Endothelial-to-mesenchymal transition in lipopolysaccharide-induced acute lung injury drives a progenitor cell-like phenotype

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 310, Issue 11, 2016, Pages L1185-L1198

  Suzuki, Toshio ^a   Tada, Yuji ^a   Nishimura, Rintaro ^a   Kawasaki, Takeshi ^a   Sekine, Ayumi ^a   Urushibara, Takashi ^a   Kato, Fumiaki ^a   Kinoshita, Taku ^a   Ikari, Jun ^a   West, James ^b   Tatsumi, Koichiro ^a  

^a CHIBA UNIVERSITY   (Japan)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Acute lung injury; Cell transformation; Endothelial to mesenchymal transition; Progenitor cells; Reactive oxygen species

Indexed keywords

ALDEHYDE DEHYDROGENASE; ALPHA SMOOTH MUSCLE ACTIN; APOCYNIN; CD133 ANTIGEN; ENDOTOXIN; MULTIDRUG RESISTANCE PROTEIN 1; REACTIVE OXYGEN METABOLITE; STEM CELL FACTOR RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; LIPOPOLYSACCHARIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BONE MARROW; CAPILLARY ENDOTHELIAL CELL; CELL DEDIFFERENTIATION; CELL PROLIFERATION; CELL TRANSFORMATION; CONTROLLED STUDY; DRY WEIGHT; ENDOTHELIAL MESENCHYMAL TRANSITION; ENZYME INHIBITION; FEMALE; HISTOLOGY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LIPOPOLYSACCHARIDE-INDUCED ACUTE LUNG INJURY; LONG TERM EXPOSURE; LUNG ALVEOLUS CELL; LUNG BLOOD VESSEL; LUNG ENDOTHELIUM; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMOOTH MUSCLE CELL; STEM CELL; ACUTE LUNG INJURY; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; CELL TRANSDIFFERENTIATION; ENDOTHELIAL PROGENITOR CELL; GENE EXPRESSION; GENETICS; IMMUNOLOGY; METABOLISM; PATHOLOGY; PHENOTYPE; PHYSIOLOGY; VASCULAR ENDOTHELIUM;

ACUTE LUNG INJURY; ANIMALS; APOPTOSIS; CELL PROLIFERATION; CELL TRANSDIFFERENTIATION; CELLS, CULTURED; ENDOTHELIAL PROGENITOR CELLS; ENDOTHELIUM, VASCULAR; FEMALE; GENE EXPRESSION; LIPOPOLYSACCHARIDES; MICE, INBRED C57BL; NADPH OXIDASE; PHENOTYPE; REACTIVE OXYGEN SPECIES; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2;

EID: 84984611251     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00074.2016     Document Type: Article

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