메뉴 건너뛰기




Volumn 7, Issue , 2016, Pages

Tregalizumab – A Monoclonal Antibody to Target Regulatory T Cells

Author keywords

autoimmunity; CD4 T cells; monoclonal antibody; regulatory T cells; rheumatoid arthritis

Indexed keywords


EID: 84984812478     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2016.00011     Document Type: Review
Times cited : (27)

References (77)
  • 1
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • 7636184
    • Sakaguchi S Sakaguchi N Asano M Itoh M Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol (1995) 155:1151–64.7636184
    • (1995) J Immunol , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 2
    • 63549103638 scopus 로고    scopus 로고
    • Regulatory T cells: from bench to bedside
    • 19272465
    • Jiang S. Regulatory T cells: from bench to bedside. Int Immunopharmacol (2009) 9(5):515–7.10.1016/j.intimp.2008.01.03819272465
    • (2009) Int Immunopharmacol , vol.9 , Issue.5 , pp. 515-517
    • Jiang, S.1
  • 3
    • 77957552569 scopus 로고    scopus 로고
    • The yin and yang of regulatory T cells and inflammation in RA
    • 20808295
    • Notley C Ehrenstein M. The yin and yang of regulatory T cells and inflammation in RA. Nat Rev Rheumatol (2010) 6(10):572–7.10.1038/nrrheum.2010.14320808295
    • (2010) Nat Rev Rheumatol , vol.6 , Issue.10 , pp. 572-577
    • Notley, C.1    Ehrenstein, M.2
  • 4
    • 0037364804 scopus 로고    scopus 로고
    • Natural versus adaptive regulatory T cells
    • 12658273
    • Bluestone JA Abbas AK. Natural versus adaptive regulatory T cells. Nat Rev Immunol (2003) 3(3):253–7.10.1038/nri103212658273
    • (2003) Nat Rev Immunol , vol.3 , Issue.3 , pp. 253-257
    • Bluestone, J.A.1    Abbas, A.K.2
  • 5
    • 79955703244 scopus 로고    scopus 로고
    • Regulatory T cells: history and perspective
    • 21287325
    • Sakaguchi S. Regulatory T cells: history and perspective. Methods Mol Biol (2011) 707:3–17.10.1007/978-1-61737-979-6_121287325
    • (2011) Methods Mol Biol , vol.707 , pp. 3-17
    • Sakaguchi, S.1
  • 6
    • 16844365788 scopus 로고    scopus 로고
    • + regulatory T cells in immunological tolerance to self and non-self
    • 15785760
    • + regulatory T cells in immunological tolerance to self and non-self. Nat Immunol (2005) 6(4):345–52.10.1038/ni117815785760
    • (2005) Nat Immunol , vol.6 , Issue.4 , pp. 345-352
    • Sakaguchi, S.1
  • 8
    • 80053262406 scopus 로고    scopus 로고
    • Human FoxP3+ regulatory T cells in systemic autoimmune diseases
    • 21621000
    • Miyara M Gorochov G Ehrenstein M Musset L Sakaguchi S Amoura Z. Human FoxP3+ regulatory T cells in systemic autoimmune diseases. Autoimmun Rev (2011) 10(12):744–55.10.1016/j.autrev.2011.05.00421621000
    • (2011) Autoimmun Rev , vol.10 , Issue.12 , pp. 744-755
    • Miyara, M.1    Gorochov, G.2    Ehrenstein, M.3    Musset, L.4    Sakaguchi, S.5    Amoura, Z.6
  • 9
    • 17644384896 scopus 로고    scopus 로고
    • + T cells with the phenotypic and functional characteristics of regulatory T cells are enriched in the synovial fluid of patients with rheumatoid arthritis
    • 15807863
    • + T cells with the phenotypic and functional characteristics of regulatory T cells are enriched in the synovial fluid of patients with rheumatoid arthritis. Clin Exp Immunol (2005) 140(2):360–7.10.1111/j.1365-2249.2005.02754.x15807863
    • (2005) Clin Exp Immunol , vol.140 , Issue.2 , pp. 360-367
    • Möttönen, M.1    Heikkinen, J.2    Mustonen, L.3    Isomäki, P.4    Luukkainen, R.5    Lassila, O.6
  • 10
    • 4444300314 scopus 로고    scopus 로고
    • + regulatory T cells in rheumatoid arthritis: differences in the presence, phenotype and function between peripheral blood and synovial fluid
    • + regulatory T cells in rheumatoid arthritis: differences in the presence, phenotype and function between peripheral blood and synovial fluid. Arthritis Rheum (2004) 50(9):2775–85.10.1002/art.20499
    • (2004) Arthritis Rheum , vol.50 , Issue.9 , pp. 2775-2785
    • Van Amelsfort, J.M.1    Jacobs, K.M.2    Bijlsma, J.W.3    Lafeber, F.P.4    Taams, L.S.5
  • 14
    • 0037436119 scopus 로고    scopus 로고
    • + T cell-mediated suppression by dendritic cells
    • + T cell-mediated suppression by dendritic cells. Science (2003) 299(5609):1033–6.10.1126/science.1078231
    • (2003) Science , vol.299 , Issue.5609 , pp. 1033-1036
    • Pasare, C.1    Medzhitov, R.2
  • 15
    • 1642321982 scopus 로고    scopus 로고
    • IL-2, regulatory T cells and tolerance
    • 15034008
    • Nelson BH. IL-2, regulatory T cells and tolerance. J Immunol (2004) 172(7):3983–8.10.4049/jimmunol.172.7.398315034008
    • (2004) J Immunol , vol.172 , Issue.7 , pp. 3983-3988
    • Nelson, B.H.1
  • 16
    • 34447250604 scopus 로고    scopus 로고
    • + regulatory T-cell functions in rheumatoid arthritis by cytokine-targeted monoclonal antibody therapy
    • 17631249
    • + regulatory T-cell functions in rheumatoid arthritis by cytokine-targeted monoclonal antibody therapy. Drug Discov Today (2007) 12(13–14):548–52.10.1016/j.drudis.2007.05.00217631249
    • (2007) Drug Discov Today , vol.12 , Issue.13–14 , pp. 548-552
    • Bayry, J.1    Sibéril, S.2    Triebel, F.3    Tough, D.F.4    Kaveri, S.V.5
  • 19
    • 77951640552 scopus 로고    scopus 로고
    • TNF activates a NF-kappaB-regulated cellular program in human CD45RA- regulatory T cells that modulates their suppressive function
    • 20181891
    • Nagar M Jacob-Hirsch J Vernitsky H Berkun Y Ben-Horin S Amariglio N et al. TNF activates a NF-kappaB-regulated cellular program in human CD45RA- regulatory T cells that modulates their suppressive function. J Immunol (2010) 184(7):3570–81.10.4049/jimmunol.090207020181891
    • (2010) J Immunol , vol.184 , Issue.7 , pp. 3570-3581
    • Nagar, M.1    Jacob-Hirsch, J.2    Vernitsky, H.3    Berkun, Y.4    Ben-Horin, S.5    Amariglio, N.6
  • 20
    • 32644482551 scopus 로고    scopus 로고
    • + cells
    • 16458015
    • + cells. Semin Immunol (2006) 18(2):78–88.10.1016/j.smim.2006.01.00616458015
    • (2006) Semin Immunol , vol.18 , Issue.2 , pp. 78-88
    • June, C.H.1    Blazar, B.R.2
  • 21
    • 78751696183 scopus 로고    scopus 로고
    • Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics
    • 20952687
    • Brunstein CG Miller JS Cao Q McKenna DH Hippen KL Curtsinger J et al. Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics. Blood (2011) 117(3):1061–70.10.1182/blood-2010-07-29379520952687
    • (2011) Blood , vol.117 , Issue.3 , pp. 1061-1070
    • Brunstein, C.G.1    Miller, J.S.2    Cao, Q.3    McKenna, D.H.4    Hippen, K.L.5    Curtsinger, J.6
  • 22
    • 79953809817 scopus 로고    scopus 로고
    • Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation
    • 21292771
    • Di Ianni M Falzetti F Carotti A Terenzi A Castellino F Bonifacio E et al. Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation. Blood (2011) 117(14):3921–8.10.1182/blood-2010-10-31189421292771
    • (2011) Blood , vol.117 , Issue.14 , pp. 3921-3928
    • Di Ianni, M.1    Falzetti, F.2    Carotti, A.3    Terenzi, A.4    Castellino, F.5    Bonifacio, E.6
  • 23
    • 84871856775 scopus 로고    scopus 로고
    • Therapeutic opportunities for manipulating T(reg) cells in autoimmunity and cancer
    • 23274471
    • von Boehmer H Daniel C. Therapeutic opportunities for manipulating T(reg) cells in autoimmunity and cancer. Nat Rev Drug Discov (2013) 12(1):51–63.10.1038/nrd368323274471
    • (2013) Nat Rev Drug Discov , vol.12 , Issue.1 , pp. 51-63
    • von Boehmer, H.1    Daniel, C.2
  • 24
    • 84871719877 scopus 로고    scopus 로고
    • Comprehensive analysis of current approaches to inhibit regulatory T cells in cancer
    • 22737608
    • Pere H Tanchot C Bayry J Terme M Taieb J Badoual C et al. Comprehensive analysis of current approaches to inhibit regulatory T cells in cancer. Oncoimmunology (2012) 1(3):326–33.10.4161/onci.1885222737608
    • (2012) Oncoimmunology , vol.1 , Issue.3 , pp. 326-333
    • Pere, H.1    Tanchot, C.2    Bayry, J.3    Terme, M.4    Taieb, J.5    Badoual, C.6
  • 25
    • 84876675357 scopus 로고    scopus 로고
    • + regulatory T cells using a novel cell-based high throughput screening assay
    • 23537702
    • + regulatory T cells using a novel cell-based high throughput screening assay. Biochem Pharmacol (2013) 85(10):1513–24.10.1016/j.bcp.2013.03.01323537702
    • (2013) Biochem Pharmacol , vol.85 , Issue.10 , pp. 1513-1524
    • Mao, R.1    Xiao, W.2    Liu, H.3    Chen, B.4    Yi, B.5    Kraj, P.6
  • 26
    • 84929670608 scopus 로고    scopus 로고
    • The impact of biological therapy on regulatory T cells in rheumatoid arthritis
    • 25667434
    • Byng-Maddick R Ehrenstein MR. The impact of biological therapy on regulatory T cells in rheumatoid arthritis. Rheumatology (Oxford) (2015) 54(5):768–75.10.1093/rheumatology/keu48725667434
    • (2015) Rheumatology (Oxford) , vol.54 , Issue.5 , pp. 768-775
    • Byng-Maddick, R.1    Ehrenstein, M.R.2
  • 27
    • 3543140687 scopus 로고    scopus 로고
    • Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNF-alpha therapy
    • Ehrenstein MR Evans JG Singh A Moore S Warnes G Isenberg DA et al. Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNF-alpha therapy. J Exp Med (2004) 200(3):277–85.10.1084/jem.20040165
    • (2004) J Exp Med , vol.200 , Issue.3 , pp. 277-285
    • Ehrenstein, M.R.1    Evans, J.G.2    Singh, A.3    Moore, S.4    Warnes, G.5    Isenberg, D.A.6
  • 28
    • 84869020571 scopus 로고    scopus 로고
    • Th17 cells are restrained by Treg cells via the inhibition of interleukin-6 in patients with rheumatoid arthritis responding to anti-tumor necrosis factor antibody therapy
    • 22674488
    • McGovern JL Nguyen DX Notley CA Mauri C Isenberg DA Ehrenstein MR. Th17 cells are restrained by Treg cells via the inhibition of interleukin-6 in patients with rheumatoid arthritis responding to anti-tumor necrosis factor antibody therapy. Arthritis Rheum (2012) 64(10):3129–38.10.1002/art.3456522674488
    • (2012) Arthritis Rheum , vol.64 , Issue.10 , pp. 3129-3138
    • McGovern, J.L.1    Nguyen, D.X.2    Notley, C.A.3    Mauri, C.4    Isenberg, D.A.5    Ehrenstein, M.R.6
  • 29
    • 79959554060 scopus 로고    scopus 로고
    • Natural but not inducible regulatory T cells require TNF-alpha signaling for in vivo function
    • 21572024
    • Housley WJ Adams CO Nichols FC Puddington L Lingenheld EG Zhu L et al. Natural but not inducible regulatory T cells require TNF-alpha signaling for in vivo function. J Immunol (2011) 186(12):6779–87.10.4049/jimmunol.100386821572024
    • (2011) J Immunol , vol.186 , Issue.12 , pp. 6779-6787
    • Housley, W.J.1    Adams, C.O.2    Nichols, F.C.3    Puddington, L.4    Lingenheld, E.G.5    Zhu, L.6
  • 30
    • 84883577100 scopus 로고    scopus 로고
    • The first decade of biologic TNF antagonists in clinical practice: lessons learned, unresolved issues and future directions
    • 20173395
    • Sfikakis PP. The first decade of biologic TNF antagonists in clinical practice: lessons learned, unresolved issues and future directions. Curr Dir Autoimmun (2010) 11:180–210.10.1159/00028920520173395
    • (2010) Curr Dir Autoimmun , vol.11 , pp. 180-210
    • Sfikakis, P.P.1
  • 31
    • 80053141949 scopus 로고    scopus 로고
    • Clinical, radiographic and functional effectiveness of tocilizumab for rheumatoid arthritis patients-REACTION 52-week study
    • Takeuchi T Tanaka Y Amano K Hoshi D Nawata M Nagasawa H et al. Clinical, radiographic and functional effectiveness of tocilizumab for rheumatoid arthritis patients-REACTION 52-week study. Rheumatology (2011) 50(10):1908–15.10.1093/rheumatology/ker221
    • (2011) Rheumatology , vol.50 , Issue.10 , pp. 1908-1915
    • Takeuchi, T.1    Tanaka, Y.2    Amano, K.3    Hoshi, D.4    Nawata, M.5    Nagasawa, H.6
  • 32
    • 70349967965 scopus 로고    scopus 로고
    • Anti-TNF biologic agents: still the therapy of choice for rheumatoid arthritis
    • 19798034
    • Taylor PC Feldmann M. Anti-TNF biologic agents: still the therapy of choice for rheumatoid arthritis. Nat Rev Rheumatol (2009) 5(10):578–82.10.1038/nrrheum.2009.18119798034
    • (2009) Nat Rev Rheumatol , vol.5 , Issue.10 , pp. 578-582
    • Taylor, P.C.1    Feldmann, M.2
  • 33
    • 0036190776 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with anakinra, a recombinant human interleukin-1 receptor antagonist, in combination with methotrexate: results of a twenty-four-week, multicenter, randomized, double-blind, placebo-controlled trial
    • 11920396
    • Cohen S Hurd E Cush J Schiff M Weinblatt ME Moreland LW et al. Treatment of rheumatoid arthritis with anakinra, a recombinant human interleukin-1 receptor antagonist, in combination with methotrexate: results of a twenty-four-week, multicenter, randomized, double-blind, placebo-controlled trial. Arthritis Rheum (2002) 46(3):614–24.10.1002/art.1014111920396
    • (2002) Arthritis Rheum , vol.46 , Issue.3 , pp. 614-624
    • Cohen, S.1    Hurd, E.2    Cush, J.3    Schiff, M.4    Weinblatt, M.E.5    Moreland, L.W.6
  • 34
    • 33748512180 scopus 로고    scopus 로고
    • Anakinra in the treatment of rheumatic disease
    • 20476905
    • Fleishmann R. Anakinra in the treatment of rheumatic disease. Expert Rev Clin Immunol (2006) 2(3):331–40.10.1586/1744666X.2.3.33120476905
    • (2006) Expert Rev Clin Immunol , vol.2 , Issue.3 , pp. 331-340
    • Fleishmann, R.1
  • 35
    • 78649906886 scopus 로고    scopus 로고
    • Interleukin-6: from identification of the cytokine to development of targeted treatments
    • 20869898
    • Assier E Boissier MC Dayer JM. Interleukin-6: from identification of the cytokine to development of targeted treatments. Joint Bone Spine (2010) 77(6):532–6.10.1016/j.jbspin.2010.07.00720869898
    • (2010) Joint Bone Spine , vol.77 , Issue.6 , pp. 532-536
    • Assier, E.1    Boissier, M.C.2    Dayer, J.M.3
  • 36
    • 46749125294 scopus 로고    scopus 로고
    • Shifting the imbalance from Th1/Th2 to Th17/treg: the changing rheumatoid arthritis paradigm
    • Boisser MC Assier E Falgarone G Bessis N. Shifting the imbalance from Th1/Th2 to Th17/treg: the changing rheumatoid arthritis paradigm. Joint Bone Spine (2008) 75(4):373–5.10.1016/j.jbspin.2008.04.005
    • (2008) Joint Bone Spine , vol.75 , Issue.4 , pp. 373-375
    • Boisser, M.C.1    Assier, E.2    Falgarone, G.3    Bessis, N.4
  • 37
    • 77951636478 scopus 로고    scopus 로고
    • Mast cells express IL-17A in rheumatoid arthritis synovium
    • 20200272
    • Heuber AJ Asquith DL Miller AM Reilly J Kerr S Leipe J et al. Mast cells express IL-17A in rheumatoid arthritis synovium. J Immunol (2010) 184(7):3336–40.10.4049/jimmunol.090356620200272
    • (2010) J Immunol , vol.184 , Issue.7 , pp. 3336-3340
    • Heuber, A.J.1    Asquith, D.L.2    Miller, A.M.3    Reilly, J.4    Kerr, S.5    Leipe, J.6
  • 38
    • 77950535421 scopus 로고    scopus 로고
    • LY2439821, a humanized anti-IL-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: a Phase 1 randomized double-blind, placebo-controlled, proof-of-concept study
    • Genovese M Van den Bosch F Roberson SA Bojin S Biagini IM Ryan P et al. LY2439821, a humanized anti-IL-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: a Phase 1 randomized double-blind, placebo-controlled, proof-of-concept study. Arthritis Rheum (2010) 62(4):929–39.10.1002/art.27334
    • (2010) Arthritis Rheum , vol.62 , Issue.4 , pp. 929-939
    • Genovese, M.1    Van den Bosch, F.2    Roberson, S.A.3    Bojin, S.4    Biagini, I.M.5    Ryan, P.6
  • 39
    • 32244435875 scopus 로고    scopus 로고
    • Deconstructing the form and function of the TCR/CD3 complex
    • 16473826
    • Kuhns MS Davis MM Garcia KC. Deconstructing the form and function of the TCR/CD3 complex. Immunity (2006) 24(2):133–9.10.1016/j.immuni.2006.01.00616473826
    • (2006) Immunity , vol.24 , Issue.2 , pp. 133-139
    • Kuhns, M.S.1    Davis, M.M.2    Garcia, K.C.3
  • 40
    • 79955009796 scopus 로고    scopus 로고
    • Secukinumab (AIN457), a novel monoclonal antibody targeting IL-17A demonstrates efficacy in active rheumatoid arthritis patients despite stable methotrexate treatment: results of a Phase IIb study
    • Genovese M Durez P Richards H Hugot S Thangavelu K Mpofu S. Secukinumab (AIN457), a novel monoclonal antibody targeting IL-17A demonstrates efficacy in active rheumatoid arthritis patients despite stable methotrexate treatment: results of a Phase IIb study. Arthritis Rheum (2011) 63(Suppl 10):401.
    • (2011) Arthritis Rheum , vol.63 , pp. 401
    • Genovese, M.1    Durez, P.2    Richards, H.3    Hugot, S.4    Thangavelu, K.5    Mpofu, S.6
  • 41
    • 24944498854 scopus 로고    scopus 로고
    • Abatacept for rheumatoid arthritis refractory to tumor necrosis factor alpha inhibition
    • 16162882
    • Genovese MC Becker JC Schiff M Luggen M Sherrer Y Kremer J et al. Abatacept for rheumatoid arthritis refractory to tumor necrosis factor alpha inhibition. N Engl J Med (2005) 353(11):1114–23.10.1056/NEJMoa05052416162882
    • (2005) N Engl J Med , vol.353 , Issue.11 , pp. 1114-1123
    • Genovese, M.C.1    Becker, J.C.2    Schiff, M.3    Luggen, M.4    Sherrer, Y.5    Kremer, J.6
  • 42
    • 80053493531 scopus 로고    scopus 로고
    • Subcutaneous abatacept versus intravenous abatacept: a Phase IIIb noninferiority study in patients with an inadequate response to methotrexate
    • 21618201
    • Genovese MC Covarrubias A Leon G Mysler E Keiserman M Valente R et al. Subcutaneous abatacept versus intravenous abatacept: a Phase IIIb noninferiority study in patients with an inadequate response to methotrexate. Arthritis Rheum (2011) 63(10):2854–64.10.1002/art.3046321618201
    • (2011) Arthritis Rheum , vol.63 , Issue.10 , pp. 2854-2864
    • Genovese, M.C.1    Covarrubias, A.2    Leon, G.3    Mysler, E.4    Keiserman, M.5    Valente, R.6
  • 43
    • 23644455857 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with the selective costimulation modulator abatercept: twelve-month results of a Phase IIb, double-blind, randomized, placebo-controlled trial
    • Kremer JM Dougados M Emery P Durez P Sibilia J Shergy W et al. Treatment of rheumatoid arthritis with the selective costimulation modulator abatercept: twelve-month results of a Phase IIb, double-blind, randomized, placebo-controlled trial. Arthritis Rheum (2005) 52(8):2263–71.10.1002/art.21201
    • (2005) Arthritis Rheum , vol.52 , Issue.8 , pp. 2263-2271
    • Kremer, J.M.1    Dougados, M.2    Emery, P.3    Durez, P.4    Sibilia, J.5    Shergy, W.6
  • 44
    • 79957630321 scopus 로고    scopus 로고
    • Efficacy of abatacept and tocilizumab in patients with rheumatoid arthritis treated in clinical practice: results from the nationwide Danish DANBIO registry
    • 21551512
    • Leffers HC Ostergaard M Glintborg B Krogh NS Foged H Tarp U et al. Efficacy of abatacept and tocilizumab in patients with rheumatoid arthritis treated in clinical practice: results from the nationwide Danish DANBIO registry. Ann Rheum Dis (2011) 70(7):1216–22.10.1136/ard.2010.14012921551512
    • (2011) Ann Rheum Dis , vol.70 , Issue.7 , pp. 1216-1222
    • Leffers, H.C.1    Ostergaard, M.2    Glintborg, B.3    Krogh, N.S.4    Foged, H.5    Tarp, U.6
  • 45
    • 74849107553 scopus 로고    scopus 로고
    • + Treg cells and induces sustained amelioration of collagen-induced arthritis
    • + Treg cells and induces sustained amelioration of collagen-induced arthritis. Arthritis Rheum (2009) 62(1):171–8.10.1002/art.25058
    • (2009) Arthritis Rheum , vol.62 , Issue.1 , pp. 171-178
    • Notley, C.A.1    McCann, F.E.2    Inglis, J.J.3    Williams, R.O.4
  • 46
    • 0020361983 scopus 로고
    • Human in vivo antigenic modulation induced by the anti-T cell OKT3 monoclonal antibody
    • 6759145
    • Chatenoud L Baudrihaye MF Kreis H Goldstein G Schindler J Bach JF. Human in vivo antigenic modulation induced by the anti-T cell OKT3 monoclonal antibody. Eur J Immunol (1982) 12(11):979–82.10.1002/eji.18301211166759145
    • (1982) Eur J Immunol , vol.12 , Issue.11 , pp. 979-982
    • Chatenoud, L.1    Baudrihaye, M.F.2    Kreis, H.3    Goldstein, G.4    Schindler, J.5    Bach, J.F.6
  • 47
    • 0027958044 scopus 로고
    • Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice
    • 8278351
    • Chatenoud L Thervet E Primo J Bach JF. Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice. Proc Natl Acad Sci U S A (1994) 91(1):123–7.10.1073/pnas.91.1.1238278351
    • (1994) Proc Natl Acad Sci U S A , vol.91 , Issue.1 , pp. 123-127
    • Chatenoud, L.1    Thervet, E.2    Primo, J.3    Bach, J.F.4
  • 48
    • 78651387929 scopus 로고    scopus 로고
    • Antibody-based therapeutics to watch in 2011
    • 21051951
    • Reichert JM. Antibody-based therapeutics to watch in 2011. MAbs (2011) 3(1):76–99.10.4161/mabs.3.1.1389521051951
    • (2011) MAbs , vol.3 , Issue.1 , pp. 76-99
    • Reichert, J.M.1
  • 49
  • 50
    • 80051471700 scopus 로고    scopus 로고
    • Teplizumab for treatment of type 1 diabetes (Protégé study): 1-year results from a randomised, placebo-controlled trial
    • 21719095
    • Sherry N Hagopian W Ludvigsson J Jain SM Wahlen J Ferry RJ Jr et al. Teplizumab for treatment of type 1 diabetes (Protégé study): 1-year results from a randomised, placebo-controlled trial. Lancet (2011) 378(9790):487–97.10.1016/S0140-6736(11)60931–821719095
    • (2011) Lancet , vol.378 , Issue.9790 , pp. 487-497
    • Sherry, N.1    Hagopian, W.2    Ludvigsson, J.3    Jain, S.M.4    Wahlen, J.5    Ferry, R.J.6
  • 51
    • 77949266510 scopus 로고    scopus 로고
    • Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass
    • 20225393
    • Keymeulen B Walter M Mathieu C Kaufman L Gorus F Hilbrands R et al. Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass. Diabetologia (2010) 53(4):614–23.10.1007/s00125-009-1644-920225393
    • (2010) Diabetologia , vol.53 , Issue.4 , pp. 614-623
    • Keymeulen, B.1    Walter, M.2    Mathieu, C.3    Kaufman, L.4    Gorus, F.5    Hilbrands, R.6
  • 54
    • 79551718666 scopus 로고    scopus 로고
    • Humanizing animal models: a key to autoimmune diabetes treatment
    • 21289271
    • Bresson D von Herrath M. Humanizing animal models: a key to autoimmune diabetes treatment. Sci Transl Med (2011) 3(68):68s4.10.1126/scitranslmed.300210221289271
    • (2011) Sci Transl Med , vol.3 , Issue.68 , pp. 68s4
    • Bresson, D.1    von Herrath, M.2
  • 55
    • 1242295282 scopus 로고    scopus 로고
    • + immunoregulatory T cells: central players in the arena of peripheral tolerance
    • + immunoregulatory T cells: central players in the arena of peripheral tolerance. Semin Immunol (2004) 16(2):81–8.10.1016/j.smim.2003.12.003
    • (2004) Semin Immunol , vol.16 , Issue.2 , pp. 81-88
    • Piccirillo, C.A.1    Shevack, E.M.2
  • 56
    • 33845882484 scopus 로고    scopus 로고
    • Biologic therapies in rheumatology: lessons learned, future directions
    • 17195034
    • Strand V Kimberly R Isaacs JD. Biologic therapies in rheumatology: lessons learned, future directions. Nat Rev Drug Discov (2007) 6(1):75–92.10.1038/nrd219617195034
    • (2007) Nat Rev Drug Discov , vol.6 , Issue.1 , pp. 75-92
    • Strand, V.1    Kimberly, R.2    Isaacs, J.D.3
  • 57
    • 77956413981 scopus 로고    scopus 로고
    • Modulation of IL-17 and Foxp3 expression in the prevention of autoimmune arthritis in mice
    • 20479941
    • Duarte J Agua-Doce A Oliveira VG Fonseca JE Graca L. Modulation of IL-17 and Foxp3 expression in the prevention of autoimmune arthritis in mice. PLoS One (2010) 5(5):e10558.10.1371/journal.pone.001055820479941
    • (2010) PLoS One , vol.5 , Issue.5 , pp. e10558
    • Duarte, J.1    Agua-Doce, A.2    Oliveira, V.G.3    Fonseca, J.E.4    Graca, L.5
  • 58
    • 33746927139 scopus 로고    scopus 로고
    • Rat cytomegalovirus infection interferes with anti-CD4 mAb-(RIB 5/2) mediated tolerance and induces chronic allograft damage
    • 16869800
    • Pascher A Proesch S Pratschke J Reutzel-Selke A Sawitzki B Lehmann M et al. Rat cytomegalovirus infection interferes with anti-CD4 mAb-(RIB 5/2) mediated tolerance and induces chronic allograft damage. Am J Transplant (2006) 6(9):2035–45.10.1111/j.1600-6143.2006.01453.x16869800
    • (2006) Am J Transplant , vol.6 , Issue.9 , pp. 2035-2045
    • Pascher, A.1    Proesch, S.2    Pratschke, J.3    Reutzel-Selke, A.4    Sawitzki, B.5    Lehmann, M.6
  • 59
    • 0028882681 scopus 로고
    • Double-blind, placebo-controlled multicenter trial using chimeric monoclonal anti-CD4 antibody, cM-T412, in rheumatoid arthritis patients receiving concomitant methotrexate
    • 7488278
    • Moreland LW Pratt PW Mayes MD Postlethwaite A Weisman MH Schnitzer T et al. Double-blind, placebo-controlled multicenter trial using chimeric monoclonal anti-CD4 antibody, cM-T412, in rheumatoid arthritis patients receiving concomitant methotrexate. Arthritis Rheum (1995) 38(11):1581–8.10.1002/art.17803811097488278
    • (1995) Arthritis Rheum , vol.38 , Issue.11 , pp. 1581-1588
    • Moreland, L.W.1    Pratt, P.W.2    Mayes, M.D.3    Postlethwaite, A.4    Weisman, M.H.5    Schnitzer, T.6
  • 60
    • 0031732198 scopus 로고    scopus 로고
    • Reduction of Th1 cell activity in peripheral circulation of patients with rheumatoid arthritis after treatment with a non-depleting humanized monocolonal antibody to CD4
    • Schulze-Koops H Davis L Haverty P Wacholtz MC Lipsky PE. Reduction of Th1 cell activity in peripheral circulation of patients with rheumatoid arthritis after treatment with a non-depleting humanized monocolonal antibody to CD4. J Rheumatol (1998) 25(11):2065–76.
    • (1998) J Rheumatol , vol.25 , Issue.11 , pp. 2065-2076
    • Schulze-Koops, H.1    Davis, L.2    Haverty, P.3    Wacholtz, M.C.4    Lipsky, P.E.5
  • 61
    • 0036160920 scopus 로고    scopus 로고
    • CD4 coating, but not CD4 depletion, is a predictor of efficacy with primatized monoclonal anti-CD4 treatment of active rheumatoid arthritis
    • 11838838
    • Mason U Aldrich J Breedveld F Davis CB Elliott M Jackson M et al. CD4 coating, but not CD4 depletion, is a predictor of efficacy with primatized monoclonal anti-CD4 treatment of active rheumatoid arthritis. J Rheumatol (2002) 29(2):220–9.11838838
    • (2002) J Rheumatol , vol.29 , Issue.2 , pp. 220-229
    • Mason, U.1    Aldrich, J.2    Breedveld, F.3    Davis, C.B.4    Elliott, M.5    Jackson, M.6
  • 62
    • 0034651966 scopus 로고    scopus 로고
    • Elimination of Fc receptor-dependent effector functions of a modified IgG4 monoclonal antibody to human CD4
    • 10657642
    • Reddy MP Kinney CAS Chaikin MA Payne A Fishman-Lobell J Tsui P et al. Elimination of Fc receptor-dependent effector functions of a modified IgG4 monoclonal antibody to human CD4. J Immunol (2000) 164(4):1925–33.10.4049/jimmunol.164.4.192510657642
    • (2000) J Immunol , vol.164 , Issue.4 , pp. 1925-1933
    • Reddy, M.P.1    Kinney, C.A.S.2    Chaikin, M.A.3    Payne, A.4    Fishman-Lobell, J.5    Tsui, P.6
  • 63
    • 0037241516 scopus 로고    scopus 로고
    • Antibody-mediated stripping of CD4 from lymphocyte cell surface in patients with rheumatoid arthritis
    • 12509613
    • Hepburn TW Totoritis MC Davis CB. Antibody-mediated stripping of CD4 from lymphocyte cell surface in patients with rheumatoid arthritis. Rheumatology (2003) 42(1):54–61.10.1093/rheumatology/keg03012509613
    • (2003) Rheumatology , vol.42 , Issue.1 , pp. 54-61
    • Hepburn, T.W.1    Totoritis, M.C.2    Davis, C.B.3
  • 64
    • 0142143823 scopus 로고    scopus 로고
    • Results of a Phase II, double-blind, randomized study of a nondepleting anti-CD4 monoclonal antibody (clenoliximab) given in combination with methotrexate (mtx) in patients with moderate to severe rheumatoid arthritis (RA)
    • Luggen ME Schechtman J Kivitz A Greenwald M Forstot J Boling E et al. Results of a Phase II, double-blind, randomized study of a nondepleting anti-CD4 monoclonal antibody (clenoliximab) given in combination with methotrexate (mtx) in patients with moderate to severe rheumatoid arthritis (RA). Ann Rheum Dis (2003) 62(Suppl 2):O0004.
    • (2003) Ann Rheum Dis , vol.62 , pp. O0004
    • Luggen, M.E.1    Schechtman, J.2    Kivitz, A.3    Greenwald, M.4    Forstot, J.5    Boling, E.6
  • 65
    • 0033787146 scopus 로고    scopus 로고
    • Pharmacokinetic, pharmacodynamic and clinical effects of a humanized IgG1 anti-CD4 monoclonal antibody in the peripheral blood and synovial fluid of rheumatoid arthritis patients
    • 11035136
    • Choy EH Connolly DJ Rapson N Jeal S Brown JC Kingsley GH et al. Pharmacokinetic, pharmacodynamic and clinical effects of a humanized IgG1 anti-CD4 monoclonal antibody in the peripheral blood and synovial fluid of rheumatoid arthritis patients. Rheumatology (2000) 39(10):1139–46.10.1093/rheumatology/39.10.113911035136
    • (2000) Rheumatology , vol.39 , Issue.10 , pp. 1139-1146
    • Choy, E.H.1    Connolly, D.J.2    Rapson, N.3    Jeal, S.4    Brown, J.C.5    Kingsley, G.H.6
  • 66
    • 0036796835 scopus 로고    scopus 로고
    • Repeat-cycle study of high-dose intravenous 4162W94 anti-CD4 humanized monoclonal antibody in rheumatoid arthritis. A randomized placebo-controlled trial
    • 12364634
    • Choy E Panayi GS Emery P Madden S Breedveld FC Kraan MC et al. Repeat-cycle study of high-dose intravenous 4162W94 anti-CD4 humanized monoclonal antibody in rheumatoid arthritis. A randomized placebo-controlled trial. Rheumatology (2002) 41(10):1142–8.10.1093/rheumatology/41.10.114212364634
    • (2002) Rheumatology , vol.41 , Issue.10 , pp. 1142-1148
    • Choy, E.1    Panayi, G.S.2    Emery, P.3    Madden, S.4    Breedveld, F.C.5    Kraan, M.C.6
  • 67
    • 84928208326 scopus 로고    scopus 로고
    • A specific CD4 epitope bound by tregalizumab mediates activation of regulatory T cells by a unique signaling pathway
    • 25512343
    • Helling B König M Dälken B Engling A Krömer W Heim K et al. A specific CD4 epitope bound by tregalizumab mediates activation of regulatory T cells by a unique signaling pathway. Immunol Cell Biol (2015) 93(4):396–405.10.1038/icb.2014.10225512343
    • (2015) Immunol Cell Biol , vol.93 , Issue.4 , pp. 396-405
    • Helling, B.1    König, M.2    Dälken, B.3    Engling, A.4    Krömer, W.5    Heim, K.6
  • 68
    • 78650830420 scopus 로고    scopus 로고
    • Selective activation of naturally occurring regulatory T cells (Tregs) by the monoclonal antibody BT-061 as a novel therapeutic opportunity: pre-clinical and early clinical results
    • Czeloth N Dälken B Engling A Osterroth F Aigner S Abufarag A et al. Selective activation of naturally occurring regulatory T cells (Tregs) by the monoclonal antibody BT-061 as a novel therapeutic opportunity: pre-clinical and early clinical results. Ann Rheum Dis (2010) 69(Suppl3):99.
    • (2010) Ann Rheum Dis , vol.69 , Issue.Suppl3 , pp. 99
    • Czeloth, N.1    Dälken, B.2    Engling, A.3    Osterroth, F.4    Aigner, S.5    Abufarag, A.6
  • 69
    • 34250336824 scopus 로고    scopus 로고
    • CD4-mediated functional activation of human CD4+CD25+ regulatory T cells
    • 17407195
    • Becker C Kubach J Wijdenes J Knop J Jonuleit H. CD4-mediated functional activation of human CD4+CD25+ regulatory T cells. Eur J Immunol (2007) 37(5):1217–23.10.1002/eji.20063648017407195
    • (2007) Eur J Immunol , vol.37 , Issue.5 , pp. 1217-1223
    • Becker, C.1    Kubach, J.2    Wijdenes, J.3    Knop, J.4    Jonuleit, H.5
  • 70
    • 79955008449 scopus 로고    scopus 로고
    • Physiologic control of the functional status of Foxp3+ regulatory T cells
    • 21464094
    • Mellor AL Munn DH. Physiologic control of the functional status of Foxp3+ regulatory T cells. J Immunol (2011) 186(8):4535–40.10.4049/jimmunol.100293721464094
    • (2011) J Immunol , vol.186 , Issue.8 , pp. 4535-4540
    • Mellor, A.L.1    Munn, D.H.2
  • 71
    • 34250376423 scopus 로고    scopus 로고
    • Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression
    • 17502663
    • Bopp T Becker C Klein M Klein-Hessling S Palmetshofer A Serfling E et al. Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression. J Exp Med (2007) 204(6):1303–10.10.1084/jem.2006212917502663
    • (2007) J Exp Med , vol.204 , Issue.6 , pp. 1303-1310
    • Bopp, T.1    Becker, C.2    Klein, M.3    Klein-Hessling, S.4    Palmetshofer, A.5    Serfling, E.6
  • 72
    • 32244436150 scopus 로고    scopus 로고
    • Pharmacokinetics/pharmacodynamics of nondepleting anti-CD4 monoclonal antibody (TRX1) in healthy human volunteers
    • 16308668
    • Ng CM Stefanich E Anand BS Fielder PJ Vaickus L. Pharmacokinetics/pharmacodynamics of nondepleting anti-CD4 monoclonal antibody (TRX1) in healthy human volunteers. Pharm Res (2006) 23(1):95–103.10.1007/s11095-005-8814-316308668
    • (2006) Pharm Res , vol.23 , Issue.1 , pp. 95-103
    • Ng, C.M.1    Stefanich, E.2    Anand, B.S.3    Fielder, P.J.4    Vaickus, L.5
  • 73
    • 85117722873 scopus 로고    scopus 로고
    • Use of a biologic marker for an integrated pharmacodynamic and clinical analysis to inform further clinical development, including dose selection for the Phase 2b trial – Treat 2b – of tregalizumab in rheumatoid arthritis
    • Dokoupilova E Jeka S Vencovsky J Badurski J Prins K Strand V et al. Use of a biologic marker for an integrated pharmacodynamic and clinical analysis to inform further clinical development, including dose selection for the Phase 2b trial – Treat 2b – of tregalizumab in rheumatoid arthritis. Arthritis Rheum (2013) 65(Suppl 10):1412.
    • (2013) Arthritis Rheum , vol.65 , pp. 1412
    • Dokoupilova, E.1    Jeka, S.2    Vencovsky, J.3    Badurski, J.4    Prins, K.5    Strand, V.6
  • 74
    • 84928212798 scopus 로고    scopus 로고
    • Selective activation of naturally occurring regulatory T cells (Tregs) by the monoclonal antibody BT-061 as a novel therapeutic opportunity in psoriasis: early clinical results after single doses
    • Abufarag A Aigner S Czeloth N Dälken B Koch H Niemann G et al. Selective activation of naturally occurring regulatory T cells (Tregs) by the monoclonal antibody BT-061 as a novel therapeutic opportunity in psoriasis: early clinical results after single doses. J Invest Dermatol (2010) 130(Issue 2):S64.
    • (2010) J Invest Dermatol , vol.130 , Issue.Issue 2 , pp. S64
    • Abufarag, A.1    Aigner, S.2    Czeloth, N.3    Dälken, B.4    Koch, H.5    Niemann, G.6
  • 75
    • 79955041532 scopus 로고    scopus 로고
    • Selective activation of naturally occurring regulatory T cells (Tregs) by the monoclonal antibody (mAb) BT-061. Markers of clinical activity and early Phase II results in patients with rheumatoid arthritis (RA)
    • Rudnev A Ragavan S Trollmo C Malmstroem V Becker C Jonuleit H et al. Selective activation of naturally occurring regulatory T cells (Tregs) by the monoclonal antibody (mAb) BT-061. Markers of clinical activity and early Phase II results in patients with rheumatoid arthritis (RA). Arthritis Rheum (2010) 62(Suppl 10):1125.
    • (2010) Arthritis Rheum , vol.62 , pp. 1125
    • Rudnev, A.1    Ragavan, S.2    Trollmo, C.3    Malmstroem, V.4    Becker, C.5    Jonuleit, H.6
  • 77
    • 84959094134 scopus 로고    scopus 로고
    • A Phase 2b study evaluating the efficacy and safety of subcutaneously administered tregalizumab in subjects with active rheumatoid arthritis (RA) despite treatment with methotrexate (MTX)
    • Available from
    • van Vollenhoven RF Keystone EC Strand V Pacheco-Tena C Vencovsky J Behrens F et al. A Phase 2b study evaluating the efficacy and safety of subcutaneously administered tregalizumab in subjects with active rheumatoid arthritis (RA) despite treatment with methotrexate (MTX). Arthritis Rheumatol (2015) 67(Suppl 10). Available from: http://acrabstracts.org/abstract/a-phase-2b-study-evaluating-the-efficacy-and-safety-of-subcutaneously-administered-tregalizumab-in-subjects-with-active-rheumatoid-arthritis-ra-despite-treatment-with-methotrexate-mtx/
    • (2015) Arthritis Rheumatol , vol.67
    • van Vollenhoven, R.F.1    Keystone, E.C.2    Strand, V.3    Pacheco-Tena, C.4    Vencovsky, J.5    Behrens, F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.