MMP-Mediated Disruption of Claudin-5 in the Blood–Brain Barrier of Rat Brain After Cerebral Ischemia

Methods in Molecular Biology

Volumn 762, Issue , 2011, Pages 333-345

  Yang, Yi ^a   Rosenberg, Gary A ^b  

^a UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

Blood brain barrier; Claudin 5; Endothelial cells; Matrix metalloproteinase and stroke; Tight junction proteins

Indexed keywords

CLDN5 PROTEIN, RAT; MATRIX METALLOPROTEINASE; MEMBRANE PROTEIN; OCCLUDIN;

ANIMAL; ARTICLE; BLOOD BRAIN BARRIER; BRAIN ISCHEMIA; CYTOLOGY; ENZYME ACTIVATION; FLUORESCENT ANTIBODY TECHNIQUE; METABOLISM; METHODOLOGY; PATHOLOGY; PERMEABILITY; PHYSIOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; RAT; TIGHT JUNCTION; WESTERN BLOTTING;

ANIMALS; BLOOD-BRAIN BARRIER; BLOTTING, WESTERN; BRAIN ISCHEMIA; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME ACTIVATION; FLUORESCENT ANTIBODY TECHNIQUE; MATRIX METALLOPROTEINASES; MEMBRANE PROTEINS; PERMEABILITY; RATS; TIGHT JUNCTIONS;

RATTUS;

EID: 79960741978     PISSN: 10643745     EISSN: 19406029     Source Type: Book Series    
DOI: 10.1007/978-1-61779-185-7_24     Document Type: Chapter

References (26)

1. Vracko, R., Basal lamina scaffold-anatomy and significance for maintenance of orderly tissue structure. Am J Pathol, 1974. 77(2): p. 314–46.
2. Hawkins, B.T. and T.P. Davis, The blood-brain barrier/neurovascular unit in health and disease. Pharmacol Rev, 2005. 57(2): p. 173–85.
3. Ballabh, P., A. Braun, and M. Nedergaard, The blood-brain barrier: an overview: structure, regulation, and clinical implications. Neurobiol Dis, 2004. 16(1): p. 1–13.
4. Brightman, M.W. and T.S. Reese, Junctions between intimately apposed cell membranes in the vertebrate brain. J Cell Biol, 1969. 40(3): p. 648–77.
5. Liebner, S., et al., Correlation of tight junction morphology with the expression of tight junction proteins in blood-brain barrier endothelial cells. Eur J Cell Biol, 2000. 79(10): p. 707–17.
6. Papadopoulos, M.C., et al., Occludin expression in microvessels of neoplastic and non-neoplastic human brain. Neuropathol Appl Neurobiol, 2001. 27(5): p. 384–95.
7. Furuse, M., et al., Occludin: a novel integral membrane protein localizing at tight junctions. J Cell Biol, 1993. 123(6 Pt 2): p. 1777–88.
8. Haskins, J., et al., ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludin. J Cell Biol, 1998. 141(1): p. 199–208.
9. Itoh, M., et al., Involvement of ZO-1 in cadherin-based cell adhesion through its direct binding to alpha catenin and actin filaments. J Cell Biol, 1997. 138(1): p. 181–92.
10. Hirase, T., et al., Regulation of tight junction permeability and occludin phosphorylation by Rhoa-p160ROCK-dependent and-independent mechanisms. J Biol Chem, 2001. 276(13): p. 10423–31.
11. Hirase, T., et al., Occludin as a possible determinant of tight junction permeability in endothelial cells. J Cell Sci, 1997. 110 (Pt 14): p. 1603–13.
12. Kanda, T., Y. Numata, and H. Mizusawa, Chronic inflammatory demyelinating polyneu-ropathy: decreased claudin-5 and relocated ZO-1. J Neurol Neurosurg Psychiatry, 2004. 75(5): p. 765–9.
13. Wen, H., et al., Selective decrease in paracellular conductance of tight junctions: role of the first extracellular domain of claudin-5. Mol Cell Biol, 2004. 24(19): p. 8408–17.
14. Dobrogowska, D.H. and A.W. Vorbrodt, Immunogold localization of tight junctional proteins in normal and osmotically-affected rat blood-brain barrier. J Mol Histol, 2004. 35(5): p. 529–39.
15. Matter, K. and M.S. Balda, Holey barrier: claudins and the regulation of brain endothelial permeability. J Cell Biol, 2003. 161(3): p. 459–60.
16. Honda, M., et al., Adrenomedullin improves the blood-brain barrier function through the expression of claudin-5. Cell Mol Neurobiol, 2006. 26(2): p. 109–18.
17. Furuse, M., et al., Claudin-1 and-2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J Cell Biol, 1998. 141(7): p. 1539–50.
18. Nitta, T., et al., Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. J Cell Biol, 2003. 161(3): p. 653–60.
19. Huber, J.D., R.D. Egleton, and T.P. Davis, Molecular physiology and pathophysiology of tight junctions in the blood-brain barrier. Trends Neurosci, 2001. 24(12): p. 719–25.
20. Mark, K.S. and T.P. Davis, Cerebral microvascular changes in permeability and tight junctions induced by hypoxia-reoxygenation. Am J Physiol Heart Circ Physiol, 2002. 282(4): p. H1485-94.
21. Witt, K.A., et al., Effects of hypoxia-reoxygenation on rat blood-brain barrier permeability and tight junctional protein expression. Am J Physiol Heart Circ Physiol, 2003. 285(6): p. H2820-31.
22. Yamagata, K., et al., Hypoxia-induced changes in tight junction permeability of brain capillary endothelial cells are associated with IL-1beta and nitric oxide. Neurobiol Dis, 2004. 17(3): p. 491–9.
23. Yang, Y., et al., Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat. J Cereb Blood Flow Metab, 2007. 27(4): p. 697–709.
24. Wolburg, H., et al., Localization of claudin-3 in tight junctions of the blood-brain barrier is selectively lost during experimental autoimmune encephalomyelitis and human glioblas-toma multiforme. Acta Neuropathol (Berl), 2003. 105(6): p. 586–92.
25. Forster, C., Tight junctions and the modulation of barrier function in disease. Histochem Cell Biol, 2008. 130(1): p. 55–70.
26. Nishida, Y., et al., Screening for control genes in mouse hippocampus after transient forebrain ischemia using high-density oligonucleotide array. J Pharmacol Sci, 2006. 101(1): p. 52–7.