-
1
-
-
4644343922
-
Bacterial persistence as a phenotypic switch
-
Balaban N.Q., Merrin J., Chait R., Kowalik L., Leibler S. Bacterial persistence as a phenotypic switch. Science 2004, 305:1622-1625.
-
(2004)
Science
, vol.305
, pp. 1622-1625
-
-
Balaban, N.Q.1
Merrin, J.2
Chait, R.3
Kowalik, L.4
Leibler, S.5
-
2
-
-
0344437730
-
The calculation of microbial assays
-
Bliss C.I. The calculation of microbial assays. Bacteriol. Rev. 1956, 20:243-258.
-
(1956)
Bacteriol. Rev.
, vol.20
, pp. 243-258
-
-
Bliss, C.I.1
-
3
-
-
79955966186
-
Resolution of gene regulatory conflicts caused by combinations of antibiotics
-
Bollenbach T., Kishony R. Resolution of gene regulatory conflicts caused by combinations of antibiotics. Mol. Cell 2011, 42:413-425.
-
(2011)
Mol. Cell
, vol.42
, pp. 413-425
-
-
Bollenbach, T.1
Kishony, R.2
-
4
-
-
70350769418
-
Nonoptimal microbial response to antibiotics underlies suppressive drug interactions
-
Bollenbach T., Quan S., Chait R., Kishony R. Nonoptimal microbial response to antibiotics underlies suppressive drug interactions. Cell 2009, 139:707-718.
-
(2009)
Cell
, vol.139
, pp. 707-718
-
-
Bollenbach, T.1
Quan, S.2
Chait, R.3
Kishony, R.4
-
5
-
-
34247277741
-
Antibiotic interactions that select against resistance
-
Chait R., Craney A., Kishony R. Antibiotic interactions that select against resistance. Nature 2007, 446:668-671.
-
(2007)
Nature
, vol.446
, pp. 668-671
-
-
Chait, R.1
Craney, A.2
Kishony, R.3
-
6
-
-
0024400856
-
Cross-resistance to fluoroquinolones in multiple-antibiotic-resistant (Mar) Escherichia coli selected by tetracycline or chloramphenicol: decreased drug accumulation associated with membrane changes in addition to OmpF reduction
-
Cohen S.P., McMurry L.M., Hooper D.C., Wolfson J.S., Levy S.B. Cross-resistance to fluoroquinolones in multiple-antibiotic-resistant (Mar) Escherichia coli selected by tetracycline or chloramphenicol: decreased drug accumulation associated with membrane changes in addition to OmpF reduction. Antimicrob. Agents Chemother. 1989, 33:1318-1325.
-
(1989)
Antimicrob. Agents Chemother.
, vol.33
, pp. 1318-1325
-
-
Cohen, S.P.1
McMurry, L.M.2
Hooper, D.C.3
Wolfson, J.S.4
Levy, S.B.5
-
7
-
-
60149109533
-
Looking ahead in cancer stem cell research
-
Dick J.E. Looking ahead in cancer stem cell research. Nat. Biotechnol. 2009, 27:44-46.
-
(2009)
Nat. Biotechnol.
, vol.27
, pp. 44-46
-
-
Dick, J.E.1
-
8
-
-
34249075147
-
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
-
Engelman J.A., Zejnullahu K., Mitsudomi T., Song Y., Hyland C., Park J.O., Lindeman N., Gale C.M., Zhao X., Christensen J., et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 2007, 316:1039-1043.
-
(2007)
Science
, vol.316
, pp. 1039-1043
-
-
Engelman, J.A.1
Zejnullahu, K.2
Mitsudomi, T.3
Song, Y.4
Hyland, C.5
Park, J.O.6
Lindeman, N.7
Gale, C.M.8
Zhao, X.9
Christensen, J.10
-
9
-
-
50149090966
-
Variability and robustness in Tcell activation from regulated heterogeneity in protein levels
-
Feinerman O., Veiga J., Dorfman J.R., Germain R.N., Altan-Bonnet G. Variability and robustness in Tcell activation from regulated heterogeneity in protein levels. Science 2008, 321:1081-1084.
-
(2008)
Science
, vol.321
, pp. 1081-1084
-
-
Feinerman, O.1
Veiga, J.2
Dorfman, J.R.3
Germain, R.N.4
Altan-Bonnet, G.5
-
10
-
-
33747620519
-
Systems biology and combination therapy in the quest for clinical efficacy
-
Fitzgerald J.B., Schoeberl B., Nielsen U.B., Sorger P.K. Systems biology and combination therapy in the quest for clinical efficacy. Nat. Chem. Biol. 2006, 2:458-466.
-
(2006)
Nat. Chem. Biol.
, vol.2
, pp. 458-466
-
-
Fitzgerald, J.B.1
Schoeberl, B.2
Nielsen, U.B.3
Sorger, P.K.4
-
11
-
-
79955515280
-
Resistance to HER2-directed antibodies and tyrosine kinase inhibitors: mechanisms and clinical implications
-
Garrett J.T., Arteaga C.L. Resistance to HER2-directed antibodies and tyrosine kinase inhibitors: mechanisms and clinical implications. Cancer Biol. Ther. 2011, 11:793-800.
-
(2011)
Cancer Biol. Ther.
, vol.11
, pp. 793-800
-
-
Garrett, J.T.1
Arteaga, C.L.2
-
12
-
-
84858424089
-
Converting cancer therapies into cures: lessons from infectious diseases
-
Glickman M.S., Sawyers C.L. Converting cancer therapies into cures: lessons from infectious diseases. Cell 2012, 148:1089-1098.
-
(2012)
Cell
, vol.148
, pp. 1089-1098
-
-
Glickman, M.S.1
Sawyers, C.L.2
-
13
-
-
0029036955
-
The search for synergy: a critical review from a response surface perspective
-
Greco W.R., Bravo G., Parsons J.C. The search for synergy: a critical review from a response surface perspective. Pharmacol. Rev. 1995, 47:331-385.
-
(1995)
Pharmacol. Rev.
, vol.47
, pp. 331-385
-
-
Greco, W.R.1
Bravo, G.2
Parsons, J.C.3
-
14
-
-
68749099671
-
Identification of selective inhibitors of cancer stem cells by high-throughput screening
-
Gupta P.B., Onder T.T., Jiang G., Tao K., Kuperwasser C., Weinberg R.A., Lander E.S. Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell 2009, 138:645-659.
-
(2009)
Cell
, vol.138
, pp. 645-659
-
-
Gupta, P.B.1
Onder, T.T.2
Jiang, G.3
Tao, K.4
Kuperwasser, C.5
Weinberg, R.A.6
Lander, E.S.7
-
15
-
-
0034609791
-
The large-scale organization of metabolic networks
-
Jeong H., Tombor B., Albert R., Oltvai Z.N., Barabási A.L. The large-scale organization of metabolic networks. Nature 2000, 407:651-654.
-
(2000)
Nature
, vol.407
, pp. 651-654
-
-
Jeong, H.1
Tombor, B.2
Albert, R.3
Oltvai, Z.N.4
Barabási, A.L.5
-
16
-
-
78650309875
-
COT drives resistance to RAF inhibition through MAP kinase pathway reactivation
-
Johannessen C.M., Boehm J.S., Kim S.Y., Thomas S.R., Wardwell L., Johnson L.A., Emery C.M., Stransky N., Cogdill A.P., Barretina J., et al. COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. Nature 2010, 468:968-972.
-
(2010)
Nature
, vol.468
, pp. 968-972
-
-
Johannessen, C.M.1
Boehm, J.S.2
Kim, S.Y.3
Thomas, S.R.4
Wardwell, L.5
Johnson, L.A.6
Emery, C.M.7
Stransky, N.8
Cogdill, A.P.9
Barretina, J.10
-
18
-
-
84859574722
-
Selective sweeps in growing microbial colonies
-
Korolev K.S., Müller M.J., Karahan N., Murray A.W., Hallatschek O., Nelson D.R. Selective sweeps in growing microbial colonies. Phys. Biol. 2012, 9:026008.
-
(2012)
Phys. Biol.
, vol.9
, pp. 026008
-
-
Korolev, K.S.1
Müller, M.J.2
Karahan, N.3
Murray, A.W.4
Hallatschek, O.5
Nelson, D.R.6
-
19
-
-
33847643207
-
Chemical combination effects predict connectivity in biological systems
-
Lehár J., Zimmermann G.R., Krueger A.S., Molnar R.A., Ledell J.T., Heilbut A.M., Short G.F., Giusti L.C., Nolan G.P., Magid O.A., et al. Chemical combination effects predict connectivity in biological systems. Mol. Syst. Biol. 2007, 3:80.
-
(2007)
Mol. Syst. Biol.
, vol.3
, pp. 80
-
-
Lehár, J.1
Zimmermann, G.R.2
Krueger, A.S.3
Molnar, R.A.4
Ledell, J.T.5
Heilbut, A.M.6
Short, G.F.7
Giusti, L.C.8
Nolan, G.P.9
Magid, O.A.10
-
20
-
-
54249089813
-
Combination chemical genetics
-
Lehár J., Stockwell B.R., Giaever G., Nislow C. Combination chemical genetics. Nat. Chem. Biol. 2008, 4:674-681.
-
(2008)
Nat. Chem. Biol.
, vol.4
, pp. 674-681
-
-
Lehár, J.1
Stockwell, B.R.2
Giaever, G.3
Nislow, C.4
-
21
-
-
10944272743
-
Antibacterial resistance worldwide: causes, challenges and responses
-
Levy S.B., Marshall B. Antibacterial resistance worldwide: causes, challenges and responses. Nat. Med. 2004, 10(12, Suppl):S122-S129.
-
(2004)
Nat. Med.
, vol.10
, Issue.12 SUPPL.
-
-
Levy, S.B.1
Marshall, B.2
-
22
-
-
0001663843
-
The problem of synergism and antagonism of combined drugs
-
Loewe S. The problem of synergism and antagonism of combined drugs. Arzneimittelforschung 1953, 3:285-290.
-
(1953)
Arzneimittelforschung
, vol.3
, pp. 285-290
-
-
Loewe, S.1
-
23
-
-
49649118852
-
Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma
-
Montagut C., Sharma S.V., Shioda T., McDermott U., Ulman M., Ulkus L.E., Dias-Santagata D., Stubbs H., Lee D.Y., Singh A., et al. Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma. Cancer Res. 2008, 68:4853-4861.
-
(2008)
Cancer Res.
, vol.68
, pp. 4853-4861
-
-
Montagut, C.1
Sharma, S.V.2
Shioda, T.3
McDermott, U.4
Ulman, M.5
Ulkus, L.E.6
Dias-Santagata, D.7
Stubbs, H.8
Lee, D.Y.9
Singh, A.10
-
24
-
-
79959222212
-
Genetic basis for daptomycin resistance in enterococci
-
Palmer K.L., Daniel A., Hardy C., Silverman J., Gilmore M.S. Genetic basis for daptomycin resistance in enterococci. Antimicrob. Agents Chemother. 2011, 55:3345-3356.
-
(2011)
Antimicrob. Agents Chemother.
, vol.55
, pp. 3345-3356
-
-
Palmer, K.L.1
Daniel, A.2
Hardy, C.3
Silverman, J.4
Gilmore, M.S.5
-
25
-
-
78650179829
-
Interdependence of behavioural variability and response to small stimuli in bacteria
-
Park H., Pontius W., Guet C.C., Marko J.F., Emonet T., Cluzel P. Interdependence of behavioural variability and response to small stimuli in bacteria. Nature 2010, 468:819-823.
-
(2010)
Nature
, vol.468
, pp. 819-823
-
-
Park, H.1
Pontius, W.2
Guet, C.C.3
Marko, J.F.4
Emonet, T.5
Cluzel, P.6
-
26
-
-
78651418282
-
Mutant BRAF melanomas-dependence and resistance
-
Poulikakos P.I., Rosen N. Mutant BRAF melanomas-dependence and resistance. Cancer Cell 2011, 19:11-15.
-
(2011)
Cancer Cell
, vol.19
, pp. 11-15
-
-
Poulikakos, P.I.1
Rosen, N.2
-
27
-
-
1642389369
-
Daptomycin synergy with rifampicin and ampicillin against vancomycin-resistant enterococci
-
Rand K.H., Houck H. Daptomycin synergy with rifampicin and ampicillin against vancomycin-resistant enterococci. J.Antimicrob. Chemother. 2004, 53:530-532.
-
(2004)
J.Antimicrob. Chemother.
, vol.53
, pp. 530-532
-
-
Rand, K.H.1
Houck, H.2
-
28
-
-
0035499267
-
Stem cells, cancer, and cancer stem cells
-
Reya T., Morrison S.J., Clarke M.F., Weissman I.L. Stem cells, cancer, and cancer stem cells. Nature 2001, 414:105-111.
-
(2001)
Nature
, vol.414
, pp. 105-111
-
-
Reya, T.1
Morrison, S.J.2
Clarke, M.F.3
Weissman, I.L.4
-
29
-
-
84861995326
-
Identification of drugs including a dopamine receptor antagonist that selectively target cancer stem cells
-
Sachlos E., Risueño R.M., Laronde S., Shapovalova Z., Lee J.H., Russell J., Malig M., McNicol J.D., Fiebig-Comyn A., Graham M., et al. Identification of drugs including a dopamine receptor antagonist that selectively target cancer stem cells. Cell 2012, 149:1284-1297.
-
(2012)
Cell
, vol.149
, pp. 1284-1297
-
-
Sachlos, E.1
Risueño, R.M.2
Laronde, S.3
Shapovalova, Z.4
Lee, J.H.5
Russell, J.6
Malig, M.7
McNicol, J.D.8
Fiebig-Comyn, A.9
Graham, M.10
-
30
-
-
78449268845
-
Interdependence of cell growth and gene expression: origins and consequences
-
Scott M., Gunderson C.W., Mateescu E.M., Zhang Z., Hwa T. Interdependence of cell growth and gene expression: origins and consequences. Science 2010, 330:1099-1102.
-
(2010)
Science
, vol.330
, pp. 1099-1102
-
-
Scott, M.1
Gunderson, C.W.2
Mateescu, E.M.3
Zhang, Z.4
Hwa, T.5
-
31
-
-
84861663597
-
Evolutionary trade-offs, Pareto optimality, and the geometry of phenotype space
-
Shoval O., Sheftel H., Shinar G., Hart Y., Ramote O., Mayo A., Dekel E., Kavanagh K., Alon U. Evolutionary trade-offs, Pareto optimality, and the geometry of phenotype space. Science 2012, 336:1157-1160.
-
(2012)
Science
, vol.336
, pp. 1157-1160
-
-
Shoval, O.1
Sheftel, H.2
Shinar, G.3
Hart, Y.4
Ramote, O.5
Mayo, A.6
Dekel, E.7
Kavanagh, K.8
Alon, U.9
-
32
-
-
84880952364
-
The strength of genetic interactions scales weakly with mutational effects
-
Velenich A., Gore J. The strength of genetic interactions scales weakly with mutational effects. Genome Biol. 2013, 14:R76.
-
(2013)
Genome Biol.
, vol.14
-
-
Velenich, A.1
Gore, J.2
-
33
-
-
84861392612
-
Trade-offs between drug toxicity and benefit in the multi-antibiotic resistance system underlie optimal growth of E. coli
-
Wood K.B., Cluzel P. Trade-offs between drug toxicity and benefit in the multi-antibiotic resistance system underlie optimal growth of E. coli. BMC Syst. Biol. 2012, 6:48.
-
(2012)
BMC Syst. Biol.
, vol.6
, pp. 48
-
-
Wood, K.B.1
Cluzel, P.2
-
34
-
-
84861133652
-
MicroSCALE screening reveals genetic modifiers of therapeutic response in melanoma
-
Wood K.C., Konieczkowski D.J., Johannessen C.M., Boehm J.S., Tamayo P., Botvinnik O.B., Mesirov J.P., Hahn W.C., Root D.E., Garraway L.A., Sabatini D.M. MicroSCALE screening reveals genetic modifiers of therapeutic response in melanoma. Sci. Signal. 2012, 5:rs4.
-
(2012)
Sci. Signal.
, vol.5
-
-
Wood, K.C.1
Konieczkowski, D.J.2
Johannessen, C.M.3
Boehm, J.S.4
Tamayo, P.5
Botvinnik, O.B.6
Mesirov, J.P.7
Hahn, W.C.8
Root, D.E.9
Garraway, L.A.10
Sabatini, D.M.11
-
35
-
-
84863600752
-
Combined EGFR/MET or EGFR/HSP90 inhibition is effective in the treatment of lung cancers codriven by mutant EGFR containing T790M and MET
-
Xu L., Kikuchi E., Xu C., Ebi H., Ercan D., Cheng K.A., Padera R., Engelman J.A., Jänne P.A., Shapiro G.I., et al. Combined EGFR/MET or EGFR/HSP90 inhibition is effective in the treatment of lung cancers codriven by mutant EGFR containing T790M and MET. Cancer Res. 2012, 72:3302-3311.
-
(2012)
Cancer Res.
, vol.72
, pp. 3302-3311
-
-
Xu, L.1
Kikuchi, E.2
Xu, C.3
Ebi, H.4
Ercan, D.5
Cheng, K.A.6
Padera, R.7
Engelman, J.A.8
Jänne, P.A.9
Shapiro, G.I.10
-
36
-
-
33645396484
-
Functional classification of drugs by properties of their pairwise interactions
-
Yeh P., Tschumi A.I., Kishony R. Functional classification of drugs by properties of their pairwise interactions. Nat. Genet. 2006, 38:489-494.
-
(2006)
Nat. Genet.
, vol.38
, pp. 489-494
-
-
Yeh, P.1
Tschumi, A.I.2
Kishony, R.3
|