Diet-induced pre-diabetes slows cardiac conductance and promotes arrhythmogenesis

Cardiovascular Diabetology

Volumn 14, Issue 1, 2015, Pages

  Axelsen, Lene Nygaard ^a   Calloe, Kirstine ^b   Braunstein, Thomas Hartig ^a   Riemann, Mads ^a   Hofgaard, Johannes Pauli ^a   Liang, Bo ^a   Jensen, Christa Funch ^a   Olsen, Kristine Boisen ^b   Bartels, Emil D ^c   Baandrup, Ulrik ^d   Jespersen, Thomas ^a   Nielsen, Lars Bo ^a,c   Holstein Rathlou, Niels Henrik ^a   Nielsen, Morten Schak ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c University of Copenhagen   (Denmark)

^d AALBORG UNIVERSITY   (Denmark)

Author keywords

Arrhythmias; Conduction velocity; Diabetes; Electrophysiology; Gap junctions

Indexed keywords

CONNEXIN 43; FRUCTOSE; GLUCOSE; ION CHANNEL; LIPID; WATER; CONNEXIN 43 PROTEIN, RAT; POTASSIUM CHANNEL; SODIUM CHANNEL; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARRHYTHMOGENESIS; ARTICLE; CARDIAC MUSCLE CELL; CONTROLLED STUDY; DIET INDUCED PRE DIABETES; ELECTROCARDIOGRAM; EX VIVO STUDY; FEEDING; GAP JUNCTION; HEART MUSCLE FIBER MEMBRANE CONDUCTANCE; HEART MUSCLE FIBROSIS; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART VENTRICLE FIBRILLATION; IMMUNOFLUORESCENCE; IMPAIRED GLUCOSE TOLERANCE; IN VIVO STUDY; ISOLATED HEART; LIPID DIET; MALE; NONHUMAN; PATCH CLAMP TECHNIQUE; POTASSIUM CURRENT; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; QRS COMPLEX; RAT; SODIUM CURRENT; THIN LAYER CHROMATOGRAPHY; WESTERN BLOTTING; ANIMAL; CARDIAC MUSCLE; DISEASE MODEL; ELECTROCARDIOGRAPHY; HEART ARRHYTHMIA; HEART CONTRACTION; HEART MUSCLE CONDUCTION SYSTEM; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; ARRHYTHMIAS, CARDIAC; CONNEXIN 43; DIABETES MELLITUS, TYPE 2; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; ELECTROCARDIOGRAPHY; FRUCTOSE; GAP JUNCTIONS; HEART CONDUCTION SYSTEM; MALE; MYOCARDIAL CONTRACTION; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION; MYOCARDIUM; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; PREDIABETIC STATE; RATS; RATS, SPRAGUE-DAWLEY; SODIUM CHANNELS; TRIGLYCERIDES;

EID: 84988942633     PISSN: None     EISSN: 14752840     Source Type: Journal    
DOI: 10.1186/s12933-015-0246-8     Document Type: Article

References (39)

1. Bergner DW, Goldberger JJ. Diabetes mellitus and sudden cardiac death: what are the data? Cardiol J. 2010;17:117-29
2. Gami AS, Witt BJ, Howard DE, Erwin PJ, Gami LA, Somers VK, et al. Metabolic syndrome and risk of incident cardiovascular events and death: a systematic review and meta-analysis of longitudinal studies. J Am Coll Cardiol. 2007;49:403-14
3. Voulgari C, Tentolouris N, Papadogiannis D, Moyssakis I, Perrea D, Kyriaki D, et al. Increased left ventricular arrhythmogenicity in metabolic syndrome and relationship with myocardial performance, risk factors for atherosclerosis, and low-grade inflammation. Metabolism. 2010;59:159-65
4. Bakth S, Arena J, Lee W, Torres R, Haider B, Patel BC, et al. Arrhythmia susceptibility and myocardial composition in diabetes. Influence of physical conditioning. J Clin Invest. 1986;77:382-95
5. Ghaly H, Boyle P, Vigmond E, Shimoni Y, Nygren A. Simulations of reduced conduction reserve in the diabetic rat heart: response to uncoupling and reduced excitability. Ann Biomed Eng. 2010;38:1415-25
6. Nygren A, Olson ML, Chen KY, Emmett T, Kargacin G, Shimoni Y. Propagation of the cardiac impulse in the diabetic rat heart: reduced conduction reserve. J Physiol. 2007;580:543-60
7. Lin H, Ogawa K, Imanaga I, Tribulova N. Remodeling of connexin 43 in the diabetic rat heart. Mol Cell Biochem. 2006;290:69-78
8. Stilli D, Lagrasta C, Berni R, Bocchi L, Savi M, Delucchi F, et al. Preservation of ventricular performance at early stages of diabetic cardiomyopathy involves changes in myocyte size, number and intercellular coupling. Basic Res Cardiol. 2007;102:488-99
9. Lin H, Mitasikova M, Dlugosova K, Okruhlicova L, Imanaga I, Ogawa K, et al. Thyroid hormones suppress epsilon-PKC signalling, down-regulate connexin-43 and increase lethal arrhythmia susceptibility in non-diabetic and diabetic rat hearts. J Physiol Pharmacol. 2008;59:271-85
10. Apaijai N, Chinda K, Palee S, Chattipakorn S, Chattipakorn N. Combined vildagliptin and metformin exert better cardioprotection than monotherapy against ischemia-reperfusion injury in obese-insulin resistant rats. PLoS One. 2014;9, e102374
11. Olsen KB, Axelsen LN, Braunstein TH, Sorensen CM, Andersen CB, Ploug T, et al. Myocardial impulse propagation is impaired in right ventricular tissue of Zucker Diabetic Fatty (ZDF) rats. Cardiovasc Diabetol. 2013;12:19
12. Axelsen LN, Lademann JB, Petersen JS, Holstein-Rathlou NH, Ploug T, Prats C, et al. Cardiac and metabolic changes in long-term high fructose-fat fed rats with severe obesity and extensive intramyocardial lipid accumulation. Am J Physiol Regul Integr Comp Physiol. 2010;298:R1560-70
13. Huang BW, Chiang MT, Yao HT, Chiang W. The effect of high-fat and high-fructose diets on glucose tolerance and plasma lipid and leptin levels in rats. Diabetes Obes Metab. 2004;6:120-6
14. Kmecova J, Klimas J. Heart rate correction of the QT duration in rats. Eur J Pharmacol. 2010;641:187-92
15. Olsen KB, Braunstein TH, Sorensen CM, Axelsen LN, Holstein-Rathlou NH, Nielsen MS. Angiotensin II does not acutely regulate conduction velocity in rat atrial tissue. Scand J Clin Lab Invest. 2011;71:492-9
16. Kjolbye AL, Knudsen CB, Jepsen T, Larsen BD, Petersen JS. Pharmacological characterization of the new stable antiarrhythmic peptide analog Ac-D-Tyr-D-Pro-D-Hyp-Gly-D-Ala-Gly-NH2 (ZP123): in vivo and in vitro studies. J Pharmacol Exp Ther. 2003;306:1191-9
17. Curtis MJ, Hancox JC, Farkas A, Wainwright CL, Stables CL, Saint DA, et al. The Lambeth Conventions (II): guidelines for the study of animal and human ventricular and supraventricular arrhythmias. Pharmacol Ther. 2013;139:213-48
18. Procida K, Jorgensen L, Schmitt N, Delmar M, Taffet SM, Holstein-Rathlou NH, et al. Phosphorylation of connexin43 on serine 306 regulates electrical coupling. Heart Rhythm. 2009;6:1632-8
19. Bartels ED, Lauritsen M, Nielsen LB. Hepatic expression of microsomal triglyceride transfer protein and in vivo secretion of triglyceride-rich lipoproteins are increased in obese diabetic mice. Diabetes. 2002;51:1233-9
20. Axelsen LN, Stahlhut M, Mohammed S, Larsen BD, Nielsen MS, Holstein-Rathlou NH, et al. Identification of ischemia-regulated phosphorylation sites in connexin43: A possible target for the antiarrhythmic peptide analogue rotigaptide (ZP123). J Mol Cell Cardiol. 2006;40:790-8
21. Himmel HM, Wettwer E, Li Q, Ravens U. Four different components contribute to outward current in rat ventricular myocytes. Am J Physiol. 1999;277:H107-18
22. Grubb S, Speerschneider T, Occhipinti D, Fiset C, Olesen SP, Thomsen MB, et al. Loss of K+ currents in heart failure is accentuated in KChIP2 deficient mice. J Cardiovasc Electrophysiol. 2014;25:896-904
23. Torres-Jacome J, Gallego M, Rodriguez-Robledo JM, Sanchez-Chapula JA, Casis O. Improvement of the metabolic status recovers cardiac potassium channel synthesis in experimental diabetes. Acta Physiol (Oxf). 2013;207:447-59
24. Siscovick D, Sotoodehnia N, Rea T, Raghunathan T, Jouven X, Lemaitre R. Type 2 diabetes mellitus and the risk of sudden cardiac arrest in the community. Rev Endocr Metab Disord. 2010;11:53-9
25. Veglio M, Bruno G, Borra M, Macchia G, Bargero G, D'Errico N, et al. Prevalence of increased QT interval duration and dispersion in type 2 diabetic patients and its relationship with coronary heart disease: a population-based cohort. J Intern Med. 2002;251:317-24
26. Ramirez AH, Schildcrout JS, Blakemore DL, Masys DR, Pulley JM, Basford MA, et al. Modulators of normal electrocardiographic intervals identified in a large electronic medical record. Heart Rhythm. 2011;8:271-7
27. Huang H, Amin V, Gurin M, Wan E, Thorp E, Homma S, et al. Diet-induced obesity causes long QT and reduces transcription of voltage-gated potassium channels. J Mol Cell Cardiol. 2013;59:151-8
28. VanHoose L, Sawers Y, Loganathan R, Vacek JL, Stehno-Bittel L, Novikova L, et al. Electrocardiographic changes with the onset of diabetes and the impact of aerobic exercise training in the Zucker Diabetic Fatty (ZDF) rat. Cardiovasc Diabetol. 2010;9:56
29. Howarth FC, Jacobson M, Shafiullah M, Adeghate E. Long-term effects of type 2 diabetes mellitus on heart rhythm in the Goto-Kakizaki rat. Exp Physiol. 2008;93:362-9
30. Yang Q, Kiyoshige K, Fujimoto T, Katayama M, Fujino K, Saito K, et al. Signalaveraging electrocardiogram in patients with diabetes mellitus. Jpn Heart J. 1990;31:25-33
31. Huisamen B, Genis A, Marais E, Lochner A. Pre-treatment with a DPP-4 inhibitor is infarct sparing in hearts from obese, pre-diabetic rats. Cardiovasc Drugs Ther. 2011;25:13-20
32. Howarth FC, Chandler NJ, Kharche S, Tellez JO, Greener ID, Yamanushi TT, et al. Effects of streptozotocin-induced diabetes on connexin43 mRNA and protein expression in ventricular muscle. Mol Cell Biochem. 2008;319:105-14
33. Axelsen LN, Calloe K, Holstein-Rathlou NH, Nielsen MS. Managing the complexity of communication: regulation of gap junctions by post-translational modification. Front Pharmacol. 2013;4:130
34. Stables CL, Musa H, Mitra A, Bhushal S, Deo M, Guerrero-Serna G, et al. Reduced Na(+) current density underlies impaired propagation in the diabetic rabbit ventricle. J Mol Cell Cardiol. 2014;69:24-31
35. Gallego M, Alday A, Urrutia J, Casis O. Transient outward potassium channel regulation in healthy and diabetic hearts. Can J Physiol Pharmacol. 2009;87:77-83
36. de Jong S, van Veen TA, van Rijen HV, de Bakker JM. Fibrosis and cardiac arrhythmias. J Cardiovasc Pharmacol. 2011;57:630-8
37. van de Weijer T, Schrauwen-Hinderling VB, Schrauwen P. Lipotoxicity in type 2 diabetic cardiomyopathy. Cardiovasc Res. 2011;92:10-8
38. Elezaby A, Sverdlov AL, Tu VH, Soni K, Luptak I, Qin F, et al. Mitochondrial remodeling in mice with cardiomyocyte-specific lipid overload. J Mol Cell Cardiol. 2015;79:275-83
39. Soltysinska E, Speerschneider T, Winther SV, Thomsen MB. Sinoatrial node dysfunction induces cardiac arrhythmias in diabetic mice. Cardiovasc Diabetol. 2014;13:122