Regional differences in cerebral blood flow and glucose utilization in diabetic man: The effect of insulin

Journal of Cerebral Blood Flow and Metabolism

Volumn 18, Issue 2, 1998, Pages 130-140

  Cranston, Iain ^a,b   Marsden, Paul ^b   Matyka, Krystyna ^a   Evans, Mark ^a   Lomas, Jill ^a   Sonksen, Peter ^b   Maisey, Michael ^b   Amiel, Stephanie A ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

Cerebral blood flow; Cerebral glucose metabolism; Diabetes mellitus; Insulin; Positron emission tomography

Indexed keywords

CATECHOLAMINE; FLUORODEOXYGLUCOSE F 18; GLUCOSE; INSULIN; INSULIN RECEPTOR; WATER O 15;

ADULT; ARTICLE; BRAIN BLOOD FLOW; BRAIN METABOLISM; CLINICAL ARTICLE; DIABETES MELLITUS; GLUCOSE UTILIZATION; HUMAN; INSULIN RELEASE; MALE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; STRESS;

EID: 0031915684     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199802000-00002     Document Type: Article

References (56)

1. Amiel SA (1995) Human insulin in hypoglycemia. A new arena? Diabetes 44:257-260
2. Amiel SA, Tamborlane WV, Simonson DC, Sherwin RS (1987) Defective glucose counterregulation after strict control of insulin dependent diabetes mellitus. New Engl J Med 316:1376-1383
3. Bartlett EJ, Brodie JD, Wolf AP, Christman DR, Laska E, Meissner M (1988) Reproducibility of cerebral glucose metabolic measurements in resting human subjects. J Cereb Blood Flow Metab 8: 502-512
4. Betz AL, Ianotti F (1983) Simultaneous determination of regional cerebral blood flow and blood brain glucose transport kinetics in gerbils. J Cereb Blood Flow Metab 3:193-199
5. Borg MA, Sherwin RS, Borg WP, Tamborlane WV, Shulman GI (1997) Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats. J Clin Invest 99:361-365
6. Borg WP, Sherwin RS, During MJ, Borg MA, Shulman GI (1995) Local ventromedial hypothalamic glucopenia triggers counterregulatory hormone release. Diabetes 44:180-184
7. Brierley JB, Brown AW, Meldrum BS (1971) The nature and time course of the neuronal alterations resulting from oligaemia and hypoglycaemia in the brain of macaca mulatta. Brain Res 25:483-499
8. 11C] 3-O-methyl-D-glucose and positron emission tomography. J Cereb Blood Flow Metab 6:240-244
9. Carson RE (1986) Parameter estimation in positron emission tomography. In: Positron Emission Tomography and Autoradiography: Principles and Applications for the Brain and Heart (Phelps M, Mazziotta J, Schelbert H, eds), New York, Raven Press, pp 347-390
10. Cremer JE, Ray DE, Sarna GS, Cunningham VJ (1981) A study of the kinetic behaviour of glucose based on simultaneous estimates of influx and phosphorylation in brain regions of rats in different physiological states. Brain Res 28; 221:331-342
11. Cunnah D, Jessop DS, Besser GM, Rees LH (1987) Measurement of corticotrophin releasing factor in man. J Endocrinol 1113:123-131
12. Davis SN, Tarumi C, Dobbins R, Neal D, Cherrington AD (1992) The effect of differing insulin levels on the counterregulatory response to equivalent hypoglycemia in conscious dogs. Am J Physiol 263:E688-E695
13. Davis SN, Goldstein RE, Jacobs J, Price L, Wolfe R, Cherrington AD (1993) The effect of differing insulin levels on the hormonal and metabolic responses to hypoglycemia in normal man. Diabetes 42:263-272
14. Davis SN, Colburn C, Dobbins R, Nadeau S, Neal S, Williams P, Cherrington AC (1995) Evidence that the brain of the conscious dog is insulin sensitive. J Clin Invest 95:593-602
15. DeFronzo RA, Tobin J, Andres R (1979) Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 237:E214-E223
16. Diamond M, Hallaman L, Starick-Zyck K, Jones M, Conolly-Howard M, Tamborlane W, Sherwin R (1991) Suppression of counterregulatory hormone response to hypoglycemia by insulin per se. J Clin Endocrinol Metab 72:1388-1390
17. Eastman RC, Carson RE, Gordon MR, Berg GW, Lillioja S, Larson SM, Roth J (1990) Brain glucose metabolism in noninsulin dependent diabetes mellitus: a study in Pima Indians using positron emission tomography during hyperinsulinaemia with a euglycaemic glucose clamp. J Clin Endocrinol Metab 71:1602-1610
18. Florant GL, Singer L, Scheurink AJ, Park CR, Richardson RD, Woods SC (1991) Intraventricular insulin reduces food intake and body weight of marmots during the summer feeding period. Physiol Behav 49:335-338
19. Goodner CJ, Berrie MA (1977) The failure of rat hypothalamic tissues to take up labelled insulin in vivo or to respond to insulin in vitro. Endocrinology 101:605-612
20. Grill V, Gutniak M, Bjorkman O, Lindqvist M, Stone-Elander S, Seitz RJ, Blomqvist G, Reichard P, Widen L (1990) Cerebral blood flow and substrate utilization in insulin treated diabetic subjects. Am J Physiol 258:E813-820
21. Grunstein HS, James DE, Strolein LH, Smythe GA, Kraegen EW (1985) Hyperinsulinemia suppresses glucose utilization in specific brain regions: in vivo studies using the euglycemic clamp in the rate. Endocrinology 116:604-610
22. Hanning I, Home PD, Alberti KGMM (1985) Measurement of free insulin concentrations: the influence of the timing and extraction of insulin antibodies. Diabetologia 28:831-835
23. Hertz MM, Paulson OB, Barry DI, Christiansen JS, Svendsen PA (1981) Insulin increases glucose transfer across the blood brain barrier in man. J Clin Invest 67:597-504
24. Hoffman EJ, Huang SC, Phelps (1979) Quantitation in positron emission computed tomography 1. Effect of object size. J Comput Asst Tomography 3:299-308
25. Hom FG, Goodner CJ, Berrie MA (1984) A [3H]2-deoxyglucose method for comparing rates of glucose metabolism and insulin responses among rat tissues in vivo. Validation of the model and the absence of an insulin effect on the brain. Diabetes 33:141-152
26. Huang SC, Phelps ME, Hoffman EJ, Sideris K, Selin C, Kuhl DE (1980) Noninvasive determination of local cerebral metabolic rate of glucose in man. Am J Physiol 288:E69-E82
27. Kenner KA, Kusari J, Heidenreich KA (1995) cDNA sequence analysis of the human brain insulin receptor. Biochem Biophys Res Comm 217:304-312
28. Kern W, Lieb K, Kerner W, Born J, Fehm HL (1990) Different effects of human and pork insulin induced hypoglycemia on neuronal function in humans. Diabetes 30:1091-1098
29. Kern W, Kerner W, Pietrowsky R, Fehm HL, Born J (1994a) Effects of insulin and hypoglycemia on the auditory brain stem response in humans J Neurophysiology 72:678-683
30. Kern W, Schlosser C, Kerner W, Pietrowsky R, Born J, Fehm HL (1994b) Evidence for effects of insulin on sensory processing in humans. Diabetes 43:351-356
31. Kerr D, Reza M, Smith N, Leatherdale B (1991) Importance of insulin in subjective, cognitive and hormonal responses to hypoglycemia in patients with IDDM. Diabetes 40:1057-1062
32. Kety SS, Schmidt CF (1948) The nitrous oxide method for the quantitative determination of cerebral blood flow in man: theory, procedure and normal values. J Clin Invest 27:476-483
33. Kotzke G, Schutt M, Missler U, Moller DE, Fehm HL, Klein HH (1995) Binding of human, porcine and bovine insulin to insulin receptors from human brain, muscle and adipocytes and to expressed recombinant alternatively spliced insulin receptor isoforms. Diabetologia 38:757-763
34. LaManna JC, Haric SI (1986) Regional studies on blood-brain barrier transport of glucose and leucine in awake and anesthetized rats. J Cereb Blood Flow Metab 6:717-723
35. Lammertsma AA, Cunningham VJ, Deiber MP, Heather JD, Bloomfield PM, Nutt J, Frakowiak RSJ, Jones T (1990) Combination of dynamic and integral methods for generating reproducible functional cerebral blood flow images. J Cereb Blood Flow Metab 10:675-686
36. Lucignani G, Namba H, Nehlig A, Porrino LJ, Kennedy C, Sokoloff L (1987) Effects of insulin in local cerebral glucose utilization in the rat. J Cereb Blood Flow Metab 7:309-314
37. Lui D, Moberg E, Kollind D, Lins PE, Adamson U (1991) A high concentration of circulating insulin suppresses glucagon response to hypoglycemia in normal man. J Clin Endocrinol Metab 73: 1123-1128
38. Macdonald IA, Lake DM (1985) An improved method for extracting catecholamines from body fluids. J Neurosci Meth 13:239-248
39. Maran A, Lomas J, Macdonald IA, Amiel SA (1995) Lack of preservation of higher brain function during hypoglycaemia in patients with intensively treated IDDM. Diabetologia 38:1412-1418
40. Mazlan M (1989) Development of an immunoradiometric assay for human growth hormone releasing factor and some applications. PhD thesis. University of London, UK
41. Mellman M, Davis M, Shamoon H (1992) Effect of physiologic hyperinsulinemia on counterregulatory responses during hypoglycemia in man. J Clin Endocrinol Metab 75:1283-1297
42. Namba H, Lucignani G, Nehlig A, Patlak C, Pettigrew K, Kennedy C, Sokoloff L (1987) Effects of insulin on hexose transport across blood-brain barrier in normoglycemia. Am J Physiol 252: E299-303
43. Nelder JA, Mead R (1965) A simple method for function minimization. Comput J 7:308-313
44. Ohta S, Meyer E, Fujita H, Reutens DC, Evans A, Gjedde A (1996) Cerebral [150] water clearance in humans determined by PET: I. Theory and normal values. J Cereb Blood Flow Metab 16:765-780
45. Phelps ME, Huang SC, Hoffman EJ, Selin C, Sokoloff L, Kuhl DE (1979) Tomographic measurement of local cerebral glucose metabolic rate in humans with (F-18)2-fluoro-2-deoxy-D-glucose: validation of method. Ann Neurol 6:371-388
46. 15O: II. Implementation and validation. J Nucl Med 24:790-798
47. Ratcheson RA, Blank AC, Ferendelli JA (1981) Regionally selective metabolic effects of hypoglycemia in brain. J Neurochem 36: 1952-1958
48. Rattarasarn C, Dagogo-Jack S, Zachwieja JJ, Cryer PE (1994) Hypoglycemia-induced autonomie failure in IDDM is specific for stimulus of hypoglycemia and is not attributable to prior autonomic activation. Diabetes 43:809-818
49. 11C] deoxyglucose. J Cereb Blood Flow Metab 5:179-192
50. Robinson B, Nagy RJ, Kempers S, Boyle PJ (1994). Brain glucose metabolism is insulin independent during hypoglycemia in normal man. Diabetes 43(Suppl 1):A152
51. Sable DB, Yeh J (1995) Growth factor receptor mRNA expression in human fetal brain. Obstet Gynecol 86:240-247
52. Schwartz M, Figelwitcz D, Baskin D, Woods S, Porte D Jr (1992) Insulin in the brain: a hormonal regulator of energy balance. Endocr Rev 13:387-414
53. 14C) deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure and normal values in the conscious and anaesthetised albino rat. J Neurochem 28:897-916
54. Stapleton JM, Morgan MJ, Liu X, et al. (1997) Cerebral glucose utilisation is reduced in second test session. J Cereb Blood Flow Metab 17:704-712
55. Steffens AB, Scheurink AJW, Porte D, Woods SC (1988) Penetration of peripheral glucose and insulin into cerebrospinal fluid in rats. Am J Physiol 244:R200-R204
56. Studholme C, Hill DLG, Hawkes DJ (1997) Automated 3D registration of magnetic resonance and positron emission tomography brain slices by multi-resolution optimisation of voxel similarity measures. Med Physics 24:25-35.