Effect of mercuric chloride intoxication and dimercaprol treatment on δ-Aminolevulinate dehydratase from brain, liver and kidney of adult-mice

Pharmacology and Toxicology

Volumn 79, Issue 3, 1996, Pages 136-143

  Emanuelli, T ^a,b   Rocha, J B T ^a   Pereira, M E ^a   Porciuncula, L O ^a   Morsch, V M ^a   Martins, A F ^a   Souza, D O G ^b  

^a FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

DIMERCAPROL; MERCURIC CHLORIDE; PORPHOBILINOGEN SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG EFFECT; ENZYME ACTIVITY; MERCURIALISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; TISSUE LEVEL; TISSUE SPECIFICITY;

ANIMALIA;

EID: 84984578359     PISSN: 09019928     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0773.1996.tb00257.x     Document Type: Article

References (46)

1. Aaseth, J. & J. Alexander: Treatment of mercuric chloride poisoning with dimercaptosuccinic acid and diuretics: preliminary studies. J. Toxicol. Clin. Toxicol. 1982, 19, 173-186.
2. Andersen, O.: Oral cadmium exposure in mice: Toxicokinetics and efficiency of chelating agents. CRC Crit. Rev. Toxicol. 1989, 20, 83-112.
3. Anner, B. M., M. Moosmayer & E. Imesh: Chelation of mercury by ouabain-sensitive and ouabain resistant renal (sodium, potassium)-ATPase. Biochem. Biophys. Res. Commun. 1990, 167, 1115-1121.
4. Barron, E. S. G., Z. B. Miller & G. Kalnitsky: The oxidation of dithiols. Biochem. J. 1947, 41, 62-68.
5. Bechara, E. J. H., M. H. G. Medeiros, H. P. Monteiro, M. Hermes-Lima, B. Pereira, M. Demasi, C. A. Acosta, D. S. P. Abdalla, J. Onuki, C. A. M. Wendel & P. Di Mascio: A free radical hypothesis of lead poisoning and inborn porphyries associated with 5-aminolevulinic acid overload. Química Nova. 1993, 16, 385-392.
6. Berlin, M. (1986). Mercury. In: Amsterdam. Vol II. Eds: L. Friberg, G. F. Nordberg and V. B. Vouk. Handbook on the Toxicology of Metals, Elsevier, 1986, pp. 387-335.
7. Bradford, M.: A rapid and sensitive method for quantitation of microgram quantities of protein utilising the principle of protein-dye binding. Anal. Biochem. 1976, 72, 248-254.
8. Cantilena, L. R., Jr. & C. D. Klaassen: Comparison of effectiveness of several chelators after single administration on the toxicity, excretion and distribution of cadmium. Toxicol. Appl. Pharmacol. 1981, 58, 452-460.
9. Chisolm, J. J.: Poisoning due to heavy metals. Pediat. Clin. North. Amer. 1970, 17, 591-615.
10. Clarkson, T. W.: The pharmacology of mercury compounds. Annu. Rev. Pharmacol. 1972, 12, 375-406.
11. Clarkson, T. W.: Molecular targets of metal toxicity. In: Chemical toxicology and clinical chemistry of metals. Eds: Stanley S. Brown and John Savory Academic Press, London, 1983, pp. 211-226.
12. Cornell, N. W. & K. E. Crivaro: Stability constant for the zinc-dithiothreitol complex. Anal. Biochem. 1972, 47, 203-208.
13. Dixon, M. & E. C. Webb: Enzymes, 2nd Ed. Longmans, London and Colchester, 1964, pp. 950.
14. Daston, G. P., R. J. Kavlock, E. H. Rogers & B. Carver: Toxicity of mercuric chloride to the developing rat kidney I. Post natal ontogeny of rat sensitivity. Toxicol. Appl. Pharmacol. 1983, 71, 24-41.
15. Ellenhorn M. J. & D. G. Barceloux: Metals and related compounds. In: Medical toxicology. New York: Elsevier, 1988, pp. 1005-1065.
16. Endo, T. & M. Sakata: Effects of sulfhydryl compounds on the accumulation, removal and cytotoxicity of inorganic mercury by primary cultures of rat renal cortical epithelial cells. Pharmacology. Toxicology. 1995, 76, 190-195.
17. Gibson, K. D., A. Neuberger & J. J. Scott: The purification and properties of delta-aminolevulinic acid dehydratase. Biochem. J. 1955, 61, 618-629.
18. Gilman, A., E. S. Philips, R. P. Allen & E. S. Koelle: The treatment of acute cadmium intoxication in rabbits with 2,3-dimercaptopropanol (dimercaprol) and other mercaptans. J. Pharmacol. Exp. Therap. 1946, 87, 85-101.
19. Hellström-Lindahl, E. & A. Oskarsson: Cellular response after mobilisation of metals by diethyldithiocarbamate in rat hepatocyte cultures. Toxicology 1990, 65, 23-32.
20. Hilmy, A. M., N. A. El-Domiaty, M. A. Kamai, M. A. Mohamed & W. E. Abou Samra: Effect of some arsenic antagonists on the toxicity, distribution and excretion of arsenite and arsenate in rats. Comp. Biochem. Physiol. 1991, 99C, 357-362.
21. Hoover, T. D. & H. V. Aposhian: Dimercaprol increases the arsenic-74 content of rabbit brain. Toxicol. Appl. Pharmacol. 1983, 70, 160-162.
22. Kazantzis, G.: Diagnosis and treatment of metal poisoning general aspects. In: Handbook on the toxicology of metals. Eds: L. Friberg, G. F. Nordberg, & V. B. Vouk, Elsevier, Amsterdam: 1986, pp. 309-311.
23. Kiyozumi, M., H. Shimada, T. Honda & S. Kojima: Studies on poisonous metals. XIX. Comparative effects of chelating agents on distribution and excretion of inorganic mercury in rats. Chem. Pharm. Bull. 1988, 36, 2599-2606.
24. Klaassen, C. D.: Heavy metals and heavy-metal antagonists. In: The pharmacological basis of therapeutics. Eds.: A. G. Gilman, T. W. Rall, A. S. Nies, & P. Taylor, Pergamon Press, New York 1990, pp. 1592-1614.
25. Kojima, S., H. Shimada & M. Kiyozumi: Comparative effects of chelating agents on distribution, excretion and renal toxicity of inorganic mercury in rats. Res. Commun. Chem. Pathol. Pharmacol. 1989, 64, 471-484.
26. Litchfield Jr., J. T. & F. Wilcoxon: A simplified method of evaluating dose-effect experiments. J. Pharmacol. Exp. Therap. 1949, 96, 99-113.
27. Lorscheider, F. L., J. V. Murray, A. O. Summers & H. Zwiers: The dental amalgam controversy inorganic mercury and the CNS: genetic linkage of mercury and antibiotic resistance in intestinal bacteria. Toxicology 1995, 97, 19-22.
28. Magos, L., S. Sparrow & R. Snowden: The comparative renotoxicology of phenylmercury and mercuric chloride. Arch. Toxicol. 1982, 50, 133-139.
29. Miller, D. M. & J. S. Woods: Redox activities of mercury-thiol complexes: implications for mercury-induced porphyria and toxicity. Chem. Biol. Interactions 1993, 88, 23-35.
30. Misra, H. P.: Generation of superoxide free radical during the autoxidation of thiols. J. Biol. Chem. 1974, 249, 2151-2155.
31. Møller-Madsen, B.: Localization of mercury in CNS of the rat. An autometallografic study. Pharmacology & Toxicology. 1994, 75, (suppl.), 2-41.
32. Nielsen, J. B. & O. Andersen: Oral mercuric chloride exposure in mice: Effects of close on intestinal absorption and relative organ distribution. Toxicology 1989, 59, 1-10.
33. Nielsen, J. B. & O. Andersen: Disposition and retention of mercuric chloride in mice after oral and parenteral administration. J. Toxicol. Environ. Health 1990, 30, 167-180.
34. Nielsen, J. B. & O. Andersen: Effect of four thiol-containing chelators on disposition of orally administered mercuric chloride. Human & Exp. Toxicol. 1991, 10, 423-430.
35. Oskarsson, A.: Effects of perinatal treatment with lead and dissufiram on ALA-D activity in blood, liver and kidney and urinary ALA excretion in rats. Pharmacology & Toxicol. 1989, 64, 344-348.
36. Pereira, B., R. Curi, E. Kokubun & E. J. H. Bechara: 5-Aminolevulinic acid-induced alterations of oxidative metabolism in sedentary and exercise-trained rats. J. Appl. Physiol. 1992, 72, 226-230.
37. Putzer, R. R., Y. Zhang, T. Prestera, W. D. Holtzelaw, K. L. Wade & P. Talalay: Mercurials and dimercaptans: Synergism in the induction of chemoprotective enzymes. Chem. Res. Toxicol. 1995, 8, 103-110.
38. Rocha, J. B. T., A. J. Freitas, M. B. Marques, M. E. Pereira, T. Emanuelli & D. O. Souza: Effects of methylmercury exposure during the second stage of rapid post-natal brain growth on negative geotaxis and on delta-aminolevulinate dehydratase of suckling rats. Brazilian J. Med. Biol Res. 1993, 26, 1077-1083.
39. Rocha, J. B. T., M. E. Pereira, T. Emanuelli, R. S. Christofari & D. O. Souza: Effect of treatment with mercuric chloride and lead acetate during the second stage of rapid post-natal brain growth on ALA-D activity in brain, liver and blood of suckling rats. Toxicology 1995, 100, 27-37.
40. Sassa, S.: Delta-aminolevulinic acid dehydratase assay. Enzyme 1982, 28, 133-145.
41. Sassa, S., H. Fujita & A. Kappas: Genetic and chemical influences on heme biosynthesis. In: Eds: Highlights of Modern Biochemistry VSP, Utrecht, A. Kotyk, J. Skoda, V. Paces and V. Kostka 1989, Vol. 1, pp. 329-338.
42. Schwartz, J. G., T. E. Snider & M. M. Montiel: Toxicity of a family from vacuumed mercury. Amer. J. Emerg. Med. 1992, 10, 258-261.
43. Singer, A. J., H. C. Mofenson, T. R. Caraccio & J. Ilasi: Mercuric chloride poisoning due to ingestion of a stool fixative. J. Toxicol. Clin. Toxicol. 1994, 32, 577-582.
44. 113Cd-nmr-studies. J. Inorg. Biochem. 1984, 20, 131-145.
45. Tarui, S.: Studies on zinc metabolism. Med. J. Osaka Univ. 1960, 10, 499-505.
46. Tsukamoto, I., T. Yoshinaga & S. Sano: The role of zinc with special reference to the essential thiol groups in delta- aminolevulinic acid dehydratase of bovine liver. Biochim. Biophys. Acta. 1979, 570, 167-178.