-
1
-
-
0024292722
-
Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes
-
doi: 0092-8674(88)90571-5
-
Almoguera, C. et al. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell 53, 549-554, doi: 0092-8674(88)90571-5 (1988)
-
(1988)
Cell
, vol.53
, pp. 549-554
-
-
Almoguera, C.1
-
2
-
-
9144266295
-
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
-
doi: S153561080300309X
-
Hingorani, S. R. et al. Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell 4, 437-450, doi: S153561080300309X (2003).
-
(2003)
Cancer Cell
, vol.4
, pp. 437-450
-
-
Hingorani, S.R.1
-
3
-
-
84960339672
-
Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions
-
Liou, G. Y. et al. Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions. Cell Rep 14, 2325-2336, doi: 10.1016/j.celrep.2016.02.029 S2211-1247(16)30132-2 (2016).
-
(2016)
Cell Rep
, vol.14
, pp. 2325-2336
-
-
Liou, G.Y.1
-
4
-
-
84866007085
-
EGF receptor is required for KRAS-induced pancreatic tumorigenesis
-
Ardito, C. M. et al. EGF receptor is required for KRAS-induced pancreatic tumorigenesis. Cancer Cell 22, 304-317, doi: 10.1016/j. ccr.2012.07.024 S1535-6108(12)00337-6 (2012).
-
(2012)
Cancer Cell
, vol.22
, pp. 304-317
-
-
Ardito, C.M.1
-
5
-
-
84866035571
-
EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma
-
Navas, C. et al. EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma. Cancer Cell 22, 318-330, doi: 10.1016/j.ccr.2012.08.001 S1535-6108(12)00338-8 (2012).
-
(2012)
Cancer Cell
, vol.22
, pp. 318-330
-
-
Navas, C.1
-
6
-
-
84893468215
-
Kras as a key oncogene and therapeutic target in pancreatic cancer
-
Collins, M. A. & Pasca di Magliano, M. Kras as a key oncogene and therapeutic target in pancreatic cancer. Front Physiol 4, 407, doi: 10.3389/fphys.2013.00407 (2013).
-
(2013)
Front Physiol
, vol.4
, pp. 407
-
-
Collins, M.A.1
Pasca di Magliano, M.2
-
7
-
-
58149359830
-
Nuclear factor-kappaB p65/relA silencing induces apoptosis and increases gemcitabine effectiveness in a subset of pancreatic cancer cells
-
Pan, X. et al. Nuclear factor-kappaB p65/relA silencing induces apoptosis and increases gemcitabine effectiveness in a subset of pancreatic cancer cells. Clin Cancer Res 14, 8143-8151, doi: 10.1158/1078-0432.CCR-08-1539 14/24/8143 (2008).
-
(2008)
Clin Cancer Res
, vol.14
, pp. 8143-8151
-
-
Pan, X.1
-
8
-
-
0032943591
-
The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells
-
Wang, W. et al. The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells. Clin Cancer Res 5, 119-127 (1999).
-
(1999)
Clin Cancer Res
, vol.5
, pp. 119-127
-
-
Wang, W.1
-
9
-
-
84871862001
-
Downregulation of TRAF2 mediates NIK-induced pancreatic cancer cell proliferation and tumorigenicity
-
Doppler, H., Liou, G. Y. & Storz, P. Downregulation of TRAF2 mediates NIK-induced pancreatic cancer cell proliferation and tumorigenicity. Plos One 8, e53676, doi: 10.1371/journal.pone.0053676 PONE-D-12-22714 (2013).
-
(2013)
Plos One
, vol.8
, pp. e53676
-
-
Doppler, H.1
Liou, G.Y.2
Storz, P.3
-
10
-
-
68949097479
-
NIK is involved in constitutive activation of the alternative NF-kappaB pathway and proliferation of pancreatic cancer cells
-
Nishina, T., Yamaguchi, N., Gohda, J., Semba, K. & Inoue, J. NIK is involved in constitutive activation of the alternative NF-kappaB pathway and proliferation of pancreatic cancer cells. Biochem Biophys Res Commun 388, 96-101, doi: 10.1016/j.bbrc.2009.07.125 S0006-291X(09)01495-8 (2009).
-
(2009)
Biochem Biophys Res Commun
, vol.388
, pp. 96-101
-
-
Nishina, T.1
Yamaguchi, N.2
Gohda, J.3
Semba, K.4
Inoue, J.5
-
11
-
-
85046913982
-
Constitutive non-canonical NFkappaB signaling in pancreatic cancer cells
-
doi: 8961
-
Wharry, C. E., Haines, K. M., Carroll, R. G. & May, M. J. Constitutive non-canonical NFkappaB signaling in pancreatic cancer cells. Cancer Biol Ther 8, 1567-1576, doi: 8961 (2009).
-
(2009)
Cancer Biol Ther
, vol.8
, pp. 1567-1576
-
-
Wharry, C.E.1
Haines, K.M.2
Carroll, R.G.3
May, M.J.4
-
12
-
-
84855946746
-
KrasG12D-induced IKK2/beta/NF-kappaB activation by IL-1alpha and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma
-
Ling, J. et al. KrasG12D-induced IKK2/beta/NF-kappaB activation by IL-1alpha and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma. Cancer Cell 21, 105-120, doi: 10.1016/j.ccr.2011.12.006 S1535-6108(11)00475-2 (2012).
-
(2012)
Cancer Cell
, vol.21
, pp. 105-120
-
-
Ling, J.1
-
13
-
-
84055217307
-
Crosstalk between the canonical NF-kappaB and Notch signaling pathways inhibits Ppargamma expression and promotes pancreatic cancer progression in mice
-
Maniati, E. et al. Crosstalk between the canonical NF-kappaB and Notch signaling pathways inhibits Ppargamma expression and promotes pancreatic cancer progression in mice. J Clin Invest 121, 4685-4699, doi: 10.1172/JCI45797 45797 (2011).
-
(2011)
J Clin Invest
, vol.121
, pp. 4685-4699
-
-
Maniati, E.1
-
14
-
-
84874601706
-
Emodin sensitizes the gemcitabine-resistant cell line Bxpc-3/Gem to gemcitabine via downregulation of NF-kappaB and its regulated targets
-
Zhang, W. et al. Emodin sensitizes the gemcitabine-resistant cell line Bxpc-3/Gem to gemcitabine via downregulation of NF-kappaB and its regulated targets. Int J Oncol 42, 1189-1196, doi: 10.3892/ijo.2013.1839 (2013).
-
(2013)
Int J Oncol
, vol.42
, pp. 1189-1196
-
-
Zhang, W.1
-
15
-
-
84874688230
-
Double inhibition of NF-kappaB and XIAP via RNAi enhances the sensitivity of pancreatic cancer cells to gemcitabine
-
Cao, L. P., Song, J. L., Yi, X. P. & Li, Y. X. Double inhibition of NF-kappaB and XIAP via RNAi enhances the sensitivity of pancreatic cancer cells to gemcitabine. Oncol Rep 29, 1659-1665, doi: 10.3892/or.2013.2246 (2013).
-
(2013)
Oncol Rep
, vol.29
, pp. 1659-1665
-
-
Cao, L.P.1
Song, J.L.2
Yi, X.P.3
Li, Y.X.4
-
16
-
-
84859710888
-
An NF-kappaB pathway-mediated positive feedback loop amplifies Ras activity to pathological levels in mice
-
Daniluk, J. et al. An NF-kappaB pathway-mediated positive feedback loop amplifies Ras activity to pathological levels in mice. J Clin Invest 122, 1519-1528, doi: 10.1172/JCI59743 59743 (2012).
-
(2012)
J Clin Invest
, vol.122
, pp. 1519-1528
-
-
Daniluk, J.1
-
17
-
-
59049087726
-
PKD3 is the predominant protein kinase D isoform in mouse exocrine pancreas and promotes hormone-induced amylase secretion
-
doi: M801697200 10.1074/jbc.M801697200
-
Chen, L. A. et al. PKD3 is the predominant protein kinase D isoform in mouse exocrine pancreas and promotes hormone-induced amylase secretion. J Biol Chem 284, 2459-2471, doi: M801697200 10.1074/jbc.M801697200 (2009).
-
(2009)
J Biol Chem
, vol.284
, pp. 2459-2471
-
-
Chen, L.A.1
-
18
-
-
84923323788
-
Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia
-
Liou, G. Y. et al. Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia. Nat Commun 6, 6200, doi: 10.1038/ncomms7200 ncomms7200 (2015).
-
(2015)
Nat Commun
, vol.6
, pp. 6200
-
-
Liou, G.Y.1
-
19
-
-
84866129127
-
G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1
-
Ferdaoussi, M. et al. G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1. Diabetologia 55, 2682-2692, doi: 10.1007/s00125-012-2650-x (2012).
-
(2012)
Diabetologia
, vol.55
, pp. 2682-2692
-
-
Ferdaoussi, M.1
-
20
-
-
0346102817
-
PKCmu prevents CD95-mediated apoptosis and enhances proliferation in pancreatic tumour cells
-
Trauzold, A. et al. PKCmu prevents CD95-mediated apoptosis and enhances proliferation in pancreatic tumour cells. Oncogene 22, 8939-8947, doi: 10.1038/sj.onc.1207001 1207001 (2003).
-
(2003)
Oncogene
, vol.22
, pp. 8939-8947
-
-
Trauzold, A.1
-
21
-
-
78049448177
-
Role of protein kinase D signaling in pancreatic cancer
-
Guha, S., Tanasanvimon, S., Sinnett-Smith, J. & Rozengurt, E. Role of protein kinase D signaling in pancreatic cancer. Biochem Pharmacol 80, 1946-1954, doi: 10.1016/j.bcp.2010.07.002 S0006-2952(10)00488-0 (2010).
-
(2010)
Biochem Pharmacol
, vol.80
, pp. 1946-1954
-
-
Guha, S.1
Tanasanvimon, S.2
Sinnett-Smith, J.3
Rozengurt, E.4
-
22
-
-
77952134654
-
A novel small-molecule inhibitor of protein kinase D blocks pancreatic cancer growth in vitro and in vivo
-
Harikumar, K. B. et al. A novel small-molecule inhibitor of protein kinase D blocks pancreatic cancer growth in vitro and in vivo. Mol Cancer Ther 9, 1136-1146, doi: 10.1158/1535-7163.MCT-09-1145 1535-7163.MCT-09-1145 (2010).
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 1136-1146
-
-
Harikumar, K.B.1
-
23
-
-
12944288130
-
Neurotensin and EGF induce synergistic stimulation of DNA synthesis by increasing the duration of ERK signaling in ductal pancreatic cancer cells
-
Kisfalvi, K., Guha, S. & Rozengurt, E. Neurotensin and EGF induce synergistic stimulation of DNA synthesis by increasing the duration of ERK signaling in ductal pancreatic cancer cells. J Cell Physiol 202, 880-890, doi: 10.1002/jcp.20187 (2005).
-
(2005)
J Cell Physiol
, vol.202
, pp. 880-890
-
-
Kisfalvi, K.1
Guha, S.2
Rozengurt, E.3
-
24
-
-
84855555542
-
Differential expression of PKD1 and PKD2 in gastric cancer and analysis of PKD1 and PKD2 function in the model system
-
doi: 2253
-
Shabelnik, M. Y. et al. Differential expression of PKD1 and PKD2 in gastric cancer and analysis of PKD1 and PKD2 function in the model system. Exp Oncol 33, 206-211, doi: 2253 (2011).
-
(2011)
Exp Oncol
, vol.33
, pp. 206-211
-
-
Shabelnik, M.Y.1
-
25
-
-
84865465399
-
Protein kinase d regulates cell death pathways in experimental pancreatitis
-
Yuan, J. et al. Protein kinase d regulates cell death pathways in experimental pancreatitis. Front Physiol 3, 60, doi: 10.3389/ fphys.2012.00060 (2012).
-
(2012)
Front Physiol
, vol.3
-
-
Yuan, J.1
-
26
-
-
57349110770
-
Protein kinase D1 mediates NF-kappaB activation induced by cholecystokinin and cholinergic signaling in pancreatic acinar cells
-
Yuan, J. et al. Protein kinase D1 mediates NF-kappaB activation induced by cholecystokinin and cholinergic signaling in pancreatic acinar cells. Am J Physiol Gastrointest Liver Physiol 295, G1190-G1201, doi: 10.1152/ajpgi.90452.2008 90452.2008 (2008).
-
(2008)
Am J Physiol Gastrointest Liver Physiol
, vol.295
, pp. G1190-G1201
-
-
Yuan, J.1
-
27
-
-
38649084117
-
PKD2, and p38 MAPK mediate Hsp27 serine-82 phosphorylation induced by neurotensin in pancreatic cancer PANC-1 cells
-
Yuan, J. & Rozengurt, E. PKD, PKD2, and p38 MAPK mediate Hsp27 serine-82 phosphorylation induced by neurotensin in pancreatic cancer PANC-1 cells. J Cell Biochem 103, 648-662, doi: 10.1002/jcb.21439 (2008).
-
(2008)
J Cell Biochem
, vol.103
, pp. 648-662
-
-
Yuan, J.1
Pkd, R.E.2
-
28
-
-
84878884564
-
GSK-3alpha promotes oncogenic KRAS function in pancreatic cancer via TAK1-TAB stabilization and regulation of noncanonical NF-kappaB
-
Bang, D., Wilson, W., Ryan, M., Yeh, J. J. & Baldwin, A. S. GSK-3alpha promotes oncogenic KRAS function in pancreatic cancer via TAK1-TAB stabilization and regulation of noncanonical NF-kappaB. Cancer Discov 3, 690-703, doi: 10.1158/2159-8290.CD-12-0541 2159-8290.CD-12-0541 (2013).
-
(2013)
Cancer Discov
, vol.3
, pp. 690-703
-
-
Bang, D.1
Wilson, W.2
Ryan, M.3
Yeh, J.J.4
Baldwin, A.S.5
-
29
-
-
84884919327
-
Pharmacologic reversion of epigenetic silencing of the PRKD1 promoter blocks breast tumor cell invasion and metastasis
-
Borges, S. et al. Pharmacologic reversion of epigenetic silencing of the PRKD1 promoter blocks breast tumor cell invasion and metastasis. Breast Cancer Res 15, R66, doi: 10.1186/bcr3460 bcr3460 (2013).
-
(2013)
Breast Cancer Res
, vol.15
, pp. R66
-
-
Borges, S.1
-
30
-
-
18244379306
-
Interactions of NF-kappaB with chromatin: The art of being at the right place at the right time
-
doi: ni1196 10.1038/ni1196
-
Natoli, G., Saccani, S., Bosisio, D. & Marazzi, I. Interactions of NF-kappaB with chromatin: the art of being at the right place at the right time. Nat Immunol 6, 439-445, doi: ni1196 10.1038/ni1196 (2005).
-
(2005)
Nat Immunol
, vol.6
, pp. 439-445
-
-
Natoli, G.1
Saccani, S.2
Bosisio, D.3
Marazzi, I.4
-
31
-
-
0033596120
-
Regulation of DNA binding by Rel/NF-kappaB transcription factors: Structural views
-
Chen, F. E. & Ghosh, G. Regulation of DNA binding by Rel/NF-kappaB transcription factors: structural views. Oncogene 18, 6845-6852, doi: 10.1038/sj.onc.1203224 (1999).
-
(1999)
Oncogene
, vol.18
, pp. 6845-6852
-
-
Chen, F.E.1
Ghosh, G.2
-
32
-
-
40949147679
-
Epigenetic inactivation of protein kinase D1 in gastric cancer and its role in gastric cancer cell migration and invasion
-
Kim, M. et al. Epigenetic inactivation of protein kinase D1 in gastric cancer and its role in gastric cancer cell migration and invasion. Carcinogenesis 29, 629-637, doi: 10.1093/carcin/bgm291 bgm291 (2008).
-
(2008)
Carcinogenesis
, vol.29
, pp. 629-637
-
-
Kim, M.1
-
33
-
-
84917710591
-
Critical role of NF-kappaB in pancreatic cancer
-
doi: 2624 10.18632/oncotarget.2624
-
Prabhu, L., Mundade, R., Korc, M., Loehrer, P. J. & Lu, T. Critical role of NF-kappaB in pancreatic cancer. Oncotarget 5, 10969-10975, doi: 2624 10.18632/oncotarget.2624 (2014).
-
(2014)
Oncotarget
, vol.5
, pp. 10969-10975
-
-
Prabhu, L.1
Mundade, R.2
Korc, M.3
Loehrer, P.J.4
Lu, T.5
-
34
-
-
0037413711
-
Protein kinase D mediates a stress-induced NF-kappaB activation and survival pathway
-
Storz, P. & Toker, A. Protein kinase D mediates a stress-induced NF-kappaB activation and survival pathway. EMBO J 22, 109-120, doi: 10.1093/emboj/cdg009 (2003).
-
(2003)
EMBO J
, vol.22
, pp. 109-120
-
-
Storz, P.1
Toker, A.2
-
35
-
-
67549112510
-
Protein kinase D1 regulates matrix metalloproteinase expression and inhibits breast cancer cell invasion
-
Eiseler, T., Doppler, H., Yan, I. K., Goodison, S. & Storz, P. Protein kinase D1 regulates matrix metalloproteinase expression and inhibits breast cancer cell invasion. Breast Cancer Res 11, R13, doi: 10.1186/bcr2232 bcr2232 (2009).
-
(2009)
Breast Cancer Res
, vol.11
, pp. R13
-
-
Eiseler, T.1
Doppler, H.2
Yan, I.K.3
Goodison, S.4
Storz, P.5
-
36
-
-
0033531795
-
Regulation of NF-kappaB RelA phosphorylation and transcriptional activity by p21(ras) and protein kinase Czeta in primary endothelial cells
-
Anrather, J., Csizmadia, V., Soares, M. P. & Winkler, H. Regulation of NF-kappaB RelA phosphorylation and transcriptional activity by p21(ras) and protein kinase Czeta in primary endothelial cells. J Biol Chem 274, 13594-13603 (1999).
-
(1999)
J Biol Chem
, vol.274
, pp. 13594-13603
-
-
Anrather, J.1
Csizmadia, V.2
Soares, M.P.3
Winkler, H.4
-
37
-
-
67149143399
-
Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
-
Olive, K. P. et al. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 324, 1457-1461, doi: 10.1126/science.1171362 1171362 (2009).
-
(2009)
Science
, vol.324
, pp. 1457-1461
-
-
Olive, K.P.1
|