A new crystal structure of the bifunctional antibiotic simocyclinone D8 bound to DNA gyrase gives fresh insight into the mechanism of inhibition

Journal of Molecular Biology

Volumn 426, Issue 10, 2014, Pages 2023-2033

  Hearnshaw, Stephen J ^a   Edwards, Marcus J ^a   Stevenson, Clare E ^a   Lawson, David M ^a   Maxwell, Anthony ^a  

^a JOHN INNES CENTRE   (United Kingdom)

Author keywords

antibiotics; DNA gyrase; DNA topoisomerase; simocyclinones; X ray crystallography

Indexed keywords

DIMER; DNA TOPOISOMERASE (ATP HYDROLYSING) A; SIMOCYCLINONE D8; ANTIINFECTIVE AGENT; COUMARIN DERIVATIVE; DNA TOPOISOMERASE (ATP HYDROLYSING); GLYCOSIDE; GYRASE INHIBITOR; PROTEIN BINDING;

ANTIBIOTIC RESISTANCE; ARTICLE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DRUG BINDING; DRUG MECHANISM; ENZYME INHIBITION; GENE MUTATION; ISOTHERMAL TITRATION CALORIMETRY; PRIORITY JOURNAL; PROTEIN DOMAIN; AMINO ACID SUBSTITUTION; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; ESCHERICHIA COLI; GENETICS; PROTEIN MULTIMERIZATION; PROTEIN QUATERNARY STRUCTURE; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

STREPTOMYCES ANTIBIOTICUS;

AMINO ACID SUBSTITUTION; ANTI-BACTERIAL AGENTS; COUMARINS; CRYSTALLOGRAPHY, X-RAY; DNA GYRASE; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; GLYCOSIDES; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; TOPOISOMERASE II INHIBITORS;

EID: 84899630220     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2014.02.017     Document Type: Article

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