Neuroprotection by a central nervous system-type prostacyclin receptor ligand demonstrated in monkeys subjected to middle cerebral artery occlusion and reperfusion: A positron emission tomography study

Stroke

Volumn 37, Issue 11, 2006, Pages 2830-2836

  Cui, Yilong ^a,b   Takamatsu, Hiroyuki ^c,d   Kakiuchi, Takeharu ^d   Ohba, Hiroyuki ^d   Kataoka, Yosky ^a,b   Yokoyama, Chihiro ^a   Onoe, Hirotaka ^a,d   Watanabe, Yumiko ^a,b   Hosoya, Takamitsu ^e   Suzuki, Masaaki ^a,e   Noyori, Ryoji ^f   Tsukada, Hideo ^c,d   Watanabe, Yasuyoshi ^a,b  

^a INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

^b OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c Hamamatsu Pharma Research   (Japan)

^d CENTRAL RESEARCH LABORATORY   (Japan)

^e GIFU UNIVERSITY   (Japan)

^f NAGOYA UNIVERSITY   (Japan)

Author keywords

Cerebral blood flow; Cerebral metabolic rate of oxygen; Middle cerebral artery occlusion; Oxygen extraction fraction; Prostacyclin receptor

Indexed keywords

16 META TOLYL 17,18,19,20 TETRANORISOCARBACYCLIN METHYL ESTER; INTRALIPOS; LIGAND; OXYGEN 15; PROSTACYCLIN RECEPTOR; 16 TOLYL 17,18,19,20 TETRANORISOCARBACYCLIN; 16-TOLYL-17,18,19,20-TETRANORISOCARBACYCLIN; DRUG DERIVATIVE; NEUROPROTECTIVE AGENT; PROSTACYCLIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD FLOW; BRAIN CIRCULATION; BRAIN CORTEX; BRAIN METABOLISM; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DIAGNOSTIC IMAGING; DRUG RECEPTOR BINDING; HEMODYNAMICS; HIPPOCAMPUS; IMAGE ANALYSIS; LIGAND BINDING; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MONKEY; NEUROPATHOLOGY; NEUROPROTECTION; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPERFUSION; STEADY STATE; ANIMAL; CEREBRAL ARTERY DISEASE; COMPARATIVE STUDY; MACACA; METABOLISM; METHODOLOGY; REPERFUSION INJURY; SCINTISCANNING;

ANIMALS; CENTRAL NERVOUS SYSTEM; EPOPROSTENOL; INFARCTION, MIDDLE CEREBRAL ARTERY; LIGANDS; MACACA FASCICULARIS; MALE; NEUROPROTECTIVE AGENTS; POSITRON-EMISSION TOMOGRAPHY; RECEPTORS, EPOPROSTENOL; REPERFUSION INJURY;

EID: 33750964739     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.0000245088.60282.22     Document Type: Article

References (23)

1. Moncada S. Eighth gaddum memorial lecture. University of london institute of education, december 1980. Biological importance of prostacyclin. Br J Pharmacol. 1982;76:3-31.
2. Gryglewski RJ, Nowak S, Kostka-Trabka E, Kusmiderski J, Dembinska-Kiec A, Bieron K, Basista M, Blaszczyk B. Treatment of ischaemic stroke with prostacyclin. Stroke. 1983;14:197-202.
3. Pluta R. Influence of prostacyclin on early morphological changes in the rabbit brain after complete 20-min ischemia. J Neurol Sci. 1985;70:305-316.
4. Hughes JT, Schianchi PM. Cerebral artery spasm. A histological study at necropsy of the blood vessels in cases of subarachnoid hemorrhage. J Neurosurg. 1978;48:515-525.
5. Takechi H, Matsumura K, Watanabe Yu, Kato K, Noyori R, Suzuki M, Watanabe Y. A novel subtype of the prostacyclin receptor expressed in the central nervous system. J Biol Chem. 1996;271:5901-5906.
6. Watanabe Yu, Matsumura K, Takechi H, Kato K, Morii H, Bjorkman M, Langstrom B, Noyori R, Suzuki M, Watanabe Y. A novel subtype of prostacyclin receptor in the central nervous system. J Neurochem. 1999;72:2583-2592.
7. Suzuki M, Kato K, Noyori R, Watanabe Yu, Takechi H, Matsumura K, Langstrom B, Watanabe Y. (15r)-16-m-tolyl-17,18,19,20-tetranoisocarbacyclin: A stable ligand with high binding affinity and selectivity for prostacyclin receptor in the central nervous system. Angew Chem Int Ed Engl. 1996;35:334-336.
8. Takamatsu H, Tsukada H, Watanabe Yu, Cui Y, Kataoka Y, Hosoya T, Suzuki M, Watanabe Y. Specific ligand for a central type prostacyclin receptor attenuates neuronal damage in a rat model of focal cerebral ischemia. Brain Res. 2002;925:176-182.
9. Cui Y, Kataoka Y, Satoh T, Yamagata A, Shirakawa N, Watanabe Yu, Suzuki M, Yanase H, Kataoka K, Watanabe Y. Protective effect of prostaglandin i(2) analogs on ischemic delayed neuronal damage in gerbils. Biochem Biophys Res Commun. 1999;265:301-304.
10. Satoh T, Ishikawa Y, Kataoka Y, Cui Y, Yanase H, Kato K, Watanabe Yu, Nakadate K, Matsumura K, Hatanaka H, Kataoka K, Noyori R, Suzuki M, Watanabe Y. CNS-specific prostacyclin ligands as neuronal survival-promoting factors in the brain. Eur J Neurosci. 1999;11:3115-3124.
11. Enblad P, Frykholm P, Valtysson J, Silander HC, Andersson J, Fasth KJ, Watanabe Y, Langstrom B, Hillered L, Persson L. Middle cerebral artery occlusion and reperfusion in primates monitored by microdialysis and sequential positron emission tomography. Stroke. 2001;32:1574-1580.
12. Frykholm P, Andersson JL, Valtysson J, Silander HC, Hillered L, Persson L, Olsson Y, Yu WR, Westerberg G, Watanabe Y, Langstrom B, Enblad P. A metabolic threshold of irreversible ischemia demonstrated by pet in a middle cerebral artery occlusion-reperfusion primate model. Acta Neurol Scand. 2000;102:18-26.
13. Wise RJ, Bernardi S, Frackowiak RS, Legg NJ, Jones T. Serial observations on the pathophysiology of acute stroke. The transition from ischaemia to infarction as reflected in regional oxygen extraction. Brain. 1983;106:197-222.
14. Pappata S, Fiorelli M, Rommel T, Hartmann A, Dettmers C, Yamaguchi T, Chabriat H, Poline JB, Crouzel C, Di Giamberardino L. PET study of changes in local brain hemodynamics and oxygen metabolism after unilateral middle cerebral artery occlusion in baboons. J Cereb Blood Flow Metab. 1993;13:416-424.
15. Takamatsu H, Tsukada H, Kakiuchi T, Nishiyama S, Noda A, Umemura K. Detection of reperfusion injury using pet in a monkey model of cerebral ischemia. J Nucl Med. 2000;41:1409-1416.
16. Touzani O, Young AR, Derlon JM, Beaudouin V, Marchal G, Rioux P, Mezenge F, Baron JC, MacKenzie ET. Sequential studies of severely hypometabolic tissue volumes after permanent middle cerebral artery occlusion. A positron emission tomographic investigation in anesthetized baboons. Stroke. 1995;26:2112-2119.
17. Recommendations for standards regarding preclinical neuroprotective and restorative drug development. Stroke. 1999;30:2752-2758.
18. Tsukada H, Fukumoto D, Nishiyama S, Sato K, Kakiuchi T. Transient focal ischemia affects the camp second messenger system and coupled dopamine d1 and 5-ht1a receptors in the living monkey brain: A positron emission tomography study using microdialysis. J Cereb Blood Flow Metab. 2004;24:898-906.
19. Umemura K, Tsukada H, Kakiuchi T, Yamada N, Matsuura H. Pet study of the neuroprotective effect of tra-418, an antiplatelet agent, in a monkey model of stroke. J Nucl Med. 2005;46:1931-1936.
20. Hudgins WR, Garcia JH. Transorbital approach to the middle cerebral artery of the squirrel monkey: A technique for experimental cerebral infarction applicable to ultrastructural studies. Stroke. 1970;1:107-111.
21. Frackowiak RS, Lenzi GL, Jones T, Heather JD. Quantitative measurement of regional cerebral blood flow and oxygen metabolism in man using 15o and positron emission tomography: Theory, procedure, and normal values. J Comput Assist Tomogr. 1980;4:727-736.
22. Sette G, Baron JC, Mazoyer B, Levasseur M, Pappata S, Crouzel C. Local brain haemodynamics and oxygen metabolism in cerebrovascular disease. Positron emission tomography. Brain. 1989;112:931-951.
23. Swanson RA, Morton MT, Tsao-Wu G, Savalos RA, Davidson C, Sharp FR. A semiautomated method for measuring brain infarct volume. J Cereb Blood Flow Metab. 1990;10:290-293.