Ingestion of wheat protein increases in vivo muscle protein synthesis rates in healthy older men in a randomized trial

Journal of Nutrition

Volumn 146, Issue 9, 2016, Pages 1651-1659

  Gorissen, Stefan H M ^a   Horstman, Astrid M H ^a   Franssen, Rinske ^a   Crombag, Julie J R ^a   Langer, Henning ^a   Bierau, Jörgen ^b   Respondek, Frederique ^c   van Loon, Luc J C ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^c Sociologue au Laboratoire Services Process Innovations   (France)

Author keywords

Leucine; Muscle protein synthesis; Plant; Wheat; Whey

Indexed keywords

CASEIN; ESSENTIAL AMINO ACID; LEUCINE; MUSCLE PROTEIN; PHENYLALANINE; PROTEIN HYDROLYSATE; TYROSINE; WHEY PROTEIN; GLUCOSE BLOOD LEVEL; PLANT PROTEIN;

AGED; AMINO ACID BLOOD LEVEL; ARTICLE; BODY MASS; CONTINUOUS INFUSION; CONTROLLED STUDY; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; INGESTION; MALE; NORMAL HUMAN; POSTPRANDIAL STATE; PROTEIN SYNTHESIS; WHEAT; WHEY; BIOSYNTHESIS; BLOOD; BLOOD PRESSURE; BODY WEIGHT; CHEMISTRY; DIET; DOUBLE BLIND PROCEDURE; DRUG EFFECTS; EXERCISE; GLUCOSE BLOOD LEVEL; METABOLISM; MUSCLE FIBRIL; RANDOMIZED CONTROLLED TRIAL; SKELETAL MUSCLE; VERY ELDERLY;

AGED; AGED, 80 AND OVER; AMINO ACIDS, ESSENTIAL; BLOOD GLUCOSE; BLOOD PRESSURE; BODY MASS INDEX; BODY WEIGHT; CASEINS; DIET; DOUBLE-BLIND METHOD; EXERCISE; HUMANS; LEUCINE; MALE; MUSCLE PROTEINS; MUSCLE, SKELETAL; MYOFIBRILS; PHENYLALANINE; PLANT PROTEINS; POSTPRANDIAL PERIOD; PROTEIN BIOSYNTHESIS; PROTEIN HYDROLYSATES; TRITICUM; WHEY PROTEINS;

EID: 84988416260     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.116.231340     Document Type: Article

References (39)

1. Haruna Y, Suzuki Y, Kawakubo K, Yanagibori R, Gunji A. Decremental reset in basal metabolism during 20-days bed rest. Acta Physiol Scand Suppl 1994;616:43-9.
2. Janssen I, Heymsfield SB, Ross R. Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability. J Am Geriatr Soc 2002;50:889-96.
3. Koopman R, van Loon LJ. Aging, exercise, and muscle protein metabolism. J Appl Physiol 2009;106:2040-8.
4. Koopman R, Crombach N, Gijsen AP, Walrand S, Fauquant J, Kies AK, Lemosquet S, Saris WH, Boirie Y, van Loon LJ. Ingestion of a protein hydrolysate is accompanied by an accelerated in vivo digestion and absorption rate when compared with its intact protein. Am J Clin Nutr 2009;90:106-15.
5. Koopman R, Walrand S, Beelen M, Gijsen AP, Kies AK, Boirie Y, Saris WH, van Loon LJ. Dietary protein digestion and absorption rates and the subsequent postprandial muscle protein synthetic response do not differ between young and elderly men. J Nutr 2009;139:1707-13.
6. Moore DR, Robinson MJ, Fry JL, Tang JE, Glover EI, Wilkinson SB, Prior T, Tarnopolsky MA, Phillips SM. Ingested protein dose response of muscle and albumin protein synthesis after resistance exercise in young men. Am J Clin Nutr 2009;89:161-8.
7. Pennings B, Boirie Y, Senden JM, Gijsen AP, Kuipers H, van Loon LJ. Whey protein stimulates postprandial muscle protein accretion more effectively than do casein and casein hydrolysate in older men. Am J Clin Nutr 2011;93:997-1005.
8. Pennings B, Groen B, de Lange A, Gijsen AP, Zorenc AH, Senden JM, van Loon LJ. Amino acid absorption and subsequent muscle protein accretion following graded intakes of whey protein in elderly men. Am J Physiol Endocrinol Metab 2012;302:E992-9.
9. Tang JE, Moore DR, Kujbida GW, Tarnopolsky MA, Phillips SM. Ingestion of whey hydrolysate, casein, or soy protein isolate: effects on mixed muscle protein synthesis at rest and following resistance exercise in young men. J Appl Physiol 2009;107:987-92.
10. Yang Y, Churchward-Venne TA, Burd NA, Breen L, Tarnopolsky MA, Phillips SM. Myofibrillar protein synthesis following ingestion of soy protein isolate at rest and after resistance exercise in elderly men. Nutr Metab (Lond) 2012;9:57.
11. Gorissen SH, Remond D, van Loon LJ. The muscle protein synthetic response to food ingestion. Meat Sci 2015;109:96-100.
12. Houston DK, Nicklas BJ, Ding J, Harris TB, Tylavsky FA, Newman AB, Lee JS, Sahyoun NR, Visser M, Kritchevsky SB. Dietary protein intake is associated with lean mass change in older, community-dwelling adults: the Health, Aging, and Body Composition (Health ABC) Study. Am J Clin Nutr 2008;87:150-5.
13. Statistics Division; FAO. FAOSTAT Food Balance Sheets. Rome (Italy): FAOSTAT; 2011.
14. Hartman JW, Tang JE, Wilkinson SB, Tarnopolsky MA, Lawrence RL, Fullerton AV, Phillips SM. Consumption of fat-free fluid milk after resistance exercise promotes greater lean mass accretion than does consumption of soy or carbohydrate in young, novice, male weightlifters. Am J Clin Nutr 2007;86:373-81.
15. Luiking YC, Engelen MP, Soeters PB, Boirie Y, Deutz NE. Differential metabolic effects of casein and soy protein meals on skeletal muscle in healthy volunteers. Clin Nutr 2011;30:65-72.
16. Phillips SM. Nutrient-rich meat proteins in offsetting age-related muscle loss. Meat Sci 2012;92:174-8.
17. Wilkinson SB, Tarnopolsky MA, Macdonald MJ, Macdonald JR, Armstrong D, Phillips SM. Consumption of fluid skim milk promotes greater muscle protein accretion after resistance exercise than does consumption of an isonitrogenous and isoenergetic soy-protein beverage. Am J Clin Nutr 2007;85:1031-40.
18. van Vliet S, Burd NA, van Loon LJ. The skeletal muscle anabolic response to plant-versus animal-based protein consumption. J Nutr 2015;145:1981-91.
19. Sarwar Gilani G, Wu Xiao C, Cockell KA. Impact of antinutritional factors in food proteins on the digestibility of protein and the bioavailability of amino acids and on protein quality. Br J Nutr 2012;108(Suppl 2):S315-32.
20. Norton LE, Wilson GJ, Layman DK, Moulton CJ, Garlick PJ. Leucine content of dietary proteins is a determinant of postprandial skeletal muscle protein synthesis in adult rats. Nutr Metab (Lond) 2012;9:67.
21. Norton LE, Layman DK, Bunpo P, Anthony TG, Brana DV, Garlick PJ. The leucine content of a complete meal directs peak activation but not duration of skeletal muscle protein synthesis and mammalian target of rapamycin signaling in rats. J Nutr 2009;139:1103-9.
22. Bauer J, Biolo G, Cederholm T, Cesari M, Cruz-Jentoft AJ, Morley JE, Phillips S, Sieber C, Stehle P, Teta D, et al. Evidence-based recommendations for optimal dietary protein intake in older people: a position paper from the PROT-AGE Study Group. J AmMed Dir Assoc 2013;14:542-59.
23. Koopman R, Beelen M, Stellingwerff T, Pennings B, Saris WH, Kies AK, Kuipers H, van Loon LJ. Coingestion of carbohydrate with protein does not further augment postexercise muscle protein synthesis. Am J Physiol Endocrinol Metab 2007;293:E833-42.
24. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 1998;15:539-53.
25. Abumrad NN, Rabin D, Diamond MP, Lacy WW. Use of a heated superficial hand vein as an alternative site for the measurement of amino acid concentrations and for the study of glucose and alanine kinetics in man. Metabolism 1981;30:936-40.
26. Bergstrom J. Percutaneous needle biopsy of skeletal muscle in physiological and clinical research. Scand J Clin Lab Invest 1975;35:609-16.
27. Waterval WA, Scheijen JL, Ortmans-Ploemen MM, Habets-van der Poel CD, Bierau J. Quantitative UPLC-MS/MS analysis of underivatised amino acids in body fluids is a reliable tool for the diagnosis and follow-up of patients with inborn errors of metabolism. Clin Chim Acta 2009;407:36-42.
28. Gorissen SH, Burd NA, Hamer HM, Gijsen AP, Groen BB, van Loon LJ. Carbohydrate coingestion delays dietary protein digestion and absorption but does not modulate postprandial muscle protein accretion. J Clin Endocrinol Metab 2014;99:2250-8.
29. Burd NA, Cermak NM, Kouw IW, Gorissen SH, Gijsen AP, van Loon LJ. The use of doubly labeled milk protein to measure postprandial muscle protein synthesis rates in vivo in humans. J Appl Physiol 2014;117:1363-70.
30. Kramer IF, Verdijk LB, Hamer HM, Verlaan S, Luiking Y, Kouw IW, Senden JM, van Kranenburg J, Gijsen AP, Poeze M, et al. Impact of the macronutrient composition of a nutritional supplement on muscle protein synthesis rates in older men: a randomized, double blind, controlled trial. J Clin Endocrinol Metab 2015;100:4124-32.
31. Boirie Y, Gachon P, Corny S, Fauquant J, Maubois JL, Beaufrere B. Acute postprandial changes in leucine metabolism as assessed with an intrinsically labeled milk protein. Am J Physiol 1996;271: E1083-91.
32. Dangin M, Guillet C, Garcia-Rodenas C, Gachon P, Bouteloup-Demange C, Reiffers-Magnani K, Fauquant J, Ballevre O, Beaufrere B. The rate of protein digestion affects protein gain differently during aging in humans. J Physiol 2003;549:635-44.
33. Sarwar Gilani G, Tomé D, Moughan PJ, Rutherfurd SM, Burlingame B. Report of a sub-committee of the 2011 FAO Consultation on ''Protein Quality Evaluation in Human Nutrition'' on: The assessment of amino acid digestibility in foods for humans and including a collation of published ileal amino acid digestibility data for human foods. Rome (Italy): FAO;2012.
34. Rutherfurd SM, Moughan PJ. Available versus digestible dietary amino acids. Br J Nutr 2012;108(Suppl 2):S298-305.
35. Wall BT, Dirks ML, Snijders T, van Dijk JW, Fritsch M, Verdijk LB, van Loon LJ. Short-term muscle disuse lowers myofibrillar protein synthesis rates and induces anabolic resistance to protein ingestion. Am J Physiol Endocrinol Metab 2016;310:E137-47.
36. Churchward-Venne TA, Snijders T, Linkens AM, Hamer HM, van Kranenburg J, van Loon LJ. Ingestion of casein in a milk matrix modulates dietary protein digestion and absorption kinetics but does not modulate postprandial muscle protein synthesis in older Men. J Nutr 2015;145:1438-45.
37. Drummond MJ, Dreyer HC, Pennings B, Fry CS, Dhanani S, Dillon EL, Sheffield-Moore M, Volpi E, Rasmussen BB. Skeletal muscle protein anabolic response to resistance exercise and essential amino acids is delayed with aging. J Appl Physiol 2008;104:1452-61.
38. Reidy PT, Walker DK, Dickinson JM, Gundermann DM, Drummond MJ, Timmerman KL, Cope MB, Mukherjea R, Jennings K, Volpi E, et al. Soy-dairy protein blend and whey protein ingestion after resistance exercise increases amino acid transport and transporter expression in human skeletal muscle. J Appl Physiol 2014;116: 1353-64.
39. Reidy PT, Walker DK, Dickinson JM, Gundermann DM, Drummond MJ, Timmerman KL, Fry CS, Borack MS, Cope MB, Mukherjea R, et al. Protein blend ingestion following resistance exercise promotes human muscle protein synthesis. J Nutr 2013;143:410-6.