Evaluation of PET ligands (+) N-[11C]ethyl-3-piperidyl benzilate and (+) N-[11C]propyl-3-piperidyl benzilate for muscarinic cholinergic receptors: A PET study with microdialysis in comparison with (+)N-[11C]methyl-3-piperidyl benzilate in the conscious monkey brain

Synapse

Volumn 40, Issue 3, 2001, Pages 159-169

  Nishiyama, Shingo ^a   Tsukada, Hideo ^a   Sato, Kengo ^a   Kakiuchi, Takeharu ^a   Ohba, Hiroyuki ^a   Harada, Norihiro ^a   Takahashi, Kazuhiro ^b  

^a HAMAMATSU PHOTONICS K K   (Japan)

^b RESEARCH INSTITUTE FOR BRAIN AND BLOOD VESSELS AKITA   (Japan)

Author keywords

(+)N 11C Ethyl 3 piperidyl benzilate; (+)N 11C Methyl 3 piperidyl benzilate; (+)N 11C Propyl 3 piperidyl benzilate; Aricept; Microdialysis; Monkey brain; Muscarinic cholinergic receptor; Positron emission tomography

Indexed keywords

ACETYLCHOLINE; BENZILIC ACID; CHOLINESTERASE INHIBITOR; DONEPEZIL; MUSCARINIC RECEPTOR; N ETHYL 3 PIPERIDYL BENZILATE C 11; N PROPYL 3 PIPERIDYL BENZILATE C 11; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN; BRAIN SLICE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG CLEARANCE; DRUG DISTRIBUTION; EXTRACELLULAR FLUID; ISOTOPE LABELING; LIGAND BINDING; MALE; MICRODIALYSIS; MONKEY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN ANALYSIS; RADIOACTIVITY; RAT; RECEPTOR AFFINITY; RECEPTOR DENSITY;

ANIMALS; BENZILATES; BINDING, COMPETITIVE; BRAIN; CARBON RADIOISOTOPES; CHOLINESTERASE INHIBITORS; CONSCIOUSNESS; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR FLUID; LIGANDS; MACACA MULATTA; MALE; METABOLIC CLEARANCE RATE; MICRODIALYSIS; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; ORGAN CULTURE TECHNIQUES; PIPERIDINES; POSITRON-EMISSION TOMOGRAPHY; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, MUSCARINIC; TIME FACTORS;

EID: 0035372008     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/syn.1038     Document Type: Article

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