Substrate-Assisted Catalysis in Polyketide Reduction Proceeds via a Phenolate Intermediate

Cell Chemical Biology

Volumn 23, Issue 9, 2016, Pages 1091-1097

  Schäfer, Martin ^a   Stevenson, Clare E M ^a   Wilkinson, Barrie ^a   Lawson, David M ^a   Buttner, Mark J ^a  

^a JOHN INNES CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARBONYL DERIVATIVE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; POLYKETIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SIMC7 PROTEIN; SIMOCYCLINONE D8; UNCLASSIFIED DRUG; ALCOHOL DEHYDROGENASE; BACTERIAL PROTEIN; COUMARIN DERIVATIVE; GLYCOSIDE; PHENOL DERIVATIVE; POLYKETIDE SYNTHASE KETOREDUCTASE;

AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; CATALYST; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; BIOCATALYSIS; CHEMISTRY; CONFORMATION; ENZYME SPECIFICITY; HUMAN; METABOLISM; MOLECULAR MODEL; POINT MUTATION;

ALCOHOL OXIDOREDUCTASES; BACTERIAL PROTEINS; BIOCATALYSIS; COUMARINS; GLYCOSIDES; HUMANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PHENOLS; POINT MUTATION; POLYKETIDES; SUBSTRATE SPECIFICITY;

EID: 84988643379     PISSN: 24519456     EISSN: 24519448     Source Type: Journal    
DOI: 10.1016/j.chembiol.2016.07.018     Document Type: Article

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