Safety of a novel galacto-oligosaccharide: Genotoxicity and repeated oral dose studies

Human and Experimental Toxicology

Volumn 28, Issue 10, 2009, Pages 619-630

  Kobayashi, T ^a   Yasutake, N ^a   Uchida, K ^a   Ohyama, W ^a   Kaneko, K ^a   Onoue, M ^a  

^a YAKULT CENTRAL INSTITUTE FOR MICROBIOLOGICAL RESEARCH   (Japan)

Author keywords

A novel galacto oligosaccharide; Genotoxicity; GOS; Repeated oral dose toxicity; Safety

Indexed keywords

GALACTOSE OLIGOSACCHARIDE; LACTOSE; WATER;

AMES TEST; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BACTERIAL MUTATION; BLOOD CHEMISTRY; BODY WEIGHT; CHINESE HAMSTER; CHROMOSOME ABERRATION; CONTROLLED STUDY; DRUG SAFETY; ENZYME ACTIVITY; ESCHERICHIA COLI; FEMALE; FIBROBLAST CULTURE; FLUID INTAKE; FOOD INTAKE; FUNGUS; GENOTOXICITY; HEMATOLOGY; HISTOPATHOLOGY; KLUYVEROMYCES; LUNG FIBROBLAST; MALE; METABOLIC ACTIVATION; MICRONUCLEUS; MOUSE; NONHUMAN; OPHTHALMOLOGY; ORGAN WEIGHT; PATHOLOGY; PRIORITY JOURNAL; RAT; RETICULOCYTE; SPOROBOLOMYCES SINGULARIS; SPRAGUE DAWLEY RAT; URINALYSIS;

ADMINISTRATION, ORAL; ANIMALS; CELL LINE; CELL PROLIFERATION; CHROMOSOME ABERRATIONS; COLONY COUNT, MICROBIAL; CONSUMER PRODUCT SAFETY; CRICETINAE; CRICETULUS; ESCHERICHIA COLI; FEMALE; FIBROBLASTS; MALE; MICE; MICE, INBRED ICR; MICROSCOPY, FLUORESCENCE; MUTAGENICITY TESTS; NO-OBSERVED-ADVERSE-EFFECT LEVEL; PREBIOTICS; RATS; RATS, SPRAGUE-DAWLEY; RETICULOCYTES; SALMONELLA TYPHIMURIUM; TOXICITY TESTS, CHRONIC; TRISACCHARIDES;

BACTERIA (MICROORGANISMS); CRICETULUS GRISEUS; ESCHERICHIA COLI; KLUYVEROMYCES LACTIS; RATTUS; SPOROBOLOMYCES SINGULARIS;

EID: 70449378043     PISSN: 09603271     EISSN: 14770903     Source Type: Journal    
DOI: 10.1177/0960327109346789     Document Type: Article

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