The prooxidant effect of 5-aminolevulinic acid in the brain tissue of rats: Implications in neuropsychiatric manifestations in porphyrias

Free Radical Biology and Medicine

Volumn 20, Issue 3, 1996, Pages 291-299

  Demasi, Marilene ^a   Penatti, Carlos A A ^a   DeLucia, Roberto ^a   Bechara, Etelvino J H ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

5 Aminolevulinic acid; Free radicals; GABAergic receptors; Iron metabolism; Lead poisoning; Oxidative brain damage; Porphyrias; Reactive oxygen species

Indexed keywords

AMINOLEVULINIC ACID; FERRITIN; FREE RADICAL; GABAERGIC RECEPTOR AFFECTING AGENT; MUSCIMOL; RADIOLIGAND; REACTIVE OXYGEN METABOLITE; THIOBARBITURIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN TISSUE; CATALYSIS; DOPAMINERGIC TRANSMISSION; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; IRON METABOLISM; LEAD POISONING; NEUROPSYCHIATRY; NONHUMAN; OXIDATIVE STRESS; PORPHYRIA; PRIORITY JOURNAL; PSYCHOMOTOR ACTIVITY; RAT; SEROTONINERGIC NERVE CELL;

ANIMALIA; TRIXIS;

EID: 0029929578     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/0891-5849(95)02035-7     Document Type: Article

References (49)

1. Hindmarsch, J. T. The porphyrias: recent advances. Clin. Chem. 32:1255-1263; 1986.
2. Medeiros, M. H. G.; Marchiori, P.; Bechara, E. J. H. Superoxide dismutase, glutathione peroxidase and catalase activities in the erythrocytes of patients with intermittent acute porphyria. Clin. Chem. 28:242; 1982.
3. Hermes-Lima, M.; Valle, V. G. R.; Vercesi, A. E.; Bechara, E. J. H. Damage to rat liver mitochondria promoted by δ-aminolevulinic acid-generated reactive oxygen species: Connections with acute intermittent porphyria and lead-poisoning. Biochem. Biophys. Acta 1056:57-63; 1991.
4. Hermes-Lima, M.; Castilho, R. P.; Valle, V. G. R.; Bechara, E. J. H.; Vercesi, A. E. Calcium-dependent mitochondrial oxidative damage promoted by 5-aminolevulinic acid. Biochem. Biophys. Acta 1180:201-206; 1992.
5. Pereira, B.; Curi, R.; Kokubun, E.; Bechara, E. J. H. 5-Aminolevulinic acid-induced alterations of oxidative metabolism in sedentary and exercise-trained rats. J. Appl. Physiol. 72:226-230; 1992.
6. Oteiza, P.; Bechara, E. J. H. 5-Aminolevulinic acid induces lipid peroxidation in cardiolipin-rich liposomes. Arch. Biochem. Biophys. 305:282-287; 1993.
7. 2+ ions. Biochem. Biophys. Acta 1225:259-263; 1993.
8. Fraga, C. G.; Onuki, J.; Lucesoli, F.; Bechara, E. J. H.; Di Mascio, P. 5-Aminolevulinic acid mediates the in vivo and in vitro formation of 8-hydroxy-2′-deoxyguanosine in DNA. Carcinogenesis 15:2241-2244; 1994.
9. 2+ ions and membrane protein thiols. Biochim. Biophys. Acta 1188:86-92; 1994.
10. Monteiro, H. P.; Abdalla, D. S. P.; Faljoni-Alário, A.; Bechara, E. J. H. Generation of active oxygen species during coupled autoxidation of oxyhemoglobin and δ-aminolevulinic acid. Biochem. Biophys. Acta 881:101-106; 1986.
11. Monteiro, H. P.; Abdalla, D. S. P.; Augusto, O.; Bechara, E. J. H. Free radical generation during δ-aminolevulinic acid autoxidation: Induction by hemoglobin and connections with porphyrinpathies. Arch. Biochem. Biophys. 271:206-216; 1989.
12. Minotti, G. The role of an endogenous nonheme iron in microsomal redox reactions. Arch. Biochem. Biophys. 297:189-198; 1992.
13. Oteiza, P. I.; Kleinman, C. G.; Demasi, M.; Bechara, E. J. H. 5-Aminolevulinic acid induces iron release from ferritin. Arch. Biochem. Biophys. 316:314-317; 1995.
14. Gorshein, A.; Weber, R. δ-Aminolevulinic acid in plasma, cerebrospinal fluid, saliva and erythrocytes: Studies in normal, uraemic and porphyric subjects. Clin. Sci. 72:103-112; 1984.
15. Minder, E. I. Measurement of 5-aminolevulinic acid by reversed phase HPLC and fluorescence detection. Clin. Chem. Acta 161:11-18; 1986.
16. Brennan, M. J. W.; Cantrill, R. C. δ-Aminolevulinic acid is a potent agonist for GABA autoreceptors. Nature 280:514-515; 1979.
17. 3H]GABA in rat brain synaptosomes. J. Neurochem. 32:1781-1786; 1979.
18. Brennan, M. J. W.; Cantrill, R. C.; Kramer, S. Effect of δ-aminolevulinic acid on GABA receptor binding in synaptic plasma membranes. Int. J. Biochem. 12:833-835; 1980.
19. Fraga, C. G.; Leibovitz, B. E.; Tappel, A. L. Lipid peroxidation measured as thiobarbituric acid-reactive substances in tissue slices: Characterization and comparison with homogenates and microsomes. Free Radic. Biol. Med. 4:155-161; 1988.
20. Recknagel, R. O.; and Glende, E. A., Jr. Spectrophotometric detection of lipid conjugated dienes. Methods Enzymol. 105:331-337; 1984.
21. Chen, P. S., Jr.; Toribara, T. Y.; Warner, H. Microdetermination of phosphorus. Anal. Chem. 28:1756-1758; 1956.
22. Levine, R. L.; Garland, D.; Oliver, C. N.; Amici, A.; Climent, I.; Lenz, A. G.; Ahn, B. W.; Shalfiel, S.; Stadtman, E. R. Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol. 186:465-478; 1990.
23. Murphy, M. E.; Kehrer, J. P. Oxidation state of tissue thiol groups and content of protein carbonyl groups in chickens with inherited muscular dystrophy. Biochem. J. 260:359-364; 1989.
24. Bralet, J.; Schreiber, L.; Bouvier, C. Effects of acidosis and anoxia on iron delocalization from brain homogenates. Biochem. Pharmacol 43:979-983; 1992.
25. Dexter, D. T.; Carayon, A.; Vidailhet, M.; Ruberg, M.; Agid, F.; Agid, Y.; Lees, A. J.; Well, F. R.; Jenner, P.; Marsden, C. D. Decreased ferritin levels in brain in Parkinson's disease. J. Neurochem. 55:16-20; 1990.
26. Maral, J.; Puget, K.; Michelson, A. M. Comparative study of superoxide dismutase, catalase and glutathione peroxidase levels in erithrocytes of different animals. Biochem. Biophys. Res. Commun. 77:1525-1535; 1977.
27. Marklund, L. S. Direct assay with potassium superoxide. In: Greenwald, R. A., ed. Handbook of methods for radical research. Boca Raton, FL: CRC Press; 1985.
28. Zukin, S. R.; Young, A. B.; Snyder, S. H. Gamma-aminobutiric acid binding to receptor sites in the rat central nervous system. Proc. Natl. Acad. Sci. USA 71:4802-4807; 1974.
29. 3H]dopamine binding associated with dopamine receptors in calf brain membranes. Mol. Pharmacol. 12:800-812; 1976.
30. 3H]spiroperidol.
31. Bylund, D. B.; Yamamura, H. I. Methods for receptor binding. In: Yamamura, H. I., ed. Method for receptor binding. New York: Raven Press; 1988:1-35.
32. Cotman, C. W.; Matthews, D. A. Synaptic plasma membranes from rat brain synaptosomes: Isolation and partial characterization. Biochem. Biophys. Acta 240:380-395; 1971.
33. Braughler, J. M. Calcium and lipid peroxidation. In: Halliwell, B., ed. Proceedings of the UpJohn Symposium. Michigan: Augusta; 1987:99-104.
34. Nachshein, D. A. Regulation of cytosolic calcium concentration in presynaptic nerve endings isolated from rat brain. J. Physiol. 363:87-101; 1985.
35. Lowry, O. H.; Rosebrough, N. J.; Farr, A. L.; Randall, R. J. Protein measurement with the Polin phenol reagent. J. Biol. Chem. 193:265-275; 1951.
36. McGillion, F. B.; Thompson, G. G.; Goldberg, A. Tissue uptake of δ-aminolevulinic acid. Biochem. Pharmacol. 24:299-301; 1974.
37. Addison, G. M.; Beamish, M. R.; Hales, C. N.; Hodkins, M.; Jacobs, A.; Llewellin, P. An immunometric assay for ferritin in the serum of normal subjects and patients with iron deficiency and iron overload. J. Clin. Pathol. 25:326-329; 1972.
38. Cook, J. D.; Lipschitz, D. A.; Miles, L. M. E.; Finch, L. A. Serum ferritin as a measure of iron stores in normal subjects. Am. J. Clin. Nutr. 27:681-687; 1974.
39. Janero, D. R. Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and lipoperoxidative tissue injury. Free Radic. Biol. Med. 9:515-540; 1990.
40. Porter, N. A. Chemistry of lipid peroxidation. Methods Enzymol. 105:273-282; 1984.
41. Tomokumi, K.; Ogata, M. Simple method for determination of urinary δ-aminolevulinic acid as index of lead exposure. Clin. Chem. 18:1534-1536; 1972.
42. Orrenius, S.; Burkitt, M. J.; Kass, G. E. N.; Dypbukt, J. M.; Nicotera, P. Calcium ions and oxidative cell injury. Ann. Neurol. 32:S33-S42; 1992.
43. Van Der Vleit, A.; Bast, A. Effect of oxidative stress on receptors and signal transmission. Chem. Biol. Int. 85:95-116; 1992.
44. White, E. J.; Clark, J. B. Menadione-treated synaptosomes as a model for post-ischemic neuronal damage. Biochem. J. 253:425-433; 1988.
45. Khun, L. C.; Hentze, M. W. Coordination of cellular iron metabolism by post-transcriptional gene regulation. J. Inorg. Chem. 47:183-193; 1992.
46. Klausner, R. D.; Roualt, T. A.; Harford, J. B. Regulating the fate of mRNA: The control of cellular iron metabolism. Cell 72:19-28; 1993.
47. Biempica, L.; Kosower, N.; Ma, M. H.; Goldfisher, S. Cytochemical and ultrastructural studies of liver in acute intermittent porphyria and porphyria cutanea tarda. Arch. Pathol. 98:336-343; 1974.
48. Hill, J. M.; Switzer, R. C. The regional distribution and cellular localization of iron in the rat brain. Neuroscience 11:595-603; 1984.
49. Granick, S.; Beale, S. I. Hemes, chlorophills and related compounds: Biosynthesis. Adv. Enzymol. 46:33-203; 1978.