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Volumn 39, Issue , 2016, Pages 101-107

Extracellular vesicles: interneural shuttles of complex messages

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN CELL; CELL COMMUNICATION; EXOSOME; GLIA CELL; HUMAN; MEMBRANE MICROPARTICLE; MICROGLIA; NERVE CELL; NERVE DEGENERATION; NERVE REGENERATION; NEUROBLAST; NEUROPATHOLOGY; NEUROPROTECTION; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; SYMPATHETIC NERVE CELL; METABOLISM; PHYSIOLOGY;

EID: 84988838796     PISSN: 09594388     EISSN: 18736882     Source Type: Journal    
DOI: 10.1016/j.conb.2016.04.016     Document Type: Review
Times cited : (110)

References (60)
  • 1
    • 84904704297 scopus 로고    scopus 로고
    • Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles
    • Colombo, M., Raposo, G., Thery, C., Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Annu Rev Cell Dev Biol 30 (2014), 255–289.
    • (2014) Annu Rev Cell Dev Biol , vol.30 , pp. 255-289
    • Colombo, M.1    Raposo, G.2    Thery, C.3
  • 2
    • 84874377202 scopus 로고    scopus 로고
    • Extracellular vesicles: exosomes, microvesicles, and friends
    • Raposo, G., Stoorvogel, W., Extracellular vesicles: exosomes, microvesicles, and friends. J Cell Biol 200 (2013), 373–383.
    • (2013) J Cell Biol , vol.200 , pp. 373-383
    • Raposo, G.1    Stoorvogel, W.2
  • 3
    • 84904657288 scopus 로고    scopus 로고
    • Biogenesis and secretion of exosomes
    • Kowal, J., Tkach, M., Thery, C., Biogenesis and secretion of exosomes. Curr Opin Cell Biol 29 (2014), 116–125.
    • (2014) Curr Opin Cell Biol , vol.29 , pp. 116-125
    • Kowal, J.1    Tkach, M.2    Thery, C.3
  • 5
    • 84890907806 scopus 로고    scopus 로고
    • Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs
    • This paper discovers a sequence motif in miRNAs that is recognized by the RNA-binding protein hnRNPA2B1. Sumoylation of hnRNPA2B1 controls binding of miRNAs and inclusion in exosomes during their biogenesis. It's the first study describing sumo-dependent sorting of exosome cargo.
    • Villarroya-Beltri, C., Gutierrez-Vazquez, C., Sanchez-Cabo, F., Perez-Hernandez, D., Vazquez, J., Martin-Cofreces, N., Martinez-Herrera, D.J., Pascual-Montano, A., Mittelbrunn, M., Sanchez-Madrid, F., Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs. Nat Commun, 4, 2013, 2980 This paper discovers a sequence motif in miRNAs that is recognized by the RNA-binding protein hnRNPA2B1. Sumoylation of hnRNPA2B1 controls binding of miRNAs and inclusion in exosomes during their biogenesis. It's the first study describing sumo-dependent sorting of exosome cargo.
    • (2013) Nat Commun , vol.4 , pp. 2980
    • Villarroya-Beltri, C.1    Gutierrez-Vazquez, C.2    Sanchez-Cabo, F.3    Perez-Hernandez, D.4    Vazquez, J.5    Martin-Cofreces, N.6    Martinez-Herrera, D.J.7    Pascual-Montano, A.8    Mittelbrunn, M.9    Sanchez-Madrid, F.10
  • 6
    • 85016448020 scopus 로고    scopus 로고
    • Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles
    • In the light of EV-heterogeneity and to harmonize the rapidly growing field, this article defines a set of biochemical, biophysical and functional standards for the experimental procedures in EV research.
    • Lötvall, J., Hill, A.F., Hochberg, F., Buzas, E.I., Di Vizio, D., Gardiner, C., Gho, Y.S., Kurochkin, I.V., Mathivanan, S., Quesenberry, P., et al. Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles. J Extracell Vesicles, 3, 2014, 26913 In the light of EV-heterogeneity and to harmonize the rapidly growing field, this article defines a set of biochemical, biophysical and functional standards for the experimental procedures in EV research.
    • (2014) J Extracell Vesicles , vol.3 , pp. 26913
    • Lötvall, J.1    Hill, A.F.2    Hochberg, F.3    Buzas, E.I.4    Di Vizio, D.5    Gardiner, C.6    Gho, Y.S.7    Kurochkin, I.V.8    Mathivanan, S.9    Quesenberry, P.10
  • 7
    • 84949934993 scopus 로고    scopus 로고
    • As we wait: coping with an imperfect nomenclature for extracellular vesicles
    • Gould, S.J., Raposo, G., As we wait: coping with an imperfect nomenclature for extracellular vesicles. J Extracell Vesicles, 2013, 2.
    • (2013) J Extracell Vesicles , pp. 2
    • Gould, S.J.1    Raposo, G.2
  • 9
    • 84947723880 scopus 로고    scopus 로고
    • Tumour exosome integrins determine organotropic metastasis
    • This study shows that exosomes from brain tropic tumor cells are internalized by brain endothelial cells and are important for preparing the pre-metastatic niche. Same is demonstrated for lung-tropic and liver-tropic tumor-derived exosomes, which enter lung and liver respectively. By profiling integrins, the authors find that the target organ tropism is defined by the pattern of integrins on the surface of exosomes.
    • Hoshino, A., Costa-Silva, B., Shen, T.L., Rodrigues, G., Hashimoto, A., Tesic Mark, M., Molina, H., Kohsaka, S., Di Giannatale, A., Ceder, S., et al. Tumour exosome integrins determine organotropic metastasis. Nature 527 (2015), 329–335 This study shows that exosomes from brain tropic tumor cells are internalized by brain endothelial cells and are important for preparing the pre-metastatic niche. Same is demonstrated for lung-tropic and liver-tropic tumor-derived exosomes, which enter lung and liver respectively. By profiling integrins, the authors find that the target organ tropism is defined by the pattern of integrins on the surface of exosomes.
    • (2015) Nature , vol.527 , pp. 329-335
    • Hoshino, A.1    Costa-Silva, B.2    Shen, T.L.3    Rodrigues, G.4    Hashimoto, A.5    Tesic Mark, M.6    Molina, H.7    Kohsaka, S.8    Di Giannatale, A.9    Ceder, S.10
  • 10
    • 84946559154 scopus 로고    scopus 로고
    • Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth
    • Zhang, L., Zhang, S., Yao, J., Lowery, F.J., Zhang, Q., Huang, W.C., Li, P., Li, M., Wang, X., Zhang, C., et al. Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth. Nature 527 (2015), 100–104.
    • (2015) Nature , vol.527 , pp. 100-104
    • Zhang, L.1    Zhang, S.2    Yao, J.3    Lowery, F.J.4    Zhang, Q.5    Huang, W.C.6    Li, P.7    Li, M.8    Wang, X.9    Zhang, C.10
  • 11
    • 23744470401 scopus 로고    scopus 로고
    • Release of extracellular membrane particles carrying the stem cell marker prominin-1 (CD133) from neural progenitors and other epithelial cells
    • Marzesco, A.M., Janich, P., Wilsch-Brauninger, M., Dubreuil, V., Langenfeld, K., Corbeil, D., Huttner, W.B., Release of extracellular membrane particles carrying the stem cell marker prominin-1 (CD133) from neural progenitors and other epithelial cells. J Cell Sci 118 (2005), 2849–2858.
    • (2005) J Cell Sci , vol.118 , pp. 2849-2858
    • Marzesco, A.M.1    Janich, P.2    Wilsch-Brauninger, M.3    Dubreuil, V.4    Langenfeld, K.5    Corbeil, D.6    Huttner, W.B.7
  • 14
  • 15
    • 84871118236 scopus 로고    scopus 로고
    • The exosome secretory pathway transports amyloid precursor protein carboxyl-terminal fragments from the cell into the brain extracellular space
    • Perez-Gonzalez, R., Gauthier, S.A., Kumar, A., Levy, E., The exosome secretory pathway transports amyloid precursor protein carboxyl-terminal fragments from the cell into the brain extracellular space. J Biol Chem 287 (2012), 43108–43115.
    • (2012) J Biol Chem , vol.287 , pp. 43108-43115
    • Perez-Gonzalez, R.1    Gauthier, S.A.2    Kumar, A.3    Levy, E.4
  • 16
    • 84897606897 scopus 로고    scopus 로고
    • C. elegans ciliated sensory neurons release extracellular vesicles that function in animal communication
    • Wang, J., Silva, M., Haas, L.A., Morsci, N.S., Nguyen, K.C., Hall, D.H., Barr, M.M., C. elegans ciliated sensory neurons release extracellular vesicles that function in animal communication. Curr Biol 24 (2014), 519–525.
    • (2014) Curr Biol , vol.24 , pp. 519-525
    • Wang, J.1    Silva, M.2    Haas, L.A.3    Morsci, N.S.4    Nguyen, K.C.5    Hall, D.H.6    Barr, M.M.7
  • 18
    • 84875495379 scopus 로고    scopus 로고
    • Regulation of postsynaptic retrograde signaling by presynaptic exosome release
    • In an elegant in vivo study on the drosophila neuromuscular junction, the authors demonstrate that exosomes deliver Synaptotagmin 4 anterogradely from the pre-synapse to the post-synapse, which enables Synaptotagmin 4 to participate in retrograde signalling.
    • Korkut, C., Li, Y., Koles, K., Brewer, C., Ashley, J., Yoshihara, M., Budnik, V., Regulation of postsynaptic retrograde signaling by presynaptic exosome release. Neuron 77 (2013), 1039–1046 In an elegant in vivo study on the drosophila neuromuscular junction, the authors demonstrate that exosomes deliver Synaptotagmin 4 anterogradely from the pre-synapse to the post-synapse, which enables Synaptotagmin 4 to participate in retrograde signalling.
    • (2013) Neuron , vol.77 , pp. 1039-1046
    • Korkut, C.1    Li, Y.2    Koles, K.3    Brewer, C.4    Ashley, J.5    Yoshihara, M.6    Budnik, V.7
  • 22
    • 84923076793 scopus 로고    scopus 로고
    • Neuronal exosomes facilitate synaptic pruning by up-regulating complement factors in microglia
    • Bahrini, I., Song, J.H., Diez, D., Hanayama, R., Neuronal exosomes facilitate synaptic pruning by up-regulating complement factors in microglia. Sci Rep, 5, 2015, 7989.
    • (2015) Sci Rep , vol.5 , pp. 7989
    • Bahrini, I.1    Song, J.H.2    Diez, D.3    Hanayama, R.4
  • 23
    • 84906220373 scopus 로고    scopus 로고
    • Activity-associated miRNA are packaged in Map1b-enriched exosomes released from depolarized neurons
    • Goldie, B.J., Dun, M.D., Lin, M., Smith, N.D., Verrills, N.M., Dayas, C.V., Cairns, M.J., Activity-associated miRNA are packaged in Map1b-enriched exosomes released from depolarized neurons. Nucleic Acids Res 42 (2014), 9195–9208.
    • (2014) Nucleic Acids Res , vol.42 , pp. 9195-9208
    • Goldie, B.J.1    Dun, M.D.2    Lin, M.3    Smith, N.D.4    Verrills, N.M.5    Dayas, C.V.6    Cairns, M.J.7
  • 25
    • 84938713652 scopus 로고    scopus 로고
    • Exosomes secreted by cortical neurons upon glutamatergic synapse activation specifically interact with neurons
    • This study shows that exosomes derived from primary cortical neurons specifically bind to other neurons, while neuroblastoma-derived exosomes are less specific and also interact with glia cells. The study suggests that cortical neuron exosomes preferentially adhere to presynaptic sites and are endocytosed.
    • Chivet, M., Javalet, C., Laulagnier, K., Blot, B., Hemming, F.J., Sadoul, R., Exosomes secreted by cortical neurons upon glutamatergic synapse activation specifically interact with neurons. J Extracell Vesicles, 3, 2014, 24722 This study shows that exosomes derived from primary cortical neurons specifically bind to other neurons, while neuroblastoma-derived exosomes are less specific and also interact with glia cells. The study suggests that cortical neuron exosomes preferentially adhere to presynaptic sites and are endocytosed.
    • (2014) J Extracell Vesicles , vol.3 , pp. 24722
    • Chivet, M.1    Javalet, C.2    Laulagnier, K.3    Blot, B.4    Hemming, F.J.5    Sadoul, R.6
  • 26
    • 84874833693 scopus 로고    scopus 로고
    • Neuronal exosomal miRNA-dependent translational regulation of astroglial glutamate transporter GLT1
    • Morel, L., Regan, M., Higashimori, H., Ng, S.K., Esau, C., Vidensky, S., Rothstein, J., Yang, Y., Neuronal exosomal miRNA-dependent translational regulation of astroglial glutamate transporter GLT1. J Biol Chem 288 (2013), 7105–7116.
    • (2013) J Biol Chem , vol.288 , pp. 7105-7116
    • Morel, L.1    Regan, M.2    Higashimori, H.3    Ng, S.K.4    Esau, C.5    Vidensky, S.6    Rothstein, J.7    Yang, Y.8
  • 28
    • 84949623094 scopus 로고    scopus 로고
    • Active endocannabinoids are secreted on extracellular membrane vesicles
    • This is the first study showing that endocannabinoids can employ EVs to cross the extracellular space and mediate signallling between microglia and neurons. N-Arachidonoylethanolamine delivered on the surface of vesicles stimulates type-1 cannabinoid receptors, inhibiting presynaptic GABAergic neurotransmission.
    • Gabrielli, M., Battista, N., Riganti, L., Prada, I., Antonucci, F., Cantone, L., Matteoli, M., Maccarrone, M., Verderio, C., Active endocannabinoids are secreted on extracellular membrane vesicles. EMBO Rep 16 (2015), 213–220 This is the first study showing that endocannabinoids can employ EVs to cross the extracellular space and mediate signallling between microglia and neurons. N-Arachidonoylethanolamine delivered on the surface of vesicles stimulates type-1 cannabinoid receptors, inhibiting presynaptic GABAergic neurotransmission.
    • (2015) EMBO Rep , vol.16 , pp. 213-220
    • Gabrielli, M.1    Battista, N.2    Riganti, L.3    Prada, I.4    Antonucci, F.5    Cantone, L.6    Matteoli, M.7    Maccarrone, M.8    Verderio, C.9
  • 30
  • 31
    • 84880950361 scopus 로고    scopus 로고
    • Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication
    • This paper demonstrates bidirectional signalling between neurons and oligodendrocytes involving exosome transfer from oligodendrocytes to neurons. Utilizing a Cre-reporter system, it is demonstrated that exosomal cargo is functional in target neurons. Neurons that receive exosomes are protected from different kinds of stress, suggesting a role in neuroprotection.
    • Frühbeis, C., Fröhlich, D., Kuo, W.P., Amphornrat, J., Thilemann, S., Saab, A.S., Kirchhoff, F., Mobius, W., Goebbels, S., Nave, K.A., et al. Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication. PLoS biology, 11, 2013, e1001604 This paper demonstrates bidirectional signalling between neurons and oligodendrocytes involving exosome transfer from oligodendrocytes to neurons. Utilizing a Cre-reporter system, it is demonstrated that exosomal cargo is functional in target neurons. Neurons that receive exosomes are protected from different kinds of stress, suggesting a role in neuroprotection.
    • (2013) PLoS biology , vol.11 , pp. e1001604
    • Frühbeis, C.1    Fröhlich, D.2    Kuo, W.P.3    Amphornrat, J.4    Thilemann, S.5    Saab, A.S.6    Kirchhoff, F.7    Mobius, W.8    Goebbels, S.9    Nave, K.A.10
  • 34
    • 84884724002 scopus 로고    scopus 로고
    • Schwann cell-derived exosomes enhance axonal regeneration in the peripheral nervous system
    • The authors describe that de-differentiated Schwann cells release exosomes, which promote axonal regeneration in vitro and in vivo after lesion of the sciatic nerve.
    • Lopez-Verrilli, M.A., Picou, F., Court, F.A., Schwann cell-derived exosomes enhance axonal regeneration in the peripheral nervous system. Glia 61 (2013), 1795–1806 The authors describe that de-differentiated Schwann cells release exosomes, which promote axonal regeneration in vitro and in vivo after lesion of the sciatic nerve.
    • (2013) Glia , vol.61 , pp. 1795-1806
    • Lopez-Verrilli, M.A.1    Picou, F.2    Court, F.A.3
  • 36
    • 84922340030 scopus 로고    scopus 로고
    • The neutral sphingomyelinase pathway regulates packaging of the prion protein into exosomes
    • Guo, B.B., Bellingham, S.A., Hill, A.F., The neutral sphingomyelinase pathway regulates packaging of the prion protein into exosomes. J Biol Chem 290 (2015), 3455–3467.
    • (2015) J Biol Chem , vol.290 , pp. 3455-3467
    • Guo, B.B.1    Bellingham, S.A.2    Hill, A.F.3
  • 39
    • 84903289462 scopus 로고    scopus 로고
    • Extracellular vesicle-mediated transfer of genetic information between the hematopoietic system and the brain in response to inflammation
    • Utilizing a genetic model involving a mouse hematopoietic Cre-driver crossed to a reporter line, the authors demonstrate that exosomes derived from hematopoietic cells enter the brain in particular under inflammatory conditions and modulate neurons. Reporter-positive neurons differed in their miRNA-profile from reporter-negative neurons indicating exosome-mediated miRNA transfer to neurons.
    • Ridder, K., Keller, S., Dams, M., Rupp, A.K., Schlaudraff, J., Turco, D.D., Starmann, J., Macas, J., Karpova, D., Devraj, K., et al. Extracellular vesicle-mediated transfer of genetic information between the hematopoietic system and the brain in response to inflammation. PLoS Biol, 12, 2014, e1001874 Utilizing a genetic model involving a mouse hematopoietic Cre-driver crossed to a reporter line, the authors demonstrate that exosomes derived from hematopoietic cells enter the brain in particular under inflammatory conditions and modulate neurons. Reporter-positive neurons differed in their miRNA-profile from reporter-negative neurons indicating exosome-mediated miRNA transfer to neurons.
    • (2014) PLoS Biol , vol.12 , pp. e1001874
    • Ridder, K.1    Keller, S.2    Dams, M.3    Rupp, A.K.4    Schlaudraff, J.5    Turco, D.D.6    Starmann, J.7    Macas, J.8    Karpova, D.9    Devraj, K.10
  • 40
    • 84897133710 scopus 로고    scopus 로고
    • Extracellular vesicles in multiple sclerosis: what are they telling us?
    • Saenz-Cuesta, M., Osorio-Querejeta, I., Otaegui, D., Extracellular vesicles in multiple sclerosis: what are they telling us?. Front Cell Neurosci, 8, 2014, 100.
    • (2014) Front Cell Neurosci , vol.8 , pp. 100
    • Saenz-Cuesta, M.1    Osorio-Querejeta, I.2    Otaegui, D.3
  • 41
    • 84944355473 scopus 로고    scopus 로고
    • Physical exercise induces rapid release of small extracellular vesicles into the circulation
    • Frühbeis, C., Helmig, S., Tug, S., Simon, P., Krämer-Albers, E.M., Physical exercise induces rapid release of small extracellular vesicles into the circulation. J Extracell Vesicles, 4, 2015, 28239.
    • (2015) J Extracell Vesicles , vol.4 , pp. 28239
    • Frühbeis, C.1    Helmig, S.2    Tug, S.3    Simon, P.4    Krämer-Albers, E.M.5
  • 42
    • 84929269782 scopus 로고    scopus 로고
    • Extracellular vesicles — their role in the packaging and spread of misfolded proteins associated with neurodegenerative diseases
    • Coleman, B.M., Hill, A.F., Extracellular vesicles — their role in the packaging and spread of misfolded proteins associated with neurodegenerative diseases. Semin Cell Dev Biol 40 (2015), 89–96.
    • (2015) Semin Cell Dev Biol , vol.40 , pp. 89-96
    • Coleman, B.M.1    Hill, A.F.2
  • 43
    • 3042788972 scopus 로고    scopus 로고
    • Cells release prions in association with exosomes
    • This article demonstrated the first association of misfolded and transmissible prions with exosomes.
    • Fevrier, B., Vilette, D., Archer, F., Loew, D., Faigle, W., Vidal, M., Laude, H., Raposo, G., Cells release prions in association with exosomes. Proc Natl Acad Sci U S A 101 (2004), 9683–9688 This article demonstrated the first association of misfolded and transmissible prions with exosomes.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 9683-9688
    • Fevrier, B.1    Vilette, D.2    Archer, F.3    Loew, D.4    Faigle, W.5    Vidal, M.6    Laude, H.7    Raposo, G.8
  • 44
    • 33947709328 scopus 로고    scopus 로고
    • Packaging of prions into exosomes is associated with a novel pathway of PrP processing
    • Vella, L.J., Sharples, R.A., Lawson, V.A., Masters, C.L., Cappai, R., Hill, A.F., Packaging of prions into exosomes is associated with a novel pathway of PrP processing. J Pathol 211 (2007), 582–590.
    • (2007) J Pathol , vol.211 , pp. 582-590
    • Vella, L.J.1    Sharples, R.A.2    Lawson, V.A.3    Masters, C.L.4    Cappai, R.5    Hill, A.F.6
  • 46
    • 84856707794 scopus 로고    scopus 로고
    • Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease
    • The presence of distinct phosphorylated forms of tau protein in exosomes isolated from CSF may provide avenues for diagnosis and also suggests the selective packaging of post-translationally modified proteins into these vesicles.
    • Saman, S., Kim, W., Raya, M., Visnick, Y., Miro, S., Saman, S., Jackson, B., McKee, A.C., Alvarez, V.E., Lee, N.C., et al. Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease. J Biol Chem 287 (2012), 3842–3849 The presence of distinct phosphorylated forms of tau protein in exosomes isolated from CSF may provide avenues for diagnosis and also suggests the selective packaging of post-translationally modified proteins into these vesicles.
    • (2012) J Biol Chem , vol.287 , pp. 3842-3849
    • Saman, S.1    Kim, W.2    Raya, M.3    Visnick, Y.4    Miro, S.5    Saman, S.6    Jackson, B.7    McKee, A.C.8    Alvarez, V.E.9    Lee, N.C.10
  • 49
    • 84977123370 scopus 로고    scopus 로고
    • Induction of alpha-synuclein aggregate formation by CSF exosomes from patients with Parkinson's disease and dementia with Lewy bodies
    • Stuendl, A., Kunadt, M., Kruse, N., Bartels, C., Moebius, W., Danzer, K.M., Mollenhauer, B., Schneider, A., Induction of alpha-synuclein aggregate formation by CSF exosomes from patients with Parkinson's disease and dementia with Lewy bodies. Brain 139 (2016), 481–494.
    • (2016) Brain , vol.139 , pp. 481-494
    • Stuendl, A.1    Kunadt, M.2    Kruse, N.3    Bartels, C.4    Moebius, W.5    Danzer, K.M.6    Mollenhauer, B.7    Schneider, A.8
  • 50
    • 84895796816 scopus 로고    scopus 로고
    • Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms
    • This article demonstrated that the intercellular transfer and propagation of misfolded SOD1 can occur both in an exosome dependent and independent manner, suggesting potential mechanisms for the spread of this misfolded protein in amyotrophic lateral sclerosis.
    • Grad, L.I., Yerbury, J.J., Turner, B.J., Guest, W.C., Pokrishevsky, E., O'Neill, M.A., Yanai, A., Silverman, J.M., Zeineddine, R., Corcoran, L., et al. Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms. Proc Natl Acad Sci U S A 111 (2014), 3620–3625 This article demonstrated that the intercellular transfer and propagation of misfolded SOD1 can occur both in an exosome dependent and independent manner, suggesting potential mechanisms for the spread of this misfolded protein in amyotrophic lateral sclerosis.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 3620-3625
    • Grad, L.I.1    Yerbury, J.J.2    Turner, B.J.3    Guest, W.C.4    Pokrishevsky, E.5    O'Neill, M.A.6    Yanai, A.7    Silverman, J.M.8    Zeineddine, R.9    Corcoran, L.10
  • 53
    • 84923049991 scopus 로고    scopus 로고
    • Extracellular vesicles from a muscle cell line (C2C12) enhance cell survival and neurite outgrowth of a motor neuron cell line (NSC-34)
    • Madison, R.D., McGee, C., Rawson, R., Robinson, G.A., Extracellular vesicles from a muscle cell line (C2C12) enhance cell survival and neurite outgrowth of a motor neuron cell line (NSC-34). J Extracell Vesicles, 2014, 3.
    • (2014) J Extracell Vesicles , pp. 3
    • Madison, R.D.1    McGee, C.2    Rawson, R.3    Robinson, G.A.4
  • 54
    • 84891481384 scopus 로고    scopus 로고
    • IFNgamma-stimulated dendritic cell exosomes as a potential therapeutic for remyelination
    • Pusic, A.D., Pusic, K.M., Clayton, B.L., Kraig, R.P., IFNgamma-stimulated dendritic cell exosomes as a potential therapeutic for remyelination. J Neuroimmunol 266 (2014), 12–23.
    • (2014) J Neuroimmunol , vol.266 , pp. 12-23
    • Pusic, A.D.1    Pusic, K.M.2    Clayton, B.L.3    Kraig, R.P.4
  • 55
    • 84890164626 scopus 로고    scopus 로고
    • Youth and environmental enrichment generate serum exosomes containing miR-219 that promote CNS myelination
    • Pusic, A.D., Kraig, R.P., Youth and environmental enrichment generate serum exosomes containing miR-219 that promote CNS myelination. Glia 62 (2014), 284–299.
    • (2014) Glia , vol.62 , pp. 284-299
    • Pusic, A.D.1    Kraig, R.P.2
  • 56
    • 84883382523 scopus 로고    scopus 로고
    • MiR-133b promotes neural plasticity and functional recovery after treatment of stroke with multipotent mesenchymal stromal cells in rats via transfer of exosome-enriched extracellular particles
    • Xin, H., Li, Y., Liu, Z., Wang, X., Shang, X., Cui, Y., Zhang, Z.G., Chopp, M., MiR-133b promotes neural plasticity and functional recovery after treatment of stroke with multipotent mesenchymal stromal cells in rats via transfer of exosome-enriched extracellular particles. Stem Cells 31 (2013), 2737–2746.
    • (2013) Stem Cells , vol.31 , pp. 2737-2746
    • Xin, H.1    Li, Y.2    Liu, Z.3    Wang, X.4    Shang, X.5    Cui, Y.6    Zhang, Z.G.7    Chopp, M.8
  • 57
    • 84887117028 scopus 로고    scopus 로고
    • Systemic administration of exosomes released from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats
    • This article showed for the first time that rats, which were subjected to the middle cerebral artery occlusion, recovered better from the ischemic insult in case they received a systemic injection of mesenchymal stromal cell-derived exosomes. Functional recovery was associated with enhanced neurite remodelling, neurogenesis and angiogenesis.
    • Xin, H., Li, Y., Cui, Y., Yang, J.J., Zhang, Z.G., Chopp, M., Systemic administration of exosomes released from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats. J Cereb Blood Flow Metab 33 (2013), 1711–1715 This article showed for the first time that rats, which were subjected to the middle cerebral artery occlusion, recovered better from the ischemic insult in case they received a systemic injection of mesenchymal stromal cell-derived exosomes. Functional recovery was associated with enhanced neurite remodelling, neurogenesis and angiogenesis.
    • (2013) J Cereb Blood Flow Metab , vol.33 , pp. 1711-1715
    • Xin, H.1    Li, Y.2    Cui, Y.3    Yang, J.J.4    Zhang, Z.G.5    Chopp, M.6
  • 58
    • 84953295050 scopus 로고    scopus 로고
    • Chromatographically isolated CD63+CD81+ extracellular vesicles from mesenchymal stromal cells rescue cognitive impairments after TBI
    • The study shows that mesenchymal stem cell EVs systemically administered to mice shortly after induction of traumatic brain injury rescued pattern separation and spatial learning impairments in these mice. The study is original in describing a work flow that controls EV isolation, quality, and potency.
    • Kim, D.K., Nishida, H., An, S.Y., Shetty, A.K., Bartosh, T.J., Prockop, D.J., Chromatographically isolated CD63+CD81+ extracellular vesicles from mesenchymal stromal cells rescue cognitive impairments after TBI. Proc Natl Acad Sci U S A 113 (2016), 170–175 The study shows that mesenchymal stem cell EVs systemically administered to mice shortly after induction of traumatic brain injury rescued pattern separation and spatial learning impairments in these mice. The study is original in describing a work flow that controls EV isolation, quality, and potency.
    • (2016) Proc Natl Acad Sci U S A , vol.113 , pp. 170-175
    • Kim, D.K.1    Nishida, H.2    An, S.Y.3    Shetty, A.K.4    Bartosh, T.J.5    Prockop, D.J.6
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    • 84942162960 scopus 로고    scopus 로고
    • Extracellular vesicles improve post-stroke neuroregeneration and prevent postischemic immunosuppression
    • Here, the therapeutic efficacy of mesenchymal stem cell (MSC)-derived exosomes is directly compared to the efficacy of MSC whole cell entities systemically applied to mice after focal cerebral ischemia. MSC-EVs and MSCs showed similar effects, and hence the authors suggest that MSC-EVs might provide a better therapeutic opportunity due to safety reasons.
    • Doeppner, T.R., Herz, J., Gorgens, A., Schlechter, J., Ludwig, A.K., Radtke, S., de Miroschedji, K., Horn, P.A., Giebel, B., Hermann, D.M., Extracellular vesicles improve post-stroke neuroregeneration and prevent postischemic immunosuppression. Stem Cells Transl Med, 2015 Here, the therapeutic efficacy of mesenchymal stem cell (MSC)-derived exosomes is directly compared to the efficacy of MSC whole cell entities systemically applied to mice after focal cerebral ischemia. MSC-EVs and MSCs showed similar effects, and hence the authors suggest that MSC-EVs might provide a better therapeutic opportunity due to safety reasons.
    • (2015) Stem Cells Transl Med
    • Doeppner, T.R.1    Herz, J.2    Gorgens, A.3    Schlechter, J.4    Ludwig, A.K.5    Radtke, S.6    de Miroschedji, K.7    Horn, P.A.8    Giebel, B.9    Hermann, D.M.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.