Wogonin inhibits the proliferation and invasion, and induces the apoptosis of HepG2 and Bel7402 HCC cells through NFB/Bcl-2, EGFR and EGFR downstream ERK/AKT signaling

International Journal of Molecular Medicine

Volumn 38, Issue 4, 2016, Pages 1250-1256

  Liu, Xiaodong ^a   Tian, Shuo ^b   Liu, Mei ^a   Jian, Lingyan ^a   Zhao, Limei ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Epidermal growth factor receptor; Hepatocellular carcinoma; Matrix metalloproteinase 2; Wogonin

Indexed keywords

CASPASE 3; CASPASE 9; CYCLIN D1; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN E; EPIDERMAL GROWTH FACTOR RECEPTOR; GELATINASE A; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BCL 2; PROTEIN KINASE B; SMALL INTERFERING RNA; SYNAPTOTAGMIN I; WOGONIN; CELL CYCLE PROTEIN; FLAVANONE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BEL7402 CELL LINE; CELL INVASION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; HEPATOCELLULAR CARCINOMA CELL LINE; HEPG2 CELL LINE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; DRUG EFFECTS; HEP-G2 CELL LINE; HUMAN; METABOLISM; TUMOR INVASION;

APOPTOSIS; CELL CYCLE PROTEINS; CELL PROLIFERATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVANONES; G1 PHASE; HEP G2 CELLS; HUMANS; NEOPLASM INVASIVENESS; NF-KAPPA B; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTOR, EPIDERMAL GROWTH FACTOR; S PHASE; SIGNAL TRANSDUCTION;

EID: 84986907345     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2016.2700     Document Type: Article

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