-
1
-
-
84904734154
-
Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the frst hour: Results from a guideline-based performance improvement program
-
Ferrer R, Martin-Loeches I, Phillips G, et al: Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the frst hour: Results from a guideline-based performance improvement program. Crit Care Med 2014; 42:1749-1755
-
(2014)
Crit Care Med
, vol.42
, pp. 1749-1755
-
-
Ferrer, R.1
Martin-Loeches, I.2
Phillips, G.3
-
2
-
-
55449090398
-
Antibiotic-associated diarrhea: Epidemiology, trends and treatment
-
McFarland LV: Antibiotic-associated diarrhea: Epidemiology, trends and treatment. Future Microbiol 2008; 3:563-578
-
(2008)
Future Microbiol
, vol.3
, pp. 563-578
-
-
McFarland, L.V.1
-
3
-
-
77950218147
-
Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department
-
Gaieski DF, Mikkelsen ME, Band RA, et al: Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department. Crit Care Med 2010; 38:1045-1053
-
(2010)
Crit Care Med
, vol.38
, pp. 1045-1053
-
-
Gaieski, D.F.1
Mikkelsen, M.E.2
Band, R.A.3
-
5
-
-
49649083648
-
The balance of reproducibility sensitivity, and specifcity of lists of differentially expressed genes in microarray studies
-
Shi L, Jones WD, Jensen RV, et al: The balance of reproducibility sensitivity, and specifcity of lists of differentially expressed genes in microarray studies. BMC Bioinformatics 2008; 9(Suppl 9):S10
-
(2008)
BMC Bioinformatics
, vol.9
, pp. S10
-
-
Shi, L.1
Jones, W.D.2
Jensen, R.V.3
-
6
-
-
0035179971
-
Replication validity of genetic association studies
-
Ioannidis JP, Ntzani EE, Trikalinos TA, et al: Replication validity of genetic association studies. Nat Genet 2001; 29:306-309
-
(2001)
Nat Genet
, vol.29
, pp. 306-309
-
-
Ioannidis, J.P.1
Ntzani, E.E.2
Trikalinos, T.A.3
-
7
-
-
84929629371
-
A comprehensive time-course-based multicohort analysis of sepsis and sterile infammation reveals a robust diagnostic gene set
-
Sweeney TE, Shidham A, Wong H R, et al: A comprehensive time-course-based multicohort analysis of sepsis and sterile infammation reveals a robust diagnostic gene set. Sci Transl Med 2015; 7:287ra71
-
(2015)
Sci Transl Med
, vol.7
, pp. 287ra71
-
-
Sweeney, T.E.1
Shidham, A.2
Wong, H.R.3
-
8
-
-
84943279884
-
A molecular biomarker to diagnose community-acquired pneumonia on intensive care unit admission
-
Scicluna BP, Klein Klouwenberg PM, van Vught LA, et al: A molecular biomarker to diagnose community-acquired pneumonia on intensive care unit admission. Am J Respir Crit Care Med 2015; 192:826-835
-
(2015)
Am J Respir Crit Care Med
, vol.192
, pp. 826-835
-
-
Scicluna, B.P.1
Klein Klouwenberg, P.M.2
Van Vught, L.A.3
-
9
-
-
84953790265
-
A molecular host response assay to discriminate between sepsis and infection-negative systemic infammation in critically ill patients: Discovery and validation in independent cohorts
-
McHugh L, Seldon TA, Brandon RA, et al: A molecular host response assay to discriminate between sepsis and infection-negative systemic infammation in critically ill patients: Discovery and validation in independent cohorts. PLoS Med 2015; 12:e1001916
-
(2015)
PLoS Med
, vol.12
, pp. e1001916
-
-
McHugh, L.1
Seldon, T.A.2
Brandon, R.A.3
-
10
-
-
53149135477
-
Key issues in conducting a meta-analysis of gene expression microarray datasets
-
Ramasamy A, Mondry A, Holmes CC, et al: Key issues in conducting a meta-analysis of gene expression microarray datasets. PLoS Med 2008; 5:e184
-
(2008)
PLoS Med
, vol.5
, pp. e184
-
-
Ramasamy, A.1
Mondry, A.2
Holmes, C.C.3
-
11
-
-
84910658471
-
OptimalCutpoints: An R Package for Selecting Optimal Cutpoints in Diagnostic Tests
-
Available at: Accessed September 20, 2016
-
Lopez-Raton M, Rodriguez-Alvarez MX, Suarez CC, et al: OptimalCutpoints: An R Package for Selecting Optimal Cutpoints in Diagnostic Tests. J Stat Soft 2014; 61:1-36. Available at: http:// www.jstatsoft.org/v61/i08/. Accessed September 20, 2016
-
(2014)
J Stat Soft
, vol.61
, pp. 1-36
-
-
Lopez-Raton, M.1
Rodriguez-Alvarez, M.X.2
Suarez, C.C.3
-
12
-
-
10844290766
-
A model-based background adjustment for oligonucleotide expression arrays
-
Wu Z, Irizarry R, Gentleman R, et al: A model-based background adjustment for oligonucleotide expression arrays. J Am Stat Assoc 2004; 99:909-917
-
(2004)
J Am Stat Assoc
, vol.99
, pp. 909-917
-
-
Wu, Z.1
Irizarry, R.2
Gentleman, R.3
-
13
-
-
79958809160
-
Development and validation of a novel molecular biomarker diagnostic test for the early detection of sepsis
-
Sutherland A, Thomas M, Brandon RA, et al: Development and validation of a novel molecular biomarker diagnostic test for the early detection of sepsis. Crit Care 2011; 15:R149
-
(2011)
Crit Care
, vol.15
, pp. R149
-
-
Sutherland, A.1
Thomas, M.2
Brandon, R.A.3
-
14
-
-
84861785677
-
Infammasome-regulated cytokines are critical mediators of acute lung injury
-
Dolinay T, Kim YS, Howrylak J, et al: Infammasome-regulated cytokines are critical mediators of acute lung injury. Am J Respir Crit Care Med 2012; 185:1225-1234
-
(2012)
Am J Respir Crit Care Med
, vol.185
, pp. 1225-1234
-
-
Dolinay, T.1
Kim, Y.S.2
Howrylak, J.3
-
15
-
-
84864910724
-
A distinct infuenza infection signature in the blood transcriptome of patients with severe community-acquired pneumonia
-
Parnell GP, McLean AS, Booth DR, et al: A distinct infuenza infection signature in the blood transcriptome of patients with severe community-acquired pneumonia. Crit Care 2012; 16:R157
-
(2012)
Crit Care
, vol.16
, pp. R157
-
-
Parnell, G.P.1
McLean, A.S.2
Booth, D.R.3
-
16
-
-
34547470882
-
Genome-level expression profles in pediatric septic shock indicate a role for altered zinc homeostasis in poor outcome
-
Wong HR, Shanley TP, Sakthivel B, et al; Genomics of Pediatric SIRS/Septic Shock Investigators: Genome-level expression profles in pediatric septic shock indicate a role for altered zinc homeostasis in poor outcome. Physiol Genomics 2007; 30:146-155
-
(2007)
Physiol Genomics
, vol.30
, pp. 146-155
-
-
Wong, H.R.1
Shanley, T.P.2
Sakthivel, B.3
-
17
-
-
82855164062
-
The infuence of developmental age on the early transcriptomic response of children with septic shock
-
Wynn JL, Cvijanovich NZ, Allen GL, et al: The infuence of developmental age on the early transcriptomic response of children with septic shock. Mol Med 2011; 17:1146-1156
-
(2011)
Mol Med
, vol.17
, pp. 1146-1156
-
-
Wynn, J.L.1
Cvijanovich, N.Z.2
Allen, G.L.3
-
18
-
-
67650470273
-
Genomic expression profling across the pediatric systemic infammatory response syndrome, sepsis, and septic shock spectrum
-
Wong HR, Cvijanovich N, Allen GL, et al; Genomics of Pediatric SIRS/ Septic Shock Investigators: Genomic expression profling across the pediatric systemic infammatory response syndrome, sepsis, and septic shock spectrum. Crit Care Med 2009; 37:1558-1566
-
(2009)
Crit Care Med
, vol.37
, pp. 1558-1566
-
-
Wong, H.R.1
Cvijanovich, N.2
Allen, G.L.3
-
19
-
-
35348925444
-
Genome-level longitudinal expression of signaling pathways and gene networks in pediatric septic shock
-
Shanley TP, Cvijanovich N, Lin R, et al: Genome-level longitudinal expression of signaling pathways and gene networks in pediatric septic shock. Mol Med 2007; 13:495-508
-
(2007)
Mol Med
, vol.13
, pp. 495-508
-
-
Shanley, T.P.1
Cvijanovich, N.2
Lin, R.3
-
20
-
-
47249122242
-
Validating the genomic signature of pediatric septic shock
-
Cvijanovich N, Shanley TP, Lin R, et al; Genomics of Pediatric SIRS/ Septic Shock Investigators: Validating the genomic signature of pediatric septic shock. Physiol Genomics 2008; 34:127-134
-
(2008)
Physiol Genomics
, vol.34
, pp. 127-134
-
-
Cvijanovich, N.1
Shanley, T.P.2
Lin, R.3
-
21
-
-
84864446365
-
Critical COPD respiratory illness is linked to increased transcriptomic activity of neutrophil proteases genes
-
Almansa R, Socias L, Sanchez-Garcia M, et al: Critical COPD respiratory illness is linked to increased transcriptomic activity of neutrophil proteases genes. BMC Res Notes 2012; 5:401
-
(2012)
BMC Res Notes
, vol.5
, pp. 401
-
-
Almansa, R.1
Socias, L.2
Sanchez-Garcia, M.3
-
22
-
-
84860500036
-
Novel biomarker combination improves the diagnosis of serious bacterial infections in Malawian children
-
Irwin AD, Marriage F, Mankhambo LA, et al; IPD Group Study: Novel biomarker combination improves the diagnosis of serious bacterial infections in Malawian children. BMC Med Genomics 2012; 5:13
-
(2012)
BMC Med Genomics
, vol.5
, pp. 13
-
-
Irwin, A.D.1
Marriage, F.2
Mankhambo, L.A.3
-
23
-
-
84928821718
-
Time since onset of disease and individual clinical markers associate with transcriptional changes in uncomplicated dengue
-
van de Weg CA, van den Ham HJ, Bijl MA, et al: Time since onset of disease and individual clinical markers associate with transcriptional changes in uncomplicated dengue. PLoS Negl Trop Dis 2015; 9:e0003522
-
(2015)
PLoS Negl Trop Dis
, vol.9
, pp. e0003522
-
-
Van De Weg, C.A.1
Van Den Ham, H.J.2
Bijl, M.A.3
-
25
-
-
76249091272
-
Genomic transcriptional profling identifes a candidate blood biomarker signature for the diagnosis of septicemic melioidosis
-
Pankla R, Buddhisa S, Berry M, et al: Genomic transcriptional profling identifes a candidate blood biomarker signature for the diagnosis of septicemic melioidosis. Genome Biol 2009; 10:R127
-
(2009)
Genome Biol
, vol.10
, pp. R127
-
-
Pankla, R.1
Buddhisa, S.2
Berry, M.3
-
26
-
-
69949148793
-
Gene expression signatures diagnose infuenza and other symptomatic respiratory viral infections in humans
-
Zaas AK, Chen M, Varkey J, et al: Gene expression signatures diagnose infuenza and other symptomatic respiratory viral infections in humans. Cell Host Microbe 2009; 6:207-217
-
(2009)
Cell Host Microbe
, vol.6
, pp. 207-217
-
-
Zaas, A.K.1
Chen, M.2
Varkey, J.3
-
27
-
-
79952395259
-
Aberrant cell cycle and apoptotic changes characterise severe infuenza A infection-a meta-analysis of genomic signatures in circulating leukocytes
-
Parnell G, McLean A, Booth D, et al: Aberrant cell cycle and apoptotic changes characterise severe infuenza A infection-a meta-analysis of genomic signatures in circulating leukocytes. PLoS One 2011; 6:e17186
-
(2011)
PLoS One
, vol.6
, pp. e17186
-
-
Parnell, G.1
McLean, A.2
Booth, D.3
-
28
-
-
77956486528
-
Host adaptive immunity defciency in severe pandemic infuenza
-
Bermejo-Martin JF, Martin-Loeches I, Rello J, et al: Host adaptive immunity defciency in severe pandemic infuenza. Crit Care 2010; 14:R167
-
(2010)
Crit Care
, vol.14
, pp. R167
-
-
Bermejo-Martin, J.F.1
Martin-Loeches, I.2
Rello, J.3
-
29
-
-
77955894773
-
An interferon-inducible neu-trophil-driven blood transcriptional signature in human tuberculosis
-
Berry MP, Graham CM, McNab FW, et al: An interferon-inducible neu-trophil-driven blood transcriptional signature in human tuberculosis. Nature 2010; 466:973-977
-
(2010)
Nature
, vol.466
, pp. 973-977
-
-
Berry, M.P.1
Graham, C.M.2
McNab, F.W.3
-
30
-
-
84907320442
-
Identifcation of a human neonatal immune-metabolic network associated with bacterial infection
-
Smith CL, Dickinson P, Forster T, et al: Identifcation of a human neonatal immune-metabolic network associated with bacterial infection. Nat Commun 2014; 5:4649
-
(2014)
Nat Commun
, vol.5
, pp. 4649
-
-
Smith, C.L.1
Dickinson, P.2
Forster, T.3
-
31
-
-
80052957457
-
Excessive innate immune response and mutant D222G/N in severe A (H1N1) pandemic infuenza
-
Berdal JE, Mollnes TE, Washre T, et al: Excessive innate immune response and mutant D222G/N in severe A (H1N1) pandemic infuenza. J Infect 2011; 63:308-316
-
(2011)
J Infect
, vol.63
, pp. 308-316
-
-
Berdal, J.E.1
Mollnes, T.E.2
Washre, T.3
-
32
-
-
84872175208
-
Gene expression-based classifers identify Staphylococcus aureus infection in mice and humans
-
Ahn SH, Tsalik EL, Cyr DD, et al: Gene expression-based classifers identify Staphylococcus aureus infection in mice and humans. PLoS One 2013; 8:e48979
-
(2013)
PLoS One
, vol.8
, pp. e48979
-
-
Ahn, S.H.1
Tsalik, E.L.2
Cyr, D.D.3
-
33
-
-
84888990746
-
Whole blood gene expression profles to assess pathogenesis and disease severity in infants with respiratory syncytial virus infection
-
Mejias A, Dimo B, Suarez NM, et al: Whole blood gene expression profles to assess pathogenesis and disease severity in infants with respiratory syncytial virus infection. PLoS Med 2013; 10:e1001549
-
(2013)
PLoS Med
, vol.10
, pp. e1001549
-
-
Mejias, A.1
Dimo, B.2
Suarez, N.M.3
-
34
-
-
84881086889
-
Gene expression profles in febrile children with defned viral and bacterial infection
-
Hu X, Yu J, Crosby SD, et al: Gene expression profles in febrile children with defned viral and bacterial infection. Proc Natl Acad Sci U S A 2013; 110:12792-12797
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 12792-12797
-
-
Hu, X.1
Yu, J.2
Crosby, S.D.3
-
35
-
-
84888618702
-
Transcriptomic profling in childhood H1N1/09 infuenza reveals reduced expression of protein synthesis genes
-
Herberg JA, Kaforou M, Gormley S, et al: Transcriptomic profling in childhood H1N1/09 infuenza reveals reduced expression of protein synthesis genes. J Infect Dis 2013; 208:1664-1668
-
(2013)
J Infect Dis
, vol.208
, pp. 1664-1668
-
-
Herberg, J.A.1
Kaforou, M.2
Gormley, S.3
-
36
-
-
84904161011
-
Dengue virus infection induces expansion of a CD14(+)CD16(+) monocyte population that stimulates plasmablast differentiation
-
Kwissa M, Nakaya HI, Onlamoon N, et al: Dengue virus infection induces expansion of a CD14(+)CD16(+) monocyte population that stimulates plasmablast differentiation. Cell Host Microbe 2014; 16:115-127
-
(2014)
Cell Host Microbe
, vol.16
, pp. 115-127
-
-
Kwissa, M.1
Nakaya, H.I.2
Onlamoon, N.3
-
37
-
-
84962951085
-
Early and dynamic changes in gene expression in septic shock patients: A genome-wide approach
-
Cazalis MA, Lepape A, Venet F, et al: Early and dynamic changes in gene expression in septic shock patients: A genome-wide approach. Intensive Care Med Exp 2014; 2:20
-
(2014)
Intensive Care Med Exp
, vol.2
, pp. 20
-
-
Cazalis, M.A.1
Lepape, A.2
Venet, F.3
-
38
-
-
84930090652
-
Superiority of transcriptional profling over procalcitonin for distinguishing bacterial from viral lower respiratory tract infections in hospitalized adults
-
Suarez NM, Bunsow E, Falsey AR, et al: Superiority of transcriptional profling over procalcitonin for distinguishing bacterial from viral lower respiratory tract infections in hospitalized adults. J Infect Dis 2015; 212:213-222
-
(2015)
J Infect Dis
, vol.212
, pp. 213-222
-
-
Suarez, N.M.1
Bunsow, E.2
Falsey, A.R.3
-
39
-
-
84936802478
-
Host transcriptional response to infuenza and other acute respiratory viral infections-A prospective cohort study
-
Zhai Y, Franco LM, Atmar RL, et al: Host transcriptional response to infuenza and other acute respiratory viral infections-A prospective cohort study. PLoS Pathog 2015; 11:e1004869
-
(2015)
PLoS Pathog
, vol.11
, pp. e1004869
-
-
Zhai, Y.1
Franco, L.M.2
Atmar, R.L.3
-
40
-
-
84942475224
-
The blood transcriptome of experimental melioidosis refects disease severity and shows considerable similarity with the human disease
-
Conejero L, Potempa K, Graham CM, et al: The blood transcriptome of experimental melioidosis refects disease severity and shows considerable similarity with the human disease. J Immunol 2015; 195:3248-3261
-
(2015)
J Immunol
, vol.195
, pp. 3248-3261
-
-
Conejero, L.1
Potempa, K.2
Graham, C.M.3
-
41
-
-
84862908403
-
A genomic storm in critically injured humans
-
Infammation and Host Response to Injury Large-Scale Collaborative Research Program
-
Xiao W, Mindrinos MN, Seok J, et al; Infammation and Host Response to Injury Large-Scale Collaborative Research Program: A genomic storm in critically injured humans. J Exp Med 2011; 208:2581-2590
-
(2011)
J Exp Med
, vol.208
, pp. 2581-2590
-
-
Xiao, W.1
Mindrinos, M.N.2
Seok, J.3
-
42
-
-
67650508418
-
A genomic score prognostic of outcome in trauma patients
-
Infammation and Host Response to Injury Large Scale Collaborative Research Program
-
Warren HS, Elson CM, Hayden DL, et al; Infammation and Host Response to Injury Large Scale Collaborative Research Program: A genomic score prognostic of outcome in trauma patients. Mol Med 2009; 15:220-227
-
(2009)
Mol Med
, vol.15
, pp. 220-227
-
-
Warren, H.S.1
Elson, C.M.2
Hayden, D.L.3
-
43
-
-
84948952180
-
Reply: Comprehensive validation of the FAIM3:PLAC8 ratio in time-matched public gene expression data
-
all the authors
-
Scicluna BP, Klein Klouwenberg PM, van der Poll T; all the authors: Reply: Comprehensive validation of the FAIM3:PLAC8 ratio in time-matched public gene expression data. Am J Respir Crit Care Med 2015; 192:1261-1262
-
(2015)
Am J Respir Crit Care Med
, vol.192
, pp. 1261-1262
-
-
Scicluna, B.P.1
Klein Klouwenberg, P.M.2
Van Der Poll, T.3
-
44
-
-
84983096128
-
Comprehensive validation of the FAIM3:PLAC8 ratio in time-matched public gene expression data
-
Sweeney TE, Khatri P: Comprehensive validation of the FAIM3:PLAC8 ratio in time-matched public gene expression data. Am J Respir Crit Care Med 2015; 192:1260-1261
-
(2015)
Am J Respir Crit Care Med
, vol.192
, pp. 1260-1261
-
-
Sweeney, T.E.1
Khatri, P.2
|