A one-generation reproduction toxicity study in rats treated orally with a novel galacto-oligosaccharide

Human and Experimental Toxicology

Volumn 33, Issue 8, 2014, Pages 814-821

  Kobayashi, T ^a   Takano, M ^b   Kaneko, K ^a   Onoue, M ^a  

^a YAKULT CENTRAL INSTITUTE FOR MICROBIOLOGICAL RESEARCH   (Japan)

^b BoZo Research Center Inc   (Japan)

Author keywords

A novel galacto oligosaccharide; a one generation reproduction toxicity study; prebiotic

Indexed keywords

GALACTOSE OLIGOSACCHARIDE; GALACTOSE; OLIGOSACCHARIDE; PREBIOTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPSY; BODY WEIGHT; CONTROLLED STUDY; COPULATION; DELIVERY; ESTRUS CYCLE; FEMALE; FERTILITY; FOOD INTAKE; GONAD FUNCTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LACTATION; MALE; MATING; NONHUMAN; PRIORITY JOURNAL; PSEUDOPREGNANCY; RAT; REFLEX; REPRODUCTION; REPRODUCTIVE TOXICITY; VAGINA SMEAR; GESTATION PERIOD; PUPIL REFLEX; RIGHTING REFLEX; SEX RATIO; AGE; ANALOGS AND DERIVATIVES; ANIMAL; DRUG EFFECTS; EATING; ENVIRONMENTAL EXPOSURE; NEWBORN; NO-OBSERVED-ADVERSE-EFFECT LEVEL; ORAL DRUG ADMINISTRATION; PREGNANCY; PRENATAL EXPOSURE; RISK ASSESSMENT; SEXUAL BEHAVIOR; SPRAGUE DAWLEY RAT; TIME; TOXICITY TESTING;

ANIMALIA; RATTUS;

ADMINISTRATION, ORAL; AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; BODY WEIGHT; EATING; FEMALE; FERTILITY; GALACTOSE; LACTATION; MALE; MATERNAL EXPOSURE; NO-OBSERVED-ADVERSE-EFFECT LEVEL; OLIGOSACCHARIDES; PATERNAL EXPOSURE; PREBIOTICS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS, SPRAGUE-DAWLEY; REPRODUCTION; RISK ASSESSMENT; SEXUAL BEHAVIOR, ANIMAL; TIME FACTORS; TOXICITY TESTS, CHRONIC;

EID: 84904717979     PISSN: 09603271     EISSN: 14770903     Source Type: Journal    
DOI: 10.1177/0960327113510328     Document Type: Article

References (16)

1. Chonnan O, Sone H, Takahashi R, et al. Undigestibility of galactooligosaccharides [in Japanese]. J Jpn Soc Food Sci Technol. 2004 ; 51: 28-33
2. Gibson GR, Roberfroid MB. Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J Nut. 1995 ; 125: 1401-1412
3. Scheppach W, Luehrs H, Menzel T. Beneficial health effects of low-digestible carbohydrate consumption. Br J Nut. 2001 ; 85: S23 - S30
4. Birkett A, Muir J, Phillips J, Jones G, et al. Resistant starch lowers fecal concentrations of ammonia and phenols in humans. Am J Clin Nut. 1996 ; 63: 766-772
5. Salminen S, Ouwehand AC, Isolauri E. Clinical applications of probiotic bacteria. Int Dairy J. 1998 ; 8: 563-572
6. Andersson H, Asp N-G, Bruce A, Roos A, et al. Health effects of probiotics and prebiotics. A literature review on human studies. Scand J Food Nut. 2001 ; 45: 58-75
7. Deguchi Y, Makino K, Iwadate E. Influence of galato-oligosaccharides on bowel habit in healthy young volunteers with constipation tendency. J Jpn Council Adv Food Ingredients Res. 2003 ; 6: 55-66
8. Kobayashi T, Yasutake N, Uchida K, et al. Safety of a novel galacto-oligosaccharide: genotoxicity and repeated oral dose studies. Hum Exp Toxicol. 2009 ; 28 (10). 619-630
9. Snedecor GW, Cochran WG Statistical methods. 8 th ed. Ames, IA: Iowa State University Press, 1989. Ames, IA: Iowa State University Press ; 1989 :
10. Dunnett CW. A multiple comparison procedure for comparing several treatments with a control. J Am Stat Assoc. 1955 ; 50: 1096-1121
11. Steel RGD. A multiple comparison rank sum test: treatments versus control. Biometrics. 1959 ; 15: 560-572
12. Sakuma A Statistical methods in pharmacometrics. University of Tokyo Press: Tokyo, Japan ; 1981: 23 387-27 389.
13. Matsumoto K, Takada T, Yuki N, et al. Effects of transgalactosylated oligosaccharides mixture (N-GOS) on human intestinal microflora [in Japanese]. J Intest Microbiol. 2004 ; 18: 25-35
14. Chonan O, Sone H, Takahashi R, et al. Undigestibility of galactooligosaccharides [in Japanese]. J Jpn Soc Food Sci Technol. 2004 ; 51: 28-33
15. Deguchi Y, Makino K, Iwadate E. Influence of galacto-oligosaccharides on bowel habit in healthy young volunteers with constipation tendency [in Japanese]. J Jpn Council Adv Food Ingredients Res. 2003 ; 6: 55-66
16. Kimura M, Ikeda M, Shibata H, Ideda S, Mastumoto K. Evaluating the laxative threshold and safety of galactooligosaccharide syrup [in Japanese]. Jpn J Food Chem. 2004 ; 11: 67-74