Effects of vitamin D supplementation on glycated haemoglobin and fasting glucose levels in hypertensive patients: a randomized controlled trial

Diabetes, Obesity and Metabolism

Volumn 18, Issue 10, 2016, Pages 1006-1012

  Grubler M R ^a,b   Gaksch, M ^a   Kienreich, K ^a   Verheyen, N ^a   Schmid, J ^a   o Hartaigh B ^c   Richtig, G ^a   Scharnagl, H ^a   Meinitzer, A ^a   Fahrleitner Pammer, A ^a   Marz W ^a,d,e   Tomaschitz, A ^a,f   Pilz, S ^a,g  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

^b BERN UNIVERSITY HOSPITAL   (Switzerland)

^c NEW YORK PRESBYTERIAN HOSPITAL   (United States)

^d SYNLAB ACADEMY   (Germany)

^e UNIVERSITY OF HEIDELBERG   (Germany)

^f Specialist Clinic for Rehabilitation Bad Aussee   (Austria)

^g VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

cardiovascular disease; randomised trial; type 2 diabetes

Indexed keywords

25 HYDROXYVITAMIN D; CALCIUM; CALCIUM CHANNEL; GLUCOSE; HEMOGLOBIN A1C; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PARATHYROID HORMONE; PLACEBO; THIAZIDE DIURETIC AGENT; VITAMIN D; 25-HYDROXYVITAMIN D; GLUCOSE BLOOD LEVEL; GLYCOSYLATED HEMOGLOBIN;

ADULT; ANALYSIS OF COVARIANCE; ARTICLE; AUSTRIA; BODY MASS; CALCIUM BLOOD LEVEL; CLINICAL EFFECTIVENESS; COHORT ANALYSIS; CONTROLLED STUDY; CORRELATION COEFFICIENT; DOUBLE BLIND PROCEDURE; FEMALE; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HEMOGLOBIN BLOOD LEVEL; HUMAN; HYPERTENSION; INSULIN RESISTANCE; LIQUID CHROMATOGRAPHY; MALE; OBESITY; PARATHYROID HORMONE BLOOD LEVEL; POST HOC ANALYSIS; RANDOMIZED CONTROLLED TRIAL; SENSITIVITY ANALYSIS; SMOKING; TANDEM MASS SPECTROMETRY; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION; AGED; ANALOGS AND DERIVATIVES; BLOOD; COMPLICATION; DIET RESTRICTION; DIET THERAPY; DIETARY SUPPLEMENT; DRUG EFFECTS; METABOLISM; MIDDLE AGED; VITAMIN D DEFICIENCY;

AGED; BLOOD GLUCOSE; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FASTING; FEMALE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; OBESITY; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 84987700926     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/dom.12709     Document Type: Article

References (62)

1. Autier P, Gandini S. Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trials. Arch Intern Med. 2007;167:1730–1737.
2. Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Guidelines for preventing and treating vitamin D deficiency and insufficiency revisited. J Clin Endocrinol Metab. 2012;97:1153–1158.
3. Macdonald HM, Wood AD, Fraser WD, Simpson WG. Vitamin D status and ill health. Lancet Diabetes Endocrinol. 2014;2(4):e8–e9.
4. Elamin MB, Abu Elnour NO, Elamin KB, et al. Vitamin D and cardiovascular outcomes: a systematic review and meta-analysis. J Clin Endocrinol Metab. 2011;96:1931–1942.
5. Kienreich K, Tomaschitz A, Verheyen N, et al. Vitamin D and cardiovascular disease. Nutrients. 2013;5:3005–3021.
6. Kienreich K, Grubler M, Tomaschitz A, et al. Vitamin D, arterial hypertension & cerebrovascular disease. Indian J Med Res. 2013;137:669–679.
7. Pilz S, Kienreich K, Rutters F, et al. Role of vitamin D in the development of insulin resistance and type 2 diabetes. Curr Diab Rep. 2012;13:261–270.
8. Seida JC, Mitri J, Colmers IN, et al. Clinical review: effect of vitamin D3 supplementation on improving glucose homeostasis and preventing diabetes: a systematic review and meta-analysis. J Clin Endocrinol Metab. 2014;99:3551–3560.
9. Huang ES, Laiteerapong N, Liu JY, John PM, Moffet HH, Karter AJ. Rates of complications and mortality in older patients with diabetes mellitus: the diabetes and aging study. JAMA Intern Med. 2014;174:251–258.
10. Lim SS, Vos T, Flaxman AD, et al. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380:2224–2260.
11. Jorde R, Schirmer H, Wilsgaard T, et al. Polymorphisms related to the serum 25-hydroxyvitamin D level and risk of myocardial infarction, diabetes, cancer and mortality. The Tromsø Study. PLoS One. 2012;7(5):e37295.
12. Rolf L, Muris A-H, Hupperts R, Damoiseaux J. Vitamin D effects on B cell function in autoimmunity. Ann N Y Acad Sci. 2014;1317:84–91.
13. Takiishi T, Gysemans C, Bouillon R, Mathieu C. Vitamin D and diabetes. Endocrinol Metab Clin North Am. 2010;39:419–446.
14. Nikooyeh B, Neyestani TR, Farvid M, et al. Daily consumption of vitamin D- or vitamin D + calcium-fortified yogurt drink improved glycemic control in patients with type 2 diabetes: a randomized clinical trial. Am J Clin Nutr. 2011;93:764–771.
15. Shab-Bidar S, Neyestani TR, Djazayery A, et al. Improvement of vitamin D status resulted in amelioration of biomarkers of systemic inflammation in the subjects with type 2 diabetes. Diabetes Metab Res Rev. 2012;28:424–430.
16. Shab-Bidar S, Neyestani TR, Djazayery A, et al. Regular consumption of vitamin D-fortified yogurt drink (Doogh) improved endothelial biomarkers in subjects with type 2 diabetes: a randomized double-blind clinical trial. BMC Med. 2011;9:125.
17. Mozaffari-Khosravi H, Hosseinzadeh-Shamsi-Anar M, Salami M-A, Hadinedoushan H, Mozayan MR. Effects of a single post-partum injection of a high dose of vitamin D on glucose tolerance and insulin resistance in mothers with first-time gestational diabetes mellitus. Diabet Med. 2012;29:36–42.
18. Mitri J, Muraru MD, Pittas AG. Vitamin D and type 2 diabetes: a systematic review. Eur J Clin Nutr. 2011;65:1005–1015.
19. George PS, Pearson ER, Witham MD. Effect of vitamin D supplementation on glycaemic control and insulin resistance: a systematic review and meta-analysis. Diabet Med. 2012;29:e142–e150.
20. Mitri J, Dawson-Hughes B, Hu FB, Pittas AG. Effects of vitamin D and calcium supplementation on pancreatic β cell function, insulin sensitivity, and glycemia in adults at high risk of diabetes: the calcium and vitamin D for diabetes mellitus (CaDDM) randomized controlled trial. Am J Clin Nutr. 2011;94:486–494.
21. Pittas AG, Harris SS, Stark PC, Dawson-Hughes B. The effects of calcium and vitamin D supplementation on blood glucose and markers of inflammation in nondiabetic adults. Diabetes Care. 2007;30:980–986.
22. von Hurst PR, Stonehouse W, Coad J. Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient–a randomised, placebo-controlled trial. Br J Nutr. 2010;103:549–555.
23. Eftekhari M, Akbarzadeh M, Dabbaghmanesh M, Hasanzadeh J. Impact of treatment with oral calcitriol on glucose indices in type 2 diabetes mellitus patients. Asia Pac J Clin Nutr. 2011;20:521–526.
24. de Zeeuw D, Agarwal R, Amdahl M, et al. Selective vitamin D receptor activation with paricalcitol for reduction of albuminuria in patients with type 2 diabetes (VITAL study): a randomised controlled trial. Lancet. 2010;376:1543–1551.
25. Harris SS, Pittas AG, Palermo NJ. A randomized, placebo-controlled trial of vitamin D supplementation to improve glycaemia in overweight and obese African Americans. Diabetes Obes Metab. 2012;14:789–794.
26. Davidson MB, Duran P, Lee ML, Friedman TC. High-dose vitamin D supplementation in people with prediabetes and hypovitaminosis D. Diabetes Care. 2013;36:260–266.
27. Ardabili HR, Gargari BP, Farzadi L. Vitamin D supplementation has no effect on insulin resistance assessment in women with polycystic ovary syndrome and vitamin D deficiency. Nutr Res (New York, NY). 2012;32:195–201.
28. Beilfuss J, Berg V, Sneve M, Jorde R, Kamycheva E. Effects of a 1-year supplementation with cholecalciferol on interleukin-6, tumor necrosis factor-alpha and insulin resistance in overweight and obese subjects. Cytokine. 2012;60:870–874.
29. Carrillo AE, Flynn MG, Pinkston C, et al. Impact of vitamin D supplementation during a resistance training intervention on body composition, muscle function, and glucose tolerance in overweight and obese adults. Clin Nutr (Edinburgh, Scotland). 2013;32:375–381.
30. Petchey WG, Hickman IJ, Prins JB, et al. Vitamin D does not improve the metabolic health of patients with chronic kidney disease stage 3-4: a randomized controlled trial. Nephrology (Carlton, Vic). 2013;18:26–35.
31. Longenecker CT, Hileman CO, Carman TL, et al. Vitamin D supplementation and endothelial function in vitamin D deficient HIV-infected patients: a randomized placebo-controlled trial. Antivir Ther. 2012;17:613–621.
32. Pilz S, Gaksch M, Kienreich K, et al. Effects of vitamin D on blood pressure and cardiovascular risk factors a randomized controlled trial. Hypertension. 2015;65:1195–1201.
33. Moher D, Hopewell S, Schulz KF, et al. CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomised trials. BMJ. 2010;340:c869.
34. Mancia G, Fagard R, Narkiewicz K, et al. 2013 ESH/ESC guidelines for the management of arterial hypertension The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J. 2013;34:2159–2219.
35. Chiolero A, Faeh D, Paccaud F, Cornuz J. Consequences of smoking for body weight, body fat distribution, and insulin resistance. Am J Clin Nutr. 2008;87:801–809.
36. Association AD. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2010;33(Suppl 1):S62–S69.
37. Grübler MR, Kienreich K, Gaksch M, et al. Aldosterone to active renin ratio is associated with nocturnal blood pressure in obese and treated hypertensive pPatients: The Styrian Hypertension Study. J Clin Hypertens. 2014;16:289–294.
38. Ó Hartaigh B, Gaksch M, Kienreich K, et al. Associations of daytime, nighttime, and 24-hour heart rate with four distinct markers of inflammation in hypertensive patients: the styrian hypertension study. J Clin Hypertens. 2014;16:856–861.
39. Carpenter JR, Goldstein H, Kenward MG. REALCOM-IMPUTE software for multilevel multiple imputation with mixed response types. J Stat Softw. 2011;1:5. December 2011. http://www.jstatsoft.org/index.php/jss/article/view/v045i05. Accessed 22 August 2015.
40. Kota SK, Jammula S, Kota SK, Tripathy PR, Panda S, Modi KD. Effect of vitamin D supplementation in type 2 diabetes patients with pulmonary tuberculosis. Diabetes Metab Syndr. 2011;5(2):85–89, DOI: 10.1016/j.dsx.2012.02.021.
41. Soric MM, Renner ET, Smith SR. Effect of daily vitamin D supplementation on HbA1c in patients with uncontrolled type 2 diabetes mellitus: a pilot study. J Diabetes. 2012;4(1):104–105, DOI: 10.1111/j.1753-0407.2011.00164.x.
42. Heshmat R, Tabatabaei-Malazy O, Abbaszadeh-Ahranjani S, et al. Effect of vitamin D on insulin resistance and anthropometric parameters in Type 2 diabetes; a randomized double-blind clinical trial. Daru J Fac Pharm Tehran Univ Med Sci. 2012;20(1):10, DOI: 10.1186/2008-2231-20-10.
43. Parekh D, Sarathi V, Shivane VK, Bandgar TR, Menon PS, Shah NS. Pilot study to evaluate the effect of short-term improvement in vitamin D status on glucose tolerance in patients with type 2 diabetes mellitus. Endocr Pract Off J Am Coll Endocrinol Am Assoc Clin Endocrinol. 2010;16(4):600–608, DOI: 10.4158/EP09300.OR.
44. Jorde R, Figenschau Y. Supplementation with cholecalciferol does not improve glycaemic control in diabetic subjects with normal serum 25-hydroxyvitamin D levels. Eur J Nutr. 2009;48(6):349–354, DOI: 10.1007/s00394-009-0020-3.
45. Sugden JA, Davies JI, Witham MD, Morris AD, Struthers AD. Vitamin D improves endothelial function in patients with type 2 diabetes mellitus and low vitamin D levels. Diabet Med. 2008;25(3):320–325, DOI: 10.1111/j.1464-5491.2007.02360.x.
46. Elkassaby S, Harrison LC, Mazzitelli N, et al. A randomised controlled trial of high dose vitamin D in recent-onset type 2 diabetes. Diabetes Res Clin Pract. 2014;106(3):576–582, DOI: 10.1016/j.diabres.2014.08.030.
47. de Boer IH, Sachs M, Hoofnagle AN, et al. Paricalcitol does not improve glucose metabolism in patients with stage 3-4 chronic kidney disease. Kidney Int. 2013;83(2):323–330, DOI: 10.1038/ki.2012.311.
48. Nagpal J, Pande JN, Bhartia A. A double-blind, randomized, placebo-controlled trial of the short-term effect of vitamin D3 supplementation on insulin sensitivity in apparently healthy, middle-aged, centrally obese men. Diabet Med J Br Diabet Assoc. 2009;26(1):19–27, DOI: 10.1111/j.1464-5491.2008.02636.x.
49. de Boer IH, Tinker LF, Connelly S, et al. Calcium plus vitamin D supplementation and the risk of incident diabetes in the Women's Health Initiative. Diabetes Care. 2008;31(4):701–707, DOI: 10.2337/dc07-1829.
50. Javed A, Vella A, Balagopal PB, et al. Cholecalciferol supplementation does not influence β-cell function and insulin action in obese adolescents: a prospective double-blind randomized trial. J Nutr. 2015;145(2):284–290, DOI: 10.3945/jn.114.202010.
51. Muldowney S, Lucey AJ, Hill TR, et al. Incremental cholecalciferol supplementation up to 15 µg/d throughout winter at 51-55° N has no effect on biomarkers of cardiovascular risk in healthy young and older adults. J Nutr. 2012;142(8):1519–1525, DOI: 10.3945/jn.111.154005.
52. Fliser D, Stefanski A, Franek E, Fode P, Gudarzi A, Ritz E. No effect of calcitriol on insulin-mediated glucose uptake in healthy subjects. Eur J Clin Invest. 1997;27(7):629–633.
53. Jorde R, Sneve M, Torjesen P, Figenschau Y. No improvement in cardiovascular risk factors in overweight and obese subjects after supplementation with vitamin D3 for 1 year. J Intern Med. 2010;267(5):462–472, DOI: 10.1111/j.1365-2796.2009.02181.x.
54. Grimnes G, Figenschau Y, Almås B, Jorde R. Vitamin D, insulin secretion, sensitivity, and lipids: results from a case-control study and a randomized controlled trial using hyperglycemic clamp technique. Diabetes. 2011;60(11):2748–2757, DOI: 10.2337/db11-0650.
55. Avenell A, Cook JA, MacLennan GS, McPherson GC. RECORD trial group. Vitamin D supplementation and type 2 diabetes: a substudy of a randomised placebo-controlled trial in older people (RECORD trial, ISRCTN 51647438). Age Ageing. 2009;38(5):606–609, DOI: 10.1093/ageing/afp109.
56. Pérez-López FR, Pasupuleti V, Mezones-Holguin E, et al. Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials. Fertil Steril. 2015;103(5):1278–1288.e4, DOI: 10.1016/j.fertnstert.2015.02.019.
57. Nigil Haroon N, Anton A, John J, Mittal M. Effect of vitamin D supplementation on glycemic control in patients with type 2 diabetes: a systematic review of interventional studies. J Diabetes Metab Disord. 2015;14:3, DOI: 10.1186/s40200-015-0130-9.
58. Norman AW, Frankel JB, Heldt AM, Grodsky GM. Vitamin D deficiency inhibits pancreatic secretion of insulin. Science. 1980;209(4458):823–825.
59. März W, Nauck M, Hoffmann MM, et al. G(−30)A Polymorphism in the Pancreatic Promoter of the Glucokinase Gene Associated With Angiographic Coronary Artery Disease and Type 2 Diabetes Mellitus. Circulation. 2004;109(23):2844–2849, DOI: 10.1161/01.CIR.0000129306.44085.C4.
60. Farrell C-JL, Martin S, McWhinney B, Straub I, Williams P, Herrmann M. State-of-the-art Vitamin D assays: a comparison of automated immunoassays with liquid chromatography–tandem mass spectrometry methods. Clin Chem. 2012;58(3):531–542, DOI: 10.1373/clinchem.2011.172155.
61. Schmid J, Kienreich K, Gaksch M, et al. The importance of assays in vitamin D status classification: a comparison of four automated 25-hydroxyvitamin D immunoassays. LaboratoriumsMedizin. 2013;37(5):261–268.
62. Holick MF, Vitamin D. Status: measurement, interpretation, and clinical application. Ann Epidemiol. 2009;19(2):73–78, DOI: 10.1016/j.annepidem.2007.12.001.