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Volumn 83, Issue 8, 2016, Pages

Anemia of chronic kidney disease: Treat it, but not too aggressively

Author keywords

[No Author keywords available]

Indexed keywords

ANTIANEMIC AGENT; EPO PROTEIN, HUMAN; ERYTHROPOIETIN;

EID: 84984611731     PISSN: 08911150     EISSN: None     Source Type: Journal    
DOI: 10.3949/ccjm.83a.15065     Document Type: Article
Times cited : (43)

References (96)
  • 2
    • 0036154114 scopus 로고    scopus 로고
    • Epidemiology of anemia associated with chronic renal insufficiency among adults in the United States: results from the Third National Health and Nutrition Examination Survey
    • Hsu CY, McCulloch CE, Curhan GC, et al. Epidemiology of anemia associated with chronic renal insufficiency among adults in the United States: results from the Third National Health and Nutrition Examination Survey. J Am Soc Nephrol 2002; 13:504-510.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 504-510
    • Hsu, C.Y.1    McCulloch, C.E.2    Curhan, G.C.3
  • 3
    • 0018726260 scopus 로고
    • Serum erythropoetin concentration in chronic renal failure: relationship to degree of anemia and excretory renal function
    • Radtke HW, Claussner A, Erbes PM, Scheuermann EH, Schoeppe W, Koch KM. Serum erythropoetin concentration in chronic renal failure: relationship to degree of anemia and excretory renal function. Blood 1979; 54:877-884.
    • (1979) Blood , vol.54 , pp. 877-884
    • Radtke, H.W.1    Claussner, A.2    Erbes, P.M.3    Scheuermann, E.H.4    Schoeppe, W.5    Koch, K.M.6
  • 4
    • 0034816679 scopus 로고    scopus 로고
    • Anemia: an early complication of chronic renal insufficiency
    • Kazmi WH, Kausz AT, Khan S, et al. Anemia: an early complication of chronic renal insufficiency. Am J Kidney Dis 2001; 38:803-812.
    • (2001) Am J Kidney Dis , vol.38 , pp. 803-812
    • Kazmi, W.H.1    Kausz, A.T.2    Khan, S.3
  • 6
    • 0037024202 scopus 로고    scopus 로고
    • Anemia is associated with worse symptoms, greater impairment in functional capacity and a significant increase in mortality in patients with advanced heart failure
    • Horwich TB, Fonarow GC, Hamilton MA, MacLellan WR, Borenstein J. Anemia is associated with worse symptoms, greater impairment in functional capacity and a significant increase in mortality in patients with advanced heart failure. J Am Coll Cardiol 2002; 39:1780-1786.
    • (2002) J Am Coll Cardiol , vol.39 , pp. 1780-1786
    • Horwich, T.B.1    Fonarow, G.C.2    Hamilton, M.A.3    MacLellan, W.R.4    Borenstein, J.5
  • 7
    • 1442265576 scopus 로고    scopus 로고
    • B-type natriuretic peptide: a biomarker for all seasons?
    • Mark DB, Felker GM. B-type natriuretic peptide: a biomarker for all seasons? N Engl J Med 2004; 350:718-720.
    • (2004) N Engl J Med , vol.350 , pp. 718-720
    • Mark, D.B.1    Felker, G.M.2
  • 8
  • 9
    • 0038458694 scopus 로고    scopus 로고
    • Chronic kidney disease, anemia, and incident stroke in a middle-aged, community-based population: the ARIC Study
    • Abramson JL, Jurkovitz CT, Vaccarino V, Weintraub WS, McClellan W. Chronic kidney disease, anemia, and incident stroke in a middle-aged, community-based population: the ARIC Study. Kidney Int 2003; 64:610-615.
    • (2003) Kidney Int , vol.64 , pp. 610-615
    • Abramson, J.L.1    Jurkovitz, C.T.2    Vaccarino, V.3    Weintraub, W.S.4    McClellan, W.5
  • 10
    • 0037014610 scopus 로고    scopus 로고
    • Anemia as a risk factor for cardiovascular disease in the Atherosclerosis Risk in Communities (ARIC) study
    • Sarnak MJ, Tighiouart H, Manjunath G, et al. Anemia as a risk factor for cardiovascular disease in the Atherosclerosis Risk in Communities (ARIC) study. J Am Coll Cardiol 2002; 40:27-33.
    • (2002) J Am Coll Cardiol , vol.40 , pp. 27-33
    • Sarnak, M.J.1    Tighiouart, H.2    Manjunath, G.3
  • 11
    • 0036296978 scopus 로고    scopus 로고
    • Anemia and renal insufficiency are independent risk factors for death among patients with congestive heart failure admitted to community hospitals: a population-based study
    • McClellan WM, Flanders WD, Langston RD, Jurkovitz C, Presley R. Anemia and renal insufficiency are independent risk factors for death among patients with congestive heart failure admitted to community hospitals: a population-based study. J Am Soc Nephrol 2002; 13:1928-1936.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 1928-1936
    • McClellan, W.M.1    Flanders, W.D.2    Langston, R.D.3    Jurkovitz, C.4    Presley, R.5
  • 12
    • 0032991310 scopus 로고    scopus 로고
    • Hematocrit levels and hospitalization risks in hemodialysis patients
    • Xia H, Ebben J, Ma JZ, Collins AJ. Hematocrit levels and hospitalization risks in hemodialysis patients. J Am Soc Nephrol 1999; 10:1309-1316.
    • (1999) J Am Soc Nephrol , vol.10 , pp. 1309-1316
    • Xia, H.1    Ebben, J.2    Ma, J.Z.3    Collins, A.J.4
  • 13
    • 0034765367 scopus 로고    scopus 로고
    • Death, hospitalization, and economic associations among incident hemodialysis patients with hematocrit values of 36 to 39%
    • Collins AJ, Li S, St Peter W, et al. Death, hospitalization, and economic associations among incident hemodialysis patients with hematocrit values of 36 to 39%. J Am Soc Nephrol 2001; 12:2465-2473.
    • (2001) J Am Soc Nephrol , vol.12 , pp. 2465-2473
    • Collins, A.J.1    Li, S.2    St Peter, W.3
  • 14
    • 33750628638 scopus 로고    scopus 로고
    • Practical approach to the diagnosis and treatment of anemia associated with CKD in elderly
    • Agarwal AK. Practical approach to the diagnosis and treatment of anemia associated with CKD in elderly. J Am Med Dir Assoc 2006; 7(suppl 9):S7-S12.
    • (2006) J Am Med Dir Assoc , vol.7 , pp. S7-S12
    • Agarwal, A.K.1
  • 15
    • 78649876180 scopus 로고    scopus 로고
    • Inhibition of prolyl hydroxylases increases erythropoietin production in ESRD
    • Bernhardt WM, Wiesener MS, Scigalla P, et al. Inhibition of prolyl hydroxylases increases erythropoietin production in ESRD. J Am Soc Nephrol 2010; 21:2151-2156.
    • (2010) J Am Soc Nephrol , vol.21 , pp. 2151-2156
    • Bernhardt, W.M.1    Wiesener, M.S.2    Scigalla, P.3
  • 16
    • 70649099473 scopus 로고    scopus 로고
    • FG-2216, a novel oral HIF-PHI, stimulates erythropoiesis and increases hemoglobin concentration in patients with non-dialysis CKD
    • Provenzano R, Fadda G, Bernardo M, et al. FG-2216, a novel oral HIF-PHI, stimulates erythropoiesis and increases hemoglobin concentration in patients with non-dialysis CKD. Am J Kidney Dis 2008; 51:B80.
    • (2008) Am J Kidney Dis , vol.51 , pp. B80
    • Provenzano, R.1    Fadda, G.2    Bernardo, M.3
  • 17
    • 0027367661 scopus 로고
    • Identification of the renal erythropoietin-producing cells using transgenic mice
    • Maxwell PH, Osmond MK, Pugh CW, et al. Identification of the renal erythropoietin-producing cells using transgenic mice. Kidney Int 1993; 44:1149-1162.
    • (1993) Kidney Int , vol.44 , pp. 1149-1162
    • Maxwell, P.H.1    Osmond, M.K.2    Pugh, C.W.3
  • 19
    • 0026526168 scopus 로고
    • Erythropoeitin: structure, control of production and function
    • Jelkmann W. Erythropoeitin: structure, control of production and function. Physiol Rev 1992; 72:449-489.
    • (1992) Physiol Rev , vol.72 , pp. 449-489
    • Jelkmann, W.1
  • 20
    • 0029051439 scopus 로고
    • Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
    • Wang GL, Jiang BH, Rue EA, Semenza GL. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA 1995; 92:5510-5514.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 5510-5514
    • Wang, G.L.1    Jiang, B.H.2    Rue, E.A.3    Semenza, G.L.4
  • 21
    • 0028816847 scopus 로고
    • Purification and characterization of hypoxia-inducible factor 1
    • Wang GL, Semenza GL. Purification and characterization of hypoxia-inducible factor 1. J Biol Chem 1995; 270:1230-1237.
    • (1995) J Biol Chem , vol.270 , pp. 1230-1237
    • Wang, G.L.1    Semenza, G.L.2
  • 22
    • 0033587146 scopus 로고    scopus 로고
    • The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
    • Maxwell PH, Wiesener MS, Chang GW, et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 1999; 399:271-275.
    • (1999) Nature , vol.399 , pp. 271-275
    • Maxwell, P.H.1    Wiesener, M.S.2    Chang, G.W.3
  • 23
    • 0030961006 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes
    • Salceda S, Caro J. Hypoxia-inducible factor 1alpha protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. J Biol Chem 1997; 272:22642-22647.
    • (1997) J Biol Chem , vol.272 , pp. 22642-22647
    • Salceda, S.1    Caro, J.2
  • 24
    • 84887002873 scopus 로고    scopus 로고
    • Erythropoietin critically regulates the terminal maturation of murine and human primitive erythroblasts
    • Malik J, Kim AR, Tyre KA, Cherukuri AR, Palis J. Erythropoietin critically regulates the terminal maturation of murine and human primitive erythroblasts. Haematologica 2013; 98:1778-1787.
    • (2013) Haematologica , vol.98 , pp. 1778-1787
    • Malik, J.1    Kim, A.R.2    Tyre, K.A.3    Cherukuri, A.R.4    Palis, J.5
  • 25
    • 0028880455 scopus 로고
    • Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor
    • Wu H, Liu X, Jaenisch R, Lodish HF. Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor. Cell 1995; 83:59-67.
    • (1995) Cell , vol.83 , pp. 59-67
    • Wu, H.1    Liu, X.2    Jaenisch, R.3    Lodish, H.F.4
  • 26
    • 0035760889 scopus 로고    scopus 로고
    • Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts
    • Socolovsky M, Nam H, Fleming MD, Haase VH, Brugnara C, Lodish HF. Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts. Blood 2001; 98:3261-3273.
    • (2001) Blood , vol.98 , pp. 3261-3273
    • Socolovsky, M.1    Nam, H.2    Fleming, M.D.3    Haase, V.H.4    Brugnara, C.5    Lodish, H.F.6
  • 29
    • 0037962795 scopus 로고    scopus 로고
    • The orchestration of body iron intake: how and where do enterocytes receive their cues?
    • Frazer DM, Anderson GJ. The orchestration of body iron intake: how and where do enterocytes receive their cues? Blood Cells Moll Dis 2003; 30:288-297.
    • (2003) Blood Cells Moll Dis , vol.30 , pp. 288-297
    • Frazer, D.M.1    Anderson, G.J.2
  • 30
    • 20444416123 scopus 로고    scopus 로고
    • The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis
    • Donovan A, Lima CA, Pinkus JL, et al. The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metab 2005; 1:191-200.
    • (2005) Cell Metab , vol.1 , pp. 191-200
    • Donovan, A.1    Lima, C.A.2    Pinkus, J.L.3
  • 31
    • 0032909207 scopus 로고    scopus 로고
    • Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse
    • Vulpe CD, Kuo YM, Murphy TL, et al. Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse. Nat Genet 1999; 21:195-199.
    • (1999) Nat Genet , vol.21 , pp. 195-199
    • Vulpe, C.D.1    Kuo, Y.M.2    Murphy, T.L.3
  • 32
    • 0028868660 scopus 로고
    • Overview and mechanisms of iron regulation
    • Bothwell TH. Overview and mechanisms of iron regulation. Nutr Rev 1995: 53:237-245.
    • (1995) Nutr Rev , vol.53 , pp. 237-245
    • Bothwell, T.H.1
  • 33
  • 34
    • 77953810574 scopus 로고    scopus 로고
    • Cytosolic and mitochondrial ferritins in the regulation of cellular iron homeostasis and oxidative damage
    • Arosio P, Levi S. Cytosolic and mitochondrial ferritins in the regulation of cellular iron homeostasis and oxidative damage. Biochim Biophys Acta 2010; 1800:783-792.
    • (2010) Biochim Biophys Acta , vol.1800 , pp. 783-792
    • Arosio, P.1    Levi, S.2
  • 35
    • 0022974645 scopus 로고
    • Plasma ferritin determination as a diagnostic tool
    • Finch CA, Bellotti V, Stray S, et al. Plasma ferritin determination as a diagnostic tool. West J Med 1986; 145:657-663.
    • (1986) West J Med , vol.145 , pp. 657-663
    • Finch, C.A.1    Bellotti, V.2    Stray, S.3
  • 36
    • 28444488323 scopus 로고    scopus 로고
    • Presence of the iron exporter ferroportin at the plasma membrane of macrophages is enhanced by iron loading and down-regulated by hepcidin
    • Delaby C, Pilard N, Goncalves AS, Beaumont C, Canonne-Hergaux F. Presence of the iron exporter ferroportin at the plasma membrane of macrophages is enhanced by iron loading and down-regulated by hepcidin. Blood 2005; 106:3979-3984.
    • (2005) Blood , vol.106 , pp. 3979-3984
    • Delaby, C.1    Pilard, N.2    Goncalves, A.S.3    Beaumont, C.4    Canonne-Hergaux, F.5
  • 37
    • 0041672570 scopus 로고    scopus 로고
    • Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation
    • Ganz T. Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood 2003; 102:783-788.
    • (2003) Blood , vol.102 , pp. 783-788
    • Ganz, T.1
  • 38
    • 0036791486 scopus 로고    scopus 로고
    • The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation
    • Nicolas G, Chauvet C, Viatte L, et al. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest 2002; 110:1037-1044.
    • (2002) J Clin Invest , vol.110 , pp. 1037-1044
    • Nicolas, G.1    Chauvet, C.2    Viatte, L.3
  • 39
    • 0014807206 scopus 로고
    • Erythropoiesis and erythropoietin in patients with chronic renal failure treated with hemodialysis and testosterone
    • DeGowin RL, Lavender AR, Forland M, Charleston D, Gottschalk A. Erythropoiesis and erythropoietin in patients with chronic renal failure treated with hemodialysis and testosterone. Ann Intern Med 1970; 72:913-918.
    • (1970) Ann Intern Med , vol.72 , pp. 913-918
    • DeGowin, R.L.1    Lavender, A.R.2    Forland, M.3    Charleston, D.4    Gottschalk, A.5
  • 40
    • 0014852824 scopus 로고
    • Erythropoietic response of dialyzed patients to testosterone administration
    • Richardson JR Jr, Weinstein MB. Erythropoietic response of dialyzed patients to testosterone administration. Ann Intern Med 1970; 73:403-407
    • (1970) Ann Intern Med , vol.73 , pp. 403-407
    • Richardson, J.R.1    Weinstein, M.B.2
  • 41
    • 0024790160 scopus 로고
    • Recombinant human erythropoietin in anemic patients with end-stage renal disease. Results of a phase III multicenter clinical trial
    • Eschbach JW, Abdulhadi MH, Browne JK, et al. Recombinant human erythropoietin in anemic patients with end-stage renal disease. Results of a phase III multicenter clinical trial. Ann Intern Med 1989; 111:992-1000.
    • (1989) Ann Intern Med , vol.111 , pp. 992-1000
    • Eschbach, J.W.1    Abdulhadi, M.H.2    Browne, J.K.3
  • 42
    • 0030004827 scopus 로고    scopus 로고
    • Controlled study on the improvement of quality of life in elderly hemodialysis patients after correcting end-stage renal disease-related anemia with erythropoietin
    • Moreno F, Aracil FJ, Pérez R, Valderrábano F. Controlled study on the improvement of quality of life in elderly hemodialysis patients after correcting end-stage renal disease-related anemia with erythropoietin. Am J Kidney Dis 1996; 27:548-556.
    • (1996) Am J Kidney Dis , vol.27 , pp. 548-556
    • Moreno, F.1    Aracil, F.J.2    Pérez, R.3    Valderrábano, F.4
  • 43
    • 0026101508 scopus 로고
    • Recombinant human erythropoietin and renal anemia: molecular biology, clinical efficacy, and nervous system effects
    • Nissenson AR, Nimer SD, Wolcott DL. Recombinant human erythropoietin and renal anemia: molecular biology, clinical efficacy, and nervous system effects. Ann Intern Med 1991; 114:402-416.
    • (1991) Ann Intern Med , vol.114 , pp. 402-416
    • Nissenson, A.R.1    Nimer, S.D.2    Wolcott, D.L.3
  • 44
    • 0033824494 scopus 로고    scopus 로고
    • Benefits of anaemia treatment on cognitive function
    • Stivelman JC. Benefits of anaemia treatment on cognitive function. Nephrol Dial Transplant 2000; 15(suppl 3):29-35.
    • (2000) Nephrol Dial Transplant , vol.15 , pp. 29-35
    • Stivelman, J.C.1
  • 45
    • 35748982914 scopus 로고    scopus 로고
    • Effect of erythropoiesis-stimulating agents on healthcare utilization, costs, and outcomes in chronic kidney disease
    • Maddux FW, Shetty S, del Aguila MA, Nelson MA, Murray BM. Effect of erythropoiesis-stimulating agents on healthcare utilization, costs, and outcomes in chronic kidney disease. Ann Pharmacother 2007; 41:1761-1769.
    • (2007) Ann Pharmacother , vol.41 , pp. 1761-1769
    • Maddux, F.W.1    Shetty, S.2    del Aguila, M.A.3    Nelson, M.A.4    Murray, B.M.5
  • 46
    • 0025139446 scopus 로고
    • Long-term cardiorespiratory effects of amelioration of renal anaemia by erythropoietin
    • Macdougall IC, Lewis NP, Saunders MJ, et al. Long-term cardiorespiratory effects of amelioration of renal anaemia by erythropoietin. Lancet 1990; 335:489-493.
    • (1990) Lancet , vol.335 , pp. 489-493
    • Macdougall, I.C.1    Lewis, N.P.2    Saunders, M.J.3
  • 47
    • 11344262637 scopus 로고    scopus 로고
    • Effects of treatment with epoetin beta on outcomes in patients with anaemia and chronic heart failure
    • Silverberg DS, Wexler D, Blum M, et al. Effects of treatment with epoetin beta on outcomes in patients with anaemia and chronic heart failure. Kidney Blood Press Res 2005; 28:41-47.
    • (2005) Kidney Blood Press Res , vol.28 , pp. 41-47
    • Silverberg, D.S.1    Wexler, D.2    Blum, M.3
  • 48
    • 34250311657 scopus 로고    scopus 로고
    • Impact of an anemia clinic on emergency room visits and hospitalizations in patients with anemia of CKD pre-dialysis
    • Perkins R, Olson S, Hansen J, Lee J, Stiles K, Lebrun C. Impact of an anemia clinic on emergency room visits and hospitalizations in patients with anemia of CKD pre-dialysis. Nephrol Nurs J 2007; 34:167-173, 182.
    • (2007) Nephrol Nurs J , vol.34
    • Perkins, R.1    Olson, S.2    Hansen, J.3    Lee, J.4    Stiles, K.5    Lebrun, C.6
  • 49
    • 0031780146 scopus 로고    scopus 로고
    • The impact of haematocrit levels and erythropoietin treatment on overall and cardiovascular mortality and morbidity-the experience of the Lombardy Dialysis Registry
    • Locatelli F, Conte F, Marcelli D. The impact of haematocrit levels and erythropoietin treatment on overall and cardiovascular mortality and morbidity-the experience of the Lombardy Dialysis Registry. Nephrol Dial Transplant 1998; 13:1642-1644.
    • (1998) Nephrol Dial Transplant , vol.13 , pp. 1642-1644
    • Locatelli, F.1    Conte, F.2    Marcelli, D.3
  • 50
    • 39049182716 scopus 로고    scopus 로고
    • 2005 Annual Report: ESRD Clinical Performance Measures Project
    • Centers for Medicare and Medicaid Services; Kinney R. 2005 Annual Report: ESRD Clinical Performance Measures Project. Am J Kidney Dis 2006; 48(suppl 2):S1-S106.
    • (2006) Am J Kidney Dis , vol.48 , pp. S1-S106
    • Kinney, R.1
  • 51
    • 68349157449 scopus 로고    scopus 로고
    • Accessed July 3, 2016
    • US Renal Data System. Annual Data Report 2006. www.usrds.org/adr.aspx. Accessed July 3, 2016.
    • Annual Data Report 2006
  • 52
    • 0032572913 scopus 로고    scopus 로고
    • The effects of normal as compared with low hematocrit values in patients with cardiac disease who are receiving hemodialysis and epoetin
    • Besarab A, Bolton WK, Browne JK, et al. The effects of normal as compared with low hematocrit values in patients with cardiac disease who are receiving hemodialysis and epoetin. N Engl J Med 1998; 339:584-590.
    • (1998) N Engl J Med , vol.339 , pp. 584-590
    • Besarab, A.1    Bolton, W.K.2    Browne, J.K.3
  • 53
    • 33750983605 scopus 로고    scopus 로고
    • Correction of anemia with epoetin alfa in chronic kidney disease
    • Singh AK, Szczech L, Tang KL, et al; CHOIR Investigators. Correction of anemia with epoetin alfa in chronic kidney disease. N Engl J Med 2006; 355:2085-2098.
    • (2006) N Engl J Med , vol.355 , pp. 2085-2098
    • Singh, A.K.1    Szczech, L.2    Tang, K.L.3
  • 54
    • 33751002326 scopus 로고    scopus 로고
    • Normalization of hemoglobin level in patients with chronic kidney disease and anemia
    • Drüeke TB, Locatelli F, Clyne N, et al; CREATE Investigators. Normalization of hemoglobin level in patients with chronic kidney disease and anemia. N Engl J Med 2006; 355:2071-2084.
    • (2006) N Engl J Med , vol.355 , pp. 2071-2084
    • Drüeke, T.B.1    Locatelli, F.2    Clyne, N.3
  • 55
    • 70949108082 scopus 로고    scopus 로고
    • A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease
    • Pfeffer MA, Burdmann EA, Chen CY, et al; TREAT Investigators. A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease. N Engl J Med 2009; 361:2019-2032.
    • (2009) N Engl J Med , vol.361 , pp. 2019-2032
    • Pfeffer, M.A.1    Burdmann, E.A.2    Chen, C.Y.3
  • 56
    • 33644876271 scopus 로고    scopus 로고
    • The effects of maintenance recombinant human erythropoietin therapy on ambulatory blood pressure recordings: conventional, Doppler, and tissue Doppler echocardiographic parameters
    • Kirkpantur A, Kahraman S, Yilmaz R, et al. The effects of maintenance recombinant human erythropoietin therapy on ambulatory blood pressure recordings: conventional, Doppler, and tissue Doppler echocardiographic parameters. Artif Organs 2005; 29:965-972.
    • (2005) Artif Organs , vol.29 , pp. 965-972
    • Kirkpantur, A.1    Kahraman, S.2    Yilmaz, R.3
  • 57
    • 32644457068 scopus 로고    scopus 로고
    • Hemoglobin cycling in hemodialysis patients treated with recombinant human erythropoietin
    • Fishbane S, Berns JS. Hemoglobin cycling in hemodialysis patients treated with recombinant human erythropoietin. Kidney Int 2005; 68:1337-1343.
    • (2005) Kidney Int , vol.68 , pp. 1337-1343
    • Fishbane, S.1    Berns, J.S.2
  • 58
    • 50849110807 scopus 로고    scopus 로고
    • Secondary analysis of the CHOIR trial epoetin-alpha dose and achieved hemoglobin outcomes
    • Szczech LA, Barnhart HX, Inrig JK, et al. Secondary analysis of the CHOIR trial epoetin-alpha dose and achieved hemoglobin outcomes. Kidney Int 2008; 74:791-798.
    • (2008) Kidney Int , vol.74 , pp. 791-798
    • Szczech, L.A.1    Barnhart, H.X.2    Inrig, J.K.3
  • 59
    • 77956704796 scopus 로고    scopus 로고
    • Erythropoietic response and outcomes in kidney disease and type 2 diabetes
    • Solomon SD, Uno H, Lewis EF, et al; Trial to Reduce Cardiovascular Events with Aranesp Therapy (TREAT) Investigators. Erythropoietic response and outcomes in kidney disease and type 2 diabetes. N Engl J Med 2010; 363:1146-1155.
    • (2010) N Engl J Med , vol.363 , pp. 1146-1155
    • Solomon, S.D.1    Uno, H.2    Lewis, E.F.3
  • 60
    • 84884333035 scopus 로고    scopus 로고
    • KDIGO Clinical Practice Guideline for Anemia in Chronic Kidney Disease
    • Kidney Disease: Improving Global Outcomes (KDIGO). KDIGO Clinical Practice Guideline for Anemia in Chronic Kidney Disease. Kidney Int Suppl 2012; 2:279-335.
    • (2012) Kidney Int Suppl , vol.2 , pp. 279-335
  • 63
    • 0030786675 scopus 로고    scopus 로고
    • Reticulocyte hemoglobin content predicts functional iron deficiency in hemodialysis patients receiving rHuEPO
    • Mittman N, Sreedhara R, Mushnick R, et al. Reticulocyte hemoglobin content predicts functional iron deficiency in hemodialysis patients receiving rHuEPO. Am J Kidney Dis 1997; 30:912-922.
    • (1997) Am J Kidney Dis , vol.30 , pp. 912-922
    • Mittman, N.1    Sreedhara, R.2    Mushnick, R.3
  • 64
    • 0034945056 scopus 로고    scopus 로고
    • The role of iron status markers in predicting response to intravenous iron in haemodialysis patients on maintenance erythropoietin
    • Tessitore N, Solero GP, Lippi G, et al. The role of iron status markers in predicting response to intravenous iron in haemodialysis patients on maintenance erythropoietin. Nephrol Dial Transplant 2001; 16:1416-1423.
    • (2001) Nephrol Dial Transplant , vol.16 , pp. 1416-1423
    • Tessitore, N.1    Solero, G.P.2    Lippi, G.3
  • 65
    • 33746568510 scopus 로고    scopus 로고
    • Iron indices: what do they really mean?
    • Coyne DW. Iron indices: what do they really mean? Kidney Int Suppl 2006; 101:S4-S8.
    • (2006) Kidney Int Suppl , vol.101 , pp. S4-S8
    • Coyne, D.W.1
  • 67
    • 33947212276 scopus 로고    scopus 로고
    • Ferric gluconate is highly efficacious in anemic hemodialysis patients with high serum ferritin and low transferrin saturation: results of the Dialysis Patients' Response to IV Iron with Elevated Ferritin (DRIVE) Study
    • Coyne DW, Kapoian T, Suki W, et al; DRIVE Study Group. Ferric gluconate is highly efficacious in anemic hemodialysis patients with high serum ferritin and low transferrin saturation: results of the Dialysis Patients' Response to IV Iron with Elevated Ferritin (DRIVE) Study. J Am Soc Nephrol 2007; 18:975-984.
    • (2007) J Am Soc Nephrol , vol.18 , pp. 975-984
    • Coyne, D.W.1    Kapoian, T.2    Suki, W.3
  • 68
    • 0018726260 scopus 로고
    • Serum erythropoietin concentration in chronic renal failure: relationship to degree of anemia and excretory renal function
    • Radtke HW, Claussner A, Erbes PM, Scheuermann EH, Schoeppe W, Koch KM. Serum erythropoietin concentration in chronic renal failure: relationship to degree of anemia and excretory renal function. Blood 1979; 54:877-884.
    • (1979) Blood , vol.54 , pp. 877-884
    • Radtke, H.W.1    Claussner, A.2    Erbes, P.M.3    Scheuermann, E.H.4    Schoeppe, W.5    Koch, K.M.6
  • 69
    • 0033963497 scopus 로고    scopus 로고
    • Mild renal dysfunction is sufficient to induce erythropoietin deficiency in patients with unexplained anaemia
    • Korte W, Cogliatti SB, Jung K, Riesen W. Mild renal dysfunction is sufficient to induce erythropoietin deficiency in patients with unexplained anaemia. Clin Chim Acta 2000; 292:149-154.
    • (2000) Clin Chim Acta , vol.292 , pp. 149-154
    • Korte, W.1    Cogliatti, S.B.2    Jung, K.3    Riesen, W.4
  • 70
    • 0034919301 scopus 로고    scopus 로고
    • Novel erythropoiesis stimulating protein for treatment of anemia in chronic renal insufficiency
    • Locatelli F, Olivares J, Walker R, et al; European/Australian NESP 980202 Study Group. Novel erythropoiesis stimulating protein for treatment of anemia in chronic renal insufficiency. Kidney Int 2001; 60:741-747.
    • (2001) Kidney Int , vol.60 , pp. 741-747
    • Locatelli, F.1    Olivares, J.2    Walker, R.3
  • 71
    • 79951910286 scopus 로고    scopus 로고
    • Use of darbepoetin alfa in the treatment of anaemia of chronic kidney disease: clinical and pharmacoeconomic considerations
    • Carrera F, Burnier M. Use of darbepoetin alfa in the treatment of anaemia of chronic kidney disease: clinical and pharmacoeconomic considerations. NDT Plus 2009; 2(suppl 1):i9-i17.
    • (2009) NDT Plus , vol.2 , pp. i9-i17
    • Carrera, F.1    Burnier, M.2
  • 72
    • 0034949634 scopus 로고    scopus 로고
    • Development and characterization of novel erythropoiesis stimulating protein (NESP)
    • Egrie JC, Browne JK. Development and characterization of novel erythropoiesis stimulating protein (NESP). Nephrol Dial Transplant 2001; 16(suppl 3):3-13.
    • (2001) Nephrol Dial Transplant , vol.16 , pp. 3-13
    • Egrie, J.C.1    Browne, J.K.2
  • 74
    • 49149113180 scopus 로고    scopus 로고
    • Greater epoetin alpha responsiveness is associated with improved survival in hemodialysis patients
    • Kilpatrick RD, Critchlow CW, Fishbane S, et al. Greater epoetin alpha responsiveness is associated with improved survival in hemodialysis patients. Clin J Am Soc Nephrol 2008; 3:1077-1083.
    • (2008) Clin J Am Soc Nephrol , vol.3 , pp. 1077-1083
    • Kilpatrick, R.D.1    Critchlow, C.W.2    Fishbane, S.3
  • 75
    • 4344581912 scopus 로고    scopus 로고
    • Revised European best practice guidelines for the management of anaemia in patients with chronic renal failure
    • Locatelli F, Aljama P, Barany P, et al; European Best Practice Guidelines Working Group. Revised European best practice guidelines for the management of anaemia in patients with chronic renal failure. Nephrol Dial Transplant 2004; 19(suppl 2):ii1-ii47.
    • (2004) Nephrol Dial Transplant , vol.19 , pp. ii1-ii47
    • Locatelli, F.1    Aljama, P.2    Barany, P.3
  • 76
    • 0035159542 scopus 로고    scopus 로고
    • The role of inflammation in the anaemia of end-stage renal disease
    • Stenvinkel P. The role of inflammation in the anaemia of end-stage renal disease. Nephrol Dial Transplant 2001; 16(suppl 7):36-40.
    • (2001) Nephrol Dial Transplant , vol.16 , pp. 36-40
    • Stenvinkel, P.1
  • 77
    • 0030938145 scopus 로고    scopus 로고
    • High C-reactive protein is a strong predictor of resistance to erythropoietin in hemodialysis patients
    • Barany P, Divino Filho JC, Bergstrom J. High C-reactive protein is a strong predictor of resistance to erythropoietin in hemodialysis patients. Am J Kidney Dis 1997; 29:565-568.
    • (1997) Am J Kidney Dis , vol.29 , pp. 565-568
    • Barany, P.1    Divino Filho, J.C.2    Bergstrom, J.3
  • 78
    • 0035168242 scopus 로고    scopus 로고
    • Hyporesponsiveness to recombinant human erythropoietin
    • Drueke T. Hyporesponsiveness to recombinant human erythropoietin. Nephrol Dial Transplant 2001; 16(suppl 7):25-28.
    • (2001) Nephrol Dial Transplant , vol.16 , pp. 25-28
    • Drueke, T.1
  • 79
    • 0029162846 scopus 로고
    • Cellular mechanism of resistance to erythropoietin
    • Casadevall N. Cellular mechanism of resistance to erythropoietin. Nephrol Dial Transplant 1995; 10(suppl 6):27-30.
    • (1995) Nephrol Dial Transplant , vol.10 , pp. 27-30
    • Casadevall, N.1
  • 80
    • 27144511465 scopus 로고    scopus 로고
    • EPO therapy during acute kidney disease: to use or not to use, that is the question
    • Kraus E, Rabb H. EPO therapy during acute kidney disease: to use or not to use, that is the question. Am J Kidney Dis 2005; 46:967-969.
    • (2005) Am J Kidney Dis , vol.46 , pp. 967-969
    • Kraus, E.1    Rabb, H.2
  • 81
    • 33748861418 scopus 로고    scopus 로고
    • Iron deficiency is a common cause of anemia in chronic kidney disease and can often be corrected with intravenous iron
    • Gotloib L, Silverberg D, Fudin R, Shostak A. Iron deficiency is a common cause of anemia in chronic kidney disease and can often be corrected with intravenous iron. J Nephrol 2006; 19:161-167.
    • (2006) J Nephrol , vol.19 , pp. 161-167
    • Gotloib, L.1    Silverberg, D.2    Fudin, R.3    Shostak, A.4
  • 82
    • 0032915659 scopus 로고    scopus 로고
    • Erythropoietin hyporesponsiveness: from iron deficiency to iron overload
    • Tarng DC, Huang TP, Chen TW, Yang WC. Erythropoietin hyporesponsiveness: from iron deficiency to iron overload. Kidney Int Suppl 1999; 69:S107-S118.
    • (1999) Kidney Int Suppl , vol.69 , pp. S107-S118
    • Tarng, D.C.1    Huang, T.P.2    Chen, T.W.3    Yang, W.C.4
  • 83
    • 0026046922 scopus 로고
    • Modulating factors in the hematopoietic response to erythropoietin
    • Drüeke TB. Modulating factors in the hematopoietic response to erythropoietin. Am J Kidney Dis 1991; 18(suppl 1):87-92.
    • (1991) Am J Kidney Dis , vol.18 , pp. 87-92
    • Drüeke, T.B.1
  • 84
    • 19044392727 scopus 로고    scopus 로고
    • The increased incidence of pure red cell aplasia with an Eprex formulation in uncoated rubber stopper syringes
    • Boven K, Stryker S, Knight J, et al. The increased incidence of pure red cell aplasia with an Eprex formulation in uncoated rubber stopper syringes. Kidney Int 2005; 67:2346-2353.
    • (2005) Kidney Int , vol.67 , pp. 2346-2353
    • Boven, K.1    Stryker, S.2    Knight, J.3
  • 85
    • 79957962714 scopus 로고    scopus 로고
    • Pure red cell aplasia induced only by intravenous administration of recombinant human erythropoietin
    • Shimizu H, Saitoh T, Ota F, et al. Pure red cell aplasia induced only by intravenous administration of recombinant human erythropoietin. Acta Haematol 2011; 126:114-118.
    • (2011) Acta Haematol , vol.126 , pp. 114-118
    • Shimizu, H.1    Saitoh, T.2    Ota, F.3
  • 86
  • 87
    • 15944374753 scopus 로고    scopus 로고
    • Recombinant human erythropoietin and overall survival in cancer patients: results of a comprehensive meta-analysis
    • Bohlius J, Langensiepen S, Schwarzer G, et al. Recombinant human erythropoietin and overall survival in cancer patients: results of a comprehensive meta-analysis. J Natl Cancer Inst 2005; 97:489-498.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 489-498
    • Bohlius, J.1    Langensiepen, S.2    Schwarzer, G.3
  • 88
    • 0142186283 scopus 로고    scopus 로고
    • Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: randomised, double-blind, placebo-controlled trial
    • Henke M, Laszig R, Rübe C, et al. Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: randomised, double-blind, placebo-controlled trial. Lancet 2003; 362:1255-1260.
    • (2003) Lancet , vol.362 , pp. 1255-1260
    • Henke, M.1    Laszig, R.2    Rübe, C.3
  • 89
    • 24944454286 scopus 로고    scopus 로고
    • Maintaining normal hemoglobin levels with epoetin alfa in mainly nonanemic patients with metastatic breast cancer receiving first-line chemotherapy: a survival study
    • Leyland-Jones B, Semiglazov V, Pawlicki M, et al. Maintaining normal hemoglobin levels with epoetin alfa in mainly nonanemic patients with metastatic breast cancer receiving first-line chemotherapy: a survival study. J Clin Oncol 2005; 23:5960-5972.
    • (2005) J Clin Oncol , vol.23 , pp. 5960-5972
    • Leyland-Jones, B.1    Semiglazov, V.2    Pawlicki, M.3
  • 90
    • 0348108097 scopus 로고    scopus 로고
    • Erythropoietin may impair, not improve, cancer survival
    • Brower V. Erythropoietin may impair, not improve, cancer survival. Nat Med 2003; 9:1439.
    • (2003) Nat Med , vol.9 , pp. 1439
    • Brower, V.1
  • 91
    • 0035328802 scopus 로고    scopus 로고
    • Erythropoietin and erythropoietin receptor expression in human cancer
    • Acs G, Acs P, Beckwith SM, et al. Erythropoietin and erythropoietin receptor expression in human cancer. Cancer Res 2001; 61:3561-3565.
    • (2001) Cancer Res , vol.61 , pp. 3561-3565
    • Acs, G.1    Acs, P.2    Beckwith, S.M.3
  • 92
    • 0037479926 scopus 로고    scopus 로고
    • Erythropoietin regulates tumour growth of human malignancies
    • Yasuda Y, Fujita Y, Matsuo T, et al. Erythropoietin regulates tumour growth of human malignancies. Carcinogenesis 2003; 24:1021-1029.
    • (2003) Carcinogenesis , vol.24 , pp. 1021-1029
    • Yasuda, Y.1    Fujita, Y.2    Matsuo, T.3
  • 93
    • 35348839061 scopus 로고    scopus 로고
    • Intravenous methoxy polyethylene glycol-epoetin beta for haemoglobin control in patients with chronic kidney disease who are on dialysis: a randomised non-inferiority trial (MAXIMA)
    • Levin NW, Fishbane S, Cañedo FV, et al; MAXIMA Study Investigators. Intravenous methoxy polyethylene glycol-epoetin beta for haemoglobin control in patients with chronic kidney disease who are on dialysis: a randomised non-inferiority trial (MAXIMA). Lancet 2007; 370:1415-1421.
    • (2007) Lancet , vol.370 , pp. 1415-1421
    • Levin, N.W.1    Fishbane, S.2    Cañedo, F.V.3
  • 94
    • 42549141095 scopus 로고    scopus 로고
    • C.E.R.A. corrects anemia in patients with chronic kidney disease not on dialysis: results of a randomized clinical trial
    • Macdougall IC, Walker R, Provenzano R, et al; ARCTOS Study Investigators. C.E.R.A. corrects anemia in patients with chronic kidney disease not on dialysis: results of a randomized clinical trial. Clin J Am Soc Nephrol 2008; 3:337-347.
    • (2008) Clin J Am Soc Nephrol , vol.3 , pp. 337-347
    • Macdougall, I.C.1    Walker, R.2    Provenzano, R.3
  • 95
    • 70649114857 scopus 로고    scopus 로고
    • Preliminary results from a randomized, single-blind, placebo-controlled trial of FG-4592, a novel hypoxia inducible factor prolyl hydroxylase inhibitor, in subjects with CKD anemia (abstract)
    • Frohna PA, Milwee S, Pinkett J, et al. Preliminary results from a randomized, single-blind, placebo-controlled trial of FG-4592, a novel hypoxia inducible factor prolyl hydroxylase inhibitor, in subjects with CKD anemia (abstract). J Am Soc Nephrol 2007; 18:763.
    • (2007) J Am Soc Nephrol , vol.18 , pp. 763
    • Frohna, P.A.1    Milwee, S.2    Pinkett, J.3
  • 96
    • 85016924015 scopus 로고    scopus 로고
    • Four-week studies of oral hypoxia-inducible factor-prolyl hydroxylase inhibitor GSK1278863 for treatment of anemia
    • Holdstock L, Meadowcroft AM, Maier R, et al. Four-week studies of oral hypoxia-inducible factor-prolyl hydroxylase inhibitor GSK1278863 for treatment of anemia. J Am Soc Nephrol 2016; 27:1234-1244.
    • (2016) J Am Soc Nephrol , vol.27 , pp. 1234-1244
    • Holdstock, L.1    Meadowcroft, A.M.2    Maier, R.3


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