Colon microflora in infants fed formula with galacto- and fructo-oligosaccharides: More like breast-fed infants

Journal of Pediatric Gastroenterology and Nutrition

Volumn 40, Issue 1, 2005, Pages 36-42

  Knol, Jan ^a   Scholtens, Petra ^a   Kafka, Corinna ^b   Steenbakkers, Jochem ^a   Groß, Sabine ^c   Helm, Klaus ^c   Klarczyk, Malte ^c   Schöpfer, Helmut ^c   Böckler, Heinz Michael ^b   Wells, John ^b  

^a NUMICO RESEARCH   (Netherlands)

^b Numico Infant Nutrition Group   (Germany)

^c NONE   (Germany)

Author keywords

Bifidobacteria; Infant formula; Intestinal flora; Prebiotics; Short chain fatty acids

Indexed keywords

ACETIC ACID; FRUCTOSE OLIGOSACCHARIDE; LACTIC ACID; PREBIOTIC AGENT; PROPIONIC ACID; SHORT CHAIN FATTY ACID;

ARTICLE; ARTIFICIAL MILK; BACTERIAL GROWTH; BIFIDOBACTERIACEAE; BIRTH WEIGHT; BREAST MILK; CLINICAL TRIAL; COLON FLORA; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FECES ANALYSIS; FEMALE; FERMENTATION MONITORING; HUMAN; INFANT; MALE; PH; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SUPPLEMENTATION;

BIFIDOBACTERIUM; COLON; DOUBLE-BLIND METHOD; FATTY ACIDS, VOLATILE; FECES; FEMALE; FERMENTATION; HUMANS; HYDROGEN-ION CONCENTRATION; IN SITU HYBRIDIZATION, FLUORESCENCE; INFANT; INFANT FORMULA; LACTIC ACID; MALE; MILK, HUMAN; OLIGOSACCHARIDES;

EID: 19944433812     PISSN: 02772116     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005176-200501000-00007     Document Type: Article

References (41)

1. Heavey P, Rowland I. The gut microflora of the developing infant: microbiology and metabolism. Microbial Ecology in Health and Disease 1999;11:75-83.
2. Orrhage K, Nord CE. Factors controlling the bacterial colonization of the intestine in breastfed infants. Acta Paediatr Suppl 1999;88:47-57.
3. Tancrede C. Role of human microflora in health and disease. Eur J Clin Microbiol Infect Dis 1992;11:1012-5.
4. van der Waaij D, Berghuis-de Vries JM, Lekkerkerk L-v. Colonization resistance of the digestive tract in conventional and antibiotic-treated mice. J Hyg 1971;69:405-11.
5. Harmsen HJ, Wildeboer-Veloo AC, Raangs GC, et al. Analysis of intestinal flora development in breast-fed and formula-fed infants by using molecular identification and detection methods. J Pediatr Gastroenterol Nutr 2000;30:61-7.
6. Fuller R. Factors affecting the composition of the intestinal microflora of the human infant. In: WC Heird, ed. Nutritional needs of the 6-12 month infant. New York, NY: Raven Press; 1991:121-30.
7. Balmer SE, Wharton BA. Diet and faecal flora in the newborn: breast milk and infant formula. Arch Dis Child 1989;64:1672-7.
8. Stark PL, Lee A. The microbial ecology of the large bowel of breast-fed and formula-fed infants during the first year of life. J Med Microbiol 1982;15:189-203.
9. Kleessen B, Bunke H, Tovar K, et al. Influence of two infant formulas and human milk on the development of the faecal flora in newborn infants. Acta Paediatr 1995;84:1347-56.
10. Mountzouris KC, McCartney AL, Gibson GR. Intestinal microflora of human infants and current trends for its nutritional modulation. Br J Nutr 2002;87:405-20.
11. Aggett PJ, Agostini C, Goulet O, et al. The nutritional and safety assessment of breast milk substitutes and other dietary products for infants: a commentary by the ESPGHAN Committee on Nutrition. J Pediatr Gastroenterol Nutr 2001;32:256-8.
12. Boehm G, Stahl B. Oligosaccharides. In: T Mattila-Sandholm, ed. Functional Dairy products. Woodhead Publ Limited;2003:203-43.
13. Boehm G, Lidestri M, Casetta P, et al. Supplementation of a bovine milk formula with an oligosaccharide mixture increases counts of faecal bifidobacteria in preterm infants. Arch Dis Child Fetal Neonatal Ed 2002;86:F178-81.
14. Moro G, Minoli I, Mosca M, et al. Dosage-related bifidogenic effects of galacto- and fructooligosaccharides in formula-fed term infants. J Pediatr Gastroenterol Nutr 2002;34:291-5.
15. Schmelzle H, Wirth S, Skopnik H, et al. Randomized Double-Blind Study of the Nutritional Efficacy and Bifidogenicity of a New Infant Formula Containing Partially Hydrolyzed Protein, a High beta-Palmitic Acid Level, and Nondigestible Oligosaccharides. J Pediatr Gastroenterol Nutr 2003;36:343-51.
16. Topping DL. Short-chain fatty acids produced by intestinal bacteria. Asia Pacific J Clin Nutr 1996;5:15-19.
17. Cummings JH, Macfarlane GT. The control and consequences of bacterial fermentation in the human colon. J Appl Bacteriol 1991;70:443-59.
18. Jiang T, Savaiano DA. Modification of colonie fermentation by bifidobacteria and pH in vitro. Impact on lactose metabolism, short-chain fatty acid, and lactate production. Dig Dis Sci 1997;42:2370-7.
19. Mortensen PB, Clausen MR. Short-chain fatty acids in the human colon: relation to gastrointestinal health and disease. Scand J Gastroenterol Suppl 1996;216:132-48.
20. Lifschitz CH, Wolin MJ, Reeds PJ. Characterization of carbohydrate fermentation in feces of formula-fed and breast-fed infants. Pediatr Res 1990;27:165-9.
21. Ogawa K, Ben RA, Pons S, et al. Volatile fatty acids, lactic acid, and pH in the stools of breast-fed and bottle-fed infants. J Pediatr Gastroenterol Nutr 1992;15:248-52.
22. Siigur U, Ormisson A, Tamm A. Faecal short-chain fatty acids in breast-fed and bottle-fed infants. Acta Paediatr 1993;82:536-8.
23. Edwards CA, Parrett AM, Balmer SE, et al. Faecal short chain fatty acids in breast-fed and formula-fed babies. Acta Paediatr 1994;83: 459-62.
24. Parrett AM, Edwards CA. In vitro fermentation of carbohydrate by breast fed and formula fed infants. Arch Dis Child 1997;76:249-53.
25. Midtvedt AC, Midtvedt T. Production of short chain fatty acids by the intestinal microflora during the first 2 years of human life. J Pediatr Gastroenterol Nutr 1992;15:395-403.
26. Langendijk PS, Schut F, Jansen GJ, et al. Quantitative fluorescence in situ hybridization of Bifidobacterium spp. with genus-specific 16S rRNA-targeted probes and its application in fecal samples. Appl Environ Microbiol 1995;61:3069-75.
27. SPSS. SPSS for Windows. Version 11.01. SPSS Inc.; 1989-2001.
28. Midtvedt AC, Carlstedt-Duke B, Norin KE, et al. Development of five metabolic activities associated with the intestinal microflora of healthy infants. J Pediatr Gastroenterol Nutr 1988;7:559-67.
29. Salminen S, Bouley C, Boutron-Ruault MC, et al. Functional food science and gastrointestinal physiology and function. Br J Nutr 1998;80:(Suppl 1):S147-71.
30. Dai D, Walker WA. Protective nutrients and bacterial colonization in the immature human gut. Adv Pediatr 1999;46:353-82.
31. Zetterstrom R, Bennet R, Nord KE. Early infant feeding and microecology of the gut. Acta Paediatr Jpn 1994;36:562-71.
32. Cummings JH, Macfarlane GT. Role of intestinal bacteria in nutrient metabolism. JPEN J Parenter Enteral Nutr 1997;21:357-65.
33. Langhendries JP, Detry J, Van Hees J, et al. Effect of a fermented infant formula containing viable bifidobacteria on the fecal flora composition and pH of healthy full-term infants. J Pediatr Gastroenterol Nutr 1995;21:177-81.
34. Adams MR, Hall CJ. Growth inhibition of food-borne pathogens by lactic acid and acetic acid and their mixtures. Int. J. Food. Sci. Technol. 1988;23:287-92.
35. Moon NJ. Inhibition of the growth of acid tolerant yeasts by acetate, lactate and their synergistic mixtures. J. Appl. Bacteriol 1983;77:412-20.
36. McWilliam Leitch EC, Stewart CS. Escherichia coli O157 and non-O157 isolates are more susceptible to L-lactate than to D-lactate. Appl Environ Micmbiol 2002;68:4676-8.
37. Gibson GR, Wang X. Regulatory effects of bifidobacteria on the growth of other colonic bacteria. J Appl Bacteriol 1994;77:412-20.
38. Cunningham-Rundles S, Lin DH. Nutrition and the immune system of the gut. Nutrition 1998;14:573-9.
39. Kalliomaki M, Kirjavainen P, Eerola E, et al. Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing. J Allergy Clin Immunol 2001;107:129-34.
40. Ouwehand AC, Isolauri E, He F, et al. Differences in Bifidobacterium flora composition in allergic and healthy infants. J Allergy Clin Immunol 2001;108:144-5.
41. Kalliomaki M, Isolauri E. Role of intestinal flora in the development of allergy. Curr Opin Allergy Clin Immunol 2003;3:15-20.