Choroid plexus transcytosis and exosome shuttling deliver folate into brain parenchyma

Nature Communications

Volumn 4, Issue , 2013, Pages

  Grapp, Marcel ^a   Wrede, Arne ^a   Schweizer, Michaela ^b   Hüwel, Sabine ^c   Galla, Hans Joachim ^c   Snaidero, Nicolas ^d   Simons, Mikael ^a,d   Bückers, Johanna ^e   Low, Philip S ^f   Urlaub, Henning ^a,e   Gärtner, Jutta ^a   Steinfeld, Robert ^a  

^a UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^b UNIVERSITY OF HAMBURG   (Germany)

^c UNIVERSITY OF MÜNSTER   (Germany)

^d MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

^e MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^f PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 METHYLTETRAHYDROFOLIC ACID; CD63 ANTIGEN; FLOTILLIN 1; FLOTILLIN 2; FOLATE RECEPTOR 1; FOLIC ACID; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; METHOTREXATE; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 4; PHOSPHOLIPASE C; TAUROCHOLIC ACID; TRANSFERRIN RECEPTOR;

BLOOD; BRAIN; DRUG; NEUROLOGY; RODENT;

ADOLESCENT; APICAL MEMBRANE; ARTICLE; ASTROCYTE; BLOOD CEREBROSPINAL FLUID BARRIER; CELLULAR DISTRIBUTION; CEREBROSPINAL FLUID; CHILD; CHOROID PLEXUS; CONTROLLED STUDY; DRUG TARGETING; ELECTRON MICROSCOPY; EXOSOME; FEMALE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOHISTOCHEMISTRY; KEARNS SAYRE SYNDROME; MALE; MASS SPECTROMETRY; MULTIVESICULAR BODY; MUTATIONAL ANALYSIS; PARENCHYMA; PRESCHOOL CHILD; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; TRANSCYTOSIS; WESTERN BLOTTING;

RATTUS;

EID: 84881321853     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms3123     Document Type: Article

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