Heart development, diseases, and regeneration - New approaches from innervation, fibroblasts, and reprogramming

Circulation Journal

Volumn 80, Issue 10, 2016, Pages 2081-2088

  Ieda, Masaki ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cardiac fibroblast; Development; Direct reprogramming; Nervous system; Regeneration

Indexed keywords

FIBROBLAST GROWTH FACTOR 10; FIBROBLAST GROWTH FACTOR 2; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; MICRORNA; MICRORNA 133; MYOCYTE ENHANCER FACTOR 2; NERVE GROWTH FACTOR; SEMAPHORIN 3A; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR TBX5; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR;

HEART ARRHYTHMIA; HEART DEVELOPMENT; HEART DISEASE; HEART FIBROBLAST; HEART INNERVATION; HEART MUSCLE FIBROSIS; HEART MUSCLE INJURY; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE HYPERTROPHY; HEART VENTRICLE TACHYCARDIA; HUMAN; MORTALITY RATE; NONHUMAN; NUCLEAR REPROGRAMMING; PAIN; PARACRINE SIGNALING; REGENERATION; REVIEW; SILENT MYOCARDIAL ISCHEMIA; ANIMAL; CARDIAC MUSCLE CELL; CARDIOMEGALY; EMBRYOLOGY; FIBROBLAST; FIBROSIS; HEART; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; REGENERATIVE MEDICINE;

ANIMALS; CARDIOMEGALY; CELLULAR REPROGRAMMING; FIBROBLASTS; FIBROSIS; HEART; HUMANS; MYOCYTES, CARDIAC; REGENERATION; REGENERATIVE MEDICINE;

EID: 84988637667     PISSN: 13469843     EISSN: 13474820     Source Type: Journal    
DOI: 10.1253/circj.CJ-16-0815     Document Type: Review

References (39)

1. Ieda M, Fukuda K, Hisaka Y, Kimura K, Kawaguchi H, Fujita J, et al. Endothelin-1 regulates cardiac sympathetic innervation in the rodent heart by controlling nerve growth factor expression. J Clin Invest 2004; 113: 876-884.
2. Ieda M, Kanazawa H, Ieda Y, Kimura K, Matsumura K, Tomita Y, et al. Nerve growth factor is critical for cardiac sensory innervation and rescues neuropathy in diabetic hearts. Circulation 2006; 114: 2351-2363.
3. Ieda M, Kanazawa H, Kimura K, Hattori F, Ieda Y, Taniguchi M, et al. Sema3a maintains normal heart rhythm through sympathetic innervation patterning. Nat Med 2007; 13: 604-612.
4. Ieda M, Tsuchihashi T, Ivey KN, Ross RS, Hong TT, Shaw RM, et al. Cardiac fibroblasts regulate myocardial proliferation through beta1 integrin signaling. Dev Cell 2009; 16: 233-244.
5. Ieda M, Fu JD, Delgado-Olguin P, Vedantham V, Hayashi Y, Bruneau BG, et al. Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell 2010; 142: 375-386.
6. Inagawa K, Miyamoto K, Yamakawa H, Muraoka N, Sadahiro T, Umei T, et al. Induction of cardiomyocyte-like cells in infarct hearts by gene transfer of Gata4, Mef2c, and Tbx5. Circ Res 2012; 111: 1147-1156.
7. Wada R, Muraoka N, Inagawa K, Yamakawa H, Miyamoto K, Sadahiro T, et al. Induction of human cardiomyocyte-like cells from fibroblasts by defined factors. Proc Natl Acad Sci USA 2013; 110: 12667-12672.
8. Muraoka N, Yamakawa H, Miyamoto K, Sadahiro T, Umei T, Isomi M, et al. MiR-133 promotes cardiac reprogramming by directly repressing Snai1 and silencing fibroblast signatures. EMBO J 2014; 33: 1565-1581.
9. Yamakawa H, Muraoka N, Miyamoto K, Sadahiro T, Isomi M, Haginiwa S, et al. Fibroblast growth factors and vascular endothelial growth factor promote cardiac reprogramming under defined conditions. Stem Cell Rep 2015; 5: 1128-1142.
10. Minamisawa M, Izawa A, Motoki H, Kashima Y, Hioki H, Abe N, et al. Prognostic significance of neuroadrenergic dysfunction for cardiovascular events in patients with acute myocardial infarction. Circ J 2015; 79: 2238-2245.
11. Kimura K, Ieda M, Fukuda K. Development, maturation, and trans-differentiation of cardiac sympathetic nerves. Circ Res 2012; 110: 325-336.
12. Lockhart ST, Turrigiano GG, Birren SJ. Nerve growth factor modulates synaptic transmission between sympathetic neurons and cardiac myocytes. J Neurosci 1997; 17: 9573-9582.
13. Snider WD. Functions of the neurotrophins during nervous system development: What the knockouts are teaching us. Cell 1994; 77: 627-638.
14. Faerman I, Faccio E, Milei J, Nuñez R, Jadzinsky M, Fox D, et al. Autonomic neuropathy and painless myocardial infarction in diabetic patients: Histologic evidence of their relationship. Diabetes 1977; 26: 1147-1158.
15. Crowley C, Spencer SD, Nishimura MC, Chen KS, Pitts-Meek S, Armanini MP, et al. Mice lacking nerve growth factor display peri- natal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons. Cell 1994; 76: 1001-1011.
16. Schmid H, Forman LA, Cao X, Sherman PS, Stevens MJ. Heterogeneous cardiac sympathetic denervation and decreased myocardial nerve growth factor in streptozotocin-induced diabetic rats: Implications for cardiac sympathetic dysinnervation complicating diabetes. Diabetes 1999; 48: 603-608.
17. Ito M, Zipes DP. Efferent sympathetic and vagal innervation of the canine right ventricle. Circulation 1994; 90: 1459-1468.
18. Behar O, Golden JA, Mashimo H, Schoen FJ, Fishman MC. Semaphorin III is needed for normal patterning and growth of nerves, bones and heart. Nature 1996; 383: 525-528.
19. Opthof T, Misier AR, Coronel R, Vermeulen JT, Verberne HJ, Frank RG, et al. Dispersion of refractoriness in canine ventricular myocardium: Effects of sympathetic stimulation. Circ Res 1991; 68: 1204-1215.
20. Cao JM, Chen LS, KenKnight BH, Ohara T, Lee MH, Tsai J, et al. Nerve sprouting and sudden cardiac death. Circ Res 2000; 86: 816-821.
21. Nakano Y, Chayama K, Ochi H, Toshishige M, Hayashida Y, Miki D, et al. A nonsynonymous polymorphism in semaphorin 3A as a risk factor for human unexplained cardiac arrest with documented ventricular fibrillation. PLoS Genet 2013; 9: e1003364, doi:10.1371/ journal.pgen.1003364.
22. Boczek NJ, Ye D, Johnson EK, Wang W, Crotti L, Tester DJ, et al. Characterization of SEMA3A-encoded semaphorin as a naturally occurring Kv4.3 protein inhibitor and its contribution to Brugada syndrome. Circ Res 2014; 115: 460-469.
23. + currents in adult mouse ventricles. J Physiol 2004; 559: 103-120.
24. Ieda M, Kimura K, Kanazawa H, Fukuda K. Regulation of cardiac nerves: A new paradigm in the management of sudden cardiac death? Curr Med Chem 2008; 15: 1731-1736.
25. Camelliti P, Borg TK, Kohl P. Structural and functional characterisation of cardiac fibroblasts. Cardiovasc Res 2005; 65: 40-51.
26. Lavine KJ, Yu K, White AC, Zhang X, Smith C, Partanen J, et al. Endocardial and epicardial derived FGF signals regulate myocardial proliferation and differentiation in vivo. Dev Cell 2005; 8: 85-95.
27. Weber KT, Brilla CG. Pathological hypertrophy and cardiac intersti- tium: Fibrosis and renin-angiotensin-aldosterone system. Circulation 1991; 83: 1849-1865.
28. Shai SY, Harpf AE, Babbitt CJ, Jordan MC, Fishbein MC, Chen J, et al. Cardiac myocyte-specific excision of the beta1 integrin gene results in myocardial fibrosis and cardiac failure. Circ Res 2002; 90: 458-464.
29. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006; 126: 663-676.
30. Srivastava D, Ieda M. Critical factors for cardiac reprogramming. Circ Res 2012; 111: 5-8.
31. Song K, Nam YJ, Luo X, Qi X, Tan W, Huang GN, et al. Heart repair by reprogramming non-myocytes with cardiac transcription factors. Nature 2012; 485: 599-604.
32. Qian L, Huang Y, Spencer CI, Foley A, Vedantham V, Liu L, et al. In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes. Nature 2012; 485: 593-598.
33. Fu JD, Stone NR, Liu L, Spencer CI, Qian L, Hayashi Y, et al. Direct reprogramming of human fibroblasts toward a cardiomyocyte-like state. Stem Cell Rep 2013; 1: 235-247.
34. Nam YJ, Song K, Luo X, Daniel E, Lambeth K, West K, et al. Reprogramming of human fibroblasts toward a cardiac fate. Proc Natl Acad Sci USA 2013; 110: 5588-5593.
35. Zhao Y, Londono P, Cao Y, Sharpe EJ, Proenza C, O’Rourke R, et al. High-efficiency reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signalling. Nat Commun 2015; 6: 8243.
36. Ifkovits JL, Addis RC, Epstein JA, Gearhart JD. Inhibition of TGF-beta signaling increases direct conversion of fibroblasts to induced cardiomyocytes. PLoS One 2014; 9: e89678, doi:10.1371/journal.pone.0089678.
37. Fu JD, Srivastava D. Direct reprogramming of fibroblasts into cardiomyocytes for cardiac regenerative medicine. Circ J 2015; 79: 245-254.
38. Sadahiro T, Yamanaka S, Ieda M. Direct cardiac reprogramming: Progress and challenges in basic biology and clinical applications. Circ Res 2015; 116: 1378-1391.
39. Noseda M, Abreu-Paiva M, Schneider MD. The quest for the adult cardiac stem cell. Circ J 2015; 79: 1422-1430.