-
1
-
-
83655197489
-
What counters antibiotic resistance in nature?
-
Chait R, Vetsigian K, Kishony R (2011) What counters antibiotic resistance in nature? Nat Chem Biol 8(1):2-5.
-
(2011)
Nat Chem Biol
, vol.8
, Issue.1
, pp. 2-5
-
-
Chait, R.1
Vetsigian, K.2
Kishony, R.3
-
2
-
-
0016430104
-
Combination versus single agent chemotherapy: A review of the basis for selection of drug treatment of cancer
-
DeVita VT, Jr, Young RC, Canellos GP (1975) Combination versus single agent chemotherapy: A review of the basis for selection of drug treatment of cancer. Cancer 35(1):98-110.
-
(1975)
Cancer
, vol.35
, Issue.1
, pp. 98-110
-
-
DeVita, V.T.1
Young, R.C.2
Canellos, G.P.3
-
3
-
-
33747620519
-
Systems biology and combination therapy in the quest for clinical efficacy
-
Fitzgerald JB, Schoeberl B, Nielsen UB, Sorger PK (2006) Systems biology and combination therapy in the quest for clinical efficacy. Nat Chem Biol 2(9):458-466.
-
(2006)
Nat Chem Biol
, vol.2
, Issue.9
, pp. 458-466
-
-
Fitzgerald, J.B.1
Schoeberl, B.2
Nielsen, U.B.3
Sorger, P.K.4
-
4
-
-
54249155522
-
Network pharmacology: The next paradigm in drug discovery
-
Hopkins AL (2008) Network pharmacology: The next paradigm in drug discovery. Nat Chem Biol 4(11):682-690.
-
(2008)
Nat Chem Biol
, vol.4
, Issue.11
, pp. 682-690
-
-
Hopkins, A.L.1
-
5
-
-
67650488269
-
Synergistic drug combinations tend to improve therapeutically relevant selectivity
-
Lehár J, et al. (2009) Synergistic drug combinations tend to improve therapeutically relevant selectivity. Nat Biotechnol 27(7):659-666.
-
(2009)
Nat Biotechnol
, vol.27
, Issue.7
, pp. 659-666
-
-
Lehár, J.1
-
6
-
-
84863600752
-
Combined EGFR/MET or EGFR/HSP90 inhibition is effective in the treatment of lung cancers codriven by mutant EGFR containing T790M and MET
-
Xu L, et al. (2012) Combined EGFR/MET or EGFR/HSP90 inhibition is effective in the treatment of lung cancers codriven by mutant EGFR containing T790M and MET. Cancer Res 72(13):3302-3311.
-
(2012)
Cancer Res
, vol.72
, Issue.13
, pp. 3302-3311
-
-
Xu, L.1
-
7
-
-
84862765955
-
Managing drug resistance in cancer: Lessons from HIV therap
-
Bock C, Lengauer T (2012) Managing drug resistance in cancer: Lessons from HIV therapy. Nat Rev Cancer 12(7):494-501.
-
(2012)
Nat Rev Cancer
, vol.12
, Issue.7
, pp. 494-501
-
-
Bock, C.1
Lengauer, T.2
-
8
-
-
84884535896
-
Cancer drug resistance: An evolving paradigm
-
Holohan C, Van Schaeybroeck S, Longley DB, Johnston PG (2013) Cancer drug resistance: An evolving paradigm. Nat Rev Cancer 13(10):714-726.
-
(2013)
Nat Rev Cancer
, vol.13
, Issue.10
, pp. 714-726
-
-
Holohan, C.1
Van Schaeybroeck, S.2
Longley, D.B.3
Johnston, P.G.4
-
9
-
-
84862830732
-
Nanoparticle-based combination therapy toward overcoming drug resistance in cancer
-
Hu C-MJ, Zhang L (2012) Nanoparticle-based combination therapy toward overcoming drug resistance in cancer. Biochem Pharmacol 83(8):1104-1111.
-
(2012)
Biochem Pharmacol
, vol.83
, Issue.8
, pp. 1104-1111
-
-
Hu, C.1
Zhang, L.2
-
10
-
-
0021118703
-
Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors
-
Chou T-C, Talalay P (1984) Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 22: 27-55.
-
(1984)
Adv Enzyme Regul
, vol.22
, pp. 27-55
-
-
Chou, T.-C.1
Talalay, P.2
-
11
-
-
84872858690
-
Genotype-selective combination therapies for melanoma identified by high-throughput drug screening
-
Held MA, et al. (2013) Genotype-selective combination therapies for melanoma identified by high-throughput drug screening. Cancer Discov 3(1):52-67.
-
(2013)
Cancer Discov
, vol.3
, Issue.1
, pp. 52-67
-
-
Held, M.A.1
-
12
-
-
26844489762
-
Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile
-
Schuldiner M, et al. (2005) Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile. Cell 123(3):507-519.
-
(2005)
Cell
, vol.123
, Issue.3
, pp. 507-519
-
-
Schuldiner, M.1
-
13
-
-
84893495182
-
Antifungal application of nonantifungal drugs
-
Stylianou M, et al. (2014) Antifungal application of nonantifungal drugs. Antimicrob Agents Chemother 58(2):1055-1062.
-
(2014)
Antimicrob Agents Chemother
, vol.58
, Issue.2
, pp. 1055-1062
-
-
Stylianou, M.1
-
14
-
-
84897034626
-
Uncovering scaling laws to infer multidrug response of resistant microbes and cancer cells
-
Wood KB, Wood KC, Nishida S, Cluzel P (2014) Uncovering scaling laws to infer multidrug response of resistant microbes and cancer cells. Cell Reports 6(6):1073-1084.
-
(2014)
Cell Reports
, vol.6
, Issue.6
, pp. 1073-1084
-
-
Wood, K.B.1
Wood, K.C.2
Nishida, S.3
Cluzel, P.4
-
15
-
-
84946384873
-
The toxicity of poisons applied jointly
-
Bliss CI (1939) The toxicity of poisons applied jointly. Ann Appl Biol 26(3):585-615.
-
(1939)
Ann Appl Biol
, vol.26
, Issue.3
, pp. 585-615
-
-
Bliss, C.I.1
-
16
-
-
0344437730
-
The calculation of microbial assays
-
Bliss CI (1956) The calculation of microbial assays. Bacteriol Rev 20(4):243-258.
-
(1956)
Bacteriol Rev
, vol.20
, Issue.4
, pp. 243-258
-
-
Bliss, C.I.1
-
17
-
-
34247277741
-
Antibiotic interactions that select against resistance
-
Chait R, Craney A, Kishony R (2007) Antibiotic interactions that select against resistance. Nature 446(7136):668-671.
-
(2007)
Nature
, vol.446
, Issue.7136
, pp. 668-671
-
-
Chait, R.1
Craney, A.2
Kishony, R.3
-
18
-
-
0001663843
-
The problem of synergism and antagonism of combined drugs
-
Loewe S (1953) The problem of synergism and antagonism of combined drugs. Arzneimittelforschung 3(6):285-290.
-
(1953)
Arzneimittelforschung
, vol.3
, Issue.6
, pp. 285-290
-
-
Loewe, S.1
-
19
-
-
0024847290
-
What is synergy?
-
Berenbaum MC (1989) What is synergy? Pharmacol Rev 41(2):93-141.
-
(1989)
Pharmacol Rev
, vol.41
, Issue.2
, pp. 93-141
-
-
Berenbaum, M.C.1
-
20
-
-
70350769418
-
Nonoptimal microbial response to antibiotics underlies suppressive drug interactions
-
Bollenbach T, Quan S, Chait R, Kishony R (2009) Nonoptimal microbial response to antibiotics underlies suppressive drug interactions. Cell 139(4):707-718.
-
(2009)
Cell
, vol.139
, Issue.4
, pp. 707-718
-
-
Bollenbach, T.1
Quan, S.2
Chait, R.3
Kishony, R.4
-
21
-
-
33645396484
-
Functional classification of drugs by properties of their pairwise interactions
-
Yeh P, Tschumi AI, Kishony R (2006) Functional classification of drugs by properties of their pairwise interactions. Nat Genet 38(4):489-494.
-
(2006)
Nat Genet
, vol.38
, Issue.4
, pp. 489-494
-
-
Yeh, P.1
Tschumi, A.I.2
Kishony, R.3
-
22
-
-
78649740382
-
Systems approaches and algorithms for discovery of combinatorial therapies
-
Wiley
-
Feala JD, et al. (2010) Systems approaches and algorithms for discovery of combinatorial therapies. Wiley Interdiscip Rev Syst Biol Med 2(2):181-193.
-
(2010)
Interdiscip Rev Syst Biol Med
, vol.2
, Issue.2
, pp. 181-193
-
-
Feala, J.D.1
-
23
-
-
58149166733
-
Search algorithms as a framework for the optimization of drug combinations
-
Calzolari D, et al. (2008) Search algorithms as a framework for the optimization of drug combinations. PLOS Comput Biol 4(12):e1000249.
-
(2008)
PLOS Comput Biol
, vol.4
, Issue.12
, pp. e1000249
-
-
Calzolari, D.1
-
24
-
-
33746622984
-
Strategies for optimizing combinations of molecularly targeted anticancer agents
-
Dancey JE, Chen HX (2006) Strategies for optimizing combinations of molecularly targeted anticancer agents. Nat Rev Drug Discov 5(8):649-659.
-
(2006)
Nat Rev Drug Discov
, vol.5
, Issue.8
, pp. 649-659
-
-
Dancey, J.E.1
Chen, H.X.2
-
25
-
-
0032563561
-
Experimental design and optimization
-
Lundstedt T, et al. (1998) Experimental design and optimization. Chemom Intell Lab Syst 42(1-2):3-40.
-
(1998)
Chemom Intell Lab Syst
, vol.42
, Issue.1-2
, pp. 3-40
-
-
Lundstedt, T.1
-
26
-
-
84884407337
-
Tumour heterogeneity in the clinic
-
Bedard PL, Hansen AR, Ratain MJ, Siu LL (2013) Tumour heterogeneity in the clinic. Nature 501(7467):355-364.
-
(2013)
Nature
, vol.501
, Issue.7467
, pp. 355-364
-
-
Bedard, P.L.1
Hansen, A.R.2
Ratain, M.J.3
Siu, L.L.4
-
27
-
-
84955447828
-
Ex vivo assessment of drug activity in patient tumor cells as a basis for tailored cancer therapy
-
Blom K, Nygren P, Alvarsson J, Larsson R, Andersson CR (2016) Ex vivo assessment of drug activity in patient tumor cells as a basis for tailored cancer therapy. J Lab Autom 21(1):178-187.
-
(2016)
J Lab Autom
, vol.21
, Issue.1
, pp. 178-187
-
-
Blom, K.1
Nygren, P.2
Alvarsson, J.3
Larsson, R.4
Andersson, C.R.5
-
28
-
-
84890040482
-
Individualized systems medicine strategy to tailor treatments for patients with chemorefractory acute myeloid leukemia
-
Pemovska T, et al. (2013) Individualized systems medicine strategy to tailor treatments for patients with chemorefractory acute myeloid leukemia. Cancer Discov 3(12):1416-1429.
-
(2013)
Cancer Discov
, vol.3
, Issue.12
, pp. 1416-1429
-
-
Pemovska, T.1
-
29
-
-
82355191818
-
Implementing multiplexed genotyping of non-small-cell lung cancers into routine clinical practice
-
Sequist LV, et al. (2011) Implementing multiplexed genotyping of non-small-cell lung cancers into routine clinical practice. Ann Oncol 22(12):2616-2624.
-
(2011)
Ann Oncol
, vol.22
, Issue.12
, pp. 2616-2624
-
-
Sequist, L.V.1
-
30
-
-
84892788440
-
Constraint-based models predict metabolic and associated cellular functions
-
Bordbar A, Monk JM, King ZA, Palsson BO (2014) Constraint-based models predict metabolic and associated cellular functions. Nat Rev Genet 15(2):107-120.
-
(2014)
Nat Rev Genet
, vol.15
, Issue.2
, pp. 107-120
-
-
Bordbar, A.1
Monk, J.M.2
King, Z.A.3
Palsson, B.O.4
-
31
-
-
28844441230
-
A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis
-
Janes KA, et al. (2005) A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis. Science 310(5754):1646-1653.
-
(2005)
Science
, vol.310
, Issue.5754
, pp. 1646-1653
-
-
Janes, K.A.1
-
32
-
-
84864369297
-
Mechanism-independent method for predicting response to multidrug combinations in bacteria
-
Wood K, Nishida S, Sontag ED, Cluzel P (2012) Mechanism-independent method for predicting response to multidrug combinations in bacteria. Proc Natl Acad Sci USA 109(30):12254-12259.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, Issue.30
, pp. 12254-12259
-
-
Wood, K.1
Nishida, S.2
Sontag, E.D.3
Cluzel, P.4
-
33
-
-
84945472787
-
Unconventional screening approaches for antibiotic discovery
-
Farha MA, Brown ED (2015) Unconventional screening approaches for antibiotic discovery. Ann N Y Acad Sci 1354(1):54-66.
-
(2015)
Ann N Y Acad Sci
, vol.1354
, Issue.1
, pp. 54-66
-
-
Farha, M.A.1
Brown, E.D.2
-
34
-
-
84892778654
-
A network inference method for large-scale unsupervised identification of novel drug-drug interactions
-
Guimerà R, Sales-Pardo M (2013) A network inference method for large-scale unsupervised identification of novel drug-drug interactions. PLOS Comput Biol 9(12): e1003374.
-
(2013)
PLOS Comput Biol
, vol.9
, Issue.12
, pp. e1003374
-
-
Guimerà, R.1
Sales-Pardo, M.2
-
35
-
-
84886714080
-
Bayesian active learning for drug combinations
-
Park M, Nassar M, Vikalo H (2013) Bayesian active learning for drug combinations. IEEE Trans Biomed Eng 60(11):3248-3255.
-
(2013)
IEEE Trans Biomed Eng
, vol.60
, Issue.11
, pp. 3248-3255
-
-
Park, M.1
Nassar, M.2
Vikalo, H.3
-
36
-
-
84931563239
-
Rapid optimization of drug combinations for the optimal angiostatic treatment of cancer
-
Weiss A, et al. (2015) Rapid optimization of drug combinations for the optimal angiostatic treatment of cancer. Angiogenesis 18(3):233-244.
-
(2015)
Angiogenesis
, vol.18
, Issue.3
, pp. 233-244
-
-
Weiss, A.1
-
37
-
-
84942795835
-
A streamlined search technology for identification of synergistic drug combinations
-
Weiss A, et al. (2015) A streamlined search technology for identification of synergistic drug combinations. Sci Rep 5:14508.
-
(2015)
Sci Rep
, vol.5
, pp. 14508
-
-
Weiss, A.1
-
38
-
-
33748794547
-
Heoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies
-
Chou T-C (2006) Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacol Rev 58(3): 621-681.
-
(2006)
Pharmacol Rev
, vol.58
, Issue.3
, pp. 621-681
-
-
Chou, T.-C.1
-
39
-
-
76549129820
-
Drug combination studies and their synergy quantification using the Chou-Talalay method
-
Chou T-C (2010) Drug combination studies and their synergy quantification using the Chou-Talalay method. Cancer Res 70(2):440-446.
-
(2010)
Cancer Res
, vol.70
, Issue.2
, pp. 440-446
-
-
Chou, T.-C.1
-
40
-
-
0027381867
-
Taxol in combination with doxorubicin or etoposide. Possible antagonism in vitro
-
Hahn SM, et al. (1993) Taxol in combination with doxorubicin or etoposide. Possible antagonism in vitro. Cancer 72(9):2705-2711.
-
(1993)
Cancer
, vol.72
, Issue.9
, pp. 2705-2711
-
-
Hahn, S.M.1
-
41
-
-
0029100273
-
Taxanes: A new class of antitumor agents
-
Huizing MT, et al. (1995) Taxanes: A new class of antitumor agents. Cancer Invest 13(4):381-404.
-
(1995)
Cancer Invest
, vol.13
, Issue.4
, pp. 381-404
-
-
Huizing, M.T.1
-
42
-
-
0033778922
-
Sequence dependent effect of paclitaxel on gemcitabine metabolism in relation to cell cycle and cytotoxicity in non-small-cell lung cancer cell lines
-
Kroep JR, et al. (2000) Sequence dependent effect of paclitaxel on gemcitabine metabolism in relation to cell cycle and cytotoxicity in non-small-cell lung cancer cell lines. Br J Cancer 83(8):1069-1076.
-
(2000)
Br J Cancer
, vol.83
, Issue.8
, pp. 1069-1076
-
-
Kroep, J.R.1
-
43
-
-
84877080561
-
Genotype to phenotype mapping and the fitness landscape of the E. Coli lac promoter
-
Otwinowski J, Nemenman I (2013) Genotype to phenotype mapping and the fitness landscape of the E. coli lac promoter. PLoS ONE 8(5):e61570.
-
(2013)
PLoS ONE
, vol.8
, Issue.5
, pp. e61570
-
-
Otwinowski, J.1
Nemenman, I.2
-
44
-
-
33646170322
-
Weak pairwise correlations imply strongly correlated network states in a neural population
-
Schneidman E, Berry MJ, Segev R, Bialek W (2006) Weak pairwise correlations imply strongly correlated network states in a neural population. Nature 440:1007-1012.
-
(2006)
Nature
, vol.440
, pp. 1007-1012
-
-
Schneidman, E.1
Berry, M.J.2
Segev, R.3
Bialek, W.4
-
46
-
-
33845762340
-
Multi-target therapeutics: When the whole is greater than the sum of the parts
-
Zimmermann GR, Lehár J, Keith CT (2007) Multi-target therapeutics: When the whole is greater than the sum of the parts. Drug Discov Today 12(1-2):34-42.
-
(2007)
Drug Discov Today
, vol.12
, Issue.1-2
, pp. 34-42
-
-
Zimmermann, G.R.1
Lehár, J.2
Keith, C.T.3
-
47
-
-
65649124513
-
Drug interactions and the evolution of antibiotic resistance
-
Yeh PJ, Hegreness MJ, Aiden AP, Kishony R (2009) Drug interactions and the evolution of antibiotic resistance. Nat Rev Microbiol 7(6):460-466.
-
(2009)
Nat Rev Microbiol
, vol.7
, Issue.6
, pp. 460-466
-
-
Yeh, P.J.1
Hegreness, M.J.2
Aiden, A.P.3
Kishony, R.4
-
48
-
-
0027131605
-
Salicylate induction of antibiotic resistance in Escherichia coli: Activation of the mar operon and a mar-independent pathway
-
Cohen SP, Levy SB, Foulds J, Rosner JL (1993) Salicylate induction of antibiotic resistance in Escherichia coli: Activation of the mar operon and a mar-independent pathway. J Bacteriol 175(24):7856-7862.
-
(1993)
J Bacteriol
, vol.175
, Issue.24
, pp. 7856-7862
-
-
Cohen, S.P.1
Levy, S.B.2
Foulds, J.3
Rosner, J.L.4
|