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1
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84904704297
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Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles
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Colombo, M., Raposo, G., Thery, C., Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Annu Rev Cell Dev Biol 30 (2014), 255–289.
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Annu Rev Cell Dev Biol
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Colombo, M.1
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2
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Extracellular vesicles: exosomes, microvesicles, and friends
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Raposo, G., Stoorvogel, W., Extracellular vesicles: exosomes, microvesicles, and friends. J Cell Biol 200 (2013), 373–383.
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J Cell Biol
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Raposo, G.1
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84904657288
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Biogenesis and secretion of exosomes
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Kowal, J., Tkach, M., Thery, C., Biogenesis and secretion of exosomes. Curr Opin Cell Biol 29 (2014), 116–125.
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Curr Opin Cell Biol
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Kowal, J.1
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4
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84939939990
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Extracellular vesicle sorting of alpha-Synuclein is regulated by sumoylation
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Kunadt, M., Eckermann, K., Stuendl, A., Gong, J., Russo, B., Strauss, K., Rai, S., Kugler, S., Falomir Lockhart, L., Schwalbe, M., et al. Extracellular vesicle sorting of alpha-Synuclein is regulated by sumoylation. Acta Neuropathol 129 (2015), 695–713.
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Acta Neuropathol
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Kunadt, M.1
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Rai, S.7
Kugler, S.8
Falomir Lockhart, L.9
Schwalbe, M.10
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5
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84890907806
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Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs
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This paper discovers a sequence motif in miRNAs that is recognized by the RNA-binding protein hnRNPA2B1. Sumoylation of hnRNPA2B1 controls binding of miRNAs and inclusion in exosomes during their biogenesis. It's the first study describing sumo-dependent sorting of exosome cargo.
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Villarroya-Beltri, C., Gutierrez-Vazquez, C., Sanchez-Cabo, F., Perez-Hernandez, D., Vazquez, J., Martin-Cofreces, N., Martinez-Herrera, D.J., Pascual-Montano, A., Mittelbrunn, M., Sanchez-Madrid, F., Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs. Nat Commun, 4, 2013, 2980 This paper discovers a sequence motif in miRNAs that is recognized by the RNA-binding protein hnRNPA2B1. Sumoylation of hnRNPA2B1 controls binding of miRNAs and inclusion in exosomes during their biogenesis. It's the first study describing sumo-dependent sorting of exosome cargo.
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Nat Commun
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Villarroya-Beltri, C.1
Gutierrez-Vazquez, C.2
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Vazquez, J.5
Martin-Cofreces, N.6
Martinez-Herrera, D.J.7
Pascual-Montano, A.8
Mittelbrunn, M.9
Sanchez-Madrid, F.10
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6
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85016448020
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Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles
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In the light of EV-heterogeneity and to harmonize the rapidly growing field, this article defines a set of biochemical, biophysical and functional standards for the experimental procedures in EV research.
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Lötvall, J., Hill, A.F., Hochberg, F., Buzas, E.I., Di Vizio, D., Gardiner, C., Gho, Y.S., Kurochkin, I.V., Mathivanan, S., Quesenberry, P., et al. Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles. J Extracell Vesicles, 3, 2014, 26913 In the light of EV-heterogeneity and to harmonize the rapidly growing field, this article defines a set of biochemical, biophysical and functional standards for the experimental procedures in EV research.
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J Extracell Vesicles
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Lötvall, J.1
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Gho, Y.S.7
Kurochkin, I.V.8
Mathivanan, S.9
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7
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As we wait: coping with an imperfect nomenclature for extracellular vesicles
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Gould, S.J., Raposo, G., As we wait: coping with an imperfect nomenclature for extracellular vesicles. J Extracell Vesicles, 2013, 2.
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J Extracell Vesicles
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Gould, S.J.1
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8
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85014619748
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Biological properties of extracellular vesicles and their physiological functions
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Yanez-Mo, M., Siljander, P.R., Andreu, Z., Zavec, A.B., Borras, F.E., Buzas, E.I., Buzas, K., Casal, E., Cappello, F., Carvalho, J., et al. Biological properties of extracellular vesicles and their physiological functions. J Extracell Vesicles, 4, 2015, 27066.
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J Extracell Vesicles
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Yanez-Mo, M.1
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Buzas, E.I.6
Buzas, K.7
Casal, E.8
Cappello, F.9
Carvalho, J.10
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9
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84947723880
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Tumour exosome integrins determine organotropic metastasis
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This study shows that exosomes from brain tropic tumor cells are internalized by brain endothelial cells and are important for preparing the pre-metastatic niche. Same is demonstrated for lung-tropic and liver-tropic tumor-derived exosomes, which enter lung and liver respectively. By profiling integrins, the authors find that the target organ tropism is defined by the pattern of integrins on the surface of exosomes.
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Hoshino, A., Costa-Silva, B., Shen, T.L., Rodrigues, G., Hashimoto, A., Tesic Mark, M., Molina, H., Kohsaka, S., Di Giannatale, A., Ceder, S., et al. Tumour exosome integrins determine organotropic metastasis. Nature 527 (2015), 329–335 This study shows that exosomes from brain tropic tumor cells are internalized by brain endothelial cells and are important for preparing the pre-metastatic niche. Same is demonstrated for lung-tropic and liver-tropic tumor-derived exosomes, which enter lung and liver respectively. By profiling integrins, the authors find that the target organ tropism is defined by the pattern of integrins on the surface of exosomes.
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(2015)
Nature
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Hoshino, A.1
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Hashimoto, A.5
Tesic Mark, M.6
Molina, H.7
Kohsaka, S.8
Di Giannatale, A.9
Ceder, S.10
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10
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84946559154
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Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth
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Zhang, L., Zhang, S., Yao, J., Lowery, F.J., Zhang, Q., Huang, W.C., Li, P., Li, M., Wang, X., Zhang, C., et al. Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth. Nature 527 (2015), 100–104.
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Nature
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Zhang, L.1
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Zhang, Q.5
Huang, W.C.6
Li, P.7
Li, M.8
Wang, X.9
Zhang, C.10
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11
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23744470401
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Release of extracellular membrane particles carrying the stem cell marker prominin-1 (CD133) from neural progenitors and other epithelial cells
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Marzesco, A.M., Janich, P., Wilsch-Brauninger, M., Dubreuil, V., Langenfeld, K., Corbeil, D., Huttner, W.B., Release of extracellular membrane particles carrying the stem cell marker prominin-1 (CD133) from neural progenitors and other epithelial cells. J Cell Sci 118 (2005), 2849–2858.
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Marzesco, A.M.1
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Dubreuil, V.4
Langenfeld, K.5
Corbeil, D.6
Huttner, W.B.7
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12
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84900036747
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Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset
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Chiasserini, D., van Weering, J.R., Piersma, S.R., Pham, T.V., Malekzadeh, A., Teunissen, C.E., de Wit, H., Jimenez, C.R., Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset. J Proteomics 106 (2014), 191–204.
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Chiasserini, D.1
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Teunissen, C.E.6
de Wit, H.7
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13
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84866343704
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Myeloid microvesicles are a marker and therapeutic target for neuroinflammation
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Verderio, C., Muzio, L., Turola, E., Bergami, A., Novellino, L., Ruffini, F., Riganti, L., Corradini, I., Francolini, M., Garzetti, L., et al. Myeloid microvesicles are a marker and therapeutic target for neuroinflammation. Ann Neurol 72 (2012), 610–624.
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Verderio, C.1
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Corradini, I.8
Francolini, M.9
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14
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Emerging roles of exosomes in neuron–glia communication
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Frühbeis, C., Fröhlich, D., Krämer-Albers, E.M., Emerging roles of exosomes in neuron–glia communication. Front Physiol, 3, 2012, 119.
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Frühbeis, C.1
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15
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84871118236
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The exosome secretory pathway transports amyloid precursor protein carboxyl-terminal fragments from the cell into the brain extracellular space
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Perez-Gonzalez, R., Gauthier, S.A., Kumar, A., Levy, E., The exosome secretory pathway transports amyloid precursor protein carboxyl-terminal fragments from the cell into the brain extracellular space. J Biol Chem 287 (2012), 43108–43115.
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Perez-Gonzalez, R.1
Gauthier, S.A.2
Kumar, A.3
Levy, E.4
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16
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84897606897
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C. elegans ciliated sensory neurons release extracellular vesicles that function in animal communication
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Wang, J., Silva, M., Haas, L.A., Morsci, N.S., Nguyen, K.C., Hall, D.H., Barr, M.M., C. elegans ciliated sensory neurons release extracellular vesicles that function in animal communication. Curr Biol 24 (2014), 519–525.
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Wang, J.1
Silva, M.2
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Morsci, N.S.4
Nguyen, K.C.5
Hall, D.H.6
Barr, M.M.7
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17
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84955652335
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Cell-specific transcriptional profiling of ciliated sensory neurons reveals regulators of behavior and extracellular vesicle biogenesis
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Wang, J., Kaletsky, R., Silva, M., Williams, A., Haas, L.A., Androwski, R.J., Landis, J.N., Patrick, C., Rashid, A., Santiago-Martinez, D., et al. Cell-specific transcriptional profiling of ciliated sensory neurons reveals regulators of behavior and extracellular vesicle biogenesis. Curr Biol 25 (2015), 3232–3238.
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Curr Biol
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Wang, J.1
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Landis, J.N.7
Patrick, C.8
Rashid, A.9
Santiago-Martinez, D.10
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18
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84875495379
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Regulation of postsynaptic retrograde signaling by presynaptic exosome release
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In an elegant in vivo study on the drosophila neuromuscular junction, the authors demonstrate that exosomes deliver Synaptotagmin 4 anterogradely from the pre-synapse to the post-synapse, which enables Synaptotagmin 4 to participate in retrograde signalling.
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Korkut, C., Li, Y., Koles, K., Brewer, C., Ashley, J., Yoshihara, M., Budnik, V., Regulation of postsynaptic retrograde signaling by presynaptic exosome release. Neuron 77 (2013), 1039–1046 In an elegant in vivo study on the drosophila neuromuscular junction, the authors demonstrate that exosomes deliver Synaptotagmin 4 anterogradely from the pre-synapse to the post-synapse, which enables Synaptotagmin 4 to participate in retrograde signalling.
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Neuron
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Korkut, C.1
Li, Y.2
Koles, K.3
Brewer, C.4
Ashley, J.5
Yoshihara, M.6
Budnik, V.7
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19
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84860852182
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Mechanism of evenness interrupted (Evi)-exosome release at synaptic boutons
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Koles, K., Nunnari, J., Korkut, C., Barria, R., Brewer, C., Li, Y., Leszyk, J., Zhang, B., Budnik, V., Mechanism of evenness interrupted (Evi)-exosome release at synaptic boutons. J Biol Chem 287 (2012), 16820–16834.
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Koles, K.1
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Li, Y.6
Leszyk, J.7
Zhang, B.8
Budnik, V.9
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20
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78751703517
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Release of exosomes from differentiated neurons and its regulation by synaptic glutamatergic activity
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Lachenal, G., Pernet-Gallay, K., Chivet, M., Hemming, F.J., Belly, A., Bodon, G., Blot, B., Haase, G., Goldberg, Y., Sadoul, R., Release of exosomes from differentiated neurons and its regulation by synaptic glutamatergic activity. Mol Cell Neurosci 46 (2011), 409–418.
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Lachenal, G.1
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Chivet, M.3
Hemming, F.J.4
Belly, A.5
Bodon, G.6
Blot, B.7
Haase, G.8
Goldberg, Y.9
Sadoul, R.10
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21
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The p75 neurotrophin receptor evades the endolysosomal route in neuronal cells, favouring multivesicular bodies specialised for exosomal release
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Escudero, C.A., Lazo, O.M., Galleguillos, C., Parraguez, J.I., Lopez-Verrilli, M.A., Cabeza, C., Leon, L., Saeed, U., Retamal, C., Gonzalez, A., et al. The p75 neurotrophin receptor evades the endolysosomal route in neuronal cells, favouring multivesicular bodies specialised for exosomal release. J Cell Sci 127 (2014), 1966–1979.
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Escudero, C.A.1
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Parraguez, J.I.4
Lopez-Verrilli, M.A.5
Cabeza, C.6
Leon, L.7
Saeed, U.8
Retamal, C.9
Gonzalez, A.10
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22
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84923076793
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Neuronal exosomes facilitate synaptic pruning by up-regulating complement factors in microglia
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Bahrini, I., Song, J.H., Diez, D., Hanayama, R., Neuronal exosomes facilitate synaptic pruning by up-regulating complement factors in microglia. Sci Rep, 5, 2015, 7989.
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Sci Rep
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Bahrini, I.1
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23
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Activity-associated miRNA are packaged in Map1b-enriched exosomes released from depolarized neurons
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Goldie, B.J., Dun, M.D., Lin, M., Smith, N.D., Verrills, N.M., Dayas, C.V., Cairns, M.J., Activity-associated miRNA are packaged in Map1b-enriched exosomes released from depolarized neurons. Nucleic Acids Res 42 (2014), 9195–9208.
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Goldie, B.J.1
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24
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Exosomes as a novel way of interneuronal communication
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Chivet, M., Javalet, C., Hemming, F., Pernet-Gallay, K., Laulagnier, K., Fraboulet, S., Sadoul, R., Exosomes as a novel way of interneuronal communication. Biochem Soc Trans 41 (2013), 241–244.
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Biochem Soc Trans
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Chivet, M.1
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Hemming, F.3
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Laulagnier, K.5
Fraboulet, S.6
Sadoul, R.7
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25
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84938713652
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Exosomes secreted by cortical neurons upon glutamatergic synapse activation specifically interact with neurons
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This study shows that exosomes derived from primary cortical neurons specifically bind to other neurons, while neuroblastoma-derived exosomes are less specific and also interact with glia cells. The study suggests that cortical neuron exosomes preferentially adhere to presynaptic sites and are endocytosed.
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Chivet, M., Javalet, C., Laulagnier, K., Blot, B., Hemming, F.J., Sadoul, R., Exosomes secreted by cortical neurons upon glutamatergic synapse activation specifically interact with neurons. J Extracell Vesicles, 3, 2014, 24722 This study shows that exosomes derived from primary cortical neurons specifically bind to other neurons, while neuroblastoma-derived exosomes are less specific and also interact with glia cells. The study suggests that cortical neuron exosomes preferentially adhere to presynaptic sites and are endocytosed.
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J Extracell Vesicles
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Chivet, M.1
Javalet, C.2
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26
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84874833693
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Neuronal exosomal miRNA-dependent translational regulation of astroglial glutamate transporter GLT1
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Morel, L., Regan, M., Higashimori, H., Ng, S.K., Esau, C., Vidensky, S., Rothstein, J., Yang, Y., Neuronal exosomal miRNA-dependent translational regulation of astroglial glutamate transporter GLT1. J Biol Chem 288 (2013), 7105–7116.
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Morel, L.1
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27
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84857998516
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Microvesicles released from microglia stimulate synaptic activity via enhanced sphingolipid metabolism
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Antonucci, F., Turola, E., Riganti, L., Caleo, M., Gabrielli, M., Perrotta, C., Novellino, L., Clementi, E., Giussani, P., Viani, P., et al. Microvesicles released from microglia stimulate synaptic activity via enhanced sphingolipid metabolism. Embo J 31 (2012), 1231–1240.
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Antonucci, F.1
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Giussani, P.9
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28
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84949623094
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Active endocannabinoids are secreted on extracellular membrane vesicles
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This is the first study showing that endocannabinoids can employ EVs to cross the extracellular space and mediate signallling between microglia and neurons. N-Arachidonoylethanolamine delivered on the surface of vesicles stimulates type-1 cannabinoid receptors, inhibiting presynaptic GABAergic neurotransmission.
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Gabrielli, M., Battista, N., Riganti, L., Prada, I., Antonucci, F., Cantone, L., Matteoli, M., Maccarrone, M., Verderio, C., Active endocannabinoids are secreted on extracellular membrane vesicles. EMBO Rep 16 (2015), 213–220 This is the first study showing that endocannabinoids can employ EVs to cross the extracellular space and mediate signallling between microglia and neurons. N-Arachidonoylethanolamine delivered on the surface of vesicles stimulates type-1 cannabinoid receptors, inhibiting presynaptic GABAergic neurotransmission.
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EMBO Rep
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Gabrielli, M.1
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29
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Serotonin stimulates secretion of exosomes from microglia cells
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Glebov, K., Lochner, M., Jabs, R., Lau, T., Merkel, O., Schloss, P., Steinhauser, C., Walter, J., Serotonin stimulates secretion of exosomes from microglia cells. Glia 63 (2015), 626–634.
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Glia
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Glebov, K.1
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30
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Astrocyte-derived ATP induces vesicle shedding and IL-1 beta release from microglia
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Bianco, F., Pravettoni, E., Colombo, A., Schenk, U., Moller, T., Matteoli, M., Verderio, C., Astrocyte-derived ATP induces vesicle shedding and IL-1 beta release from microglia. J Immunol 174 (2005), 7268–7277.
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Bianco, F.1
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31
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84880950361
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Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication
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This paper demonstrates bidirectional signalling between neurons and oligodendrocytes involving exosome transfer from oligodendrocytes to neurons. Utilizing a Cre-reporter system, it is demonstrated that exosomal cargo is functional in target neurons. Neurons that receive exosomes are protected from different kinds of stress, suggesting a role in neuroprotection.
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Frühbeis, C., Fröhlich, D., Kuo, W.P., Amphornrat, J., Thilemann, S., Saab, A.S., Kirchhoff, F., Mobius, W., Goebbels, S., Nave, K.A., et al. Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication. PLoS biology, 11, 2013, e1001604 This paper demonstrates bidirectional signalling between neurons and oligodendrocytes involving exosome transfer from oligodendrocytes to neurons. Utilizing a Cre-reporter system, it is demonstrated that exosomal cargo is functional in target neurons. Neurons that receive exosomes are protected from different kinds of stress, suggesting a role in neuroprotection.
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PLoS biology
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Frühbeis, C.1
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32
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79551542416
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Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis
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Fitzner, D., Schnaars, M., van Rossum, D., Krishnamoorthy, G., Dibaj, P., Bakhti, M., Regen, T., Hanisch, U.K., Simons, M., Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis. J Cell Sci 124 (2011), 447–458.
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33
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Multifaceted effects of oligodendroglial exosomes on neurons: impact on neuronal firing rate, signal transduction and gene regulation
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Fröhlich, D., Kuo, W.P., Frühbeis, C., Sun, J.J., Zehendner, C.M., Luhmann, H.J., Pinto, S., Toedling, J., Trotter, J., Krämer-Albers, E.M., Multifaceted effects of oligodendroglial exosomes on neurons: impact on neuronal firing rate, signal transduction and gene regulation. Philos Trans R Soc Lond B Biol Sci, 2014, 369.
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(2014)
Philos Trans R Soc Lond B Biol Sci
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Fröhlich, D.1
Kuo, W.P.2
Frühbeis, C.3
Sun, J.J.4
Zehendner, C.M.5
Luhmann, H.J.6
Pinto, S.7
Toedling, J.8
Trotter, J.9
Krämer-Albers, E.M.10
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34
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Schwann cell-derived exosomes enhance axonal regeneration in the peripheral nervous system
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The authors describe that de-differentiated Schwann cells release exosomes, which promote axonal regeneration in vitro and in vivo after lesion of the sciatic nerve.
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Lopez-Verrilli, M.A., Picou, F., Court, F.A., Schwann cell-derived exosomes enhance axonal regeneration in the peripheral nervous system. Glia 61 (2013), 1795–1806 The authors describe that de-differentiated Schwann cells release exosomes, which promote axonal regeneration in vitro and in vivo after lesion of the sciatic nerve.
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Glia
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, pp. 1795-1806
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Lopez-Verrilli, M.A.1
Picou, F.2
Court, F.A.3
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35
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40049112564
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Ceramide triggers budding of exosome vesicles into multivesicular endosomes
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Trajkovic, K., Hsu, C., Chiantia, S., Rajendran, L., Wenzel, D., Wieland, F., Schwille, P., Brugger, B., Simons, M., Ceramide triggers budding of exosome vesicles into multivesicular endosomes. Science 319 (2008), 1244–1247.
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(2008)
Science
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Trajkovic, K.1
Hsu, C.2
Chiantia, S.3
Rajendran, L.4
Wenzel, D.5
Wieland, F.6
Schwille, P.7
Brugger, B.8
Simons, M.9
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36
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84922340030
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The neutral sphingomyelinase pathway regulates packaging of the prion protein into exosomes
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Guo, B.B., Bellingham, S.A., Hill, A.F., The neutral sphingomyelinase pathway regulates packaging of the prion protein into exosomes. J Biol Chem 290 (2015), 3455–3467.
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J Biol Chem
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Guo, B.B.1
Bellingham, S.A.2
Hill, A.F.3
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37
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77951183654
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Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C
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Hsu, C., Morohashi, Y., Yoshimura, S., Manrique-Hoyos, N., Jung, S., Lauterbach, M.A., Bakhti, M., Gronborg, M., Mobius, W., Rhee, J., et al. Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C. J Cell Biol 189 (2010), 223–232.
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(2010)
J Cell Biol
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Hsu, C.1
Morohashi, Y.2
Yoshimura, S.3
Manrique-Hoyos, N.4
Jung, S.5
Lauterbach, M.A.6
Bakhti, M.7
Gronborg, M.8
Mobius, W.9
Rhee, J.10
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38
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84881321853
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Choroid plexus transcytosis and exosome shuttling deliver folate into brain parenchyma
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Grapp, M., Wrede, A., Schweizer, M., Huwel, S., Galla, H.J., Snaidero, N., Simons, M., Buckers, J., Low, P.S., Urlaub, H., et al. Choroid plexus transcytosis and exosome shuttling deliver folate into brain parenchyma. Nat Commun, 4, 2013, 2123.
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(2013)
Nat Commun
, vol.4
, pp. 2123
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Grapp, M.1
Wrede, A.2
Schweizer, M.3
Huwel, S.4
Galla, H.J.5
Snaidero, N.6
Simons, M.7
Buckers, J.8
Low, P.S.9
Urlaub, H.10
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39
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84903289462
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Extracellular vesicle-mediated transfer of genetic information between the hematopoietic system and the brain in response to inflammation
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Utilizing a genetic model involving a mouse hematopoietic Cre-driver crossed to a reporter line, the authors demonstrate that exosomes derived from hematopoietic cells enter the brain in particular under inflammatory conditions and modulate neurons. Reporter-positive neurons differed in their miRNA-profile from reporter-negative neurons indicating exosome-mediated miRNA transfer to neurons.
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Ridder, K., Keller, S., Dams, M., Rupp, A.K., Schlaudraff, J., Turco, D.D., Starmann, J., Macas, J., Karpova, D., Devraj, K., et al. Extracellular vesicle-mediated transfer of genetic information between the hematopoietic system and the brain in response to inflammation. PLoS Biol, 12, 2014, e1001874 Utilizing a genetic model involving a mouse hematopoietic Cre-driver crossed to a reporter line, the authors demonstrate that exosomes derived from hematopoietic cells enter the brain in particular under inflammatory conditions and modulate neurons. Reporter-positive neurons differed in their miRNA-profile from reporter-negative neurons indicating exosome-mediated miRNA transfer to neurons.
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(2014)
PLoS Biol
, vol.12
, pp. e1001874
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Ridder, K.1
Keller, S.2
Dams, M.3
Rupp, A.K.4
Schlaudraff, J.5
Turco, D.D.6
Starmann, J.7
Macas, J.8
Karpova, D.9
Devraj, K.10
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40
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Extracellular vesicles in multiple sclerosis: what are they telling us?
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Saenz-Cuesta, M., Osorio-Querejeta, I., Otaegui, D., Extracellular vesicles in multiple sclerosis: what are they telling us?. Front Cell Neurosci, 8, 2014, 100.
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(2014)
Front Cell Neurosci
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, pp. 100
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Saenz-Cuesta, M.1
Osorio-Querejeta, I.2
Otaegui, D.3
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41
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Physical exercise induces rapid release of small extracellular vesicles into the circulation
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Frühbeis, C., Helmig, S., Tug, S., Simon, P., Krämer-Albers, E.M., Physical exercise induces rapid release of small extracellular vesicles into the circulation. J Extracell Vesicles, 4, 2015, 28239.
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(2015)
J Extracell Vesicles
, vol.4
, pp. 28239
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Frühbeis, C.1
Helmig, S.2
Tug, S.3
Simon, P.4
Krämer-Albers, E.M.5
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42
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84929269782
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Extracellular vesicles — their role in the packaging and spread of misfolded proteins associated with neurodegenerative diseases
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Coleman, B.M., Hill, A.F., Extracellular vesicles — their role in the packaging and spread of misfolded proteins associated with neurodegenerative diseases. Semin Cell Dev Biol 40 (2015), 89–96.
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(2015)
Semin Cell Dev Biol
, vol.40
, pp. 89-96
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Coleman, B.M.1
Hill, A.F.2
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43
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3042788972
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Cells release prions in association with exosomes
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This article demonstrated the first association of misfolded and transmissible prions with exosomes.
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Fevrier, B., Vilette, D., Archer, F., Loew, D., Faigle, W., Vidal, M., Laude, H., Raposo, G., Cells release prions in association with exosomes. Proc Natl Acad Sci U S A 101 (2004), 9683–9688 This article demonstrated the first association of misfolded and transmissible prions with exosomes.
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(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 9683-9688
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Fevrier, B.1
Vilette, D.2
Archer, F.3
Loew, D.4
Faigle, W.5
Vidal, M.6
Laude, H.7
Raposo, G.8
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44
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33947709328
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Packaging of prions into exosomes is associated with a novel pathway of PrP processing
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Vella, L.J., Sharples, R.A., Lawson, V.A., Masters, C.L., Cappai, R., Hill, A.F., Packaging of prions into exosomes is associated with a novel pathway of PrP processing. J Pathol 211 (2007), 582–590.
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(2007)
J Pathol
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, pp. 582-590
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Vella, L.J.1
Sharples, R.A.2
Lawson, V.A.3
Masters, C.L.4
Cappai, R.5
Hill, A.F.6
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45
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33746593662
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Alzheimer's disease beta-amyloid peptides are released in association with exosomes
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Rajendran, L., Honsho, M., Zahn, T.R., Keller, P., Geiger, K.D., Verkade, P., Simons, K., Alzheimer's disease beta-amyloid peptides are released in association with exosomes. Proc Natl Acad Sci U S A 103 (2006), 11172–11177.
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(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 11172-11177
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Rajendran, L.1
Honsho, M.2
Zahn, T.R.3
Keller, P.4
Geiger, K.D.5
Verkade, P.6
Simons, K.7
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46
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Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease
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The presence of distinct phosphorylated forms of tau protein in exosomes isolated from CSF may provide avenues for diagnosis and also suggests the selective packaging of post-translationally modified proteins into these vesicles.
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Saman, S., Kim, W., Raya, M., Visnick, Y., Miro, S., Saman, S., Jackson, B., McKee, A.C., Alvarez, V.E., Lee, N.C., et al. Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease. J Biol Chem 287 (2012), 3842–3849 The presence of distinct phosphorylated forms of tau protein in exosomes isolated from CSF may provide avenues for diagnosis and also suggests the selective packaging of post-translationally modified proteins into these vesicles.
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(2012)
J Biol Chem
, vol.287
, pp. 3842-3849
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Saman, S.1
Kim, W.2
Raya, M.3
Visnick, Y.4
Miro, S.5
Saman, S.6
Jackson, B.7
McKee, A.C.8
Alvarez, V.E.9
Lee, N.C.10
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47
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84917736593
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Plasma exosomal alpha-synuclein is likely CNS-derived and increased in Parkinson's disease
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Shi, M., Liu, C., Cook, T.J., Bullock, K.M., Zhao, Y., Ginghina, C., Li, Y., Aro, P., Dator, R., He, C., et al. Plasma exosomal alpha-synuclein is likely CNS-derived and increased in Parkinson's disease. Acta Neuropathol 128 (2014), 639–650.
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(2014)
Acta Neuropathol
, vol.128
, pp. 639-650
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Shi, M.1
Liu, C.2
Cook, T.J.3
Bullock, K.M.4
Zhao, Y.5
Ginghina, C.6
Li, Y.7
Aro, P.8
Dator, R.9
He, C.10
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48
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77952648551
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Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival
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Emmanouilidou, E., Melachroinou, K., Roumeliotis, T., Garbis, S.D., Ntzouni, M., Margaritis, L.H., Stefanis, L., Vekrellis, K., Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival. J Neurosci 30 (2010), 6838–6851.
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(2010)
J Neurosci
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, pp. 6838-6851
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Emmanouilidou, E.1
Melachroinou, K.2
Roumeliotis, T.3
Garbis, S.D.4
Ntzouni, M.5
Margaritis, L.H.6
Stefanis, L.7
Vekrellis, K.8
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49
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Induction of alpha-synuclein aggregate formation by CSF exosomes from patients with Parkinson's disease and dementia with Lewy bodies
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Stuendl, A., Kunadt, M., Kruse, N., Bartels, C., Moebius, W., Danzer, K.M., Mollenhauer, B., Schneider, A., Induction of alpha-synuclein aggregate formation by CSF exosomes from patients with Parkinson's disease and dementia with Lewy bodies. Brain 139 (2016), 481–494.
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(2016)
Brain
, vol.139
, pp. 481-494
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Stuendl, A.1
Kunadt, M.2
Kruse, N.3
Bartels, C.4
Moebius, W.5
Danzer, K.M.6
Mollenhauer, B.7
Schneider, A.8
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50
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Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms
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This article demonstrated that the intercellular transfer and propagation of misfolded SOD1 can occur both in an exosome dependent and independent manner, suggesting potential mechanisms for the spread of this misfolded protein in amyotrophic lateral sclerosis.
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Grad, L.I., Yerbury, J.J., Turner, B.J., Guest, W.C., Pokrishevsky, E., O'Neill, M.A., Yanai, A., Silverman, J.M., Zeineddine, R., Corcoran, L., et al. Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms. Proc Natl Acad Sci U S A 111 (2014), 3620–3625 This article demonstrated that the intercellular transfer and propagation of misfolded SOD1 can occur both in an exosome dependent and independent manner, suggesting potential mechanisms for the spread of this misfolded protein in amyotrophic lateral sclerosis.
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(2014)
Proc Natl Acad Sci U S A
, vol.111
, pp. 3620-3625
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Grad, L.I.1
Yerbury, J.J.2
Turner, B.J.3
Guest, W.C.4
Pokrishevsky, E.5
O'Neill, M.A.6
Yanai, A.7
Silverman, J.M.8
Zeineddine, R.9
Corcoran, L.10
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51
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TDP-43 is intercellularly transmitted across axon terminals
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Feiler, M.S., Strobel, B., Freischmidt, A., Helferich, A.M., Kappel, J., Brewer, B.M., Li, D., Thal, D.R., Walther, P., Ludolph, A.C., et al. TDP-43 is intercellularly transmitted across axon terminals. J Cell Biol 211 (2015), 897–911.
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(2015)
J Cell Biol
, vol.211
, pp. 897-911
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Feiler, M.S.1
Strobel, B.2
Freischmidt, A.3
Helferich, A.M.4
Kappel, J.5
Brewer, B.M.6
Li, D.7
Thal, D.R.8
Walther, P.9
Ludolph, A.C.10
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53
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84923049991
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Extracellular vesicles from a muscle cell line (C2C12) enhance cell survival and neurite outgrowth of a motor neuron cell line (NSC-34)
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Madison, R.D., McGee, C., Rawson, R., Robinson, G.A., Extracellular vesicles from a muscle cell line (C2C12) enhance cell survival and neurite outgrowth of a motor neuron cell line (NSC-34). J Extracell Vesicles, 2014, 3.
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(2014)
J Extracell Vesicles
, pp. 3
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Madison, R.D.1
McGee, C.2
Rawson, R.3
Robinson, G.A.4
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54
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IFNgamma-stimulated dendritic cell exosomes as a potential therapeutic for remyelination
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Pusic, A.D., Pusic, K.M., Clayton, B.L., Kraig, R.P., IFNgamma-stimulated dendritic cell exosomes as a potential therapeutic for remyelination. J Neuroimmunol 266 (2014), 12–23.
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(2014)
J Neuroimmunol
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Pusic, A.D.1
Pusic, K.M.2
Clayton, B.L.3
Kraig, R.P.4
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55
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84890164626
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Youth and environmental enrichment generate serum exosomes containing miR-219 that promote CNS myelination
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Pusic, A.D., Kraig, R.P., Youth and environmental enrichment generate serum exosomes containing miR-219 that promote CNS myelination. Glia 62 (2014), 284–299.
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(2014)
Glia
, vol.62
, pp. 284-299
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Pusic, A.D.1
Kraig, R.P.2
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56
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MiR-133b promotes neural plasticity and functional recovery after treatment of stroke with multipotent mesenchymal stromal cells in rats via transfer of exosome-enriched extracellular particles
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Xin, H., Li, Y., Liu, Z., Wang, X., Shang, X., Cui, Y., Zhang, Z.G., Chopp, M., MiR-133b promotes neural plasticity and functional recovery after treatment of stroke with multipotent mesenchymal stromal cells in rats via transfer of exosome-enriched extracellular particles. Stem Cells 31 (2013), 2737–2746.
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(2013)
Stem Cells
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, pp. 2737-2746
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Xin, H.1
Li, Y.2
Liu, Z.3
Wang, X.4
Shang, X.5
Cui, Y.6
Zhang, Z.G.7
Chopp, M.8
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57
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Systemic administration of exosomes released from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats
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This article showed for the first time that rats, which were subjected to the middle cerebral artery occlusion, recovered better from the ischemic insult in case they received a systemic injection of mesenchymal stromal cell-derived exosomes. Functional recovery was associated with enhanced neurite remodelling, neurogenesis and angiogenesis.
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Xin, H., Li, Y., Cui, Y., Yang, J.J., Zhang, Z.G., Chopp, M., Systemic administration of exosomes released from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats. J Cereb Blood Flow Metab 33 (2013), 1711–1715 This article showed for the first time that rats, which were subjected to the middle cerebral artery occlusion, recovered better from the ischemic insult in case they received a systemic injection of mesenchymal stromal cell-derived exosomes. Functional recovery was associated with enhanced neurite remodelling, neurogenesis and angiogenesis.
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(2013)
J Cereb Blood Flow Metab
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, pp. 1711-1715
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Xin, H.1
Li, Y.2
Cui, Y.3
Yang, J.J.4
Zhang, Z.G.5
Chopp, M.6
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58
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Chromatographically isolated CD63+CD81+ extracellular vesicles from mesenchymal stromal cells rescue cognitive impairments after TBI
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The study shows that mesenchymal stem cell EVs systemically administered to mice shortly after induction of traumatic brain injury rescued pattern separation and spatial learning impairments in these mice. The study is original in describing a work flow that controls EV isolation, quality, and potency.
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Kim, D.K., Nishida, H., An, S.Y., Shetty, A.K., Bartosh, T.J., Prockop, D.J., Chromatographically isolated CD63+CD81+ extracellular vesicles from mesenchymal stromal cells rescue cognitive impairments after TBI. Proc Natl Acad Sci U S A 113 (2016), 170–175 The study shows that mesenchymal stem cell EVs systemically administered to mice shortly after induction of traumatic brain injury rescued pattern separation and spatial learning impairments in these mice. The study is original in describing a work flow that controls EV isolation, quality, and potency.
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(2016)
Proc Natl Acad Sci U S A
, vol.113
, pp. 170-175
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Kim, D.K.1
Nishida, H.2
An, S.Y.3
Shetty, A.K.4
Bartosh, T.J.5
Prockop, D.J.6
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59
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Extracellular vesicles improve post-stroke neuroregeneration and prevent postischemic immunosuppression
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Here, the therapeutic efficacy of mesenchymal stem cell (MSC)-derived exosomes is directly compared to the efficacy of MSC whole cell entities systemically applied to mice after focal cerebral ischemia. MSC-EVs and MSCs showed similar effects, and hence the authors suggest that MSC-EVs might provide a better therapeutic opportunity due to safety reasons.
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Doeppner, T.R., Herz, J., Gorgens, A., Schlechter, J., Ludwig, A.K., Radtke, S., de Miroschedji, K., Horn, P.A., Giebel, B., Hermann, D.M., Extracellular vesicles improve post-stroke neuroregeneration and prevent postischemic immunosuppression. Stem Cells Transl Med, 2015 Here, the therapeutic efficacy of mesenchymal stem cell (MSC)-derived exosomes is directly compared to the efficacy of MSC whole cell entities systemically applied to mice after focal cerebral ischemia. MSC-EVs and MSCs showed similar effects, and hence the authors suggest that MSC-EVs might provide a better therapeutic opportunity due to safety reasons.
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(2015)
Stem Cells Transl Med
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Doeppner, T.R.1
Herz, J.2
Gorgens, A.3
Schlechter, J.4
Ludwig, A.K.5
Radtke, S.6
de Miroschedji, K.7
Horn, P.A.8
Giebel, B.9
Hermann, D.M.10
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60
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Extracellular vesicles from neural stem cells transfer IFN-gamma via Ifngr1 to activate Stat1 signaling in target cells
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Cossetti, C., Iraci, N., Mercer, T.R., Leonardi, T., Alpi, E., Drago, D., Alfaro-Cervello, C., Saini, H.K., Davis, M.P., Schaeffer, J., et al. Extracellular vesicles from neural stem cells transfer IFN-gamma via Ifngr1 to activate Stat1 signaling in target cells. Mol Cell 56 (2014), 193–204.
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(2014)
Mol Cell
, vol.56
, pp. 193-204
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Cossetti, C.1
Iraci, N.2
Mercer, T.R.3
Leonardi, T.4
Alpi, E.5
Drago, D.6
Alfaro-Cervello, C.7
Saini, H.K.8
Davis, M.P.9
Schaeffer, J.10
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