The mitochondrial fusion-related proteins Mfn2 and OPA1 are transcriptionally induced during differentiation of bone marrow progenitors to immature dendritic cells

Molecules and Cells

Volumn 38, Issue 1, 2014, Pages 89-94

  Ryu, Seung Wook ^a   Han, Eun Chun ^a   Yoon, Jonghee ^a   Choi, Chulhee ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

Differentiation; Immature dendritic cells; Mfn2; Migration; Mitochondrial dynamics; OPA1

Indexed keywords

CD86 ANTIGEN; CHEMOKINE RECEPTOR CCR7; GLYCOPROTEIN P 15095; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HYBRID PROTEIN; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; MITOCHONDRIAL FUSION RELATED PROTEINS OPA1; MITOCHONDRIAL PROTEIN; MITOFUSIN 2; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; CCR7 PROTEIN, MOUSE; GUANOSINE TRIPHOSPHATASE; MFN2 PROTEIN, MOUSE; OPA1 PROTEIN (GTPASE), MOUSE;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL MIGRATION; CELL SURFACE; DENDRITIC CELL; FEMALE; HEMATOPOIETIC STEM CELL; MITOCHONDRIAL DYNAMICS; MOUSE; NONHUMAN; PHENOTYPE; UPREGULATION; ANIMAL; BONE MARROW CELL; C57BL MOUSE; CELL CULTURE; CELL MOTION; CYTOLOGY; GENE SILENCING; GENETICS; PHYSIOLOGY;

ANIMALS; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL MOVEMENT; CELLS, CULTURED; DENDRITIC CELLS; FEMALE; GENE KNOCKDOWN TECHNIQUES; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; GTP PHOSPHOHYDROLASES; MICE; MICE, INBRED C57BL; MITOCHONDRIAL DYNAMICS; RECEPTORS, CCR7; UP-REGULATION;

EID: 84985911790     PISSN: 10168478     EISSN: 02191032     Source Type: Journal    
DOI: 10.14348/molcells.2015.2285     Document Type: Article

References (29)

1. Aihara, T., Nakamura, N., Honda, S., and Hirose, S. (2009). A novel potential role for gametogenetin-binding protein 1 (GGNBP1) in mitochondrial morphogenesis during spermatogenesis in mice. Biol. Reprod. 80, 762-770.
2. Bach, D., Pich, S., Soriano, F. X., Vega, N., Baumgartner, B., Oriola, J., Daugaard, J. R., Lloberas, J., Camps, M., Zierath, J. R., et al. (2003). Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism. A novel regulatory mechanism altered in obesity. J. Biol. Chem. 278, 17190-17197.
3. Banchereau, J., and Steinman, R. M. (1998). Dendritic cells and the control of immunity. Nature 392, 245-252.
4. Barbieri, E., Battistelli, M., Casadei, L., Vallorani, L., Piccoli, G., Guescini, M., Gioacchini, A. M., Polidori, E., Zeppa, S., Ceccaroli, P., et al. (2011). Morphofunctional and biochemical approaches for studying mitochondrial changes during myoblasts differentiation. J. Aging Res. 2011, 845379.
5. Bustos, R. I., Jensen, E. L., Ruiz, L. M., Rivera, S., Ruiz, S., Simon, F., Riedel, C., Ferrick, D., and Elorza, A. A. (2013). Copper deficiency alters cell bioenergetics and induces mitochondrial fusion through up-regulation of MFN2 and OPA1 in erythropoietic cells. Biochem. Biophys. Res. Commun. 437, 426-432.
6. Caffin, F., Prola, A., Piquereau, J., Novotova, M., David, D. J., Garnier, A., Fortin, D., Alavi, M. V., Veksler, V., Ventura-Clapier, R., et al. (2013). Altered skeletal muscle mitochondrial biogenesis but improved endurance capacity in trained OPA1-deficient mice. J. Physiol. 591, 6017-6037.
7. Campello, S., Lacalle, R. A., Bettella, M., Manes, S., Scorrano, L., and Viola, A. (2006). Orchestration of lymphocyte chemotaxis by mitochondrial dynamics. J. Exp. Med. 203, 2879-2886.
8. Dallman, P. R., and Goodman, J. R. (1970). Enlargement of mitochondrial compartment in iron and copper deficiency. Blood 35, 496-505.
9. Del Prete, A., Zaccagnino, P., Di Paola, M., Saltarella, M., Oliveros Celis, C., Nico, B., Santoro, G., and Lorusso, M. (2008). Role of mitochondria and reactive oxygen species in dendritic cell differentiation and functions. Free Radic. Biol. Med. 44, 1443-1451.
10. Detmer, S. A., and Chan, D. C. (2007). Functions and dysfunctions of mitochondrial dynamics. Nat. Rev. Mol. Cell. Biol. 8, 870-879.
11. Favre, C., Zhdanov, A., Leahy, M., Papkovsky, D., and O’Connor, R. (2010). Mitochondrial pyrimidine nucleotide carrier (PNC1) regulates mitochondrial biogenesis and the invasive phenotype of cancer cells. Oncogene 29, 3964-3976.
12. Geissmann, F., Dieu-Nosjean, M. C., Dezutter, C., Valladeau, J., Kayal, S., Leborgne, M., Brousse, N., Saeland, S., and Davoust, J. (2002). Accumulation of immature Langerhans cells in human lymph nodes draining chronically inflamed skin. J. Exp. Med. 196, 417-430.
13. Kraft, C. S., LeMoine, C. M., Lyons, C. N., Michaud, D., Mueller, C. R., and Moyes, C. D. (2006). Control of mitochondrial biogenesis during myogenesis. Am. J. Physiol. Cell Physiol. 290, C1119-1127.
14. Liesa, M., Borda-d’Agua, B., Medina-Gomez, G., Lelliott, C. J., Paz, J. C., Rojo, M., Palacin, M., Vidal-Puig, A., and Zorzano, A. (2008). Mitochondrial fusion is increased by the nuclear coactivator PGC-1beta. PLoS One 3, e3613.
15. Liesa, M., Palacin, M., and Zorzano, A. (2009). Mitochondrial dynamics in mammalian health and disease. Physiol. Rev. 89, 799-845.
16. Otera, H., Wang, C., Cleland, M. M., Setoguchi, K., Yokota, S., Youle, R. J., and Mihara, K. (2010). Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells. J. Cell Biol. 191, 1141-1158.
17. Pich, S., Bach, D., Briones, P., Liesa, M., Camps, M., Testar, X., Palacin, M., and Zorzano, A. (2005). The Charcot-Marie-Tooth type 2A gene product, Mfn2, up-regulates fuel oxidation through expression of OXPHOS system. Hum. Mol. Genet. 14, 1405-1415.
18. Ryu, S. W., Yoon, J., Yim, N., Choi, K., and Choi, C. (2013). Downregulation of OPA3 is responsible for transforming growth factor-beta-induced mitochondrial elongation and F-actin rearrangement in retinal pigment epithelial ARPE-19 cells. PLoS One 8, e63495.
19. Sallusto, F., Mackay, C. R., and Lanzavecchia, A. (2000). The role of chemokine receptors in primary, effector, and memory immune responses. Annu. Rev. Immunol. 18, 593-620.
20. Santel, A., and Fuller, M. T. (2001). Control of mitochondrial morphology by a human mitofusin. J. Cell Sci. 114, 867-874.
21. Shen, J., Liu, X., Yu, W. M., Liu, J., Nibbelink, M. G., Guo, C., Finkel, T., and Qu, C. K. (2011). A critical role of mitochondrial phosphatase Ptpmt1 in embryogenesis reveals a mitochondrial metabolic stress-induced differentiation checkpoint in embryonic stem cells. Mol. Cell Biol. 31, 4902-4916.
22. Thundathil, J., Filion, F., and Smith, L. C. (2005). Molecular control of mitochondrial function in preimplantation mouse embryos. Mol. Reprod. Dev. 71, 405-413.
23. Toki, S., Goleniewska, K., Huckabee, M. M., Zhou, W., Newcomb, D. C., Fitzgerald, G. A., Lawson, W. E., and Peebles, R. S., Jr. (2013). PGI (2) signaling inhibits antigen uptake and increases migration of immature dendritic cells. J. Leukoc. Biol. 94, 77-88.
24. Vafai, S. B., and Mootha, V. K. (2012). Mitochondrial disorders as windows into an ancient organelle. Nature 491, 374-383.
25. Wasilewski, M., Semenzato, M., Rafelski, S. M., Robbins, J., Bakardjiev, A. I., and Scorrano, L. (2012). Optic atrophy 1-dependent mitochondrial remodeling controls steroidogenesis in trophoblasts. Curr. Biol. 22, 1228-1234.
26. Wong, E. D., Wagner, J. A., Gorsich, S. W., McCaffery, J. M., Shaw, J. M., and Nunnari, J. (2000). The dynamin-related GTPase, Mgm1p, is an intermembrane space protein required for maintenance of fusion competent mitochondria. J. Cell Biol. 151, 341-352.
27. Zaccagnino, P., Saltarella, M., Maiorano, S., Gaballo, A., Santoro, G., Nico, B., Lorusso, M., and Del Prete, A. (2012). An active mitochondrial biogenesis occurs during dendritic cell differentiation. Int. J. Biochem. Cell Biol. 44, 1962-1969.
28. Zhao, J., Zhang, J., Yu, M., Xie, Y., Huang, Y., Wolff, D. W., Abel, P. W., and Tu, Y. (2013). Mitochondrial dynamics regulates migration and invasion of breast cancer cells. Oncogene 32, 4814-4824.
29. Zorzano, A., Hernandez-Alvarez, M. I., Palacin, M., and Mingrone, G. (2010). Alterations in the mitochondrial regulatory pathways constituted by the nuclear co-factors PGC-1alpha or PGC-1beta and mitofusin 2 in skeletal muscle in type 2 diabetes. Biochim. Biophys. Acta 1797, 1028-1033.