Investigations into the mechanism of 2,3-dimercaptopropanol neurotoxicity

Neurochemical Research

Volumn 25, Issue 12, 2000, Pages 1553-1558

  Nogueira, C W ^a,b   Soares, F A ^a   Bolzan, R C ^a   Jacques Silva, M C ^a   Souza, D O ^b   Rocha, J B T ^a  

^a FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

^b FEDERAL UNIVERSITY OF RIO GRANDE   (Brazil)

Author keywords

2,3 Dimercaptopropanol; Glutamatergic and GABAergic systems; Muscimol; Seizures

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; ATROPINE; BACLOFEN; CARBAMAZEPINE; CATION CHANNEL; DIAZEPAM; DIMERCAPROL; DIZOCILPINE; GLUTAMATE RECEPTOR; GLUTAMIC ACID; GUANOSINE PHOSPHATE; MUSCIMOL; NIFEDIPINE; PHENOBARBITAL; PHENOTHIAZINE; VALPROIC ACID; ZINC CHLORIDE;

ANIMAL TISSUE; ARTICLE; MALE; MOUSE; NEUROTOXICITY; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; SEIZURE; SURVIVAL TIME; TISSUE LEVEL;

ANIMALIA;

EID: 84984577712     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1026658217907     Document Type: Article

References (50)

1. Risk-factors for encephalopathy and mortality during melarsoprol treatment of Trypanosoma-Brucel-Gambiense sleeping sickness
2. Topical chemotherapy for experimental murine African CNS-trypanosomiasis: The successful use of the arsenical, melarsoprol, combined with the 5-nitroimidazoles, fexinidazole or MK-436
3. Topical chemotherapy for experimental African trypanosomiasis with cerebral involvement: The use of melarsoprol combined with the 5-nitroimidazole, megazol
4. Controlled study of meso-2,3-dimercaptosuccinic acid for the management of childhood lead intoxication
5. Human studies with the chelating agents, DMPS and DMSA
6. The pharmacology of mercury compounds
7. Mercury-An element of mystery
8. Mercury kinetics in a case of severe mercuric chloride poisoning treated with dimercapto-1-propane sulphonate (DMPS)
9. Sodium 2,3-dimercapto-1-propanesulfonate (DMPS) treatment does not redistribute lead or mercury to the brain of rats
10. Treatment of mercury and lead poisonings with dimercaptosuccinic acid and sodium dimercaptopropanesulfonate
11. Aminolevulinate dehydratase inhibition by 2,3-dimercaptopropanol is mediated by chelation of zinc from a site involved in maintaining cysteinyl residues in a reduced state
12. BAL increases the arsenic-74 content of rabbit brain
13. DMSA and DMPS-water soluble antidotes for heavy metals poisoning
14. Eccitazione centrale da molecole a struttura tiolica
15. Selective modulation of NMDA responses by reduction and oxidation
16. Oxigen free-radicals regulate NMDA receptor function via a redox modulatory site
17. Identification of two cysteine residues that are required for redox modulation of the NMDA subtype of glutamate receptor
18. A possible role of glutathione as an endogenous agonist at the N-methyl-d-Aspartate recognition domain in rat brain
19. 2+ antagonize NMDA GABA responses of hippocampal-neurons
20. Zinc selectively blocks the action of N-Methyl-D-Aspartate on cortical-neurons
21. Effect of zinc on NMDA receptor-mediated channel currents in cortical-neurons
22. Isolation of synaptic plasma membrane from brain by combined flotation-sedimentation density gradient centrifugation
23. The prooxidant effect of 5-aminolevulinic acid in the brain tissue of rats: Implications in neuropsychiatric manifestations in porphyrias
24. Protein measurement with the Folin phenol reagent
25. A· receptor pharmacology
26. The novel anticonvulsam MK-801 binds to the activated state of the N-methyl-D-aspartate receptor in rat brain
27. Comparative anticonvulsant and mechanistic profile of the estabilished and newer antiepileptic drugs
28. Effects of the antiepileptic drug valproate on metabolism and function of inhibitory and excitatory amino-acids in the brain
29. Contribution of nicotinic receptors to the function of synapses in the central nervous system: The action of choline as a selective agonist of alpha 7 receptors
30. Terfenadine: A review of its pharmacodynamic properties and therapeutic efficacy
31. 2+ channel blockade and the antielectroshock activity of NMDA receptor antagonists, CPG 40116 and CPG 43487, in mice
32. GABA B receptor pharmacology
33. Guanosine and GMP prevent seizures induced by quinolinic acid in mice
34. Guanine nucleotides are competitive inhibitors of N-methyl-D-aspartate at its receptor site both in vitro and in vivo
35. Differential effects of guanine nucleotides on kainic acid binding and on adenylate cyclase in chick optic tectum
36. Effects of guanine nucleotides on glutamate-induced chemiluminescence of hippocampal slices submitted to hypoxia
37. Guanine nucleotides inhibit the stimulation of GFAP phosphorylation by glutamate
38. Tissue sulphydryl groups
39. Diphenyl diselenide and ascorbic acid changes deposition of selenium and ascorbic acid in liver and brain of mice
40. Effect of mercuric chloride intoxication and dimercaprol treatment on δ-aminolevulinate dehydratase from brain, liver and kidney of adult mice
41. Mechanisms of action of antiepiletic drugs
42. Clinical significance of animal seizure models and mechanism of action studies of potential antiepileptic
43. Micromolar concentrations of Zn antagonize NMDA and GABA responses of hippocampal neurons
44. Molecular diversity of the NMDA receptor channel
45. Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs
46. Zinc has opposite effects on NMDA and non-NMDA receptors expressed in Xenopus oocytes
47. Zinc and brain injury
48. 2+ fluxes
49. Differential modulation by sulphydryl redox agents and glutathione of GABA-evoked and Glycine-evoked currents in rat retinal ganglion-cells