High Glucose-Induced Oxidative Stress Mediates Apoptosis and Extracellular Matrix Metabolic Imbalances Possibly via p38 MAPK Activation in Rat Nucleus Pulposus Cells

Journal of Diabetes Research

Volumn 2016, Issue , 2016, Pages

  Cheng, Xiaofei ^a   Ni, Bin ^b   Zhang, Feng ^a   Hu, Ying ^c   Zhao, Jie ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c Shanghai Railway Bureau Center for Disease Control and Prevention   (China)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACETYLCYSTEINE; AGGRECAN; COLLAGEN TYPE 2; GLUCOSE; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSCRIPTION FACTOR SOX9; MESSENGER RNA; SCAVENGER; TISSUE INHIBITOR OF METALLOPROTEINASE-1 PROTEIN, RAT;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; EXTRACELLULAR MATRIX; GENE EXPRESSION; MALE; METABOLIC BALANCE; NONHUMAN; NUCLEUS PULPOSUS; OXIDATIVE STRESS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; CYTOLOGY; DRUG EFFECTS; GENETICS; HUMAN; HYPERGLYCEMIA; METABOLISM;

ACETYLCYSTEINE; AGGRECANS; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL SURVIVAL; CELLS, CULTURED; COLLAGEN TYPE II; EXTRACELLULAR MATRIX; FREE RADICAL SCAVENGERS; GLUCOSE; HUMANS; HYPERGLYCEMIA; MATRIX METALLOPROTEINASE 3; NUCLEUS PULPOSUS; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SOX9 TRANSCRIPTION FACTOR; TISSUE INHIBITOR OF METALLOPROTEINASE-1;

EID: 84985990097     PISSN: 23146745     EISSN: 23146753     Source Type: Journal    
DOI: 10.1155/2016/3765173     Document Type: Article

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