Diet-induced obesity causes long QT and reduces transcription of voltage-gated potassium channels

Journal of Molecular and Cellular Cardiology

Volumn 59, Issue , 2013, Pages 151-158

  Huang, Haiyan ^a   Amin, Vaibhav ^a   Gurin, Michael ^a   Wan, Elaine ^a   Thorp, Edward ^b   Homma, Shunichi ^a   Morrow, John P ^a  

^a College of Physicians and Surgeons of Columbia University ^*  (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Arrhythmia; Cyclic AMP response element binding protein; Kv1.5; Obesity; Protein kinase D

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; MESSENGER RNA; POTASSIUM CHANNEL KV1.5; PROTEIN KINASE D; SMALL INTERFERING RNA; PROTEIN KINASE C; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET INDUCED OBESITY; ENZYME INHIBITION; GENE EXPRESSION; GENE KNOCKDOWN; HEART REPOLARIZATION; HEART VENTRICLE EXTRASYSTOLE; HUMAN; LIPOTOXICITY; MALE; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN DNA BINDING; PROTEIN EXPRESSION; QT PROLONGATION; RAT; TRANSCRIPTION REGULATION; WILD TYPE MOUSE; ANIMAL; C57BL MOUSE; CELL LINE; CHROMATIN IMMUNOPRECIPITATION; HEART ARRHYTHMIA; IMMUNOBLOTTING; LIPID DIET; LONG QT SYNDROME; METABOLISM; OBESITY; REAL TIME POLYMERASE CHAIN REACTION;

ANIMALS; ARRHYTHMIAS, CARDIAC; CELL LINE; CHROMATIN IMMUNOPRECIPITATION; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DIET, HIGH-FAT; IMMUNOBLOTTING; KV1.5 POTASSIUM CHANNEL; LONG QT SYNDROME; MALE; MICE; MICE, INBRED C57BL; OBESITY; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN KINASE C; RATS; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84875921754     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2013.03.007     Document Type: Article

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