Ultrasmall dual-modality silica nanoparticle drug conjugates: Design, synthesis, and characterization

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 22, 2015, Pages 7119-7130

  Yoo, Barney ^a   Ma, Kai ^b   Zhang, Li ^a   Burns, Andrew ^c   Sequeira, Sonia ^a   Mellinghoff, Ingo ^a   Brennan, Cameron ^a   Wiesner, Ulrich ^b   Bradbury, Michelle S ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Cornell University   (United States)

^c GE GLOBAL RESEARCH   (United States)

Author keywords

Cancer; Drug conjugate; Drug delivery; Kinase inhibitor; Nanoparticle

Indexed keywords

9 FLUORENYLMETHOXYCARBONYL N AMIDO POLYETHYLENE(GLYCOL) AMINOPROPYL O DES MORPHOLINO GEFITINIB; AMINO POLYETHYLENE(GLYCOL) AMINOPROPYL O DES MORPHOLINO GEFITINIB; AMINOPROPYL O DES MORPHOLINO GEFITINIB; GEFITINIB; MACROGOL; MORPHOLINO OLIGONUCLEOTIDE; N (TERT BUTYLOXYCARBONYL) AMINOPROPYL O DES MORPHOLINO GEFITINIB; O DES MORPHOLINO GEFITINIB; SILICA NANOPARTICLE; UNCLASSIFIED DRUG; DRUG CARRIER; EPIDERMAL GROWTH FACTOR RECEPTOR; NANOPARTICLE; PEPTIDE HYDROLASE; PROTEIN BINDING; PROTEIN KINASE INHIBITOR; QUINAZOLINE DERIVATIVE; SILICON DIOXIDE;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG COATING; DRUG CONJUGATION; DRUG DESIGN; DRUG DISTRIBUTION; DRUG RETENTION; DRUG STRUCTURE; ENZYME INHIBITION; IN VITRO STUDY; ISOTOPE LABELING; LUNG CANCER CELL LINE; NANOANALYSIS; NANOFABRICATION; NANOPHARMACEUTICS; PARTICLE SIZE; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; METABOLISM; PHOSPHORYLATION; SYNTHESIS; TUMOR CELL LINE;

CELL LINE, TUMOR; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG CARRIERS; DRUG DESIGN; HUMANS; NANOPARTICLES; PEPTIDE HYDROLASES; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; SILICON DIOXIDE;

EID: 84946198953     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2015.09.050     Document Type: Article

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