-
1
-
-
58149202128
-
Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls
-
Baud V, Karin M, (2009) Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls. Nat Rev Drug Discov 8: 33-40.
-
(2009)
Nat Rev Drug Discov
, vol.8
, pp. 33-40
-
-
Baud, V.1
Karin, M.2
-
2
-
-
16844366650
-
Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugs
-
Nakanishi C, Toi M, (2005) Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugs. Nat Rev Cancer 5: 297-309.
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 297-309
-
-
Nakanishi, C.1
Toi, M.2
-
3
-
-
0031897632
-
NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses
-
Ghosh S, May MJ, Kopp EB, (1998) NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol 16: 225-260.
-
(1998)
Annu Rev Immunol
, vol.16
, pp. 225-260
-
-
Ghosh, S.1
May, M.J.2
Kopp, E.B.3
-
4
-
-
0034745420
-
NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100
-
Xiao G, Harhaj EW, Sun SC, (2001) NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100. Mol Cell 7: 401-409.
-
(2001)
Mol Cell
, vol.7
, pp. 401-409
-
-
Xiao, G.1
Harhaj, E.W.2
Sun, S.C.3
-
5
-
-
0037931474
-
RelB/p50 dimers are differentially regulated by tumor necrosis factor-alpha and lymphotoxin-beta receptor activation: critical roles for p100
-
Derudder E, Dejardin E, Pritchard LL, Green DR, Korner M, et al. (2003) RelB/p50 dimers are differentially regulated by tumor necrosis factor-alpha and lymphotoxin-beta receptor activation: critical roles for p100. J Biol Chem 278: 23278-23284.
-
(2003)
J Biol Chem
, vol.278
, pp. 23278-23284
-
-
Derudder, E.1
Dejardin, E.2
Pritchard, L.L.3
Green, D.R.4
Korner, M.5
-
6
-
-
56349164232
-
Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling
-
Vallabhapurapu S, Matsuzawa A, Zhang W, Tseng PH, Keats JJ, et al. (2008) Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling. Nat Immunol 9: 1364-1370.
-
(2008)
Nat Immunol
, vol.9
, pp. 1364-1370
-
-
Vallabhapurapu, S.1
Matsuzawa, A.2
Zhang, W.3
Tseng, P.H.4
Keats, J.J.5
-
7
-
-
36048999753
-
IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis
-
Varfolomeev E, Blankenship JW, Wayson SM, Fedorova AV, Kayagaki N, et al. (2007) IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis. Cell 131: 669-681.
-
(2007)
Cell
, vol.131
, pp. 669-681
-
-
Varfolomeev, E.1
Blankenship, J.W.2
Wayson, S.M.3
Fedorova, A.V.4
Kayagaki, N.5
-
8
-
-
0037149542
-
TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2
-
Li X, Yang Y, Ashwell JD, (2002) TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2. Nature 416: 345-347.
-
(2002)
Nature
, vol.416
, pp. 345-347
-
-
Li, X.1
Yang, Y.2
Ashwell, J.D.3
-
9
-
-
0034607655
-
Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli
-
Yang Y, Fang S, Jensen JP, Weissman AM, Ashwell JD, (2000) Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli. Science 288: 874-877.
-
(2000)
Science
, vol.288
, pp. 874-877
-
-
Yang, Y.1
Fang, S.2
Jensen, J.P.3
Weissman, A.M.4
Ashwell, J.D.5
-
10
-
-
79952498248
-
TNFR1-induced activation of the classical NF-kappaB pathway
-
Wajant H, Scheurich P, (2011) TNFR1-induced activation of the classical NF-kappaB pathway. FEBS J 278: 862-876.
-
(2011)
FEBS J
, vol.278
, pp. 862-876
-
-
Wajant, H.1
Scheurich, P.2
-
11
-
-
58149359830
-
Nuclear factor-kappaB p65/relA silencing induces apoptosis and increases gemcitabine effectiveness in a subset of pancreatic cancer cells
-
Pan X, Arumugam T, Yamamoto T, Levin PA, Ramachandran V, et al. (2008) Nuclear factor-kappaB p65/relA silencing induces apoptosis and increases gemcitabine effectiveness in a subset of pancreatic cancer cells. Clin Cancer Res 14: 8143-8151.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 8143-8151
-
-
Pan, X.1
Arumugam, T.2
Yamamoto, T.3
Levin, P.A.4
Ramachandran, V.5
-
12
-
-
1842850737
-
Increased expression of NF-kappa B subunits in human pancreatic cancer cells
-
Chandler NM, Canete JJ, Callery MP, (2004) Increased expression of NF-kappa B subunits in human pancreatic cancer cells. J Surg Res 118: 9-14.
-
(2004)
J Surg Res
, vol.118
, pp. 9-14
-
-
Chandler, N.M.1
Canete, J.J.2
Callery, M.P.3
-
13
-
-
0032943591
-
The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells
-
Wang W, Abbruzzese JL, Evans DB, Larry L, Cleary KR, et al. (1999) The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells. Clin Cancer Res 5: 119-127.
-
(1999)
Clin Cancer Res
, vol.5
, pp. 119-127
-
-
Wang, W.1
Abbruzzese, J.L.2
Evans, D.B.3
Larry, L.4
Cleary, K.R.5
-
14
-
-
68949097479
-
NIK is involved in constitutive activation of the alternative NF-kappaB pathway and proliferation of pancreatic cancer cells
-
Nishina T, Yamaguchi N, Gohda J, Semba K, Inoue J, (2009) NIK is involved in constitutive activation of the alternative NF-kappaB pathway and proliferation of pancreatic cancer cells. Biochem Biophys Res Commun 388: 96-101.
-
(2009)
Biochem Biophys Res Commun
, vol.388
, pp. 96-101
-
-
Nishina, T.1
Yamaguchi, N.2
Gohda, J.3
Semba, K.4
Inoue, J.5
-
15
-
-
85046913982
-
Constitutive non-canonical NFkappaB signaling in pancreatic cancer cells
-
Wharry CE, Haines KM, Carroll RG, May MJ, (2009) Constitutive non-canonical NFkappaB signaling in pancreatic cancer cells. Cancer Biol Ther 8: 1567-1576.
-
(2009)
Cancer Biol Ther
, vol.8
, pp. 1567-1576
-
-
Wharry, C.E.1
Haines, K.M.2
Carroll, R.G.3
May, M.J.4
-
16
-
-
56349164239
-
Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK
-
Zarnegar BJ, Wang Y, Mahoney DJ, Dempsey PW, Cheung HH, et al. (2008) Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK. Nat Immunol 9: 1371-1378.
-
(2008)
Nat Immunol
, vol.9
, pp. 1371-1378
-
-
Zarnegar, B.J.1
Wang, Y.2
Mahoney, D.J.3
Dempsey, P.W.4
Cheung, H.H.5
-
17
-
-
77956407149
-
NF-kappaB inducing kinase: a key regulator in the immune system and in cancer
-
Thu YM, Richmond A, (2010) NF-kappaB inducing kinase: a key regulator in the immune system and in cancer. Cytokine Growth Factor Rev 21: 213-226.
-
(2010)
Cytokine Growth Factor Rev
, vol.21
, pp. 213-226
-
-
Thu, Y.M.1
Richmond, A.2
-
18
-
-
33748052706
-
IKKalpha controls p52/RelB at the skp2 gene promoter to regulate G1- to S-phase progression
-
Schneider G, Saur D, Siveke JT, Fritsch R, Greten FR, et al. (2006) IKKalpha controls p52/RelB at the skp2 gene promoter to regulate G1- to S-phase progression. EMBO J 25: 3801-3812.
-
(2006)
EMBO J
, vol.25
, pp. 3801-3812
-
-
Schneider, G.1
Saur, D.2
Siveke, J.T.3
Fritsch, R.4
Greten, F.R.5
-
19
-
-
25844459154
-
NF-kappaB: linking inflammation and immunity to cancer development and progression
-
Karin M, Greten FR, (2005) NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 5: 749-759.
-
(2005)
Nat Rev Immunol
, vol.5
, pp. 749-759
-
-
Karin, M.1
Greten, F.R.2
-
20
-
-
34547562418
-
Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma
-
Annunziata CM, Davis RE, Demchenko Y, Bellamy W, Gabrea A, et al. (2007) Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma. Cancer Cell 12: 115-130.
-
(2007)
Cancer Cell
, vol.12
, pp. 115-130
-
-
Annunziata, C.M.1
Davis, R.E.2
Demchenko, Y.3
Bellamy, W.4
Gabrea, A.5
-
21
-
-
34547660308
-
Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma
-
Keats JJ, Fonseca R, Chesi M, Schop R, Baker A, et al. (2007) Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma. Cancer Cell 12: 131-144.
-
(2007)
Cancer Cell
, vol.12
, pp. 131-144
-
-
Keats, J.J.1
Fonseca, R.2
Chesi, M.3
Schop, R.4
Baker, A.5
-
22
-
-
34547126428
-
The inhibitors of apoptosis (IAPs) as cancer targets
-
Hunter AM, LaCasse EC, Korneluk RG, (2007) The inhibitors of apoptosis (IAPs) as cancer targets. Apoptosis 12: 1543-1568.
-
(2007)
Apoptosis
, vol.12
, pp. 1543-1568
-
-
Hunter, A.M.1
LaCasse, E.C.2
Korneluk, R.G.3
-
23
-
-
20144387486
-
CD95 and TRAF2 promote invasiveness of pancreatic cancer cells
-
Trauzold A, Roder C, Sipos B, Karsten K, Arlt A, et al. (2005) CD95 and TRAF2 promote invasiveness of pancreatic cancer cells. FASEB J 19: 620-622.
-
(2005)
FASEB J
, vol.19
, pp. 620-622
-
-
Trauzold, A.1
Roder, C.2
Sipos, B.3
Karsten, K.4
Arlt, A.5
-
24
-
-
45549083656
-
Human pancreatic duct epithelial cell model for KRAS transformation
-
Radulovich N, Qian JY, Tsao MS, (2008) Human pancreatic duct epithelial cell model for KRAS transformation. Methods Enzymol 439: 1-13.
-
(2008)
Methods Enzymol
, vol.439
, pp. 1-13
-
-
Radulovich, N.1
Qian, J.Y.2
Tsao, M.S.3
-
25
-
-
0030695339
-
Characterization of NEDD8, a developmentally down-regulated ubiquitin-like protein
-
Kamitani T, Kito K, Nguyen HP, Yeh ET, (1997) Characterization of NEDD8, a developmentally down-regulated ubiquitin-like protein. J Biol Chem 272: 28557-28562.
-
(1997)
J Biol Chem
, vol.272
, pp. 28557-28562
-
-
Kamitani, T.1
Kito, K.2
Nguyen, H.P.3
Yeh, E.T.4
-
26
-
-
84856032510
-
Protein kinase D1 maintains the epithelial phenotype by inducing a DNA-bound, inactive SNAI1 transcriptional repressor complex
-
Bastea LI, Doppler H, Balogun B, Storz P, (2012) Protein kinase D1 maintains the epithelial phenotype by inducing a DNA-bound, inactive SNAI1 transcriptional repressor complex. PLoS One 7: e30459.
-
(2012)
PLoS One
, vol.7
-
-
Bastea, L.I.1
Doppler, H.2
Balogun, B.3
Storz, P.4
-
27
-
-
62649104179
-
Loss of cell-cell contacts induces NF-kappaB via RhoA-mediated activation of protein kinase D1
-
Cowell CF, Yan IK, Eiseler T, Leightner AC, Doppler H, et al. (2009) Loss of cell-cell contacts induces NF-kappaB via RhoA-mediated activation of protein kinase D1. J Cell Biochem 106: 714-728.
-
(2009)
J Cell Biochem
, vol.106
, pp. 714-728
-
-
Cowell, C.F.1
Yan, I.K.2
Eiseler, T.3
Leightner, A.C.4
Doppler, H.5
|