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Volumn 164, Issue 4, 2000, Pages 1925-1933

Elimination of Fc receptor-dependent effector functions of a modified IgG4 monoclonal antibody to human CD4

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CLENOLIXIMAB; FC RECEPTOR; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G4; KELIXIMAB; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

EID: 0034651966     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.4.1925     Document Type: Article
Times cited : (120)

References (41)
  • 1
    • 0026211179 scopus 로고
    • Cd4: Its structure, role in immune function and aids pathogenesis, and potential as a pharmacological target
    • Sweet, R. W., A. Truneh, and W. A. Hendrickson. 1991. CD4: its structure, role in immune function and AIDS pathogenesis, and potential as a pharmacological target. Curr. Opin. Biotechnol. 2:622.
    • (1991) Curr. Opin. Biotechnol. , vol.2 , pp. 622
    • Sweet, R.W.1    Truneh, A.2    Hendrickson, W.A.3
  • 3
    • 0026752620 scopus 로고
    • The importance of the t cell in initiating and maintaining the chronic synovitis of rheumatoid arthritis
    • Panayi, G. S., J. S. Lanchbury, and G. H. Kingsley. 1992. The importance of the T cell in initiating and maintaining the chronic synovitis of rheumatoid arthritis. Arthritis Rheum. 35:729.
    • (1992) Arthritis Rheum. , vol.35 , pp. 729
    • Panayi, G.S.1    Lanchbury, J.S.2    Kingsley, G.H.3
  • 4
    • 0027285558 scopus 로고
    • The use of monoclonal antibodies to achieve immunological tolerance
    • Waldmann, H., and S. Cobbold. 1993. The use of monoclonal antibodies to achieve immunological tolerance. Immunol. Today 14:245.
    • (1993) Immunol. Today , vol.14 , pp. 245
    • Waldmann, H.1    Cobbold, S.2
  • 5
    • 0027172969 scopus 로고
    • Immunosuppressive therapy of autoimmune diseases
    • Bach, J. F. 1993. Immunosuppressive therapy of autoimmune diseases. Immunol. Today 14:322.
    • (1993) Immunol. Today , vol.14 , pp. 322
    • Bach, J.F.1
  • 7
    • 0023759102 scopus 로고
    • Anti-cd4 and anti-cd2 monoclonal antibody infusions in subjects with multiple sclerosis: Immunosuppressive effects and human anti-mouse responses
    • Hafler D. A., J. Ritz, S. Schlossman, and H. Weiner. 1988. Anti-CD4 and anti-CD2 monoclonal antibody infusions in subjects with multiple sclerosis: immunosuppressive effects and human anti-mouse responses. J. Immunol. 141:131.
    • (1988) J. Immunol. , vol.141 , pp. 131
    • Hafler, D.A.1    Ritz, J.2    Schlossman, S.3    Weiner, H.4
  • 8
    • 0025360302 scopus 로고
    • Monoclonal antibody therapy in systemic vasculitis
    • Mathieson, P.W., S. P. Cobbold, and P. Hale. 1990. Monoclonal antibody therapy in systemic vasculitis. N. Engl. Med. 323:250.
    • (1990) N. Engl. Med. , vol.323 , pp. 250
    • Mathieson, P.W.1    Cobbold, S.P.2    Hale, P.3
  • 10
    • 14744294919 scopus 로고
    • "Primatization" of recombinant antibodies for immunotherapy of human diseases: A macaque/human chimeric antibody against human cd4
    • Newman R., J. Alberts, and D. Anderson. 1992. "Primatization" of recombinant antibodies for immunotherapy of human diseases: a macaque/human chimeric antibody against human CD4. Bio/Technology 10:1415.
    • (1992) Bio/technology , vol.10 , pp. 1415
    • Newman, R.1    Alberts, J.2    Anderson, D.3
  • 14
    • 0026680392 scopus 로고
    • The use of a non-depleting anti-cd4 monoclonal antibody to re-establish tolerance to cells in nod mice
    • Hutchings, P., L. O'Reilly, N. M. Parish, H. Waldman, and A. Cooke. 1992. The use of a non-depleting anti-CD4 monoclonal antibody to re-establish tolerance to cells in NOD mice. Eur. J. Immunol. 22:1913.
    • (1992) Eur. J. Immunol. , vol.22 , pp. 1913
    • Hutchings, P.1    O'Reilly, L.2    Parish, N.M.3    Waldman, H.4    Cooke, A.5
  • 16
    • 0032480574 scopus 로고    scopus 로고
    • Randomized, dose-ranging, placebo-controlled study of chimeric antibody to cd4 (keliximab) in chronic severe asthma
    • Kon, O. M., B. S. Sihra, C. H. Compton, T. B. Leonard, A. B. Kay and N. C. Barnes. 1998. Randomized, dose-ranging, placebo-controlled study of chimeric antibody to CD4 (keliximab) in chronic severe asthma. Lancet 352:1109.
    • (1998) Lancet , vol.352 , pp. 1109
    • Kon, O.M.1    Sihra, B.S.2    Compton, C.H.3    Leonard, T.B.4    Kay, A.B.5    Barnes, N.C.6
  • 20
    • 0020630397 scopus 로고
    • Isolation of human blood monocytes with nycodenz, a new non-ionic iodinated gradient medium
    • Boyum, A. 1983. Isolation of human blood monocytes with Nycodenz, a new non-ionic iodinated gradient medium. Scand. J. Immunol. 17:429.
    • (1983) Scand. J. Immunol. , vol.17 , pp. 429
    • Boyum, A.1
  • 21
    • 0031588898 scopus 로고    scopus 로고
    • A non-radioactive complement-dependent cytotoxicity assay for anti-cd20 monoclonal antibody
    • Gazzano, S., H. P. Ralph, T. C. Ryskamp, A. B. Chen, and V. R. Mukku. 1996. A non-radioactive complement-dependent cytotoxicity assay for anti-CD20 monoclonal antibody. J. Immunol. Methods 202:163.
    • (1996) J. Immunol. Methods , vol.202 , pp. 163
    • Gazzano, S.1    Ralph, H.P.2    Ryskamp, T.C.3    Chen, A.B.4    Mukku, V.R.5
  • 22
    • 0030584783 scopus 로고    scopus 로고
    • Humanization and molecular modeling of the anti-cd4 monoclonal antibody, okt4a
    • Pulito, V. L., V. A. Roberts, and J. R. Adair. 1996. Humanization and molecular modeling of the anti-CD4 monoclonal antibody, OKT4A. J. Immunol. 156:2840.
    • (1996) J. Immunol. , vol.156 , pp. 2840
    • Pulito, V.L.1    Roberts, V.A.2    Adair, J.R.3
  • 23
    • 84959744414 scopus 로고
    • Advances in immunotherapy of rheumatoid arthritis: Clinical and immunological findings following treatment with anti-cd4 antibodies
    • Horneff, G., F. Emmrich, and G. R. Burmester. 1993. Advances in immunotherapy of rheumatoid arthritis: clinical and immunological findings following treatment with anti-CD4 antibodies. Br. J. Rheumatol. 32:39.
    • (1993) Br. J. Rheumatol. , vol.32 , pp. 39
    • Horneff, G.1    Emmrich, F.2    Burmester, G.R.3
  • 24
    • 0030785717 scopus 로고    scopus 로고
    • Differential functional effects of a humanized anti-cd4 antibody on resting and activated human t cells
    • Brett, S. J., W. Rowan, M. Smith, M. Batholomew, and J. P. Tite. 1997. Differential functional effects of a humanized anti-CD4 antibody on resting and activated human T cells. Immunology 91:346.
    • (1997) Immunology , vol.91 , pp. 346
    • Brett, S.J.1    Rowan, W.2    Smith, M.3    Batholomew, M.4    Tite, J.P.5
  • 25
    • 0031106547 scopus 로고    scopus 로고
    • Clinical significance of igg fc receptors and fcγr-directed immunotherapies
    • Deo, Y. M., R. F. Graziano, R. Repp, and J. G. J. vande Winkel. 1997. Clinical significance of IgG Fc receptors and FcγR-directed immunotherapies, Immunol. Today 18:127.
    • (1997) Immunol. Today , vol.18 , pp. 127
    • Deo, Y.M.1    Graziano, R.F.2    Repp, R.3    Vande Winkel, J.G.J.4
  • 26
    • 0345337424 scopus 로고    scopus 로고
    • Induction of igg rheumatoid factor (rf) production by antibody-antibody (rf-like) immune complexes: The role of t cells, complement and fcγ receptors
    • Nordstrom E, E. Moller, and M. Abedi-Vaugerdi. 1998. Induction of IgG rheumatoid factor (RF) production by antibody-antibody (RF-like) immune complexes: the role of T cells, complement and Fcγ receptors. J Autoimmun. 11:131.
    • (1998) J Autoimmun. , vol.11 , pp. 131
    • Nordstrom, E.1    Moller, E.2    Abedi-Vaugerdi, M.3
  • 27
    • 0024747168 scopus 로고
    • Anti-cd4 antibody treatment of patients with rheumatoid arthritis. Ii. Effect of in vivo treatment on in vitro proliferative response of cd4 cells
    • Walker, C., C. Herzog, P. Rieber, G. Riethmuller, W. Muller, and W. J. Pichler, 1989. Anti-CD4 antibody treatment of patients with rheumatoid arthritis. II. Effect of in vivo treatment on in vitro proliferative response of CD4 cells. J. Autoimmun. 2:643.
    • (1989) J. Autoimmun. , vol.2 , pp. 643
    • Walker, C.1    Herzog, C.2    Rieber, P.3    Riethmuller, G.4    Muller, W.5    Pichler, W.J.6
  • 28
    • 0030209984 scopus 로고    scopus 로고
    • Anergy-associated t cell antigen presentation: A mechanism of infectious tolerance in experimental autoimmune encephalomyelitis
    • Mannie, M. D., S. K. Rendall, P. V. Arnold, J. P. Nardella, and G. A. White. 1996. Anergy-associated T cell antigen presentation: a mechanism of infectious tolerance in experimental autoimmune encephalomyelitis. J. Immunol. 157:1062.
    • (1996) J. Immunol. , vol.157 , pp. 1062
    • Mannie, M.D.1    Rendall, S.K.2    Arnold, P.V.3    Nardella, J.P.4    White, G.A.5
  • 30
    • 0024416006 scopus 로고
    • Monoclonal antibodies that bind to distinct epitopes or fcγri are able to trigger receptor function
    • Guyre, P. M., R. F. Graziano, B. A. Vance, P. M. Morganelli, and M. W. Fanger. 1989. Monoclonal antibodies that bind to distinct epitopes or FcγRI are able to trigger receptor function. J. Immunol. 143:1650.
    • (1989) J. Immunol. , vol.143 , pp. 1650
    • Guyre, P.M.1    Graziano, R.F.2    Vance, B.A.3    Morganelli, P.M.4    Fanger, M.W.5
  • 32
    • 0023933120 scopus 로고
    • Localization of the binding site for the high-affinity fc receptor on igg
    • Duncan, A. R., J. M. Woof, L. J. Patridge, and G. Winter. 1988. Localization of the binding site for the high-affinity Fc receptor on IgG. Nature 332:563.
    • (1988) Nature , vol.332 , pp. 563
    • Duncan, A.R.1    Woof, J.M.2    Patridge, L.J.3    Winter, G.4
  • 37
    • 0024424859 scopus 로고
    • The igg subclass pattern of complement activation depends upon density and antibody and complement activation
    • Garred, P., T. E. Michaelson, and A. Aase. 1989. The IgG subclass pattern of complement activation depends upon density and antibody and complement activation. Scand. J. Immunol. 30:379.
    • (1989) Scand. J. Immunol. , vol.30 , pp. 379
    • Garred, P.1    Michaelson, T.E.2    Aase, A.3
  • 38
    • 0029033110 scopus 로고
    • Functional analysis of the effects of a fully humanized anti-cd4 antibody on resting and activating human t cells
    • Bartholomew, M., S. Brett, K. Barber, C. Rossman, S. Crowe, and J. Tite. 1995. Functional analysis of the effects of a fully humanized anti-CD4 antibody on resting and activating human T cells. Immunology 85:41.
    • (1995) Immunology , vol.85 , pp. 41
    • Bartholomew, M.1    Brett, S.2    Barber, K.3    Rossman, C.4    Crowe, S.5    Tite, J.6
  • 39
    • 0027458717 scopus 로고
    • The generation of a humanized, non-mitogenic cd3 monoclonal antibody which retains in vitro immunosuppressive properties
    • Bolt, S., E. Routledge, I. Lloyd, L. Chatenoud, H. Pope, S. D. Gorman, M. Clark, and H. Waldmann. 1993. The generation of a humanized, non-mitogenic CD3 monoclonal antibody which retains in vitro immunosuppressive properties. Eur. J. Immunol. 23:403.
    • (1993) Eur. J. Immunol. , vol.23 , pp. 403
    • Bolt, S.1    Routledge, E.2    Lloyd, I.3    Chatenoud, L.4    Pope, H.5    Gorman, S.D.6    Clark, M.7    Waldmann, H.8
  • 41
    • 0031874950 scopus 로고    scopus 로고
    • Monoclonal antibody therapy in rheumatoid arthritis
    • Choy, E. H. S., G. H. Kingsley, and G. S. Panayi. 1998. Monoclonal antibody therapy in rheumatoid arthritis. Br. J. Rheumatol. 37:484.
    • (1998) Br. J. Rheumatol. , vol.37 , pp. 484
    • Choy, E.H.S.1    Kingsley, G.H.2    Panayi, G.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.