Differences in regional brain responses to food ingestion after Roux-en-Y gastric bypass and the role of gut peptides: A neuroimaging study

Diabetes Care

Volumn 39, Issue 10, 2016, Pages 1787-1795

  Hunt, Katharine F ^a,b   Dunn, Joel T ^a   Le Roux, Carel W ^c,d   Reed, Laurence J ^e   Marsden, Paul K ^a   Patel, Ameet G ^b   Amiel, Stephanie A ^a,b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b KING'S COLLEGE HOSPITAL NHS FOUNDATION TRUST   (United Kingdom)

^c UNIVERSITY COLLEGE DUBLIN   (Ireland)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

^e NORTH MIDDLESEX UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORODEOXYGLUCOSE F 18; GASTRIC INHIBITORY POLYPEPTIDE; GASTROINTESTINAL HORMONE; GLUCAGON; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; INSULIN; METFORMIN; PEPTIDE YY; SOMATOSTATIN; TETRAHYDROLIPSTATIN; TOPIRAMATE;

ADULT; ARTICLE; BODY WEIGHT; BRAIN MAPPING; BRAIN REGION; CONTROLLED STUDY; DEFAULT MODE NETWORK; DIET RESTRICTION; DISEASE COURSE; DORSOLATERAL PREFRONTAL CORTEX; DRUG DOSE REDUCTION; DRUG EFFECT; EPIGASTRIC FULLNESS; FEMALE; FOOD INTAKE; GASTRIC BYPASS SURGERY; HORMONE RESPONSE; HUMAN; HYPOTHALAMUS; MAJOR CLINICAL STUDY; MALE; MEDIAL ORBITOFRONTAL CORTEX; NAUSEA; NEUROIMAGING; OBESITY; POSITRON EMISSION TOMOGRAPHY; PROTEIN FUNCTION; RACE DIFFERENCE; SEX DIFFERENCE; BLOOD; BODY MASS; BRAIN; DIAGNOSTIC IMAGING; EATING; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; PHYSIOLOGY; POSTPRANDIAL STATE; YOUNG ADULT;

ADULT; BODY MASS INDEX; BRAIN; EATING; FEMALE; FLUORODEOXYGLUCOSE F18; GASTRIC BYPASS; GLUCAGON-LIKE PEPTIDE 1; HUMANS; HYPOTHALAMUS; INSULIN; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NEUROIMAGING; OBESITY; PEPTIDE YY; POSTPRANDIAL PERIOD; SOMATOSTATIN; YOUNG ADULT;

EID: 84988935785     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc15-2721     Document Type: Article

References (39)

1. Sjöström L, Peltonen M, Jacobson P, et al. Bariatric surgery and long-term cardiovascular events. JAMA 2012;307:56-65
2. Sandoval D. Bariatric surgeries: Beyond restriction and malabsorption. Int J Obes 2011; 35(Suppl. 3):S45-S49
3. Olbers T, Björkman S, Lindroos A, et al. Body composition, dietary intake, and energy expenditure after laparoscopic Roux-en-Y gastric bypass and laparoscopic vertical banded gastroplasty: A randomized clinical trial. Ann Surg 2006;244:715-722
4. van de Sande-Lee S, Pereira FRS, Cintra DE, et al. Partial reversibility of hypothalamic dysfunction and changes in brain activity after body mass reduction in obese subjects. Diabetes 2011;60:1699-1704
5. Meek CL, Lewis HB, Reimann F, Gribble FM, Park AJ. The effect of bariatric surgery on gastrointestinal and pancreatic peptide hormones. Peptides 2016;77:28-37
6. le Roux CW, Welbourn R, Werling M, et al. Gut hormones as mediators of appetite and weight loss after Roux-en-Y gastric bypass. Ann Surg 2007;246:780-785
7. Goldstone AP, Miras AD, Scholtz S, et al. Link between increased satiety gut hormones and reduced food reward after gastric bypass surgery for obesity. J Clin EndocrinolMetab 2016;101:599-609
8. Barrington S, Maisey M, Wahl R. Atlas of Clinical Positron Emission Tomography. 2nd ed. London, Hodder Arnold, 2006
9. Dunn JP, Cowan RL, Volkow ND, et al. Decreased dopamine type 2 receptor availability after bariatric surgery: Preliminary findings. Brain Res 2010;1350:123-130
10. Steele KE, Prokopowicz GP, Schweitzer MA, et al. Alterations of central dopamine receptors before and after gastric bypass surgery. Obes Surg 2010;20:369-374
11. Ochner CN, Stice E, Hutchins E, et al. Relation between changes in neural responsivity and reductions in desire to eat high-calorie foods following gastric bypass surgery. Neuroscience 2012;209:128-135
12. Ochner CN, Kwok Y, Conceição E, et al. Selective reduction in neural responses to high calorie foods following gastric bypass surgery. Ann Surg 2011;253:502-507
13. Scholtz S, Miras AD, Chhina N, et al. Obese patients after gastric bypass surgery have lower brain-hedonic responses to food than after gastric banding. Gut 2014;63:891-902
14. Cranston I, Marsden P, Matyka K, et al. Regional differences in cerebral blood flow and glucose utilization in diabetic man: The effect of insulin. J Cereb Blood Flow Metab 1998;18: 130-140
15. Anthony K, Reed LJ, Dunn JT, et al. Attenuation of insulin-evoked responses in brain networks controlling appetite and reward in insulin resistance: The cerebral basis for impaired control of food intake in metabolic syndrome?. Diabetes 2006;55:2986-2992
16. Bingham EM, Hopkins D, Smith D, et al. The role of insulin in human brain glucose metabolism: An 18fluoro-deoxyglucose positron emission tomography study. Diabetes 2002;51:3384-3390
17. Tziortzi AC, Searle GE, Tzimopoulou S, et al. Imaging dopamine receptors in humans with [11C]-(+)-PHNO: Dissection of D3 signal and anatomy. Neuroimage 2011;54:264-277
18. Baroncini M, Jissendi P, Balland E, et al. MRI atlas of the human hypothalamus. Neuroimage 2012;59:168-180
19. Levy JC, Matthews DR, Hermans MP. Correct homeostasis model assessment (HOMA) evaluation uses the computer program. Diabetes Care 1998;21:2191-2192
20. le Roux CW, Aylwin SJ, Batterham RL, et al. Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters. Ann Surg 2006;243:108-114
21. Berthoud HR. The neurobiology of food intake in an obesogenic environment. Proc Nutr Soc 2012;71:478-487
22. Gautier JF, Del Parigi A, Chen K, et al. Effect of satiation on brain activity in obese and lean women. Obes Res 2001;9:676-684
23. Small DM, Zatorre RJ, Dagher A, Evans AC, Jones-Gotman M. Changes in brain activity related to eating chocolate: Frompleasure to aversion. Brain 2001;124:1720-1733
24. Hinton EC, Parkinson JA, Holland AJ, Arana FS, Roberts AC, Owen AM. Neural contributions to the motivational control of appetite in humans. Eur J Neurosci 2004;20:1411-1418
25. Gautier JF, Chen K, Salbe AD, et al. Differential brain responses to satiation in obese and lean men. Diabetes 2000;49:838-846
26. Smeets PA, de Graaf C, Stafleu A, van Osch MJ, Nievelstein RA, van der Grond J. Effect of satiety on brain activation during chocolate tasting in men and women. Am J Clin Nutr 2006;83:1297-1305
27. Uher R, Treasure J, Heining M, Brammer MJ, Campbell IC. Cerebral processing of foodrelated stimuli: Effects of fasting and gender. Behav Brain Res 2006;169:111-119
28. Führer D, Zysset S, Stumvoll M. Brain activity in hunger and satiety: An exploratory visually stimulated FMRI study. Obesity (Silver Spring) 2008;16:945-950
29. LaBar KS, Gitelman DR, Parrish TB, Kim YH, Nobre AC, Mesulam MM. Hunger selectively modulates corticolimbic activation to food stimuli in humans. Behav Neurosci 2001;115:493-500
30. Raichle ME. The brain's default mode network. Annu Rev Neurosci 2015;38:433-447
31. Le DS, Pannacciulli N, Chen K, et al. Less activation in the left dorsolateral prefrontal cortex in the reanalysis of the response to a meal in obese than in lean women and its association with successfulweight loss. Am J Clin Nutr 2007; 86:573-579
32. McCaffery JM, Haley AP, Sweet LH, et al. Differential functional magnetic resonance imaging response to food pictures in successful weight-loss maintainers relative to normalweight and obese controls. Am J Clin Nutr 2009;90:928-934
33. Stoeckel LE, Weller RE, Cook EW 3rd, Twieg DB, Knowlton RC, Cox JE. Widespread rewardsystem activation in obese women in response to pictures of high-calorie foods. Neuroimage 2008;41:636-647
34. Rothemund Y, Preuschhof C, Bohner G, et al. Differential activation of the dorsal striatum by high-calorie visual food stimuli in obese individuals. Neuroimage 2007;37:410-421
35. Elliott JA, Jackson S, King S, et al. Gut hormone suppression increases food intake after esophagectomy with gastric conduit reconstruction. Ann Surg 2015;262:824-829; discussion 829-830
36. Stengel A, Goebel M, Wang L, et al. Activation of brain somatostatin 2 receptors stimulates feeding in mice: Analysis of food intake microstructure. Physiol Behav 2010;101:614-622
37. Woods SC, Lotter EC, McKay LD, Porte D Jr. Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons. Nature 1979;282:503-505
38. Brüning JC, Gautam D, Burks DJ, et al. Role of brain insulin receptor in control of body weight and reproduction. Science 2000;289: 2122-2125
39. Benedict C, Kern W, Schultes B, Born J, Hallschmid M. Differential sensitivity of men and women to anorexigenic and memory-improving effects of intranasal insulin. J Clin Endocrinol Metab 2008;93:1339-1344