Organoselenium compounds prevent hyperphosphorylation of cytoskeletal proteins induced by the neurotoxic agent diphenyl ditelluride in cerebral cortex of young rats

Toxicology

Volumn 210, Issue 2-3, 2005, Pages 213-222

  Moretto, M B ^a   Funchal, C ^b   Zeni, G ^a   Rocha, J B T ^a   Pessoa Pureur, R ^b  

^a FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Ebselen; Intermediate filaments; Neuroprotection; Organochalcogens; Organotellurium; Protein phosphorylation

Indexed keywords

CYTOSKELETON PROTEIN; DIPHENYL DISELENIDE; DIPHENYL DITELLURIDE; EBSELEN; GLIAL FIBRILLARY ACIDIC PROTEIN; NEUROFILAMENT PROTEIN; NEUROTOXIN; ORGANOSELENIUM DERIVATIVE; PHOSPHORUS 32; PROTEIN SUBUNIT; TELLURIUM; TELLURIUM DERIVATIVE; TYLOXAPOL; UNCLASSIFIED DRUG; VIMENTIN;

ANIMAL TISSUE; ARTICLE; BRAIN CORTEX LESION; CONCENTRATION RESPONSE; CONTROLLED STUDY; IN VITRO STUDY; NERVE CELL; NERVE CELL LESION; NERVE DEGENERATION; NEUROFILAMENT; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT;

EID: 84984586116     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2005.02.003     Document Type: Article

References (58)

1. B. Alberts, A. Johnson, J. Lewis, M. Raff, K. Roberts, and P. Walter The cytoskeleton B. Alberts A. Johnson J. Lewis M. Raff K. Roberts P. Walter Molecular Biology of the Cell 2002 Garland Science New York 907 982
2. L.M.V. de Almeida, C. Funchal, P.L. Pelaez, F.D.B. Pessutto, S.O. Loureiro, L. Vivian, M. Wajner, and R. Pessoa-Pureur Effect of propionic and methylmalonic acids on the in vitro phosphorylation of intermediate filaments from cerebral cortex of rats during development Metab. Brain Dis. 18 2003 207 219
3. G. Benitez-King, G. Ramirez-Rodriguez, L. Ortiz, and I. Meza The neuronal cytoskeleton as a potential therapeutical target in neurodegenerative diseases and schizophrenia Curr. Drug Targets CNS Neurol. Disord. 3 2004 515 533
4. V.C. Borges, C.W. Nogueira, G. Zeni, and J.B.T. Rocha Organochalcogens affect the glutamatergic neurotransmission in human platelets Neurochem. Res. 29 2004 1505 1509
5. T. Branco, R. Meirelles, B.B. da Rocha, A. de Mattos-Dutra, M. Wajner, and R. Pessoa-Pureur Alpha-ketoisocaproate increases the in vitro 32P incorporation into intermediate filaments in cerebral cortex of rats Neuroreport 11 2000 3545 3550
6. M.Z. Daiber, M. Bachscmid, and V. Ullrich Ebselen as a peroxynitrite scavenger in vitro and ex vivo Biochem. Pharmacol. 59 2000 153 160
7. D.A. Dawson, H. Masayasu, D.I. Graham, and I.M. Macrae The neuroprotective efficacy of ebselen (a glutathione-peroxidase mimic) on brain-damage induced by transient focal cerebral-ischemia in the rat Neurosci. Lett. 185 1995 65 69
8. J. Diaz-Nido, and J. Avila Aluminium induces the in vitro aggregation of bovine brain cytoskeletal proteins Neurosci. Lett. 110 1990 221 226
9. C. Eliasson, C. Sahlgren, C.H. Berthold, J. Stakeberg, J.E. Celis, C. Betsholtz, J.E. Eriksson, and M. Pekny Intermediate filament protein partnership in astrocytes J. Biol Chem. 274 1999 23996 24006
10. L. Engman Expedient synthesis of Ebselen and related compounds J. Org. Chem. 54 1989 2964 2966
11. C. Funchal, P. de Lima Pelaez, S. Oliveira Loureiro, L. Vivian, F. Dall Bello Pessutto, L.M.V. de Almeida, S. Tchernin-Wofchuk, M. Wajner, and R. Pessoa-Pureur α-Ketoisocaproic acid regulates phosphorylation of intermediate filaments in postnatal rat cortical slices through ionotropic glutamatergic receptors Dev. Brain Res. 139 2002 267 276
12. C. Funchal, L.M. de Almeida, S. Oliveira Loureiro, L. Vivian, P. de Lima Pelaez, F. Dall Bello Pessutto, A.M. Rosa, M. Wajner, and R. Pessoa-Pureur In vitro phosphorylation of cytoskeletal proteins from cerebral cortex of rats Brain Res Prot. 11 2003 111 118
13. G. Ghisleni, L.O. Porciuncula, H. Cimarostia, J.B.T. Rocha, C.G. Salbego, and D.O. Souza Diphenyl diselenide protects rat hippocampal slices submitted to oxygen-glucose deprivation and diminishes inducible nitric oxide synthase immunocontent Brain Res. 986 2003 196 199
14. B.G. Gold, and D.R. Austin Regulation of aberrant neurofilament phosphorylation in neuronal perikarya. III. Alterations following single and continuous B,B′iminodipropionitrile administrations Brain Res. 563 1991 151 162
15. W.S. Haller, and K.J. Irgolic Diaryl ditellurides from grignard-reagents and elemental tellurium J. Organomet. Chem. 38 1972 97 103
16. N. Inagaki, K. Tsujimura, J. Tanaka, M. Sekimata, Y. Kamei, and M. Inagaki Visualization of protein kinase activities in single cells by antibodies against phosphorylated vimentin and GFAP Neurochem. Res. 21 1996 795 800
17. K. Iqbal, T. Zaidi, C. Bancher, and I. Grundke-Iqbal Alzheimer paired helical filaments. Restoration of the biological activity by dephosphorylation FEBS Lett. 349 1994 104 108
18. K. Iqbal, A.C. Alonso, E. El-Akkad, C.X. Gong, N. Haque, S. Khatoon, J.J. Pei, I. Tsujio, J.Z. Wang, and I. Grundke-Iqbal Significance and mechanism of Alzheimer neurofibrillary degeneration and therapeutic targets to inhibit this lesion J. Mol. Neurosci. 19 2002 95 99
19. K.F. Jensen, D.M. Lapadula, J. Knoth-Anderson, N. Haykal-Coates, and M.B. Abou-Donia Anomalous phosphorylated neurofilament aggregations in central and peripheral axons of hens treated with tri-o-cresyl phosphate (TOCP) J. Neurosci. Res. 33 1992 455 460
20. L. Klotz, and H. Sies Defenses against peroxynitrite: selenocompounds and flavonoids Toxicol. Lett. 140 2003 125
21. L.O. Klotz, K.D. Kroncke, D.P. Buchczyk, and H. Sies Role of copper, zinc, selenium and tellurium in the cellular defense against oxidative and nitrosative stress J. Nutr. 133 2003 1448S 1451S
22. U.K. Laemmli Cleavage of structural proteins during the assembly of the head of bacteriophage T4 Nature 277 1970 680 685
23. N.J. Lamb, A. Fernandez, J.R. Feramisco, and W.J. Welch Modulation of vimentin containing filament distribution and phosphorylation in living fibroblasts by the cAMP dependent protein kinase J. Cell Biol. 108 1989 2409 2422
24. D.M. Lapadula, R.D. Irwin, E. Suwita, and M.B. Abou-Donia Cross-linking of neurofilament proteins of rat spinal cord in vivo after administration of 2,5-hexanedione J. Neurochem. 46 1986 1843 1850
25. O.H. Lowry, N.J. Rosebrough, A.L. Farr, and R.J. Randall Protein measurement with the Folin phenol reagent J. Biol. Chem. 193 1951 265 267
26. E.N. Maciel, R.C. Bolzan, A.L. Braga, and J.B.T. Rocha Diphenyl diselenide diphenyl ditelluride differentially affect delta-aminolevulinate dehydratase from liver, kidney, and brain of mice J. Biochem. Mol. Toxicol. 14 2000 310 319
27. R. Martin, R. Door, A. Ziegler, W. Warchol, J. Hahn, and D. Breitig Neurofilament phosphorylation and axon diameter in the squid giant fibre system Neuroscience 88 1999 327 336
28. A. Mattos-Dutra de, M.S. de Freitas, N. Schroder, C.S.F. Lisboa, R. Pessoa-Pureur, and M. Wajner In vitro phosphorylation of cytoskeletal proteins in the rat cerebral córtex is decreased by propionic acid Exp. Neurol. 147 1999 238 247
29. F.C. Meotti, V.C. Borges, G. Zeni, J.B.T. Rocha, and C.W. Nogueira Potential renal and hepatic toxicity of diphenyl diselenide, diphenyl ditelluride and ebselen for rats and mice Toxicol. Lett. 143 2003 9 16
30. M.B. Moretto, J.I. Rossato, C.W. Nogueira, C.W. Zeni, and J.B.T. Rocha Voltage-dependent ebselen and diorganochalcogenides inhibition of Ca-45(2+) influx into brain synaptosomes J. Biochem. Mol. Tox. 17 2003 154 160
31. M.B. Moretto, C. Funchal, G. Zeni, R. Pessoa-Pureur, and J.B.T. Rocha Selenium compounds prevent the effects of methylmercury on the in vitro phosphorylation of cytoskeletal proteins in cerebral cortex of young rats Toxicol. Sci. 84 2005 1 8
32. A. Muller, E. Cadenas, P. Graf, and H. Sies A novel biologically active seleno-organic compound-I glutathione peroxidase-like activity in vitro and antioxidant capacity of PZ 51 (Ebselen) Biochem. Pharmacol. 15 1984 3235 3239
33. C.W. Nogueira, L.N. Rotta, M.L. Perry, D.O. Souza, and J.B.T. Rocha Diphenyl diselenide and diphenyl ditelluride affect the rat glutamatergic system in vitro and in vivo Brain Res. 906 2001 157 163
34. C.W. Nogueira, F.C. Meotti, E. Curte, C. Pilissão, G. Zeni, and J.B.T. Rocha Investigations into the potential neurotoxicity induced by diselenides in mice and rats Toxicology 183 2003 29 37
35. C.W. Nogueira, E.B. Quinhones, E.A.C. Jung, G. Zeni, and J.B.T. Rocha Evidence for anti-inflamatory and antinociceptive of diphenyl diselenide Inflamm. Res. 52 2003 56 63
36. C.W. Nogueira, G. Zeni, and J.B.T. Rocha Organoselenium and organotellurium compounds: toxicology and pharmacology Chem. Rev. 104 2004 255 285
37. C.W. Nogueira, L.N. Rotta, G. Zeni, D.O. Souza, and J.B.T. Rocha Exposure to ebselen changes glutamate uptake and release by rat brain synaptosomes Neurochem. Res. 27 2002 283 288
38. J.P. O'Callaghan A potential role for altered protein phosphorylation in the mediation of developmental neurotoxicity Neurotoxicology 15 1994 29 40
39. M. Parnham, and H. Sies Ebselen:prospective therapy for cerebral ischaemia Expert Opin. Investig. Drugs 9 2000 607 619
40. C. Paulmier Selenium Reagents and Intermediates in Organic Synthesis 1986 Pergamon Press New York p. 463
41. R.G. Pearson, H. Sobel, and J. Songstad Nucleophilic reactivity constants toward methyl iodide and trans-[PT(PY)2CL2] J. Am. Chem. Soc. 90 1968 319 326
42. N. Petragnani Tellurium in Organic Synthesis 1994 Academic Press San Diego p. 248
43. R.S. Pollenz, and K.D. McCarthy Analysis of cyclic AMP-dependent changes in intermediate filament protein phosphorylation and cell morphology in cultured astroglia J. Neurochem. 47 1986 9 17
44. L. Porciuncula, O. Rocha, J.B.T. Boeck, C.R. Vendite, and D.O Souza Ebselen prevents excitotoxicity provoked by glutamate in rat cerebellar granule neurons Neurosci. Lett. 299 2001 217 220
45. L.O. Porciuncula, J.B.T. Rocha, H. Cimarosti, L. Vinade, G. Ghisleni, C.G. Salbego, and D.O. Souza Neuroprotective effect of ebselen on rat hippocampal slices submitted to oxygen-glucose deprivation: correlation with immunocontent of inducible nitric oxide synthase Neurosci. Lett. 346 2003 101 104
46. K. Reagan, M.A. Wilmarth, M.B. Friedman, and Abou-Donia In vitro calcium and calmodulin-dependent kinase-mediated phosphorylation of rat brain and spinal cord neurofilament proteins is increased by glycidamide administration Brain Res. 671 1995 12 20
47. J.I. Rossato, G. Zeni, C.F. Mello, M.E. Rubin, and J.B.T. Rocha Ebselen blocks the quinolinic acid-induced production of thiobarbituric acid reactive species but does not prevent the behavioral alterations produced by intra-striatal quinolinic-acid administration in the rat Neurosci. Lett. 318 2002 137 140
48. J.I. Rossato, L.A. Ketzer, F.B. Centuriao, S.J.N. Silva, D.S. Ludtke, G. Zeni, A.L. Braga, M.A. Rubin, and J.B.T. Rocha Antioxidant properties of new chalcogenides against lipid peroxidation in rat brain Neurochem. Res. 27 2002 297 303
49. T.B. Shea, J.F. Clarke, T.R. Wheelock, P. Paskevich, and R. Nixon Aluminium salts induce the accumulation of neurofilaments in perikarya of NB2a/d1 neuroblastoma Brain Res. 181 1989 263 272
50. Stangherlin, E.C., Favero-Junior, A., Zeni, G., Rocha, J.B.T., Nogueira, C.W., in press Teratogenic vulnerability of rat fetuses to diphenyl ditelluride: prenatal assessment. Toxicology 207, 231-239.
51. B.B. Walbran, and E. Robins Effects of central nervous system accumulation of tellurium on behavior in rats Pharmacol. Biochem. Behav. 9 1978 297 300
52. D.F. Watson, F.N. Nachtman, R.W. Kuncl, and J.W. Griffin Altered neurofilament phosphorylation and beta tubulin isotypes in Charcot-Marie-Tooth disease type 1 Neurology 44 1994 2383 2387
53. E. Widy-Tyszkiewicz, A. Piechal, B. Gajkowska, and M. Smialek Tellurium-induced cognitive deficits in rats are related to neuropathological changes in the central nervous system Toxicol. Lett. 131 2002 203 214
54. +2/calmodulin-dependent kinase phosphorylation of cytoskeletal proteins in the rat central nervous system Brain Res. 628 1993 293 300
55. T. Yamaguchi, K. Sano, K. Takakura, I. Saito, Y. Shinohara, T. Asano, and H. Yasuhara Ebselen in acute ischemic stroke: a placebo-controlled, double-blind clinical trial Stroke 29 1998 12 17
56. G.R. Zeni, H. Formiga, and J.V. Comasseto Improved procedure for the hydrotelluration of alkynes Tetrahedron Lett. 41 2000 1311 1313
57. G.R. Zeni, O. Barros, S. Do Rego, A.V. Moro, A.L. Braga, and C. Peppe Hydroteluration of Aminoalkynes Chem. Commun. 11 2003 1258 1259
58. G.R. Zeni, M.P. Stracke, C.W. Nogueira, A.L. Braga, P.H. Menezes, and H.A. Stefani Hydroselenation of alkynes by lithium butylselenolate: an approach in the syntheis of vinylic selenides Org. Lett. 6 2004 1135 1138