Animal pet research with non-human primates for drug development in pre-clinical stage — the hamamatsu experience

Trends on the Role of PET in Drug Development

Volumn , Issue , 2012, Pages 241-259

  Tsukada, Hideo ^a  

^a CENTRAL RESEARCH LABORATORY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84986588484     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1142/9789814317740_0010     Document Type: Chapter

References (45)

1. Abi-Dargham A, Mawlawi O, et al. Prefrontal dopamine D1 receptors and working memory in schizophrenia. J Neurosci 2002; 22: 3708-3719.
2. Cui Y, Takamatsu H, et al. Neuroprotection by a CNS-type prostacyclin receptor ligand in middle cerebral artery occlusion and reperfusion model of monkeys: a positron emission tomography study. Stroke 2006; 37: 2830-2836.
3. Deutch AY, Tam SY, et al. Mesolimbic and mesocortical dopamine activation induced by phencyclidine: contrasting pattern to striatal response. Eur J Pharmacol 1987;134: 257-264.
4. Domino EF, Tsukada H. Nicotine normalization or sensitization of monkey striatal dopamine release. Eur J Pharmacol 2009a; 607: 91-95.
5. Domino EF, Harada N, et al. Positron emission tomographic measure of brain dopamine dependence to nicotine as a model of drugs of abuse. Psychopharm 2009b; 204: 149-153.
6. Goldman-Rakic PS. Circuitry of prefrontal cortex and the regulation of behavior by representational knowledge. In: Handbook of Physiology (eds.) F Plum F, V Mountcasle V. Bethesda: American Physiological Society, 1987, pp. 373-412.
7. Harada N, Nishiyama S, et al. Age-related changes in the striatal dopaminergic system in the living brain: a multiparametric PET study in conscious monkeys. Synapse 2002a; 45: 38-45.
8. Harada N, Ohba H, et al. Age differences of phosphodiesterase type-IV and its functional response to dopamine Dj receptor modulation in the living brain: a PET study in conscious monkeys. Synapse 2002b; 44: 139-145.
9. 11C]CHIBA-1001 as a novel PET ligand for alpha-7 nicotinic receptors in the brain: A PET study in conscious monkeys. PLoS ONE 2008a; 3: e3231.
10. Hashimoto K, Ishima T, et al. Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the novel selective a7 nicotinic receptor agonist SSR180711. Biol. Psychiat2008b; 63: 92-97.
11. Hohmann C, Antuono P, et al. Basal forebrain cholinergic neurons and Alzheimer’s disease. In: Psychopharmacology of the aging Nervous System (eds.) LL Iversen, SD Iversen, SD Snyder. New York: Plenum, 1998, pp.69-106.
12. Irie T, Fukushi K, et al. Design and evaluation of radioactive analogues for mapping brain acetylcholinesterase (AChE) in vivo. Nucl Med Biol 1994; 21: 801-808.
13. Javitt DC, Zukin SR. Recent advances in phencyclidine model of schizophrenia. Am J Psychiat 1991; 148: 1301-1308.
14. 2A receptors: PET study in the conscious monkey brain. Brain Res 2000; 883: 135-142.
15. 11C](-)McN5652 in conscious monkeys. Synapse 2001; 40: 170-179.
16. Kawaguchi A, Fukumoto D, et al. Liposome-encapsulated hemoglobin reduced the size of cerebral infarction in the rat: evaluation with photochemically induced thrombosis of the middle cerebral artery. Stroke 2007; 38: 1626-1632.
17. Klunk WE, Wang Y, et al. Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain. Life Sci 2001; 69: 1471-1484.
18. Muramatsu S, Okuno T, et al. Multi-tracer assessment of dopamine function after transplantation of embryonic stem cell-derived neural stem cells in a primate model of Parkinson’s disease. Synapse 2009; 63: 541-548.
19. Muramatsu S, Tsukada H, et al. Gene therapy for Parkinson’s disease using recombinant adeno-associated viral vectors. Exp Opin Biol Ther 2005; 5: 667-671.
20. Nishimura Y, Onoe H, et al. Time-dependent central compensatory mechanism of finger dexterity after spinal-cord injury. Science 2007; 318: 1150-1155.
21. 11C]methyl-3-piperidyl benzilate in the conscious monkey brain. Synapse 2001; 40: 159-169.
22. 18F]FDDNP. Synapse 2008; 62: 472-475.
23. Noda A, Takamatsu H, et al. Determination of kinetic rate constants for FDG and partition coefficient of water in conscious macaque and alterations in aging or anesthesia examined on parametric images with an anatomic standardization technique. J Cereb Blood Flow Metab 2003; 23: 1441-1447.
24. 2 receptors and response to methamphetamine challenge in monkey brain. Synapse 2009; 63: 534-537.
25. nC]3NMPB enantiomers in rats for studying muscarinic cholinergic receptors using PET. JLabe//ed Compds Rad 1997; 40: 613-615.
26. Takamatsu H, Tsukada H, et al. Detection of reperfusion injury using positron emission tomography in a monkey model of cerebral ischemia. J Nuc/Med, 2000; 41:1409-1416.
27. Takamatsu H, Tsukada H, et al. FK506 attenuates early neuronal death in a monkey model of stroke. J Nuc/Med 2001; 42: 1833-1840.
28. 2 receptors in the rat brain: an in vivo study using positron emission tomography. J Neurosci 1996; 16: 7670-7677.
29. Tsukada H, Nishiyama S, et al. Isoflurane anesthesia enhances the inhibitory effects of cocaine and GBR12909 on dopamine transporter: PET studies in combination with microdialysis in the monkey brain. Brain Res 1999; 849: 85-96.
30. 2 receptor availability in vivo by regulating receptor affinity induced by facilitated synaptic dopamine turnover: PET studies with microdialysis in the conscious monkey brain. J Neurosci 2000a; 20: 7067-7073.
31. nC]raclopride binding with no alterations in static dopamine concentrations in the striatal extracellular fluid in the monkey brain: multi-parametric PET studies combined with microdialysis analysis. Synapse 2000b; 37: 95-103.
32. 1 receptors: PET studies in the conscious monkey brain. Synapse 2001a; 42: 258-265.
33. 11C]WAY-100635 in conscious monkeys. Synapse 2001b; 42: 242-251.
34. nC]methyl-3-piperidyl benzilate in the brains of conscious monkeys. Synapse 2001c; 41: 248-257.
35. nC]P-CIT-FE in the monkey brain. Synapse 2001d; 42: 273-280.
36. nC]4-MPB. Synapse 2001e; 39: 182-192.
37. nC]raclopride binding in unanesthetized monkeys. Synapse 2002; 45: 207-212.
38. 1A receptors in the living monkey brain: a PET study using microdialysis. J Cereb Blood Flow Metab 2004a; 24: 898-906.
39. Tsukada H, Nishiyama S, et al. Effects of acute acetylcholinestrase inhibition on the cerebral cholinergic neuronal system and cognitive function: functional imaging of the conscious monkey brain using animal PET in combination with microdialysis. Synapse 2004b; 52: 1-10.
40. nC]raclopride binding in the conscious monkey brain. Synapse 2005a; 57: 120-122.
41. 1 receptor binding and decreased working memory performance produced by repeated pretreatment with MK-801: a PET study in conscious monkeys. Neuropsychopharmacology 2005b; 30: 2144-2153.
42. 1 receptor binding in prefrontal cortex of conscious monkeys. Neuropsychopharmacology 2005c; 30: 1861-1869.
43. Umemura K, Tsukada H, et al. Positron emission tomographic study of the neuroprotective effect of TRA-418, an anti-platelet agent, in a monkey model of stroke. J Nucl Med 2005; 46: 1931-1936.
44. Watanabe M, Okada H, et al. A high resolution animal PET scanner using compact PS-PMT detectors. IEEE Trans Nucl Sci 1997; 44: 1277-1282.
45. Yokoyama C, Tsukada H, et al. A dynamic shift of neural network activity before and after learning-set formation. Cereb Cortex 2005; 15: 796-801.