by trapping T cells in mesenteric lymph nodes. Gastroenterology. 2006;131(6):1812–1825.
    • (2006) Gastroenterology , vol.131 , Issue.6 , pp. 1812-1825
    • Dalmasso, G.1    Cottrez, F.2    Imbert, V.3
  • 87
    • 0027482862 scopus 로고
    • Inhibition of Candida albicans translocation from the gastrointestinal tract of mice by oral administration of Saccharomyces boulardii
    • Berg R, Bernasconi P, Fowler D, Gautreaux M. Inhibition of Candida albicans translocation from the gastrointestinal tract of mice by oral administration of Saccharomyces boulardii. J Infect Dis. 1993; 168(5):1314–1318.
    • (1993) J Infect Dis , vol.168 , Issue.5 , pp. 1314-1318
    • Berg, R.1    Bernasconi, P.2    Fowler, D.3    Gautreaux, M.4
  • 88
    • 84903975395 scopus 로고    scopus 로고
    • Saccharomyces boulardii administration changes gut microbiota and reduces hepatic steatosis, low-grade inflammation, and fat mass in obese and type 2 diabetic db/db mice
    • Everard A, Matamoros Sb, Geurts L, Delzenne NM, Cani PD. Saccharomyces boulardii administration changes gut microbiota and reduces hepatic steatosis, low-grade inflammation, and fat mass in obese and type 2 diabetic db/db mice. MBio. 2014;5(3):e01011–e01014.
    • (2014) Mbio , vol.5 , Issue.3 , pp. e01011-e01014
    • Everard, A.1    Matamoros, S.2    Geurts, L.3    Delzenne, N.M.4    Cani, P.D.5
  • 89
    • 79952163522 scopus 로고    scopus 로고
    • Rice bran fermented with Saccharomyces boulardii generates novel metabolite profiles with bioactivity
    • Ryan EP, Heuberger AL, Weir TL, Barnett B, Broeckling CD, Prenni JE. Rice bran fermented with Saccharomyces boulardii generates novel metabolite profiles with bioactivity. J Agric Food Chem. 2011;59(5):1862–1870.
    • (2011) J Agric Food Chem , vol.59 , Issue.5 , pp. 1862-1870
    • Ryan, E.P.1    Heuberger, A.L.2    Weir, T.L.3    Barnett, B.4    Broeckling, C.D.5    Prenni, J.E.6
  • 90
    • 69249150150 scopus 로고    scopus 로고
    • Saccharomyces boulardii inhibits EGF receptor signaling and intestinal tumor growth in apcmin mice
    • Chen X, Fruehauf J, Goldsmith JD, et al. Saccharomyces boulardii inhibits EGF receptor signaling and intestinal tumor growth in apcmin mice. Gastroenterology. 2009;137(3):914–923.
    • (2009) Gastroenterology , vol.137 , Issue.3 , pp. 914-923
    • Chen, X.1    Fruehauf, J.2    Goldsmith, J.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.